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The map label for this gene is hldE [H]

Identifier: 154247697

GI number: 154247697

Start: 4180558

End: 4182006

Strand: Direct

Name: hldE [H]

Synonym: Xaut_3773

Alternate gene names: 154247697

Gene position: 4180558-4182006 (Clockwise)

Preceding gene: 154247696

Following gene: 154247698

Centisome position: 78.75

GC content: 72.81

Gene sequence:

>1449_bases
ATGGCGGGTAAAGGCGCGGCAGGCGCGGTGGGTCCCATCGCCGTCATCGGCGACGTGATGGTGGATCGCTATATCGTCGG
TTCCGTTTCGCGCATCTCGCCGGAGGCGCCGGTGCCGGTGCTGGTGCACGGCGCCGAGCGCATCGTGCCGGGCGGCGCCG
CCAACGTGGCGGCCAATGCCGCGGCGCTGGGAGCGCAGGTGATCCTGGTGGGCCTCACCGGCGCCGATCCGGAGGCCGAG
GCGTTGAAGGACGCGCTTTCCGCCTATCGCGACATTGACCTGTCCAGCCTGGTGGCGGACGGGGGGCGGCCCACCATCAC
CAAGACGCGGGTGATGAGCGGGCGCCAGCAGATCGTCCGCATCGATGCCGAGGTCCTGACCCCGCCGGCCGACGACACCG
TCGCGCGCCTTGTCGCGACCGTGGAAGAGGCGGTGGGGCGCAGCTCGGTGGTGGTGCTGTCCGACTATGCCAAGGGCGTG
CTGTCGGATGTGGTCATCGGCGCCGCCATCGCTGCGGCGCAGGCGAAGGGCGTGCCGGTGATCGTCGATCCCAAGCGCCG
CACCTTCGAGGCCTATCGCGGCGCGACGCTGGTCACCCCCAACCGGCTGGAACTGGCCGCCGCCACCGGCCTGCCCGACA
CCACCGACGCCGAGGCGGCCCTGGCGGCCGAGGCTGCGTCCGGCCAGTTCGGCGGCGACGTGCTGGTGACCCGCGCCGAG
AAGGGCATGACGCTGTGGCGCCGCAACGGGCAGGTGCTGCATGTGCCGGCCCAGGCCCGCGAGGTGTTCGACGTGTCGGG
TGCCGGCGATACGGCGCTGGCGGCACTGGCCGTCTCCCTCGCCTCCGGGCACACGCTGGAGACCAGCGTGCATTTCGCCA
ATGCCGCCGCCGCGGTCGCGGTAGGCAAGATCGGCACGGCAGTGGTGACGCGGGCGGAACTCAACGCGGCCCTCGACGCC
AGCGTGCCCGAGGGCGCGGCCCCCGGCGCGCTGGTGGACCGTGCCCGGGCCGCCGCCGTCATCGCCGGCTGGCAGGCGGC
AGGCGCCCGCGTGGTCTTCACCAATGGCTGCTTTGATCTGGTCCATCCCGGCCACGTCGCCATCCTGGAGGCGGCGGCGC
GGGAGGGCGACCGGCTGGTGGTGGCGCTGAACACCGATGCCTCGGTGCAGCGCCTGAAGGGGCCGACCCGTCCGGTGCAG
GACGAGGCTGCGCGCGCCCGCGTCATCGGTGCGCTGCGCTGCGTCGACCTGGTGGTGCTGTTCGAGGAGGACACCCCGCT
GGAGATCATCACCGCGCTCGGTCCGGACGTGCTGGTGAAGGGCGCCGATTACCGCGAGGACCAGGTGGTGGGCGGCGACG
TGGTGAAGTCGCGCGGCGGGCGGGTCGCCCTGATCCCGCTGGTGGAGGGGCGCTCCACGTCAGCGCTGGTGGCGAAGGCG
AAAGGGTAG

Upstream 100 bases:

>100_bases
GGCGGGCTTCACGCGTCCCTTCACCTCACTGGAGGACGGGGTCGCGTCCTATGTGAACGGCCATCTGAAGCCGCGCAACG
CGGCGTGAGGACAGAGCATC

Downstream 100 bases:

>100_bases
GGGACAGGGCGTGGCATGCAGACGCCTGCCGGATCCGCTACATGAAGTGATTTTGAATTATTCATTTATTTCAATTATTT
GTCTGCGATTGCTAAAGTCT

Product: rfaE bifunctional protein

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MAGKGAAGAVGPIAVIGDVMVDRYIVGSVSRISPEAPVPVLVHGAERIVPGGAANVAANAAALGAQVILVGLTGADPEAE
ALKDALSAYRDIDLSSLVADGGRPTITKTRVMSGRQQIVRIDAEVLTPPADDTVARLVATVEEAVGRSSVVVLSDYAKGV
LSDVVIGAAIAAAQAKGVPVIVDPKRRTFEAYRGATLVTPNRLELAAATGLPDTTDAEAALAAEAASGQFGGDVLVTRAE
KGMTLWRRNGQVLHVPAQAREVFDVSGAGDTALAALAVSLASGHTLETSVHFANAAAAVAVGKIGTAVVTRAELNAALDA
SVPEGAAPGALVDRARAAAVIAGWQAAGARVVFTNGCFDLVHPGHVAILEAAAREGDRLVVALNTDASVQRLKGPTRPVQ
DEAARARVIGALRCVDLVVLFEEDTPLEIITALGPDVLVKGADYREDQVVGGDVVKSRGGRVALIPLVEGRSTSALVAKA
KG

Sequences:

>Translated_482_residues
MAGKGAAGAVGPIAVIGDVMVDRYIVGSVSRISPEAPVPVLVHGAERIVPGGAANVAANAAALGAQVILVGLTGADPEAE
ALKDALSAYRDIDLSSLVADGGRPTITKTRVMSGRQQIVRIDAEVLTPPADDTVARLVATVEEAVGRSSVVVLSDYAKGV
LSDVVIGAAIAAAQAKGVPVIVDPKRRTFEAYRGATLVTPNRLELAAATGLPDTTDAEAALAAEAASGQFGGDVLVTRAE
KGMTLWRRNGQVLHVPAQAREVFDVSGAGDTALAALAVSLASGHTLETSVHFANAAAAVAVGKIGTAVVTRAELNAALDA
SVPEGAAPGALVDRARAAAVIAGWQAAGARVVFTNGCFDLVHPGHVAILEAAAREGDRLVVALNTDASVQRLKGPTRPVQ
DEAARARVIGALRCVDLVVLFEEDTPLEIITALGPDVLVKGADYREDQVVGGDVVKSRGGRVALIPLVEGRSTSALVAKA
KG
>Mature_481_residues
AGKGAAGAVGPIAVIGDVMVDRYIVGSVSRISPEAPVPVLVHGAERIVPGGAANVAANAAALGAQVILVGLTGADPEAEA
LKDALSAYRDIDLSSLVADGGRPTITKTRVMSGRQQIVRIDAEVLTPPADDTVARLVATVEEAVGRSSVVVLSDYAKGVL
SDVVIGAAIAAAQAKGVPVIVDPKRRTFEAYRGATLVTPNRLELAAATGLPDTTDAEAALAAEAASGQFGGDVLVTRAEK
GMTLWRRNGQVLHVPAQAREVFDVSGAGDTALAALAVSLASGHTLETSVHFANAAAAVAVGKIGTAVVTRAELNAALDAS
VPEGAAPGALVDRARAAAVIAGWQAAGARVVFTNGCFDLVHPGHVAILEAAAREGDRLVVALNTDASVQRLKGPTRPVQD
EAARARVIGALRCVDLVVLFEEDTPLEIITALGPDVLVKGADYREDQVVGGDVVKSRGGRVALIPLVEGRSTSALVAKAK
G

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=470, Percent_Identity=44.6808510638298, Blast_Score=348, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 48901; Mature: 48770

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKGAAGAVGPIAVIGDVMVDRYIVGSVSRISPEAPVPVLVHGAERIVPGGAANVAANA
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEECCHHCCCCCCCHHHHHH
AALGAQVILVGLTGADPEAEALKDALSAYRDIDLSSLVADGGRPTITKTRVMSGRQQIVR
HHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEHHHHHCCCCEEEE
IDAEVLTPPADDTVARLVATVEEAVGRSSVVVLSDYAKGVLSDVVIGAAIAAAQAKGVPV
ECHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
IVDPKRRTFEAYRGATLVTPNRLELAAATGLPDTTDAEAALAAEAASGQFGGDVLVTRAE
EECCCHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECC
KGMTLWRRNGQVLHVPAQAREVFDVSGAGDTALAALAVSLASGHTLETSVHFANAAAAVA
CCCEEEECCCCEEEECHHHHHEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
VGKIGTAVVTRAELNAALDASVPEGAAPGALVDRARAAAVIAGWQAAGARVVFTNGCFDL
HHCCCHHEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCEEEEECCCHHH
VHPGHVAILEAAAREGDRLVVALNTDASVQRLKGPTRPVQDEAARARVIGALRCVDLVVL
CCCCHHEEHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEEE
FEEDTPLEIITALGPDVLVKGADYREDQVVGGDVVKSRGGRVALIPLVEGRSTSALVAKA
ECCCCCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHCCCCEEEEEEEECCCCCCEEEEEC
KG
CC
>Mature Secondary Structure 
AGKGAAGAVGPIAVIGDVMVDRYIVGSVSRISPEAPVPVLVHGAERIVPGGAANVAANA
CCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEECCHHCCCCCCCHHHHHH
AALGAQVILVGLTGADPEAEALKDALSAYRDIDLSSLVADGGRPTITKTRVMSGRQQIVR
HHCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEHHHHHCCCCEEEE
IDAEVLTPPADDTVARLVATVEEAVGRSSVVVLSDYAKGVLSDVVIGAAIAAAQAKGVPV
ECHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEE
IVDPKRRTFEAYRGATLVTPNRLELAAATGLPDTTDAEAALAAEAASGQFGGDVLVTRAE
EECCCHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEECC
KGMTLWRRNGQVLHVPAQAREVFDVSGAGDTALAALAVSLASGHTLETSVHFANAAAAVA
CCCEEEECCCCEEEECHHHHHEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHH
VGKIGTAVVTRAELNAALDASVPEGAAPGALVDRARAAAVIAGWQAAGARVVFTNGCFDL
HHCCCHHEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCCEEEEECCCHHH
VHPGHVAILEAAAREGDRLVVALNTDASVQRLKGPTRPVQDEAARARVIGALRCVDLVVL
CCCCHHEEHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHHEEEEEEEE
FEEDTPLEIITALGPDVLVKGADYREDQVVGGDVVKSRGGRVALIPLVEGRSTSALVAKA
ECCCCCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHCCCCEEEEEEEECCCCCCEEEEEC
KG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA