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The map label for this gene is cobQ

Identifier: 154247702

GI number: 154247702

Start: 4184641

End: 4186107

Strand: Direct

Name: cobQ

Synonym: Xaut_3778

Alternate gene names: 154247702

Gene position: 4184641-4186107 (Clockwise)

Preceding gene: 154247701

Following gene: 154247704

Centisome position: 78.82

GC content: 70.21

Gene sequence:

>1467_bases
ATGGCACGCGCGCTGATGTTCCAGGGCACCGGGTCGGACGTGGGCAAGTCGCTCCTCGTCGCCGGCCTTGCGCGTGCCTT
CACCCTGCGCGGGCTGAAGGTGCGCCCGTTCAAGCCACAGAACATGTCCAACAATGCCGCCGTCACGGCTGACGGCGGCG
AGATCGGCCGGGCGCAGGCGCTGCAGGCGCGGGCGGCACGGGTGCCCCTCAGCGTCCATATGAACCCGGTGCTACTGAAG
CCGCAGGGCGAAACCGGCGCGCAGGTGGTGGTGCAGGGCCGCGTCCACGGCACCGCCAAGGCGGCGGCCTACCAGGGCAT
GAAGCCGTCGCTGCTGCCCTTCGTGCTGGACAGCTTCGACCGCCTGAAGGCCGAGGCCGACCTGGTGCTAGTGGAAGGGG
CGGGCAGCGCCTCCGAGGTCAATTTGCGCACCGGCGACATCGCCAACATGGGCTTTGCCCGCGCGGCGGACGTGCCGGTG
GTGGTCATCGGCGATATCGACCGGGGCGGCGTGATCGCGTCGCTGGTGGGGACGAAGGCGGTGATCGATGCCGCCGATGC
CGCGCTCATCAAGGGCTTCGTCGTCAACCGCTTCCGGGGCGACCCGAGCCTGTTTGCCACCGGCATGGAGCTGATCGCCC
GCCAGACCGGCTGGGCGGCGCTGGGGCTGGTGCCGCATTTCTCCGAAGCCATCCGCCTGCCGGCGGAGGACGCACTGGCG
CTGTCTGCCCCGCCCGCTCCCAAGCCGAGGGCTCGGACCAGGATCTGCGTGCCCATCCTGCCCCACGTCTCCAATTTCGA
CGATCTCGACCCGCTGGACGCCGAGCCCTCCGTGGAGGTCCGCCGCATCCGCCCTCATGAGACGCTGCCGGTGGATACGG
ACCTGGTGCTGCTCATCGGCTCGAAGGCCACCATTGCCGACCTCGCAGCGCTCAAGGCCGAGGGGCTTCACCACGACATC
CTCGCCTTCGCCCGGCGCGGCGGCCATGTGATGGGCCTGTGCGGCGGCTACCAGATGCTGGGCGAGACCATCGCCGATCC
CGACGGTATCGAGGGCGAAGCGAAGATCGCCCGCGGCCTCGGCCTGCTCAAGGTCCACACCGTGCTGTCGCCGGAAAAGC
GACTGGTGGAGGTGGCGGGCGTGGCGCTGGATCCTGCCGTCGCCGCGCCGTTCTCCGGCTACGAGATGCACATGGGCGTA
ACCGCCGGCGCGGATGCGGAACAGCCCTTCGCCGTGCTCTCCGATGGGCGGCAGGACGGCGCCCGATCCGCTTCTGGTCG
GGTCAGCGGCACCTATGTGCACGGCCTGTTCGCCTCCGATGCCTTCCGCAGCGGGCTGCTCGGTGCGCTCGGCGGGGCCC
CGTCGCAGGCGGCCTATGAGCAGGGTGTGGAGGAGACGCTGGATCGCCTCGCCGCGCACCTCGCCGCCCATCTCGACCTC
GACCTGCTGTTCAGCCTCGCCAGATGA

Upstream 100 bases:

>100_bases
GAGCTGGTCGCGGCCGCGGATCTCGTCACCGAGATGGGGCTGGTGAAGCACCATTTTGCGGCCGGCGTGAAGGCGCAGGC
CGGGATCGAGTTCTGATCGG

Downstream 100 bases:

>100_bases
AGGGGGCCGCGGCGCCCGCGAGCACCAGCAGCACCATCAGCGCATCCGCCCGGCGGTAGAGCCGCAGCGCCGCGCGCACG
TCCTTCGCCGTTGCCTCCCG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MARALMFQGTGSDVGKSLLVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQALQARAARVPLSVHMNPVLLK
PQGETGAQVVVQGRVHGTAKAAAYQGMKPSLLPFVLDSFDRLKAEADLVLVEGAGSASEVNLRTGDIANMGFARAADVPV
VVIGDIDRGGVIASLVGTKAVIDAADAALIKGFVVNRFRGDPSLFATGMELIARQTGWAALGLVPHFSEAIRLPAEDALA
LSAPPAPKPRARTRICVPILPHVSNFDDLDPLDAEPSVEVRRIRPHETLPVDTDLVLLIGSKATIADLAALKAEGLHHDI
LAFARRGGHVMGLCGGYQMLGETIADPDGIEGEAKIARGLGLLKVHTVLSPEKRLVEVAGVALDPAVAAPFSGYEMHMGV
TAGADAEQPFAVLSDGRQDGARSASGRVSGTYVHGLFASDAFRSGLLGALGGAPSQAAYEQGVEETLDRLAAHLAAHLDL
DLLFSLAR

