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The map label for this gene is hldD [H]

Identifier: 154247696

GI number: 154247696

Start: 4179535

End: 4180545

Strand: Direct

Name: hldD [H]

Synonym: Xaut_3772

Alternate gene names: 154247696

Gene position: 4179535-4180545 (Clockwise)

Preceding gene: 154247695

Following gene: 154247697

Centisome position: 78.73

GC content: 67.85

Gene sequence:

>1011_bases
ATGACCCGATCGGTGGCGCTCAGCCGCGACCTCCTCCTCGTCACGGGCGGGGCGGGCTTCATCGGCTCCAACATCGCCCG
TGCCGCCGCCGAAGATGGCTATCGCGTGGTGGTGGCCGACTGGCTGGAGGATGGCCCCAAATGGCGCAACATCTCCGACA
TCGCGCTGCATGACGTGATCCGCCCGGAGACGGTGAACGCCTTCGTGGAGAAGGAGGGCGGCCGGCTTGCCGCCGTGGTG
CACATGGGCGCGATCTCCGCCACCACCGAGCGCGATGCCGACAAGATCGTTGCCCGCAACATCCGCTCGACGCTGGATCT
GTGGGAGCTGTGTGCGCGGAAGGCGCTGGGCCTCGTCTTCGCCTCCTCGGCCGCGACCTATGGCGACGGTACCTCCGGCT
TCGTGGATTCGGAGGAAGCGGCGGACCTTGGCGCCCTGGCGCCGCTCAATCCCTACGGCTGGTCGAAGCTGTTCGTGGAT
CGCCGCATCATGGCCGACGTGGCGGAGGGCCGGCCGCGCCCGCCGCAGTTCGCGGGCCTGCGCTTCTTCAACGTCTACGG
CCCCGGCGAGGGCCACAAGGGCGACATGCGCTCGGTGGTGCACAAGATCTATCCGGCTGCGGCGGCCGGGGAGGATGTGA
CCCTCTTCAAGTCCCACGATCCGCGCTACGAGGATGGCGGCCAATTGCGCGACTTCGTCCATGTGGGCGATTGCGTGGAG
GTGGTGCGCTGGCTGCTGGAGAGCCCGGACGTGTCCGGCATCTTCAATGTGGGCACCGGGGAGGCGCGGTCGTTCGCGGA
TCTCGCCAGGGCGGTGTTCTCGGCGCTGGGCGAGGAACCGCGCATCGCCTACGTGGACATGCCGGAAAGCCTGCAGAAGG
CCTACCAGTATTTCACCCAGGCCGATGTCTCGAAGCTACGCGCGGCGGGCTTCACGCGTCCCTTCACCTCACTGGAGGAC
GGGGTCGCGTCCTATGTGAACGGCCATCTGAAGCCGCGCAACGCGGCGTGA

Upstream 100 bases:

>100_bases
CGGGCGCTGGCGGCGCTGACGGCCTGAACCGGGCCGAACATGGACAAAAGGGGGCGCGGGTGGCACACCCTGCGCCCGAC
CTGAAGATGGGATGTTCCAC

Downstream 100 bases:

>100_bases
GGACAGAGCATCATGGCGGGTAAAGGCGCGGCAGGCGCGGTGGGTCCCATCGCCGTCATCGGCGACGTGATGGTGGATCG
CTATATCGTCGGTTCCGTTT

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTRSVALSRDLLLVTGGAGFIGSNIARAAAEDGYRVVVADWLEDGPKWRNISDIALHDVIRPETVNAFVEKEGGRLAAVV
HMGAISATTERDADKIVARNIRSTLDLWELCARKALGLVFASSAATYGDGTSGFVDSEEAADLGALAPLNPYGWSKLFVD
RRIMADVAEGRPRPPQFAGLRFFNVYGPGEGHKGDMRSVVHKIYPAAAAGEDVTLFKSHDPRYEDGGQLRDFVHVGDCVE
VVRWLLESPDVSGIFNVGTGEARSFADLARAVFSALGEEPRIAYVDMPESLQKAYQYFTQADVSKLRAAGFTRPFTSLED
GVASYVNGHLKPRNAA

Sequences:

>Translated_336_residues
MTRSVALSRDLLLVTGGAGFIGSNIARAAAEDGYRVVVADWLEDGPKWRNISDIALHDVIRPETVNAFVEKEGGRLAAVV
HMGAISATTERDADKIVARNIRSTLDLWELCARKALGLVFASSAATYGDGTSGFVDSEEAADLGALAPLNPYGWSKLFVD
RRIMADVAEGRPRPPQFAGLRFFNVYGPGEGHKGDMRSVVHKIYPAAAAGEDVTLFKSHDPRYEDGGQLRDFVHVGDCVE
VVRWLLESPDVSGIFNVGTGEARSFADLARAVFSALGEEPRIAYVDMPESLQKAYQYFTQADVSKLRAAGFTRPFTSLED
GVASYVNGHLKPRNAA
>Mature_335_residues
TRSVALSRDLLLVTGGAGFIGSNIARAAAEDGYRVVVADWLEDGPKWRNISDIALHDVIRPETVNAFVEKEGGRLAAVVH
MGAISATTERDADKIVARNIRSTLDLWELCARKALGLVFASSAATYGDGTSGFVDSEEAADLGALAPLNPYGWSKLFVDR
RIMADVAEGRPRPPQFAGLRFFNVYGPGEGHKGDMRSVVHKIYPAAAAGEDVTLFKSHDPRYEDGGQLRDFVHVGDCVEV
VRWLLESPDVSGIFNVGTGEARSFADLARAVFSALGEEPRIAYVDMPESLQKAYQYFTQADVSKLRAAGFTRPFTSLEDG
VASYVNGHLKPRNAA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=296, Percent_Identity=26.6891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI56118217, Length=296, Percent_Identity=26.6891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI189083684, Length=296, Percent_Identity=26.6891891891892, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790049, Length=319, Percent_Identity=40.1253918495298, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1786974, Length=290, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=317, Percent_Identity=27.1293375394322, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36395; Mature: 36264

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSVALSRDLLLVTGGAGFIGSNIARAAAEDGYRVVVADWLEDGPKWRNISDIALHDVI
CCCCCEECCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCHHHHHHHHC
RPETVNAFVEKEGGRLAAVVHMGAISATTERDADKIVARNIRSTLDLWELCARKALGLVF
CCHHHHHHHHCCCCEEEEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSAATYGDGTSGFVDSEEAADLGALAPLNPYGWSKLFVDRRIMADVAEGRPRPPQFAGL
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
RFFNVYGPGEGHKGDMRSVVHKIYPAAAAGEDVTLFKSHDPRYEDGGQLRDFVHVGDCVE
EEEEEECCCCCCCCHHHHHHHHHHCHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
VVRWLLESPDVSGIFNVGTGEARSFADLARAVFSALGEEPRIAYVDMPESLQKAYQYFTQ
HHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
ADVSKLRAAGFTRPFTSLEDGVASYVNGHLKPRNAA
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TRSVALSRDLLLVTGGAGFIGSNIARAAAEDGYRVVVADWLEDGPKWRNISDIALHDVI
CCCCEECCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCHHHHHHHHC
RPETVNAFVEKEGGRLAAVVHMGAISATTERDADKIVARNIRSTLDLWELCARKALGLVF
CCHHHHHHHHCCCCEEEEEEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSAATYGDGTSGFVDSEEAADLGALAPLNPYGWSKLFVDRRIMADVAEGRPRPPQFAGL
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCE
RFFNVYGPGEGHKGDMRSVVHKIYPAAAAGEDVTLFKSHDPRYEDGGQLRDFVHVGDCVE
EEEEEECCCCCCCCHHHHHHHHHHCHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
VVRWLLESPDVSGIFNVGTGEARSFADLARAVFSALGEEPRIAYVDMPESLQKAYQYFTQ
HHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
ADVSKLRAAGFTRPFTSLEDGVASYVNGHLKPRNAA
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA