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The map label for this gene is cutS [H]

Identifier: 154247683

GI number: 154247683

Start: 4162574

End: 4163977

Strand: Direct

Name: cutS [H]

Synonym: Xaut_3759

Alternate gene names: 154247683

Gene position: 4162574-4163977 (Clockwise)

Preceding gene: 154247682

Following gene: 154247684

Centisome position: 78.41

GC content: 71.08

Gene sequence:

>1404_bases
GTGGCCATCGCCTTCGTGCTGAACGGCGAAAGCGTGCGGGAGGCGACAGCTGCCCCCTCCACGACCGTGCTCGATTATCT
GCGCACAAGAGCCCATCTCACCGGCACCAAGGAAGGCTGCGCCGAAGGCGATTGCGGCGCCTGCACCATCGCCATCGGAC
GGGCGGATGGGGAGGGGGTGCGCTGGCAGGCGGCCAATGCCTGCCTCATGCTGCTGTCGCAGCTCGACGGCGCTCTGGTG
AAGACGGTGGAGGGGCTGGCGACCGGCGATGCGCTGCATCCTGTCCAGCTGGTGCTCGCCGAGAGCGACGGCACCCAATG
CGGCTTCTGCACGCCGGGCATCGTCATGTCGCTCTATGTGCTCCAGCAGGACGGGGCGGCGGATGACGCAACGATACACG
AAGCGCTGGCCGGAAACCTGTGCCGCTGCACCGGCTATCGCCCCATCGTCGACGCCGCCCGCGCGCTCTGTGCCGCCCCT
CAGGCGCGCGAGCCAGCCGTGGCCGCGCCGCGCCCGAGCACGGCCCATGGAGCGGCGGGCGAGCTGCACCTGTCCCCCGA
CAATCTGGCCGATCTCGTCGCCCTGCGCGCCACCCATCCGGAGGCCGTGCTAATCGCGGGGGCGACCGATCTCGGTCTCA
TTGCCTCCAAGCAGCGGCGGGGTTTTTCCCTCGCCATCTCCACCCGCCGCGTGGCCGAGCTGAAGCATGTCACGCGGGAG
CCGGATGGCCTCGTCGTCGGTGCGGCGGTGACCTATGCGGACGGCCTCCCGGCAGTGGAGGCGGCCTTTCCCGCCTTCGG
CGCGCTCATCCGGCGCATCGGCTCGCGGCAGATCCGGGCGCTGGGCACCTTCGGCGGCAATCTCGGCACCGCCTCCCCGG
TGGGGGACACCCTGCCGGTGCTGCTCGCCCTCGACGCGCAGGTGGAACTGGCCGGGCCGGCGGGTTCCCGCTGGATGAAG
GTGGACGATTTCCTCACCGGCTATCGCACCACGGCATTGGCACCGGACGAGGTGATCGCGGCGCTGCGCCTGCCATACCT
TGCCGAGGGCGAGCAGCTTCACGTCTGGAAGCTCTCGAAGCGCCACGACCAGGACATCTCCACGGTGCTCGCCGCCTTCC
GCGTGCGGATCGCCGACGGCGTGCTGGTGTCGATCGAGGCCGCCTTCGGTGGCATGGCCGAGCGGGCGAAGCGGGCACGG
GCGCTGGAAGCCGCTCTCACCGGTGCCCCGTGGGGCGAGGCTGCGCCCGAGCGTATCGAGGCGGCGCTCGCGGCCGATTT
CGCCCCGCTCTCCGATCACCGCGCCAGCGCCGCCTATCGCCGGGCGGCGGCGGCCAATCTCGTCCGGCGGCTGCATCTTG
CCACCATGCGACCGGACGTGGCGATCGAGGTCCACGCCCTATGA

Upstream 100 bases:

>100_bases
GCGGTGGAGGGCATCCTCATGTACGCCATTTTCGCCGCCTTCGAGCGCCGCATGGTGGCCTGGGCGTTCCGCTCCTCCAC
CGGCGCGGGAGGCTGACCGG

Downstream 100 bases:

>100_bases
GCCGCGTGGTCCATGCTCCCGCCCGCCACGAGAGCGCCAGCGCCCATGTGAGCGGGCGTGCGCTCTATCTCGACGACATG
CCGGAGCCGCCCGGCCTGCT

Product: xanthine dehydrogenase small subunit

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAIAFVLNGESVREATAAPSTTVLDYLRTRAHLTGTKEGCAEGDCGACTIAIGRADGEGVRWQAANACLMLLSQLDGALV
KTVEGLATGDALHPVQLVLAESDGTQCGFCTPGIVMSLYVLQQDGAADDATIHEALAGNLCRCTGYRPIVDAARALCAAP
QAREPAVAAPRPSTAHGAAGELHLSPDNLADLVALRATHPEAVLIAGATDLGLIASKQRRGFSLAISTRRVAELKHVTRE
PDGLVVGAAVTYADGLPAVEAAFPAFGALIRRIGSRQIRALGTFGGNLGTASPVGDTLPVLLALDAQVELAGPAGSRWMK
VDDFLTGYRTTALAPDEVIAALRLPYLAEGEQLHVWKLSKRHDQDISTVLAAFRVRIADGVLVSIEAAFGGMAERAKRAR
ALEAALTGAPWGEAAPERIEAALAADFAPLSDHRASAAYRRAAAANLVRRLHLATMRPDVAIEVHAL

Sequences:

>Translated_467_residues
MAIAFVLNGESVREATAAPSTTVLDYLRTRAHLTGTKEGCAEGDCGACTIAIGRADGEGVRWQAANACLMLLSQLDGALV
KTVEGLATGDALHPVQLVLAESDGTQCGFCTPGIVMSLYVLQQDGAADDATIHEALAGNLCRCTGYRPIVDAARALCAAP
QAREPAVAAPRPSTAHGAAGELHLSPDNLADLVALRATHPEAVLIAGATDLGLIASKQRRGFSLAISTRRVAELKHVTRE
PDGLVVGAAVTYADGLPAVEAAFPAFGALIRRIGSRQIRALGTFGGNLGTASPVGDTLPVLLALDAQVELAGPAGSRWMK
VDDFLTGYRTTALAPDEVIAALRLPYLAEGEQLHVWKLSKRHDQDISTVLAAFRVRIADGVLVSIEAAFGGMAERAKRAR
ALEAALTGAPWGEAAPERIEAALAADFAPLSDHRASAAYRRAAAANLVRRLHLATMRPDVAIEVHAL
>Mature_466_residues
AIAFVLNGESVREATAAPSTTVLDYLRTRAHLTGTKEGCAEGDCGACTIAIGRADGEGVRWQAANACLMLLSQLDGALVK
TVEGLATGDALHPVQLVLAESDGTQCGFCTPGIVMSLYVLQQDGAADDATIHEALAGNLCRCTGYRPIVDAARALCAAPQ
AREPAVAAPRPSTAHGAAGELHLSPDNLADLVALRATHPEAVLIAGATDLGLIASKQRRGFSLAISTRRVAELKHVTREP
DGLVVGAAVTYADGLPAVEAAFPAFGALIRRIGSRQIRALGTFGGNLGTASPVGDTLPVLLALDAQVELAGPAGSRWMKV
DDFLTGYRTTALAPDEVIAALRLPYLAEGEQLHVWKLSKRHDQDISTVLAAFRVRIADGVLVSIEAAFGGMAERAKRARA
LEAALTGAPWGEAAPERIEAALAADFAPLSDHRASAAYRRAAAANLVRRLHLATMRPDVAIEVHAL

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=489, Percent_Identity=32.9243353783231, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI71773480, Length=483, Percent_Identity=30.2277432712215, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1789231, Length=267, Percent_Identity=29.2134831460674, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786480, Length=168, Percent_Identity=39.2857142857143, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789232, Length=154, Percent_Identity=39.6103896103896, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17539860, Length=460, Percent_Identity=27.1739130434783, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17540638, Length=157, Percent_Identity=45.859872611465, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32566215, Length=373, Percent_Identity=28.686327077748, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737937, Length=525, Percent_Identity=32.9523809523809, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24647197, Length=508, Percent_Identity=29.7244094488189, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647195, Length=370, Percent_Identity=31.8918918918919, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24647199, Length=502, Percent_Identity=29.8804780876494, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24647201, Length=511, Percent_Identity=26.614481409002, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24647193, Length=508, Percent_Identity=29.3307086614173, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 48703; Mature: 48572

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAFVLNGESVREATAAPSTTVLDYLRTRAHLTGTKEGCAEGDCGACTIAIGRADGEGV
CEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCC
RWQAANACLMLLSQLDGALVKTVEGLATGDALHPVQLVLAESDGTQCGFCTPGIVMSLYV
EEHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHEEHE
LQQDGAADDATIHEALAGNLCRCTGYRPIVDAARALCAAPQAREPAVAAPRPSTAHGAAG
EECCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ELHLSPDNLADLVALRATHPEAVLIAGATDLGLIASKQRRGFSLAISTRRVAELKHVTRE
EEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHCC
PDGLVVGAAVTYADGLPAVEAAFPAFGALIRRIGSRQIRALGTFGGNLGTASPVGDTLPV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCCEE
LLALDAQVELAGPAGSRWMKVDDFLTGYRTTALAPDEVIAALRLPYLAEGEQLHVWKLSK
EEEECCEEEEECCCCCCCEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
RHDQDISTVLAAFRVRIADGVLVSIEAAFGGMAERAKRARALEAALTGAPWGEAAPERIE
CCCHHHHHHHHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AALAADFAPLSDHRASAAYRRAAAANLVRRLHLATMRPDVAIEVHAL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure 
AIAFVLNGESVREATAAPSTTVLDYLRTRAHLTGTKEGCAEGDCGACTIAIGRADGEGV
EEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCC
RWQAANACLMLLSQLDGALVKTVEGLATGDALHPVQLVLAESDGTQCGFCTPGIVMSLYV
EEHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHEEHE
LQQDGAADDATIHEALAGNLCRCTGYRPIVDAARALCAAPQAREPAVAAPRPSTAHGAAG
EECCCCCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
ELHLSPDNLADLVALRATHPEAVLIAGATDLGLIASKQRRGFSLAISTRRVAELKHVTRE
EEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHCC
PDGLVVGAAVTYADGLPAVEAAFPAFGALIRRIGSRQIRALGTFGGNLGTASPVGDTLPV
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCCCCEE
LLALDAQVELAGPAGSRWMKVDDFLTGYRTTALAPDEVIAALRLPYLAEGEQLHVWKLSK
EEEECCEEEEECCCCCCCEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCC
RHDQDISTVLAAFRVRIADGVLVSIEAAFGGMAERAKRARALEAALTGAPWGEAAPERIE
CCCHHHHHHHHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AALAADFAPLSDHRASAAYRRAAAANLVRRLHLATMRPDVAIEVHAL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10482497; 2818128; 10966817; 11076018 [H]