Sequences:

>Translated_488_residues
MARALMFQGTGSDVGKSLLVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQALQARAARVPLSVHMNPVLLK
PQGETGAQVVVQGRVHGTAKAAAYQGMKPSLLPFVLDSFDRLKAEADLVLVEGAGSASEVNLRTGDIANMGFARAADVPV
VVIGDIDRGGVIASLVGTKAVIDAADAALIKGFVVNRFRGDPSLFATGMELIARQTGWAALGLVPHFSEAIRLPAEDALA
LSAPPAPKPRARTRICVPILPHVSNFDDLDPLDAEPSVEVRRIRPHETLPVDTDLVLLIGSKATIADLAALKAEGLHHDI
LAFARRGGHVMGLCGGYQMLGETIADPDGIEGEAKIARGLGLLKVHTVLSPEKRLVEVAGVALDPAVAAPFSGYEMHMGV
TAGADAEQPFAVLSDGRQDGARSASGRVSGTYVHGLFASDAFRSGLLGALGGAPSQAAYEQGVEETLDRLAAHLAAHLDL
DLLFSLAR
>Mature_487_residues
ARALMFQGTGSDVGKSLLVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQALQARAARVPLSVHMNPVLLKP
QGETGAQVVVQGRVHGTAKAAAYQGMKPSLLPFVLDSFDRLKAEADLVLVEGAGSASEVNLRTGDIANMGFARAADVPVV
VIGDIDRGGVIASLVGTKAVIDAADAALIKGFVVNRFRGDPSLFATGMELIARQTGWAALGLVPHFSEAIRLPAEDALAL
SAPPAPKPRARTRICVPILPHVSNFDDLDPLDAEPSVEVRRIRPHETLPVDTDLVLLIGSKATIADLAALKAEGLHHDIL
AFARRGGHVMGLCGGYQMLGETIADPDGIEGEAKIARGLGLLKVHTVLSPEKRLVEVAGVALDPAVAAPFSGYEMHMGVT
AGADAEQPFAVLSDGRQDGARSASGRVSGTYVHGLFASDAFRSGLLGALGGAPSQAAYEQGVEETLDRLAAHLAAHLDLD
LLFSLAR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_XANP2 (A7ILW0)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001418660.1
- ProteinModelPortal:   A7ILW0
- STRING:   A7ILW0
- GeneID:   5421437
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_3778
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   XAUT78245:XAUT_3778-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 50841; Mature: 50710

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 334-334 ACT_SITE 434-434

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARALMFQGTGSDVGKSLLVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCCHHHH
LQARAARVPLSVHMNPVLLKPQGETGAQVVVQGRVHGTAKAAAYQGMKPSLLPFVLDSFD
HHHHHHCCCEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHH
RLKAEADLVLVEGAGSASEVNLRTGDIANMGFARAADVPVVVIGDIDRGGVIASLVGTKA
HHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCHHCCCCEEEEECCCCCCEEHHHHHHHH
VIDAADAALIKGFVVNRFRGDPSLFATGMELIARQTGWAALGLVPHFSEAIRLPAEDALA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCHHCEE
LSAPPAPKPRARTRICVPILPHVSNFDDLDPLDAEPSVEVRRIRPHETLPVDTDLVLLIG
ECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEC
SKATIADLAALKAEGLHHDILAFARRGGHVMGLCGGYQMLGETIADPDGIEGEAKIARGL
CCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHCC
GLLKVHTVLSPEKRLVEVAGVALDPAVAAPFSGYEMHMGVTAGADAEQPFAVLSDGRQDG
CEEEEEECCCCHHHHHHHHCCEECCHHHCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCC
ARSASGRVSGTYVHGLFASDAFRSGLLGALGGAPSQAAYEQGVEETLDRLAAHLAAHLDL
CCCCCCCCCEEEEEEEHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
DLLFSLAR
HHHHHHCC
>Mature Secondary Structure 
ARALMFQGTGSDVGKSLLVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQA
CCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCCCCCHHHH
LQARAARVPLSVHMNPVLLKPQGETGAQVVVQGRVHGTAKAAAYQGMKPSLLPFVLDSFD
HHHHHHCCCEEECCCEEEEECCCCCCCEEEEEECCCCCHHHHHHCCCCCCHHHHHHHHHH
RLKAEADLVLVEGAGSASEVNLRTGDIANMGFARAADVPVVVIGDIDRGGVIASLVGTKA
HHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCHHCCCCEEEEECCCCCCEEHHHHHHHH
VIDAADAALIKGFVVNRFRGDPSLFATGMELIARQTGWAALGLVPHFSEAIRLPAEDALA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHCCCCHHCEE
LSAPPAPKPRARTRICVPILPHVSNFDDLDPLDAEPSVEVRRIRPHETLPVDTDLVLLIG
ECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEC
SKATIADLAALKAEGLHHDILAFARRGGHVMGLCGGYQMLGETIADPDGIEGEAKIARGL
CCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHCC
GLLKVHTVLSPEKRLVEVAGVALDPAVAAPFSGYEMHMGVTAGADAEQPFAVLSDGRQDG
CEEEEEECCCCHHHHHHHHCCEECCHHHCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCC
ARSASGRVSGTYVHGLFASDAFRSGLLGALGGAPSQAAYEQGVEETLDRLAAHLAAHLDL
CCCCCCCCCEEEEEEEHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
DLLFSLAR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA