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The map label for this gene is livG [H]

Identifier: 154247825

GI number: 154247825

Start: 4319920

End: 4320846

Strand: Direct

Name: livG [H]

Synonym: Xaut_3902

Alternate gene names: 154247825

Gene position: 4319920-4320846 (Clockwise)

Preceding gene: 154247824

Following gene: 154247826

Centisome position: 81.37

GC content: 69.15

Gene sequence:

>927_bases
ATGGCGAACCTTGATCCCGTGGCCGGCGCACGGGCGCCGATCCTGGCGGTGGACCACCTGTCCATGCGCTTTGGCGGCCT
GATCGCCGTGAATGACGTGTCCTTCGTCGCCGCCCGCGGCGAGGTGACGGCGGTGATCGGGCCCAACGGCGCCGGCAAGA
CCACCGTGTTCAACTGCATCACCGGCTTCTACAAGCCGTCCGCCGGCCGCCTCGCCCTGTTCCACGGCGGCGCGGCGACG
CCCGGCGAGCTCGATGCCGTCACCGCCTCCGGCCTGTCCTGGGGCCGCACCGGGGCGGGGGCGCTCTATCTGCTGGAGCG
GCTGCCCGACCACAAGGTGGCGTCCTGGGCGCGGGTGGCCCGCACCTTCCAGAATATCCGCCTGTTCTCGGGCATGACCG
TGCTGGAAAACCTGCTGGTGGCGCAGCACATGTCGCTCACCAGCGCCGGCCTGCTCAACCCCGCCGCCATCCTCAACCTG
CCGTCCTGGAAGCGCCAGCAGAAGGGCGCCATGGACAAGGCCCTCTATTGGCTGCACCAGATCGGCCTGATGGAGCGTGC
CGACGACCCGGCCGGCGACCTGCCCTATGGCGACCAGCGGCGCCTGGAGATCGCCCGCGCCATGTGCACCAACCCGGTGC
TGCTCTGCCTCGACGAGCCGGCGGCGGGGCTAAACCCGCGCGAATCGGCGGCGCTCAACGAGCTGCTCCTCTCCATCCGG
CGCGACCACGACACCTCGATCCTGCTCATCGAGCACGACATGTCGGTGGTGATGGAGATTTCCGACCACGTGGTCGTGCT
GGAATATGGCTGCAAGATCGCCGACGGCACGCCGCAGGAGGTGCGCACCGATCCCAAGGTCATCGCCTCCTACCTCGGTG
TCGAGGAGGAAGAGGCGGCCGTGGTGGAAGCGCAGGTGGGCGCATGA

Upstream 100 bases:

>100_bases
TGTGGCGCCCGCGCGGCCTCGTCTCCTCGCGCCTGCCCACCATCTTCCTGAAGGAACGCAAGGCGGTCTCCTCGGCCCTC
GTCAAGGAGGGCCACGGCTG

Downstream 100 bases:

>100_bases
CGGCCCAGACCCTTGCCCCCGGAGCCGTGGCCGCCCAGCCGGCGCCGAAAGGCCAGCCGCTGCTGTCGGTCAGCGGCGTC
ACCGCCTATTACGGCAAGAT

Product: ABC transporter-like protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein G [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MANLDPVAGARAPILAVDHLSMRFGGLIAVNDVSFVAARGEVTAVIGPNGAGKTTVFNCITGFYKPSAGRLALFHGGAAT
PGELDAVTASGLSWGRTGAGALYLLERLPDHKVASWARVARTFQNIRLFSGMTVLENLLVAQHMSLTSAGLLNPAAILNL
PSWKRQQKGAMDKALYWLHQIGLMERADDPAGDLPYGDQRRLEIARAMCTNPVLLCLDEPAAGLNPRESAALNELLLSIR
RDHDTSILLIEHDMSVVMEISDHVVVLEYGCKIADGTPQEVRTDPKVIASYLGVEEEEAAVVEAQVGA

Sequences:

>Translated_308_residues
MANLDPVAGARAPILAVDHLSMRFGGLIAVNDVSFVAARGEVTAVIGPNGAGKTTVFNCITGFYKPSAGRLALFHGGAAT
PGELDAVTASGLSWGRTGAGALYLLERLPDHKVASWARVARTFQNIRLFSGMTVLENLLVAQHMSLTSAGLLNPAAILNL
PSWKRQQKGAMDKALYWLHQIGLMERADDPAGDLPYGDQRRLEIARAMCTNPVLLCLDEPAAGLNPRESAALNELLLSIR
RDHDTSILLIEHDMSVVMEISDHVVVLEYGCKIADGTPQEVRTDPKVIASYLGVEEEEAAVVEAQVGA
>Mature_307_residues
ANLDPVAGARAPILAVDHLSMRFGGLIAVNDVSFVAARGEVTAVIGPNGAGKTTVFNCITGFYKPSAGRLALFHGGAATP
GELDAVTASGLSWGRTGAGALYLLERLPDHKVASWARVARTFQNIRLFSGMTVLENLLVAQHMSLTSAGLLNPAAILNLP
SWKRQQKGAMDKALYWLHQIGLMERADDPAGDLPYGDQRRLEIARAMCTNPVLLCLDEPAAGLNPRESAALNELLLSIRR
DHDTSILLIEHDMSVVMEISDHVVVLEYGCKIADGTPQEVRTDPKVIASYLGVEEEEAAVVEAQVGA

