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The map label for this gene is dxs

Identifier: 154248651

GI number: 154248651

Start: 5252670

End: 5254601

Strand: Reverse

Name: dxs

Synonym: Xaut_4733

Alternate gene names: 154248651

Gene position: 5254601-5252670 (Counterclockwise)

Preceding gene: 154248652

Following gene: 154248642

Centisome position: 98.98

GC content: 69.31

Gene sequence:

>1932_bases
GTGACTTTGCTGAAGACCCCGCTGCTCGATACCATTCGCGATGCCGCCGACGTGCGGCGCCTGCCCCAGGACAAGCTGGC
CCAGCTCGCCGCCGAACTGCGCGCGGAGACCATCGATGCCGTCTCCGTGACCGGCGGGCATCTGGGCGCGGGCCTGGGCG
TGGTCGAGCTGACGGTGGCCCTGCACCACGTGTTCAACACCCCCCATGATCGCCTGATCTGGGATGTCGGCCACCAGTGC
TACCCTCACAAGATTCTCACCGGCCGGCGCGACCGCATCCGCACCCTGCGCCAGGGCGGTGGCCTGTCCGGCTTCACCCG
CCGGGCGGAGAGCGAATACGACCCGTTCGGGGCGGCGCACTCCTCTACCTCGATCTCCGCTGGCCTCGGCATGGCGGTGG
CACGGGACCTCTCGGGGGAAGAGCGCAACGTGGTGTGCGTGATCGGCGACGGCGCCATGTCGGCGGGCATGGCCTATGAG
GCCATGAACAATGCCGGCGCCATGGATTCGCGCCTCATCGTCATCCTCAACGACAACGACATGTCCATCGCCCCGCCCAC
CGGGGCCATGTCGGCCTATCTGGCGCGGCTCATCTCGGGGCAGACCTACCGCTCGCTGCGGGAGATCGGCAAGCAGATCG
CCGGTCATTTGCCCAAGTTCGTTGAGCGCGGCGCGGCGCGGGCTGAGGAATTCGCCCGTGGCTTCTGGACCGGCGGCACC
CTGTTCGAGGAACTGGGCTTCTATTATGTGGGGCCCATCGACGGGCACAATCTCGACCACCTGCTGCCCGTGCTGAAGAA
CGTGCGGGACGCCAAGACCGGCCCGATCCTGGTCCATGTGGTGACCCAGAAGGGCAAGGGCTACGCCCCCGCGGAGGCCA
GCGCCGACAAGTATCACGGCGTGGTCAAGTTCGACGTGGTGACCGGCGCTCAGGTGAAGGCGAAGTCCAACGCCCCCTCC
TACACCCGCGTGTTCGCCGAGAGCCTCATTTCACAGGCTCGGCATGATCCCAAGGTGGTCGCCATCACCGCCGCCATGCC
CTCGGGCACAGGGCTGGACCTGTTCGGGCAGGTCTATCCCGAGCGCACCTTCGACGTGGGCATCGCCGAGCAGCATGCGG
TGACGTTTGCCGCCGGGCTCGCGGCGGAAGGCTTCAAGCCGTTCTGCGCGCTCTATTCCACCTTCCTCCAGCGGGCCTAC
GACCAGGTGGTGCACGATGTGGCGCTGCAGGGCCTGCCGGTGCGCTTCATCATCGACCGCGCCGGCCTCGTCGGCGCGGA
CGGGGCGACCCATGCGGGCGCCTTCGACATCGCCTTCCTCGCCTGCCTGCCGGGCATGACCGTGATGGCCCCCGCCGACG
AGGCGGAGCTGGTGCACATGATGGCGACCATGGTGGCCTTCGACGACGGCCCCTCGGCGGTGCGCTTTCCCCGTGGGGAA
GGCGTGGGGGTGGAGCGGCCCGAGCGCGGCGAGGTCCTGCCCATCGGCAAGGGACGCATCGTGCACGGAACCGGGGAGGG
CGACATTGCGCTGCTCTCCCTCGGCACCCGCCTTGCCGCGTGCCTTGATGCCGCCGAGCGGCTGGAGGCGGCGGGCTTCA
CCGTCACCGTGGCCGACGCCCGCTTCGCCAAGCCCCTCGACCGGGAGCTGGTGCTGAAGCTCGCCGCCGGCCATGGCGCG
CTGGTCACGGTGGAAGAGGGCTCGGTGGGCGGCTTCGGCAGCCATGTGCTCCAGCTGGTCACCGACGAGGGCCTGCTGGA
CCGCGGCGCCGTGAAGGTGCGCGCCATGGTGCTCCCCGACATCTACATCGACCAGGAGACCCAGGCCCGCCAACTGGCTG
CCGCCGGCCTCGACGCCGACGCCATCGTGGCCAAGGTGGAAGGCCTGCTGGGCAAGGCCAAGGCCGGGGTGAGCCTGCAC
AAGGCGGGGTGA

Upstream 100 bases:

>100_bases
AGCCGCCTGCTGACCCCGTTCCCACCGGCCTTGTCCGTTGCATGCCACCGCGCGCGTGTGTAAGGCTCATTTTCCCGGTT
CGTTCCGGACGGAGTTGTCC

Downstream 100 bases:

>100_bases
GGGGGCGTCAGGGGTTGGAGGCGACCACCGCCACCGCCGCCACATTCCGCCGGTGCACCGCCTCATAGGGCTCGAAATAC
GTCACGACCCCGGTTGCGAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MTLLKTPLLDTIRDAADVRRLPQDKLAQLAAELRAETIDAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAVARDLSGEERNVVCVIGDGAMSAGMAYE
AMNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGQTYRSLREIGKQIAGHLPKFVERGAARAEEFARGFWTGGT
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDAKTGPILVHVVTQKGKGYAPAEASADKYHGVVKFDVVTGAQVKAKSNAPS
YTRVFAESLISQARHDPKVVAITAAMPSGTGLDLFGQVYPERTFDVGIAEQHAVTFAAGLAAEGFKPFCALYSTFLQRAY
DQVVHDVALQGLPVRFIIDRAGLVGADGATHAGAFDIAFLACLPGMTVMAPADEAELVHMMATMVAFDDGPSAVRFPRGE
GVGVERPERGEVLPIGKGRIVHGTGEGDIALLSLGTRLAACLDAAERLEAAGFTVTVADARFAKPLDRELVLKLAAGHGA
LVTVEEGSVGGFGSHVLQLVTDEGLLDRGAVKVRAMVLPDIYIDQETQARQLAAAGLDADAIVAKVEGLLGKAKAGVSLH
KAG

Sequences:

>Translated_643_residues
MTLLKTPLLDTIRDAADVRRLPQDKLAQLAAELRAETIDAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAVARDLSGEERNVVCVIGDGAMSAGMAYE
AMNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGQTYRSLREIGKQIAGHLPKFVERGAARAEEFARGFWTGGT
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDAKTGPILVHVVTQKGKGYAPAEASADKYHGVVKFDVVTGAQVKAKSNAPS
YTRVFAESLISQARHDPKVVAITAAMPSGTGLDLFGQVYPERTFDVGIAEQHAVTFAAGLAAEGFKPFCALYSTFLQRAY
DQVVHDVALQGLPVRFIIDRAGLVGADGATHAGAFDIAFLACLPGMTVMAPADEAELVHMMATMVAFDDGPSAVRFPRGE
GVGVERPERGEVLPIGKGRIVHGTGEGDIALLSLGTRLAACLDAAERLEAAGFTVTVADARFAKPLDRELVLKLAAGHGA
LVTVEEGSVGGFGSHVLQLVTDEGLLDRGAVKVRAMVLPDIYIDQETQARQLAAAGLDADAIVAKVEGLLGKAKAGVSLH
KAG
>Mature_642_residues
TLLKTPLLDTIRDAADVRRLPQDKLAQLAAELRAETIDAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQCY
PHKILTGRRDRIRTLRQGGGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAVARDLSGEERNVVCVIGDGAMSAGMAYEA
MNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGQTYRSLREIGKQIAGHLPKFVERGAARAEEFARGFWTGGTL
FEELGFYYVGPIDGHNLDHLLPVLKNVRDAKTGPILVHVVTQKGKGYAPAEASADKYHGVVKFDVVTGAQVKAKSNAPSY
TRVFAESLISQARHDPKVVAITAAMPSGTGLDLFGQVYPERTFDVGIAEQHAVTFAAGLAAEGFKPFCALYSTFLQRAYD
QVVHDVALQGLPVRFIIDRAGLVGADGATHAGAFDIAFLACLPGMTVMAPADEAELVHMMATMVAFDDGPSAVRFPRGEG
VGVERPERGEVLPIGKGRIVHGTGEGDIALLSLGTRLAACLDAAERLEAAGFTVTVADARFAKPLDRELVLKLAAGHGAL
VTVEEGSVGGFGSHVLQLVTDEGLLDRGAVKVRAMVLPDIYIDQETQARQLAAAGLDADAIVAKVEGLLGKAKAGVSLHK
AG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=540, Percent_Identity=24.4444444444444, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4507521, Length=540, Percent_Identity=24.4444444444444, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI225637459, Length=508, Percent_Identity=23.8188976377953, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI225637461, Length=508, Percent_Identity=23.8188976377953, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI225637463, Length=508, Percent_Identity=23.8188976377953, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI133778974, Length=507, Percent_Identity=22.4852071005917, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=52.6315789473684, Blast_Score=624, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17539652, Length=546, Percent_Identity=23.8095238095238, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45551847, Length=625, Percent_Identity=24.32, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550715, Length=625, Percent_Identity=24.32, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645119, Length=504, Percent_Identity=25.3968253968254, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24666278, Length=476, Percent_Identity=26.890756302521, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_XANP2 (A7IPK6)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419609.1
- ProteinModelPortal:   A7IPK6
- SMR:   A7IPK6
- STRING:   A7IPK6
- GeneID:   5425321
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4733
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   XAUT78245:XAUT_4733-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67986; Mature: 67854

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLKTPLLDTIRDAADVRRLPQDKLAQLAAELRAETIDAVSVTGGHLGAGLGVVELTVA
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHH
LHHVFNTPHDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTRRAESEYDPFGAAH
HHHHHCCCCHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCC
SSTSISAGLGMAVARDLSGEERNVVCVIGDGAMSAGMAYEAMNNAGAMDSRLIVILNDND
CCCCHHHCCCHHHHHCCCCCCCCEEEEECCCCHHCCHHHHHHCCCCCCCCEEEEEECCCC
MSIAPPTGAMSAYLARLISGQTYRSLREIGKQIAGHLPKFVERGAARAEEFARGFWTGGT
CEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDAKTGPILVHVVTQKGKGYAPAEASADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHCC
VVKFDVVTGAQVKAKSNAPSYTRVFAESLISQARHDPKVVAITAAMPSGTGLDLFGQVYP
EEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHCC
ERTFDVGIAEQHAVTFAAGLAAEGFKPFCALYSTFLQRAYDQVVHDVALQGLPVRFIIDR
CCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
AGLVGADGATHAGAFDIAFLACLPGMTVMAPADEAELVHMMATMVAFDDGPSAVRFPRGE
CCEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCC
GVGVERPERGEVLPIGKGRIVHGTGEGDIALLSLGTRLAACLDAAERLEAAGFTVTVADA
CCCCCCCCCCCEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCC
RFAKPLDRELVLKLAAGHGALVTVEEGSVGGFGSHVLQLVTDEGLLDRGAVKVRAMVLPD
HHCCCCCHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCC
IYIDQETQARQLAAAGLDADAIVAKVEGLLGKAKAGVSLHKAG
EEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
TLLKTPLLDTIRDAADVRRLPQDKLAQLAAELRAETIDAVSVTGGHLGAGLGVVELTVA
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHH
LHHVFNTPHDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTRRAESEYDPFGAAH
HHHHHCCCCHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCC
SSTSISAGLGMAVARDLSGEERNVVCVIGDGAMSAGMAYEAMNNAGAMDSRLIVILNDND
CCCCHHHCCCHHHHHCCCCCCCCEEEEECCCCHHCCHHHHHHCCCCCCCCEEEEEECCCC
MSIAPPTGAMSAYLARLISGQTYRSLREIGKQIAGHLPKFVERGAARAEEFARGFWTGGT
CEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LFEELGFYYVGPIDGHNLDHLLPVLKNVRDAKTGPILVHVVTQKGKGYAPAEASADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHCC
VVKFDVVTGAQVKAKSNAPSYTRVFAESLISQARHDPKVVAITAAMPSGTGLDLFGQVYP
EEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHCC
ERTFDVGIAEQHAVTFAAGLAAEGFKPFCALYSTFLQRAYDQVVHDVALQGLPVRFIIDR
CCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
AGLVGADGATHAGAFDIAFLACLPGMTVMAPADEAELVHMMATMVAFDDGPSAVRFPRGE
CCEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEECCCCC
GVGVERPERGEVLPIGKGRIVHGTGEGDIALLSLGTRLAACLDAAERLEAAGFTVTVADA
CCCCCCCCCCCEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEECCC
RFAKPLDRELVLKLAAGHGALVTVEEGSVGGFGSHVLQLVTDEGLLDRGAVKVRAMVLPD
HHCCCCCHHHHHHEECCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCC
IYIDQETQARQLAAAGLDADAIVAKVEGLLGKAKAGVSLHKAG
EEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA