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The map label for this gene is nodT [H]

Identifier: 154246392

GI number: 154246392

Start: 2737595

End: 2739139

Strand: Direct

Name: nodT [H]

Synonym: Xaut_2451

Alternate gene names: 154246392

Gene position: 2737595-2739139 (Clockwise)

Preceding gene: 154246390

Following gene: 154246393

Centisome position: 51.57

GC content: 72.49

Gene sequence:

>1545_bases
ATGGCGTCCATGACGCATCGGGTGTTGGCGCGGGTTCGGGCGCAGGTTCCGACGCGGATTCTGGCACGGGTGGCGGCCGG
GCCGCTGGCGGCGCTGGTGCTGTCGGGCTGCGCCGTGGGGCCGGGCTACGAGACACCGCAACTCGCCATGCCCGACCACT
GGAGCAGCGGGCGCGGCGCGAGGGCGGAGGTCGCGCCGCAGCTCCAGCGCTGGTGGCGACGGCTGGGCGATGGCGTGCTC
GACGGGCTGATGGAGGAAGCGGTGGCCGGCAATCTCGACGTGGCGACTGCCAAGGCCAAGGTGCGTGCGGCCCGTGCCAC
CTATCGCGAGCAGGTGGGCGCCCTGTTTCCGCAGGTCACCGGCAACGCCTCCGCCACACGGGGCGACAATGGCGGCAACG
TGGGGTCGGGGGGCGATGTCACCGTCGCCAGCACCTATGGCCAGTATCAGGCGGGGCTCGACGCCAGCTGGGAAATCGAC
CTGTTCGGCGCCAACCGCCGGGGCGTGGAGGCCGCTGCCTACGGCTCGGATGCAGCGGTGGACGATCTCGACGCCGCCCT
CGTCACCCTCGTGGGCGACGTGGCCACCAATTATATCGACGCGCGCGGATATCAGGCGCGCATCGCGCTCGCCCGCCGCA
CCGCGAGCGCCCAGCGCGAGACCGCCGCGCTGACCAGGCGCAAGCTCGACGCCGGCGGCGCCTCTGCTCTGGATGCCGCC
AATGCGGCCGGGCAGGCGGCCAGTACCGAGGCGGACATTCCAGAGCTTGAAGCGGCCTATGCCCAGAGCGTGCATCGCCT
GTCCGTGCTCACGGGGCGGGAGCCGGCGGCGCTCACCGGACGGTTGGAGCGTCCGCGCGCGGTACCGGCGCCGCGCCTGC
CGGTGCCCAAGGGCATTCCAGCGCAGGTGCTCACCGCCCGCCCGGACGTGCGCGCCGCCGAGCGGCGGCTGGGCCAGTCC
ACGGCGCTGGTGGGGCAGGCGACGGCCAACCGCTATCCCTCCATCAGCCTCGCCGGCACGCTCAACACCACCGGAACGCA
ACTGGGGGATCTGGCGCGCGGCTCCTCCATCAGCTGGTCGTTCGGGCCGACACTGACGGTGCCGATCTTCACCGGCGGGC
AGCTCAAGGCGGCGCAGGAACTGGCGGAGGCAGAGCGCGACCAGTCGTTCCTCGCCTATCGCGCGGCGGTGCTCACCGCG
CTGGAGGATGTGGAGAATGCCTCCGTCTCCCTCGGCAAGCAGCGCCTGAAGGCCGGCCGGCTCGCCGCCTCCGCCGCCTC
CTACCGCGAGGCGGGGCGGCTCTCCCACGCGCTCTATGGGGCGGGCTCGTCGAGCTTCCTCGACGTGCTCACCGCCGAGC
GCTCGCTCTATGCGGCCGAGACGGCGCTGATCGAGAGCCGGGTGGCGGTGGCGACCTATTATGTGGCGCTCAACAAGGCG
CTGGGCGGCGGCTGGGACGGGGCGGTGGACACGACCACGCCGGTGGTCGTGGACGACAATACCGGCCCCCATTTCGCGCG
CCTGCCGGCGTCGGCAATCCAGTGA

Upstream 100 bases:

>100_bases
GGTCCTATTGCGGTCACCTCGACCGTGACACTGGGGCCATGAACCGGCCCACCCCCTCGACCCCTTCCGCTCCCGCCTCT
GTGCGCCGGGACGTCCCGGC

Downstream 100 bases:

>100_bases
GGCCGTCGGCATGAACGCGCTTCCGCCCTTCGATCCGGCGCCGGCCGCCACCCACCGCGACCCCGCGCCCAAGCTGCCCG
CGCGCCCGTCGCGCCGGCTC

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MASMTHRVLARVRAQVPTRILARVAAGPLAALVLSGCAVGPGYETPQLAMPDHWSSGRGARAEVAPQLQRWWRRLGDGVL
DGLMEEAVAGNLDVATAKAKVRAARATYREQVGALFPQVTGNASATRGDNGGNVGSGGDVTVASTYGQYQAGLDASWEID
LFGANRRGVEAAAYGSDAAVDDLDAALVTLVGDVATNYIDARGYQARIALARRTASAQRETAALTRRKLDAGGASALDAA
NAAGQAASTEADIPELEAAYAQSVHRLSVLTGREPAALTGRLERPRAVPAPRLPVPKGIPAQVLTARPDVRAAERRLGQS
TALVGQATANRYPSISLAGTLNTTGTQLGDLARGSSISWSFGPTLTVPIFTGGQLKAAQELAEAERDQSFLAYRAAVLTA
LEDVENASVSLGKQRLKAGRLAASAASYREAGRLSHALYGAGSSSFLDVLTAERSLYAAETALIESRVAVATYYVALNKA
LGGGWDGAVDTTTPVVVDDNTGPHFARLPASAIQ

