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The map label for this gene is cytR [H]

Identifier: 154248656

GI number: 154248656

Start: 5259397

End: 5260452

Strand: Reverse

Name: cytR [H]

Synonym: Xaut_4738

Alternate gene names: 154248656

Gene position: 5260452-5259397 (Counterclockwise)

Preceding gene: 154248663

Following gene: 154248653

Centisome position: 99.09

GC content: 69.98

Gene sequence:

>1056_bases
GTGACTGAAACCCCTCGTCTGCACCCCACCCTTCAAGCGGTCGCGGACGCGGCCGGTGTGCACCGCTCCACCGCCTCGCG
GGCGCTCAATCCGCAGACCGCCCACCTCGTCGCCGATGACGTGGCCGAGCGGATCCAGGCCGCGGCCCGGCGGCTGGGAT
ATCGTCGCGACGCCATGGCCGCTGGCCTGCGTACCAAGCATTCCCATCTCGTCGGCATCGCTGTTCCCGACATGGCCAAT
CTGGTCTTCGCGCCAATTCTTTGCGGCATCGAGGACGTGCTCGCGAAGAACGGGTATTCCGCCCTCATCGCCAATACAGG
CTCGGACGTGGCGCGGCAGATCGATGTGGTCGACCAGTTGATCGGGCGCCGGGTGGAAGGTCTCATCCTCGCCACCGTGC
AGCAGGAGGACGATCCGGTCCTCACCCGCTGCCTCGAAGCGCGCGTGCCGACCGTGCTGGTCAATCGTGCCGAGGCGCGC
CACCGGGCGCCGGCCGTCATATCCGATGATCTCAACGGGATGCGCATCGCGGTGGAGCACCTCATCGGGCTCGGGCACCG
GCGCATCGGACACCTCGCCGGGCCGCAGAACCTCTCCACCGGCGTGCTGCGCCTGCAGGGCTTCCGAGAGGCAATGGAGC
GCGCCGGGCTGGACGCCTCAGCGGTGATGTGTGCTTCCGCCTACAGCCGTGAAGCCGGGGCGGTGGCGGGCGGGGCGCTG
CTCGACCGGTTCGGCGACCTCACCGCGGTGGCCGCCGCCAACGACCTGCTGGCGCTGGGCCTTTATGGCGCGCTGGGCGA
GCGGGGCCTGTCCTGTCCCGCCGACGTGTCGGTGGTGGGGCACAACGACATGCCGCTGGTGGACATGGTCAGCCCGCCTT
TGACCTCTGTGCGGATCCGTCATCAGGAAATGGGCGCGGAGGCGGCGCGCCTGCTGCTGGAGCAGATGTCCGGCGCGGCC
AGCGGCATCACCATCCGTGTCACCCCGCCCGAGCTGATCGTGCGCGGCTCCACCGGGCGCCGCGCTGCCAGGAGCAGGAA
GGCGCCGGCGAAGTAG

Upstream 100 bases:

>100_bases
TGATGTGCAATCGATTGCAAAGTGTCAAGCGCCTTGTCCGGCCGGGGTGCGGATGCGATAGAGGGCGACGTGCGAACCTG
CGGAGCCTCGTCCCCCCAAC

Downstream 100 bases:

>100_bases
GGTCATGCCCGGCGGGGCTGGGCAGAGCACGTTCCCCTGTCCCGAAATGACACGTCTTCCCGTCCGCATCGGCACGCAGG
GCGAACAGGGCGGGACCGAA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTETPRLHPTLQAVADAAGVHRSTASRALNPQTAHLVADDVAERIQAAARRLGYRRDAMAAGLRTKHSHLVGIAVPDMAN
LVFAPILCGIEDVLAKNGYSALIANTGSDVARQIDVVDQLIGRRVEGLILATVQQEDDPVLTRCLEARVPTVLVNRAEAR
HRAPAVISDDLNGMRIAVEHLIGLGHRRIGHLAGPQNLSTGVLRLQGFREAMERAGLDASAVMCASAYSREAGAVAGGAL
LDRFGDLTAVAAANDLLALGLYGALGERGLSCPADVSVVGHNDMPLVDMVSPPLTSVRIRHQEMGAEAARLLLEQMSGAA
SGITIRVTPPELIVRGSTGRRAARSRKAPAK

Sequences:

>Translated_351_residues
MTETPRLHPTLQAVADAAGVHRSTASRALNPQTAHLVADDVAERIQAAARRLGYRRDAMAAGLRTKHSHLVGIAVPDMAN
LVFAPILCGIEDVLAKNGYSALIANTGSDVARQIDVVDQLIGRRVEGLILATVQQEDDPVLTRCLEARVPTVLVNRAEAR
HRAPAVISDDLNGMRIAVEHLIGLGHRRIGHLAGPQNLSTGVLRLQGFREAMERAGLDASAVMCASAYSREAGAVAGGAL
LDRFGDLTAVAAANDLLALGLYGALGERGLSCPADVSVVGHNDMPLVDMVSPPLTSVRIRHQEMGAEAARLLLEQMSGAA
SGITIRVTPPELIVRGSTGRRAARSRKAPAK
>Mature_350_residues
TETPRLHPTLQAVADAAGVHRSTASRALNPQTAHLVADDVAERIQAAARRLGYRRDAMAAGLRTKHSHLVGIAVPDMANL
VFAPILCGIEDVLAKNGYSALIANTGSDVARQIDVVDQLIGRRVEGLILATVQQEDDPVLTRCLEARVPTVLVNRAEARH
RAPAVISDDLNGMRIAVEHLIGLGHRRIGHLAGPQNLSTGVLRLQGFREAMERAGLDASAVMCASAYSREAGAVAGGALL
DRFGDLTAVAAANDLLALGLYGALGERGLSCPADVSVVGHNDMPLVDMVSPPLTSVRIRHQEMGAEAARLLLEQMSGAAS
GITIRVTPPELIVRGSTGRRAARSRKAPAK

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=29.607250755287, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=29.0322580645161, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788474, Length=336, Percent_Identity=30.952380952381, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=30.3448275862069, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786540, Length=332, Percent_Identity=29.5180722891566, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786268, Length=304, Percent_Identity=26.3157894736842, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789068, Length=316, Percent_Identity=26.5822784810127, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=28.8343558282209, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787906, Length=336, Percent_Identity=25, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=23.4042553191489, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790715, Length=312, Percent_Identity=25.6410256410256, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789456, Length=340, Percent_Identity=25, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37027; Mature: 36896

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETPRLHPTLQAVADAAGVHRSTASRALNPQTAHLVADDVAERIQAAARRLGYRRDAMA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLRTKHSHLVGIAVPDMANLVFAPILCGIEDVLAKNGYSALIANTGSDVARQIDVVDQL
HCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IGRRVEGLILATVQQEDDPVLTRCLEARVPTVLVNRAEARHRAPAVISDDLNGMRIAVEH
HHHHHCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
LIGLGHRRIGHLAGPQNLSTGVLRLQGFREAMERAGLDASAVMCASAYSREAGAVAGGAL
HHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
LDRFGDLTAVAAANDLLALGLYGALGERGLSCPADVSVVGHNDMPLVDMVSPPLTSVRIR
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHH
HQEMGAEAARLLLEQMSGAASGITIRVTPPELIVRGSTGRRAARSRKAPAK
HHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHEEECCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TETPRLHPTLQAVADAAGVHRSTASRALNPQTAHLVADDVAERIQAAARRLGYRRDAMA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AGLRTKHSHLVGIAVPDMANLVFAPILCGIEDVLAKNGYSALIANTGSDVARQIDVVDQL
HCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
IGRRVEGLILATVQQEDDPVLTRCLEARVPTVLVNRAEARHRAPAVISDDLNGMRIAVEH
HHHHHCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCHHHHHHH
LIGLGHRRIGHLAGPQNLSTGVLRLQGFREAMERAGLDASAVMCASAYSREAGAVAGGAL
HHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHH
LDRFGDLTAVAAANDLLALGLYGALGERGLSCPADVSVVGHNDMPLVDMVSPPLTSVRIR
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHH
HQEMGAEAARLLLEQMSGAASGITIRVTPPELIVRGSTGRRAARSRKAPAK
HHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHEEECCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]