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The map label for this gene is clcA [H]

Identifier: 154246401

GI number: 154246401

Start: 2749733

End: 2751112

Strand: Reverse

Name: clcA [H]

Synonym: Xaut_2460

Alternate gene names: 154246401

Gene position: 2751112-2749733 (Counterclockwise)

Preceding gene: 154246402

Following gene: 154246391

Centisome position: 51.82

GC content: 70.94

Gene sequence:

>1380_bases
GTGATTCCCTCCGCGCCTGTCGATCCCCGCCGAACGCCGCGCGACGCCGTTTATTACGCCCTCGCCGCCGGGTCCGGGCT
TGTGGTAGGCGCGGTGGGCACGGTCTTCCACATGGCCGTGGATGGGATTTCCCGGTGGCCGGACCTTGTGCGCGCACATC
TCGACGGTCCCCTGCTCTATCTCGCCATGTCGGCGGTGGCGGCGGTGATGGTGGCGGCGGCGGTGGCCCTGGTGCGCGCC
TTCGCGCCCGAGGCGGCCGGATCTGGCGTACAGGAGATCGAGGGGGCGCTGGAAGGCCTGCGGCCGGTGCGCTGGAAGCG
GGTGCTGCCGGTGAAGTTCGTCGGCGGCGTGCTGGCGCTGGGCTCAGGCCTGGTGGCCGGACGGGAGGGGCCGACCATCC
ACATGGGCGCCGCCATCACCAAGGCCCTGTCGGACGCGGTCGGGCTCGGCACCCGGGATACACGCGGCCTGCTTGCCGCC
GGCGCGGCGGCCGGGCTGGCCGCCGCCTTCAACGCCCCGCTGGCCGCCATCCTGTTCGTGATCGAGGAGACGCGGCGCCA
ATTTCCCTATGGCCTGCGCACCTATAGCGCCGTCATCCTCTGTTCGGTGGCCAGCGCTGTGATGGCCGAGGCCATCAACG
GCTCCGGACCGGACATGAAGCTCGCGGTACCGGACATGCCCCTCCTGCTGCTGCCCGCATTCGTGGTTCTGGGGGCGGTG
CTGGGGGCGGTGGGGGTGGCCTTCAACCACGCGCTGGTGGCGTCGCTGGATGCGGCGCGGCGGCTGGCGCTGAAGGTCTC
GCCCTATCTGCTGCCGGTGCTGGTGGGGGCGGCGGTGGGGCCGCTTATCCTGCTGCGGCCGGAGGCGACCTTCGGCGGCG
AGCAGCTGGCGGTGTCCCTGCCCGGCCTCGGCCTGCCGGCGCTAACGCTGGCGGGCATCGTCATCATCCGCTTCGCCATG
ACCATGGCGAGCTACTCCACTGGAATTCCAGGCGGAATCTTCGCCCCGATCCTGGCGTTGGCGACCGCCGTTGGGGTCCT
GTTCGCGACCCTGCTGGCGCTGGCGGTGCCGATGCCTCCCGATGCGGTGGCGGCGTTCGGGGTCGCCGCCATGGGCGGGT
TGTTCTCGGCCACGGTGCGGGCGCCGCTGGTGGGCATGGTGCTGGTGGCCGAACTTACCGGCGCCTATGACCTTCTTGTT
CCAGTGATTTTGACCTGCGTTACCGCCAATCTGGTGGCCGAGGCGCTGGGCGGAAAGCCCATCTACGAGGTGCTGCTGGA
CCGCACCCTGCGCCTTGCCGGAACCCCGCGCCACGAGGCCCCGCCCGCCAGCGAGGAGCTCGGCGGCTGGGACGAACGCG
AACGGAAGACGAAGGTCTAA

Upstream 100 bases:

>100_bases
ACTTCCACTCCACCTGAGACGGAGTTGCTTGCCCCGGCGCACCTGCCTCCGCTAAGCCTTAAGGGAGCACCGTTGCTCCT
TCTTGCTCCCGAGGCCTTGC

Downstream 100 bases:

>100_bases
CCCTCTATCAGATCAGGATTATCCAGAAACGGCAGGACCTCGCCCGGCGGCCCGCGCCGGGTGATGCGGCCGGCCTCCAG
CACCACGATCTCGTCCATGC

Product: chloride channel core protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MIPSAPVDPRRTPRDAVYYALAAGSGLVVGAVGTVFHMAVDGISRWPDLVRAHLDGPLLYLAMSAVAAVMVAAAVALVRA
FAPEAAGSGVQEIEGALEGLRPVRWKRVLPVKFVGGVLALGSGLVAGREGPTIHMGAAITKALSDAVGLGTRDTRGLLAA
GAAAGLAAAFNAPLAAILFVIEETRRQFPYGLRTYSAVILCSVASAVMAEAINGSGPDMKLAVPDMPLLLLPAFVVLGAV
LGAVGVAFNHALVASLDAARRLALKVSPYLLPVLVGAAVGPLILLRPEATFGGEQLAVSLPGLGLPALTLAGIVIIRFAM
TMASYSTGIPGGIFAPILALATAVGVLFATLLALAVPMPPDAVAAFGVAAMGGLFSATVRAPLVGMVLVAELTGAYDLLV
PVILTCVTANLVAEALGGKPIYEVLLDRTLRLAGTPRHEAPPASEELGGWDERERKTKV

Sequences:

>Translated_459_residues
MIPSAPVDPRRTPRDAVYYALAAGSGLVVGAVGTVFHMAVDGISRWPDLVRAHLDGPLLYLAMSAVAAVMVAAAVALVRA
FAPEAAGSGVQEIEGALEGLRPVRWKRVLPVKFVGGVLALGSGLVAGREGPTIHMGAAITKALSDAVGLGTRDTRGLLAA
GAAAGLAAAFNAPLAAILFVIEETRRQFPYGLRTYSAVILCSVASAVMAEAINGSGPDMKLAVPDMPLLLLPAFVVLGAV
LGAVGVAFNHALVASLDAARRLALKVSPYLLPVLVGAAVGPLILLRPEATFGGEQLAVSLPGLGLPALTLAGIVIIRFAM
TMASYSTGIPGGIFAPILALATAVGVLFATLLALAVPMPPDAVAAFGVAAMGGLFSATVRAPLVGMVLVAELTGAYDLLV
PVILTCVTANLVAEALGGKPIYEVLLDRTLRLAGTPRHEAPPASEELGGWDERERKTKV
>Mature_459_residues
MIPSAPVDPRRTPRDAVYYALAAGSGLVVGAVGTVFHMAVDGISRWPDLVRAHLDGPLLYLAMSAVAAVMVAAAVALVRA
FAPEAAGSGVQEIEGALEGLRPVRWKRVLPVKFVGGVLALGSGLVAGREGPTIHMGAAITKALSDAVGLGTRDTRGLLAA
GAAAGLAAAFNAPLAAILFVIEETRRQFPYGLRTYSAVILCSVASAVMAEAINGSGPDMKLAVPDMPLLLLPAFVVLGAV
LGAVGVAFNHALVASLDAARRLALKVSPYLLPVLVGAAVGPLILLRPEATFGGEQLAVSLPGLGLPALTLAGIVIIRFAM
TMASYSTGIPGGIFAPILALATAVGVLFATLLALAVPMPPDAVAAFGVAAMGGLFSATVRAPLVGMVLVAELTGAYDLLV
PVILTCVTANLVAEALGGKPIYEVLLDRTLRLAGTPRHEAPPASEELGGWDERERKTKV