Sequences:

>Translated_514_residues
MASMTHRVLARVRAQVPTRILARVAAGPLAALVLSGCAVGPGYETPQLAMPDHWSSGRGARAEVAPQLQRWWRRLGDGVL
DGLMEEAVAGNLDVATAKAKVRAARATYREQVGALFPQVTGNASATRGDNGGNVGSGGDVTVASTYGQYQAGLDASWEID
LFGANRRGVEAAAYGSDAAVDDLDAALVTLVGDVATNYIDARGYQARIALARRTASAQRETAALTRRKLDAGGASALDAA
NAAGQAASTEADIPELEAAYAQSVHRLSVLTGREPAALTGRLERPRAVPAPRLPVPKGIPAQVLTARPDVRAAERRLGQS
TALVGQATANRYPSISLAGTLNTTGTQLGDLARGSSISWSFGPTLTVPIFTGGQLKAAQELAEAERDQSFLAYRAAVLTA
LEDVENASVSLGKQRLKAGRLAASAASYREAGRLSHALYGAGSSSFLDVLTAERSLYAAETALIESRVAVATYYVALNKA
LGGGWDGAVDTTTPVVVDDNTGPHFARLPASAIQ
>Mature_513_residues
ASMTHRVLARVRAQVPTRILARVAAGPLAALVLSGCAVGPGYETPQLAMPDHWSSGRGARAEVAPQLQRWWRRLGDGVLD
GLMEEAVAGNLDVATAKAKVRAARATYREQVGALFPQVTGNASATRGDNGGNVGSGGDVTVASTYGQYQAGLDASWEIDL
FGANRRGVEAAAYGSDAAVDDLDAALVTLVGDVATNYIDARGYQARIALARRTASAQRETAALTRRKLDAGGASALDAAN
AAGQAASTEADIPELEAAYAQSVHRLSVLTGREPAALTGRLERPRAVPAPRLPVPKGIPAQVLTARPDVRAAERRLGQST
ALVGQATANRYPSISLAGTLNTTGTQLGDLARGSSISWSFGPTLTVPIFTGGQLKAAQELAEAERDQSFLAYRAAVLTAL
EDVENASVSLGKQRLKAGRLAASAASYREAGRLSHALYGAGSSSFLDVLTAERSLYAAETALIESRVAVATYYVALNKAL
GGGWDGAVDTTTPVVVDDNTGPHFARLPASAIQ

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=463, Percent_Identity=30.6695464362851, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI2367348, Length=438, Percent_Identity=26.027397260274, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 53379; Mature: 53248

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASMTHRVLARVRAQVPTRILARVAAGPLAALVLSGCAVGPGYETPQLAMPDHWSSGRGA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RAEVAPQLQRWWRRLGDGVLDGLMEEAVAGNLDVATAKAKVRAARATYREQVGALFPQVT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
GNASATRGDNGGNVGSGGDVTVASTYGQYQAGLDASWEIDLFGANRRGVEAAAYGSDAAV
CCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEEEECCCCCCEEECCCCCCCH
DDLDAALVTLVGDVATNYIDARGYQARIALARRTASAQRETAALTRRKLDAGGASALDAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
NAAGQAASTEADIPELEAAYAQSVHRLSVLTGREPAALTGRLERPRAVPAPRLPVPKGIP
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
AQVLTARPDVRAAERRLGQSTALVGQATANRYPSISLAGTLNTTGTQLGDLARGSSISWS
HHHEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCCCEEE
FGPTLTVPIFTGGQLKAAQELAEAERDQSFLAYRAAVLTALEDVENASVSLGKQRLKAGR
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAASAASYREAGRLSHALYGAGSSSFLDVLTAERSLYAAETALIESRVAVATYYVALNKA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGGWDGAVDTTTPVVVDDNTGPHFARLPASAIQ
HCCCCCCCCCCCCCEEEECCCCCCHHCCCHHHCC
>Mature Secondary Structure 
ASMTHRVLARVRAQVPTRILARVAAGPLAALVLSGCAVGPGYETPQLAMPDHWSSGRGA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
RAEVAPQLQRWWRRLGDGVLDGLMEEAVAGNLDVATAKAKVRAARATYREQVGALFPQVT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
GNASATRGDNGGNVGSGGDVTVASTYGQYQAGLDASWEIDLFGANRRGVEAAAYGSDAAV
CCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCEEEEEEECCCCCCEEECCCCCCCH
DDLDAALVTLVGDVATNYIDARGYQARIALARRTASAQRETAALTRRKLDAGGASALDAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
NAAGQAASTEADIPELEAAYAQSVHRLSVLTGREPAALTGRLERPRAVPAPRLPVPKGIP
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
AQVLTARPDVRAAERRLGQSTALVGQATANRYPSISLAGTLNTTGTQLGDLARGSSISWS
HHHEECCCCHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCCCEEE
FGPTLTVPIFTGGQLKAAQELAEAERDQSFLAYRAAVLTALEDVENASVSLGKQRLKAGR
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAASAASYREAGRLSHALYGAGSSSFLDVLTAERSLYAAETALIESRVAVATYYVALNKA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGGWDGAVDTTTPVVVDDNTGPHFARLPASAIQ
HCCCCCCCCCCCCCEEEECCCCCCHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]