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The map label for this gene is fsr [H]

Identifier: 154246460

GI number: 154246460

Start: 2814322

End: 2815566

Strand: Reverse

Name: fsr [H]

Synonym: Xaut_2519

Alternate gene names: 154246460

Gene position: 2815566-2814322 (Counterclockwise)

Preceding gene: 154246461

Following gene: 154246454

Centisome position: 53.03

GC content: 72.21

Gene sequence:

>1245_bases
ATGCCGGCCCGGGGAGGAGTGTCGATCGTGACCATGAATGCGCGAACGGCCGAATGGCCGGCCGGGGAAGTCTCCACCAT
CGGCGCCGTGGGCGTCGCCCATTTCTGCAGCCACCTGCTCCAGCTCGCCCTCGCCCCCCTGTTCCTGATGATGCGGGCGG
ACCTCGGCGTCTCCTTCGTCGCCCTGGGCGCGGTGCTCGCGGTGTTTTATCTCTTCTCCGGGGTTGGACAGGTGACTGCC
GGCATCCTGGTGGATCGCTTCGGCGCCCATCGTCTGCTCCTCGCCGGCGTGCTGCTGCAGGGCACCGCCACGGCGGCCAT
GGGCCTTGCGCCCCATTACCTGGTGCTGCTGCCGCTCGCCGCCCTCGCCGGCCTCGGCAACTCGGTCTACCACCCGGCGG
ATCTCTCCATCCTCAGCCACAAGGTGGCGCCGGCCCGGCTCGGGCGCGCCTTCGCCGCCCATGTGATCGCCGGCAGCATC
GGCTTTGCGCTCTCCCCCCTCGTCTCCGCCGCCATCGCCACGGCCTATGGCTGGCGCACCGCGCTCGGCGCCATGGGGCT
CGGCGTGGCGGTGCTCGGCCTCGTGCTGCTGGTCTGCCGCAAGGCCCTGAAGACCGATCCGGAGCAGGGTGCCGCGCACA
GCGCCAAGGCCGCGCACGGCCCCGCCCCCACCTTCTTCCAGGTGCTGGCCATGCCGGTGGTGCTCACGGCCTTCCTGTAT
TTCCTCCTCACCTCCATCTCGCTGTCGGGCATCCAGAGCTTCTCCATCGTCGCCCTGAAGGAGGGCTTCGGCGCCACGGT
GGCGCTGGCGACGCTGGCGGTCGCGCTCTACCAGTGCGGCAATGCGGCAGGCGTCGCCCTGGGCGGGGCGGTGGCGGACC
GCACCGCCAACCATCACCTCATCGCCATGGGCGGGCTCGCCTGCGCCTGCGCGCTGGCGCTGCTCGCGGCCCTGCTGGTG
GTGCCGCCGGAGGTGACCGTGGGCCTGGTGGCGCTGGTGGGCTTCGCCATGGGCATGACCACGCCGTCCCGCGACGTGCT
GGTGCGCGGCGCCGCGCCGGCGGGGGCGACGGGCAAGGTGTTCGGCGTGGTCTATTCGGGCTACGACATCGGCGCGCTCT
TGGGCCCGCTGATGTTCGGCCTCATGCTCGACCACCACCTGCCGCGCCTGGTGTTCGTGGGCGCGGCGATCCCCCTCGGC
CTCGCGGTGCTGACCGCCTTCGCGGTGCGCCGCCGGCCGCAGTGA

Upstream 100 bases:

>100_bases
GCCAGCGGGCACGGAAGCACAAGGGCAGGGATCAACCCCGCCGCGGACCAGACGAGGGGAGGCGCAATAACCGGCGGCAA
TCGCCGGAAGGGACGGCATC

Downstream 100 bases:

>100_bases
GCGGAGCGGCTGTTATGCCATCGGCCTTATGTCTTCGACCGAGGCCGTCAGGCCCGCCAGGCGCCGCGGGGGCTTGGCCC
GCGGCTTCAGGGCCTGGCCG

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPARGGVSIVTMNARTAEWPAGEVSTIGAVGVAHFCSHLLQLALAPLFLMMRADLGVSFVALGAVLAVFYLFSGVGQVTA
GILVDRFGAHRLLLAGVLLQGTATAAMGLAPHYLVLLPLAALAGLGNSVYHPADLSILSHKVAPARLGRAFAAHVIAGSI
GFALSPLVSAAIATAYGWRTALGAMGLGVAVLGLVLLVCRKALKTDPEQGAAHSAKAAHGPAPTFFQVLAMPVVLTAFLY
FLLTSISLSGIQSFSIVALKEGFGATVALATLAVALYQCGNAAGVALGGAVADRTANHHLIAMGGLACACALALLAALLV
VPPEVTVGLVALVGFAMGMTTPSRDVLVRGAAPAGATGKVFGVVYSGYDIGALLGPLMFGLMLDHHLPRLVFVGAAIPLG
LAVLTAFAVRRRPQ

Sequences:

>Translated_414_residues
MPARGGVSIVTMNARTAEWPAGEVSTIGAVGVAHFCSHLLQLALAPLFLMMRADLGVSFVALGAVLAVFYLFSGVGQVTA
GILVDRFGAHRLLLAGVLLQGTATAAMGLAPHYLVLLPLAALAGLGNSVYHPADLSILSHKVAPARLGRAFAAHVIAGSI
GFALSPLVSAAIATAYGWRTALGAMGLGVAVLGLVLLVCRKALKTDPEQGAAHSAKAAHGPAPTFFQVLAMPVVLTAFLY
FLLTSISLSGIQSFSIVALKEGFGATVALATLAVALYQCGNAAGVALGGAVADRTANHHLIAMGGLACACALALLAALLV
VPPEVTVGLVALVGFAMGMTTPSRDVLVRGAAPAGATGKVFGVVYSGYDIGALLGPLMFGLMLDHHLPRLVFVGAAIPLG
LAVLTAFAVRRRPQ
>Mature_413_residues
PARGGVSIVTMNARTAEWPAGEVSTIGAVGVAHFCSHLLQLALAPLFLMMRADLGVSFVALGAVLAVFYLFSGVGQVTAG
ILVDRFGAHRLLLAGVLLQGTATAAMGLAPHYLVLLPLAALAGLGNSVYHPADLSILSHKVAPARLGRAFAAHVIAGSIG
FALSPLVSAAIATAYGWRTALGAMGLGVAVLGLVLLVCRKALKTDPEQGAAHSAKAAHGPAPTFFQVLAMPVVLTAFLYF
LLTSISLSGIQSFSIVALKEGFGATVALATLAVALYQCGNAAGVALGGAVADRTANHHLIAMGGLACACALALLAALLVV
PPEVTVGLVALVGFAMGMTTPSRDVLVRGAAPAGATGKVFGVVYSGYDIGALLGPLMFGLMLDHHLPRLVFVGAAIPLGL
AVLTAFAVRRRPQ

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=294, Percent_Identity=25.5102040816327, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI2367379, Length=183, Percent_Identity=26.2295081967213, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41912; Mature: 41781

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARGGVSIVTMNARTAEWPAGEVSTIGAVGVAHFCSHLLQLALAPLFLMMRADLGVSFV
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALGAVLAVFYLFSGVGQVTAGILVDRFGAHRLLLAGVLLQGTATAAMGLAPHYLVLLPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHH
ALAGLGNSVYHPADLSILSHKVAPARLGRAFAAHVIAGSIGFALSPLVSAAIATAYGWRT
HHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAMGLGVAVLGLVLLVCRKALKTDPEQGAAHSAKAAHGPAPTFFQVLAMPVVLTAFLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FLLTSISLSGIQSFSIVALKEGFGATVALATLAVALYQCGNAAGVALGGAVADRTANHHL
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCHHHHHCCCCCEE
IAMGGLACACALALLAALLVVPPEVTVGLVALVGFAMGMTTPSRDVLVRGAAPAGATGKV
EEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCE
FGVVYSGYDIGALLGPLMFGLMLDHHLPRLVFVGAAIPLGLAVLTAFAVRRRPQ
EEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PARGGVSIVTMNARTAEWPAGEVSTIGAVGVAHFCSHLLQLALAPLFLMMRADLGVSFV
CCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
ALGAVLAVFYLFSGVGQVTAGILVDRFGAHRLLLAGVLLQGTATAAMGLAPHYLVLLPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHH
ALAGLGNSVYHPADLSILSHKVAPARLGRAFAAHVIAGSIGFALSPLVSAAIATAYGWRT
HHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAMGLGVAVLGLVLLVCRKALKTDPEQGAAHSAKAAHGPAPTFFQVLAMPVVLTAFLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FLLTSISLSGIQSFSIVALKEGFGATVALATLAVALYQCGNAAGVALGGAVADRTANHHL
HHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHCHHHHHCCCCCEE
IAMGGLACACALALLAALLVVPPEVTVGLVALVGFAMGMTTPSRDVLVRGAAPAGATGKV
EEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCE
FGVVYSGYDIGALLGPLMFGLMLDHHLPRLVFVGAAIPLGLAVLTAFAVRRRPQ
EEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]