Click here to switch to the map view.

The map label for this gene is adk

Identifier: 154248694

GI number: 154248694

Start: 5302460

End: 5303047

Strand: Reverse

Name: adk

Synonym: Xaut_4777

Alternate gene names: 154248694

Gene position: 5303047-5302460 (Counterclockwise)

Preceding gene: 154248695

Following gene: 154248693

Centisome position: 99.89

GC content: 68.03

Gene sequence:

>588_bases
ATGAGGCTGGTGCTGCTCGGGCCGCCCGGGGCGGGTAAGGGAACCCAGGCACAACGGCTGGTCGCCCGTCATGGGATCGT
CCAGCTCTCCACCGGCGACATGCTGCGCGCCGCCGTGGCCGCCGGTACACCGGTGGGCCTGAAGGCGAAGGCGGTCATGG
ATGCCGGCGGCCTCGTCTCCGACGAGATCGTGATCGGCATCATCGCCGAGCGCCTCGATTCGCCGGATGCGAAGAACGGC
TTCATCCTGGATGGCTTCCCGCGCACGGTGGCGCAGGCCGAGGCCCTCGACCAGCTCCTTGCCAGCAAGGGCCTCAAGCT
CGATGCGGTGATCGAGCTGGTGGTGGATCAGGAGAAGCTGGTGAACCGCATCCTCAACCGCGCCGCCGAGGCCCAGGCCA
AGGGCGAAGCGGTGCGCAAGGATGACGATCCGGTGGTCTTCAAGACCCGCCTGGAGGCCTACAACCGCGATACGGCGGTG
GTGGCGCCCTATTACAAGGCGCGCGGCCAGCTGAAGCAGATCGACGGCATGGCGCCCATCGATCAGGTCACCGCCGCCAT
CGACGGGGTGCTCGCTGAAGCGGCGTGA

Upstream 100 bases:

>100_bases
ACCATGGATACGGTGTCCCAGATCCAGGGGCATCTGTTGGCCCACCAGTACGAAGGTCTGGTCAAGAAGGCCAAGCTGCG
CGGAGGGAGGAGAAGATAAT

Downstream 100 bases:

>100_bases
TGCCATGGAGGGTCTTCGCCGCGCCATCGGCGAGATCCTTCTGGATCACTGGGATCCCATCGGGGTCGCGGGGGAAGCCG
CGGCTCGCGATGGGTATGAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRLVLLGPPGAGKGTQAQRLVARHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMDAGGLVSDEIVIGIIAERLDSPDAKNG
FILDGFPRTVAQAEALDQLLASKGLKLDAVIELVVDQEKLVNRILNRAAEAQAKGEAVRKDDDPVVFKTRLEAYNRDTAV
VAPYYKARGQLKQIDGMAPIDQVTAAIDGVLAEAA

Sequences:

>Translated_195_residues
MRLVLLGPPGAGKGTQAQRLVARHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMDAGGLVSDEIVIGIIAERLDSPDAKNG
FILDGFPRTVAQAEALDQLLASKGLKLDAVIELVVDQEKLVNRILNRAAEAQAKGEAVRKDDDPVVFKTRLEAYNRDTAV
VAPYYKARGQLKQIDGMAPIDQVTAAIDGVLAEAA
>Mature_195_residues
MRLVLLGPPGAGKGTQAQRLVARHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMDAGGLVSDEIVIGIIAERLDSPDAKNG
FILDGFPRTVAQAEALDQLLASKGLKLDAVIELVVDQEKLVNRILNRAAEAQAKGEAVRKDDDPVVFKTRLEAYNRDTAV
VAPYYKARGQLKQIDGMAPIDQVTAAIDGVLAEAA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=216, Percent_Identity=43.9814814814815, Blast_Score=167, Evalue=5e-42,
Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=43.9814814814815, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI4502011, Length=188, Percent_Identity=30.8510638297872, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=33.502538071066, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=33.502538071066, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=33.502538071066, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=33.502538071066, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=32.994923857868, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144899, Length=194, Percent_Identity=31.9587628865979, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI28144897, Length=194, Percent_Identity=31.9587628865979, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=28.494623655914, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=40.5529953917051, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=39.2523364485981, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=35.8288770053476, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550688, Length=193, Percent_Identity=28.4974093264249, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=28.4210526315789, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=29.8507462686567, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=44.9760765550239, Blast_Score=161, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=33.502538071066, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322828, Length=172, Percent_Identity=28.4883720930233, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=43.3333333333333, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=34.5177664974619, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=34.5177664974619, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24663208, Length=194, Percent_Identity=31.9587628865979, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17647141, Length=194, Percent_Identity=31.9587628865979, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=26.8421052631579, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=26.8421052631579, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_XANP2 (A7IPP9)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419652.1
- ProteinModelPortal:   A7IPP9
- SMR:   A7IPP9
- STRING:   A7IPP9
- GeneID:   5421011
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4777
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   TRLMEYY
- ProtClustDB:   PRK00279
- BioCyc:   XAUT78245:XAUT_4777-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20503; Mature: 20503

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQAQRLVARHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMDAGGLVS
CEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DEIVIGIIAERLDSPDAKNGFILDGFPRTVAQAEALDQLLASKGLKLDAVIELVVDQEKL
HHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHH
VNRILNRAAEAQAKGEAVRKDDDPVVFKTRLEAYNRDTAVVAPYYKARGQLKQIDGMAPI
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHCCCCEEEECHHHHCCCHHHHCCCCCH
DQVTAAIDGVLAEAA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLVLLGPPGAGKGTQAQRLVARHGIVQLSTGDMLRAAVAAGTPVGLKAKAVMDAGGLVS
CEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCCHHHHHCCCCCCC
DEIVIGIIAERLDSPDAKNGFILDGFPRTVAQAEALDQLLASKGLKLDAVIELVVDQEKL
HHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHH
VNRILNRAAEAQAKGEAVRKDDDPVVFKTRLEAYNRDTAVVAPYYKARGQLKQIDGMAPI
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHCCCCEEEECHHHHCCCHHHHCCCCCH
DQVTAAIDGVLAEAA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA