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The map label for this gene is macA [H]

Identifier: 154246393

GI number: 154246393

Start: 2739150

End: 2740436

Strand: Direct

Name: macA [H]

Synonym: Xaut_2452

Alternate gene names: 154246393

Gene position: 2739150-2740436 (Clockwise)

Preceding gene: 154246392

Following gene: 154246394

Centisome position: 51.6

GC content: 70.86

Gene sequence:

>1287_bases
ATGAACGCGCTTCCGCCCTTCGATCCGGCGCCGGCCGCCACCCACCGCGACCCCGCGCCCAAGCTGCCCGCGCGCCCGTC
GCGCCGGCTCTGGCGCTGGGGCGCGCTCGCGGTGCTGCTTGCGGTCGCGGCCTATGGCTATTCCCGATTCACCGCGCCCG
ATCCCGGCAGCGCGCTGATGACTGCTGTCGTCACCCGGGGCGACGTGGCCGAGACCGTGCTCGCCAGCGGCACGCTGAAG
CCGTCGCGGCTGGTGGCGGTGGGCGCGCAGGCGTCCGGCCGCATCACCTCGGTCAAGGTGCGGCTGGGGCAGAAGGTGAC
GGCCGGCGACCTCGTGGCCGAGATCGATTCCGTCACCCAGCAGAACGCGCTCGGCACGGCGGAGGCGTCGCTCGCCAATG
TCCGCGCCCAGAAGGCGGAGAAGGAGGCGACCCTCGGCCTCAACGAGCAGACGCTGGCCCGCCAGCGCACCATGGTGGCG
CAGAAGGCGGTGTCGCAGGCCGATTTCGAGACCGCCGAGGCCGCCGTGAAGGTCACCCGCGCCCAGCTCGCGGCGCTGGA
GGCGCAGATCGTGGAGGCCGCCATCGCGGTGGAGACGGCCCGCGCCAACCTCGGCTACACCCGCATCACCGCCCCCATCG
ACGGCACGGTGCTCGCCCTCGTGGCCCAGGAGGGCCAGACGGTGAACGCGACCCAGTCGGCGCCCACCATCGTCATCCTC
GGCGCCCTCGACGTGATGACGGTGCGGGCGGAAATCTCCGAAGCCGACATCGTGAAGGTGGCACCAAGCATGTCCCTGTG
GTTCACCATCCTCGGCGCCCCGGACATCCGCTATGACGGCAAGCTCGCGTTCATCGAGCCGGCGCCGGAAACGATCAAGA
CCGACAGCAGCTTCACCACCACGAGCACATCTTCTTCTTCGTCGTCTTCTTCCTCGTCCAGTTCTTCCTCAGCCATCTAC
TACATGGGCCTGTTCGACGTGCCGAACCCGGAGGGGCGGCTGCGCACCTACATGACGGCGGAGGTGCACATCGTCCTCGG
CGAGGCCAAAGGGGTGCTCACCGTTCCCGCCACCGCGCTCGAGCGCGACGGGGCGGGCGACAGCGTGCGCGTGGTGGAGC
CGGACGGCACGCTGGCGCGGCGCAAGGTGGAGGTGGGTCTCAACGACAAGATCACCGCCGAGATCCGCTCCGGGCTGAAG
GCGGGCGAGCGGGTGGTGACCGGCGAGAAGGTGCAGGGCGCCGCCACGGCCTCGCGCATGCCCGGCCCGCCGCCCATGGG
GTTCTAG

Upstream 100 bases:

>100_bases
GACGGGGCGGTGGACACGACCACGCCGGTGGTCGTGGACGACAATACCGGCCCCCATTTCGCGCGCCTGCCGGCGTCGGC
AATCCAGTGAGGCCGTCGGC

Downstream 100 bases:

>100_bases
CCATGCGCATGGAGCGGGTGCCTCTCATTGAACTTTGTGGCCTCAGCCGCGCCTATCCGGCCGGCGAAGGCACCATCACG
GTGCTGAAGGACATCACCCT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNALPPFDPAPAATHRDPAPKLPARPSRRLWRWGALAVLLAVAAYGYSRFTAPDPGSALMTAVVTRGDVAETVLASGTLK
PSRLVAVGAQASGRITSVKVRLGQKVTAGDLVAEIDSVTQQNALGTAEASLANVRAQKAEKEATLGLNEQTLARQRTMVA
QKAVSQADFETAEAAVKVTRAQLAALEAQIVEAAIAVETARANLGYTRITAPIDGTVLALVAQEGQTVNATQSAPTIVIL
GALDVMTVRAEISEADIVKVAPSMSLWFTILGAPDIRYDGKLAFIEPAPETIKTDSSFTTTSTSSSSSSSSSSSSSSAIY
YMGLFDVPNPEGRLRTYMTAEVHIVLGEAKGVLTVPATALERDGAGDSVRVVEPDGTLARRKVEVGLNDKITAEIRSGLK
AGERVVTGEKVQGAATASRMPGPPPMGF

Sequences:

>Translated_428_residues
MNALPPFDPAPAATHRDPAPKLPARPSRRLWRWGALAVLLAVAAYGYSRFTAPDPGSALMTAVVTRGDVAETVLASGTLK
PSRLVAVGAQASGRITSVKVRLGQKVTAGDLVAEIDSVTQQNALGTAEASLANVRAQKAEKEATLGLNEQTLARQRTMVA
QKAVSQADFETAEAAVKVTRAQLAALEAQIVEAAIAVETARANLGYTRITAPIDGTVLALVAQEGQTVNATQSAPTIVIL
GALDVMTVRAEISEADIVKVAPSMSLWFTILGAPDIRYDGKLAFIEPAPETIKTDSSFTTTSTSSSSSSSSSSSSSSAIY
YMGLFDVPNPEGRLRTYMTAEVHIVLGEAKGVLTVPATALERDGAGDSVRVVEPDGTLARRKVEVGLNDKITAEIRSGLK
AGERVVTGEKVQGAATASRMPGPPPMGF
>Mature_428_residues
MNALPPFDPAPAATHRDPAPKLPARPSRRLWRWGALAVLLAVAAYGYSRFTAPDPGSALMTAVVTRGDVAETVLASGTLK
PSRLVAVGAQASGRITSVKVRLGQKVTAGDLVAEIDSVTQQNALGTAEASLANVRAQKAEKEATLGLNEQTLARQRTMVA
QKAVSQADFETAEAAVKVTRAQLAALEAQIVEAAIAVETARANLGYTRITAPIDGTVLALVAQEGQTVNATQSAPTIVIL
GALDVMTVRAEISEADIVKVAPSMSLWFTILGAPDIRYDGKLAFIEPAPETIKTDSSFTTTSTSSSSSSSSSSSSSSAIY
YMGLFDVPNPEGRLRTYMTAEVHIVLGEAKGVLTVPATALERDGAGDSVRVVEPDGTLARRKVEVGLNDKITAEIRSGLK
AGERVVTGEKVQGAATASRMPGPPPMGF

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=383, Percent_Identity=38.1201044386423, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87082036, Length=331, Percent_Identity=24.4712990936556, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789929, Length=340, Percent_Identity=26.1764705882353, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44648; Mature: 44648

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALPPFDPAPAATHRDPAPKLPARPSRRLWRWGALAVLLAVAAYGYSRFTAPDPGSALM
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
TAVVTRGDVAETVLASGTLKPSRLVAVGAQASGRITSVKVRLGQKVTAGDLVAEIDSVTQ
HHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
QNALGTAEASLANVRAQKAEKEATLGLNEQTLARQRTMVAQKAVSQADFETAEAAVKVTR
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAALEAQIVEAAIAVETARANLGYTRITAPIDGTVLALVAQEGQTVNATQSAPTIVIL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCCEEEEE
GALDVMTVRAEISEADIVKVAPSMSLWFTILGAPDIRYDGKLAFIEPAPETIKTDSSFTT
ECCEEEEEEHHCCCCCEEEECCCCEEEEEEECCCCCEECCEEEEECCCCHHEECCCCEEE
TSTSSSSSSSSSSSSSSAIYYMGLFDVPNPEGRLRTYMTAEVHIVLGEAKGVLTVPATAL
ECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEECCCCEEECCHHHH
ERDGAGDSVRVVEPDGTLARRKVEVGLNDKITAEIRSGLKAGERVVTGEKVQGAATASRM
CCCCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHCCC
PGPPPMGF
CCCCCCCC
>Mature Secondary Structure
MNALPPFDPAPAATHRDPAPKLPARPSRRLWRWGALAVLLAVAAYGYSRFTAPDPGSALM
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
TAVVTRGDVAETVLASGTLKPSRLVAVGAQASGRITSVKVRLGQKVTAGDLVAEIDSVTQ
HHHHCCCCHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
QNALGTAEASLANVRAQKAEKEATLGLNEQTLARQRTMVAQKAVSQADFETAEAAVKVTR
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAALEAQIVEAAIAVETARANLGYTRITAPIDGTVLALVAQEGQTVNATQSAPTIVIL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEECCCCCCEEEEE
GALDVMTVRAEISEADIVKVAPSMSLWFTILGAPDIRYDGKLAFIEPAPETIKTDSSFTT
ECCEEEEEEHHCCCCCEEEECCCCEEEEEEECCCCCEECCEEEEECCCCHHEECCCCEEE
TSTSSSSSSSSSSSSSSAIYYMGLFDVPNPEGRLRTYMTAEVHIVLGEAKGVLTVPATAL
ECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEECCCCEEECCHHHH
ERDGAGDSVRVVEPDGTLARRKVEVGLNDKITAEIRSGLKAGERVVTGEKVQGAATASRM
CCCCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHCCC
PGPPPMGF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]