Specific function: Component of the leucine-specific transport system [H]

COG id: COG0411

COG function: function code E; ABC-type branched-chain amino acid transport systems, ATPase component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI105990541, Length=253, Percent_Identity=25.6916996047431, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789864, Length=281, Percent_Identity=49.4661921708185, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1790525, Length=276, Percent_Identity=23.5507246376812, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788225, Length=274, Percent_Identity=26.6423357664234, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786398, Length=258, Percent_Identity=29.4573643410853, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789032, Length=271, Percent_Identity=24.3542435424354, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789672, Length=275, Percent_Identity=21.8181818181818, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789593, Length=279, Percent_Identity=25.089605734767, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082268, Length=291, Percent_Identity=25.085910652921, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787370, Length=292, Percent_Identity=24.6575342465753, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI87081709, Length=277, Percent_Identity=23.4657039711191, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788644, Length=276, Percent_Identity=27.1739130434783, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788761, Length=282, Percent_Identity=24.113475177305, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786872, Length=275, Percent_Identity=24, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788210, Length=278, Percent_Identity=26.978417266187, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI48995001, Length=270, Percent_Identity=26.2962962962963, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788165, Length=278, Percent_Identity=26.2589928057554, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI48994997, Length=276, Percent_Identity=24.6376811594203, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790544, Length=275, Percent_Identity=24, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788450, Length=287, Percent_Identity=23.6933797909408, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081834, Length=252, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789962, Length=265, Percent_Identity=25.2830188679245, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787089, Length=255, Percent_Identity=23.921568627451, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787758, Length=258, Percent_Identity=24.031007751938, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788897, Length=267, Percent_Identity=23.9700374531835, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787164, Length=256, Percent_Identity=23.828125, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789586, Length=268, Percent_Identity=25.7462686567164, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790190, Length=244, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 32943; Mature: 32812

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLDPVAGARAPILAVDHLSMRFGGLIAVNDVSFVAARGEVTAVIGPNGAGKTTVFNCI
CCCCCCCCCCCCCEEEEEHHHHHHCCEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHH
TGFYKPSAGRLALFHGGAATPGELDAVTASGLSWGRTGAGALYLLERLPDHKVASWARVA
HHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
RTFQNIRLFSGMTVLENLLVAQHMSLTSAGLLNPAAILNLPSWKRQQKGAMDKALYWLHQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCHHHHHHCCHHHHHHHHHH
IGLMERADDPAGDLPYGDQRRLEIARAMCTNPVLLCLDEPAAGLNPRESAALNELLLSIR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
RDHDTSILLIEHDMSVVMEISDHVVVLEYGCKIADGTPQEVRTDPKVIASYLGVEEEEAA
CCCCCEEEEEECCCEEEEECCCCEEEEEECCEECCCCHHHHCCCHHHHHHHHCCCCHHHE
VVEAQVGA
EEEEECCC
>Mature Secondary Structure 
ANLDPVAGARAPILAVDHLSMRFGGLIAVNDVSFVAARGEVTAVIGPNGAGKTTVFNCI
CCCCCCCCCCCCEEEEEHHHHHHCCEEEECCCEEEEECCCEEEEECCCCCCCHHHHHHH
TGFYKPSAGRLALFHGGAATPGELDAVTASGLSWGRTGAGALYLLERLPDHKVASWARVA
HHCCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
RTFQNIRLFSGMTVLENLLVAQHMSLTSAGLLNPAAILNLPSWKRQQKGAMDKALYWLHQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCHHHHHHCCHHHHHHHHHH
IGLMERADDPAGDLPYGDQRRLEIARAMCTNPVLLCLDEPAAGLNPRESAALNELLLSIR
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHH
RDHDTSILLIEHDMSVVMEISDHVVVLEYGCKIADGTPQEVRTDPKVIASYLGVEEEEAA
CCCCCEEEEEECCCEEEEECCCCEEEEEECCEECCCCHHHHCCCHHHHHHHHCCCCHHHE
VVEAQVGA
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]