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The map label for this gene is cobB1 [H]

Identifier: 154248093

GI number: 154248093

Start: 4620600

End: 4621370

Strand: Direct

Name: cobB1 [H]

Synonym: Xaut_4173

Alternate gene names: 154248093

Gene position: 4620600-4621370 (Clockwise)

Preceding gene: 154248089

Following gene: 154248094

Centisome position: 87.03

GC content: 65.63

Gene sequence:

>771_bases
ATGATCTTTGACACCGATCTCAAGGGCGCCCAGGCGCGTCTCGCCGAACTTCTCGATGAGGCGTCCTGCGCCGTCGCCTT
TACCGGCGCCGGCCTTTCGACGGAATGCGGCATTCCCGATTTCCGCTCCCCCGGCGGGCTGTGGACCCAGAACAAGCCGA
TCCCGTTCGATGTCTTCGTGTCCCACAAGGCGGCGCGGAACGAGGCGTGGCGGCGCAAGTTCGCCATGGAGGAGGCCTTT
GCCTCCGCCCGCCCTGGCCGCGGCCACAGGGCCCTTGCCCGGCTGCACGGACACGGGCGGCTCAAGGGCATCATCACCCA
GAATATCGACGGCCTGCATCAGGCCTCCGGCGTGCCCGACGCGGCGCTGATCGAACTGCACGGCAACGGCACCTACGCCA
CCTGCCTCGACTGCGGCGCGCGCTATGAGCTGGATTGGGTCAAGGCGCGATTCGATGCCTCCGGCGGATCAGCCCCCGAT
TGCCCCGAATGCGGGGGACCCATCAAGGCAGCCACCATCTCCTTCGGGCAGGCCATGCCCGAGACGGAAATGGCTCGGGC
GGATGAACTGACCCGCAAGTGCGATCTGTTCATTGTCATCGGCTCGTCGCTGGTGGTGTTCCCGGCGGCGGGATTCCCGC
TGAAGGCCAAGAAGAAGGGTGCACGGCTGGTGATCCTCAACCGCGAGCCCACGGATTTCGACGAATTGGCCGATCTTGTG
GTGCGCACCGAGATCGGCGACCTGTTGGAACCCTTTGCACAGGACGCATGA

Upstream 100 bases:

>100_bases
GGAGCGCGGCGCTCCGGATGGGGATAGGGTCCGCGCCGGCCGGCGTAGCCGGCGCCGTTTGGGCAAGTGGAGGGCGCCGG
TGGGCCGGCGCTGCTGACGT

Downstream 100 bases:

>100_bases
TGCCGCAGGCTCTCGCCGAGGTCTTCCACCAAGGCCTGGCGCGAAGAGAGGGTGCGAAGAGGGTGGGCGAAGCCCCGGCG
AGTTGCTATCCTGAAACCGG

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIFDTDLKGAQARLAELLDEASCAVAFTGAGLSTECGIPDFRSPGGLWTQNKPIPFDVFVSHKAARNEAWRRKFAMEEAF
ASARPGRGHRALARLHGHGRLKGIITQNIDGLHQASGVPDAALIELHGNGTYATCLDCGARYELDWVKARFDASGGSAPD
CPECGGPIKAATISFGQAMPETEMARADELTRKCDLFIVIGSSLVVFPAAGFPLKAKKKGARLVILNREPTDFDELADLV
VRTEIGDLLEPFAQDA

Sequences:

>Translated_256_residues
MIFDTDLKGAQARLAELLDEASCAVAFTGAGLSTECGIPDFRSPGGLWTQNKPIPFDVFVSHKAARNEAWRRKFAMEEAF
ASARPGRGHRALARLHGHGRLKGIITQNIDGLHQASGVPDAALIELHGNGTYATCLDCGARYELDWVKARFDASGGSAPD
CPECGGPIKAATISFGQAMPETEMARADELTRKCDLFIVIGSSLVVFPAAGFPLKAKKKGARLVILNREPTDFDELADLV
VRTEIGDLLEPFAQDA
>Mature_256_residues
MIFDTDLKGAQARLAELLDEASCAVAFTGAGLSTECGIPDFRSPGGLWTQNKPIPFDVFVSHKAARNEAWRRKFAMEEAF
ASARPGRGHRALARLHGHGRLKGIITQNIDGLHQASGVPDAALIELHGNGTYATCLDCGARYELDWVKARFDASGGSAPD
CPECGGPIKAATISFGQAMPETEMARADELTRKCDLFIVIGSSLVVFPAAGFPLKAKKKGARLVILNREPTDFDELADLV
VRTEIGDLLEPFAQDA

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=257, Percent_Identity=35.408560311284, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI300797597, Length=252, Percent_Identity=34.1269841269841, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI6912662, Length=253, Percent_Identity=33.596837944664, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI6912660, Length=223, Percent_Identity=34.0807174887892, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI63054862, Length=207, Percent_Identity=34.2995169082126, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI300795542, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI7657575, Length=228, Percent_Identity=33.7719298245614, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI13787215, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI6912664, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706712, Length=258, Percent_Identity=29.4573643410853, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI13775602, Length=216, Percent_Identity=31.4814814814815, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI13775600, Length=216, Percent_Identity=31.4814814814815, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI300797705, Length=191, Percent_Identity=30.3664921465969, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI215982798, Length=164, Percent_Identity=34.7560975609756, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI308199517, Length=230, Percent_Identity=33.4782608695652, Blast_Score=91, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71990482, Length=269, Percent_Identity=28.2527881040892, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17567771, Length=269, Percent_Identity=27.8810408921933, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=271, Percent_Identity=28.0442804428044, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17541892, Length=221, Percent_Identity=33.0316742081448, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17505510, Length=234, Percent_Identity=28.6324786324786, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325242, Length=257, Percent_Identity=31.5175097276265, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320397, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648389, Length=210, Percent_Identity=35.7142857142857, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571445, Length=276, Percent_Identity=30.7971014492754, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24645650, Length=262, Percent_Identity=30.9160305343511, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17137536, Length=246, Percent_Identity=30.8943089430894, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571443, Length=216, Percent_Identity=28.7037037037037, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI28571441, Length=216, Percent_Identity=28.7037037037037, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27497; Mature: 27497

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFDTDLKGAQARLAELLDEASCAVAFTGAGLSTECGIPDFRSPGGLWTQNKPIPFDVFV
CEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
SHKAARNEAWRRKFAMEEAFASARPGRGHRALARLHGHGRLKGIITQNIDGLHQASGVPD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCC
AALIELHGNGTYATCLDCGARYELDWVKARFDASGGSAPDCPECGGPIKAATISFGQAMP
EEEEEEECCCCEEEEECCCCCCEEEHEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCCC
ETEMARADELTRKCDLFIVIGSSLVVFPAAGFPLKAKKKGARLVILNREPTDFDELADLV
HHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
VRTEIGDLLEPFAQDA
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIFDTDLKGAQARLAELLDEASCAVAFTGAGLSTECGIPDFRSPGGLWTQNKPIPFDVFV
CEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
SHKAARNEAWRRKFAMEEAFASARPGRGHRALARLHGHGRLKGIITQNIDGLHQASGVPD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCC
AALIELHGNGTYATCLDCGARYELDWVKARFDASGGSAPDCPECGGPIKAATISFGQAMP
EEEEEEECCCCEEEEECCCCCCEEEHEEEEECCCCCCCCCCCCCCCCCEEEEEHHCCCCC
ETEMARADELTRKCDLFIVIGSSLVVFPAAGFPLKAKKKGARLVILNREPTDFDELADLV
HHHHHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
VRTEIGDLLEPFAQDA
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]