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=462, Percent_Identity=27.4891774891775, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI55770840, Length=462, Percent_Identity=27.4891774891775, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4557473, Length=466, Percent_Identity=27.6824034334764, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI189217923, Length=466, Percent_Identity=27.6824034334764, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI189217921, Length=466, Percent_Identity=27.6824034334764, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI153252026, Length=450, Percent_Identity=27.3333333333333, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI119433677, Length=426, Percent_Identity=26.056338028169, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI283806622, Length=443, Percent_Identity=26.410835214447, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI156104869, Length=443, Percent_Identity=26.410835214447, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI283806618, Length=443, Percent_Identity=26.410835214447, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI283806616, Length=432, Percent_Identity=26.3888888888889, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786350, Length=451, Percent_Identity=37.6940133037694, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87081943, Length=176, Percent_Identity=31.25, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532615, Length=433, Percent_Identity=25.635103926097, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71985148, Length=513, Percent_Identity=25.7309941520468, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71980828, Length=438, Percent_Identity=24.4292237442922, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980824, Length=438, Percent_Identity=24.4292237442922, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71980820, Length=443, Percent_Identity=24.1534988713318, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985141, Length=267, Percent_Identity=29.9625468164794, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71996455, Length=436, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71996452, Length=436, Percent_Identity=22.9357798165138, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559050, Length=437, Percent_Identity=25.858123569794, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24665008, Length=448, Percent_Identity=27.6785714285714, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551566, Length=430, Percent_Identity=26.9767441860465, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922112, Length=452, Percent_Identity=25.4424778761062, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078208, Length=408, Percent_Identity=23.7745098039216, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281361606, Length=408, Percent_Identity=23.7745098039216, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573073, Length=408, Percent_Identity=23.7745098039216, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28573075, Length=408, Percent_Identity=24.0196078431373, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281361608, Length=408, Percent_Identity=24.0196078431373, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 46760; Mature: 46760

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSAPVDPRRTPRDAVYYALAAGSGLVVGAVGTVFHMAVDGISRWPDLVRAHLDGPLLY
CCCCCCCCCCCCCHHHHEEHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LAMSAVAAVMVAAAVALVRAFAPEAAGSGVQEIEGALEGLRPVRWKRVLPVKFVGGVLAL
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHH
GSGLVAGREGPTIHMGAAITKALSDAVGLGTRDTRGLLAAGAAAGLAAAFNAPLAAILFV
CCCCEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
IEETRRQFPYGLRTYSAVILCSVASAVMAEAINGSGPDMKLAVPDMPLLLLPAFVVLGAV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHH
LGAVGVAFNHALVASLDAARRLALKVSPYLLPVLVGAAVGPLILLRPEATFGGEQLAVSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEC
PGLGLPALTLAGIVIIRFAMTMASYSTGIPGGIFAPILALATAVGVLFATLLALAVPMPP
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAVAAFGVAAMGGLFSATVRAPLVGMVLVAELTGAYDLLVPVILTCVTANLVAEALGGKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCH
IYEVLLDRTLRLAGTPRHEAPPASEELGGWDERERKTKV
HHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHCCCC
>Mature Secondary Structure
MIPSAPVDPRRTPRDAVYYALAAGSGLVVGAVGTVFHMAVDGISRWPDLVRAHLDGPLLY
CCCCCCCCCCCCCHHHHEEHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LAMSAVAAVMVAAAVALVRAFAPEAAGSGVQEIEGALEGLRPVRWKRVLPVKFVGGVLAL
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHH
GSGLVAGREGPTIHMGAAITKALSDAVGLGTRDTRGLLAAGAAAGLAAAFNAPLAAILFV
CCCCEECCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
IEETRRQFPYGLRTYSAVILCSVASAVMAEAINGSGPDMKLAVPDMPLLLLPAFVVLGAV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHH
LGAVGVAFNHALVASLDAARRLALKVSPYLLPVLVGAAVGPLILLRPEATFGGEQLAVSL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEC
PGLGLPALTLAGIVIIRFAMTMASYSTGIPGGIFAPILALATAVGVLFATLLALAVPMPP
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAVAAFGVAAMGGLFSATVRAPLVGMVLVAELTGAYDLLVPVILTCVTANLVAEALGGKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCH
IYEVLLDRTLRLAGTPRHEAPPASEELGGWDERERKTKV
HHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA