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The map label for this gene is gyaR [H]

Identifier: 154246383

GI number: 154246383

Start: 2728276

End: 2729211

Strand: Direct

Name: gyaR [H]

Synonym: Xaut_2442

Alternate gene names: 154246383

Gene position: 2728276-2729211 (Clockwise)

Preceding gene: 154246382

Following gene: 154246385

Centisome position: 51.39

GC content: 69.44

Gene sequence:

>936_bases
ATGAAACCCGAGATCATCCAGTATTGCCCGCTGATGCCGGGCCTCGAGGCAGCGCTGGCCGAGCGCTTCACCGTGCATCG
CTTCTTCGAGGACAAGGACCCCGAGGGCTTCCTCGCCCACCATGCTGGTACCATCCGCGGTTTCGTCACCGGCGGCCATC
TGGGCCTGCCGCCGGACCTCGGCGCGAAGCTGCCGGCGCTGGAGATCGTCGCCATCAACGGCGTGGGCTTCGACAAGGTG
GACCTCAACGAGGCCAAGCGCCGGGGCGTCCGCGTCGCCAATACGCCGGACGTGCTCACCGAGGACGTGGCGGACCTCGC
CATCGGCCTGTCCATCGCGCTGCTGCGGCAGATCGTGAAGGGCGATGCCTATGTGCGCGCCGGCCAGTGGCTGGGCGGCG
ACCTTGCGCTGGGCGCCAAGGTCTCGCGGCGGCGCTTCGGCATTTTCGGGCTGGGCCGCATCGGCCGGGCCATCGCGCGG
CGGCTGGAGGGTTTCGACGCCCAGATCGCCTACAGCGACCGGGTCAATCTCGATGTGCCGTATGATTTTGAAGACACGCC
CCAGGCGCTGGCGGCGCGCAGCGATGTGTTCGTGGTGGCGGCGGCGGCCTCCGCCGAGACGCGCAACGTCATCGACCGCT
CGGTCATTGATGCCATCGGGCCGAAGGGCATCATCGTCAACGTGGCGCGCGGCTCGCTGGTGGATGAGCCGGCGCTGCTG
GCGGCGCTGAAGGAGGGCCGCATCGGCGGCGCCGCGCTCGACGTGTTCGCCGACGAGCCGCGGGTACCGGACGGCTTCTT
CGGCCTGCCCAACGTGGTGCTCACGCCCCACATGGCGAGCGCCACCGGCGAAACCCGGCAGGCCATGGCGGACCTTGTGC
TGGCCAATCTGGTGGCGCACTTCGCCGGCGAGCCTTTGCCTACCGCGCTGGTGTAA

Upstream 100 bases:

>100_bases
AGCCCGGACATGACGGGAGTCATCGCGATTATGCCTTTTTGAGTTTCCAGACGGGCTCCTAAAGCCGAGGCATCTTCCGG
CCATTTGTCAGAGGACACAC

Downstream 100 bases:

>100_bases
GGCGGGGGAATCCGAACCAGCGGGACGGCCTCACTCCTCCCGCGCCAGCTTCTCGTCGCGGGCGGCTGCCACTTCCTCGG
CCAGCGCCTCCAGCACCGGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKPEIIQYCPLMPGLEAALAERFTVHRFFEDKDPEGFLAHHAGTIRGFVTGGHLGLPPDLGAKLPALEIVAINGVGFDKV
DLNEAKRRGVRVANTPDVLTEDVADLAIGLSIALLRQIVKGDAYVRAGQWLGGDLALGAKVSRRRFGIFGLGRIGRAIAR
RLEGFDAQIAYSDRVNLDVPYDFEDTPQALAARSDVFVVAAAASAETRNVIDRSVIDAIGPKGIIVNVARGSLVDEPALL
AALKEGRIGGAALDVFADEPRVPDGFFGLPNVVLTPHMASATGETRQAMADLVLANLVAHFAGEPLPTALV

Sequences:

>Translated_311_residues
MKPEIIQYCPLMPGLEAALAERFTVHRFFEDKDPEGFLAHHAGTIRGFVTGGHLGLPPDLGAKLPALEIVAINGVGFDKV
DLNEAKRRGVRVANTPDVLTEDVADLAIGLSIALLRQIVKGDAYVRAGQWLGGDLALGAKVSRRRFGIFGLGRIGRAIAR
RLEGFDAQIAYSDRVNLDVPYDFEDTPQALAARSDVFVVAAAASAETRNVIDRSVIDAIGPKGIIVNVARGSLVDEPALL
AALKEGRIGGAALDVFADEPRVPDGFFGLPNVVLTPHMASATGETRQAMADLVLANLVAHFAGEPLPTALV
>Mature_311_residues
MKPEIIQYCPLMPGLEAALAERFTVHRFFEDKDPEGFLAHHAGTIRGFVTGGHLGLPPDLGAKLPALEIVAINGVGFDKV
DLNEAKRRGVRVANTPDVLTEDVADLAIGLSIALLRQIVKGDAYVRAGQWLGGDLALGAKVSRRRFGIFGLGRIGRAIAR
RLEGFDAQIAYSDRVNLDVPYDFEDTPQALAARSDVFVVAAAASAETRNVIDRSVIDAIGPKGIIVNVARGSLVDEPALL
AALKEGRIGGAALDVFADEPRVPDGFFGLPNVVLTPHMASATGETRQAMADLVLANLVAHFAGEPLPTALV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=254, Percent_Identity=36.2204724409449, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI23308577, Length=245, Percent_Identity=33.0612244897959, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4557497, Length=230, Percent_Identity=33.4782608695652, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI61743967, Length=230, Percent_Identity=33.4782608695652, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI145580578, Length=252, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4557499, Length=252, Percent_Identity=31.7460317460317, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=30.9236947791165, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=33.6477987421384, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789279, Length=235, Percent_Identity=31.9148936170213, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=28.4644194756554, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081824, Length=141, Percent_Identity=29.7872340425532, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=31.1284046692607, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=234, Percent_Identity=32.0512820512821, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=294, Percent_Identity=31.9727891156463, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=278, Percent_Identity=26.978417266187, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=230, Percent_Identity=30, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=281, Percent_Identity=25.6227758007117, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=272, Percent_Identity=36.0294117647059, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24585514, Length=272, Percent_Identity=36.0294117647059, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI28574282, Length=272, Percent_Identity=36.0294117647059, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI28574284, Length=272, Percent_Identity=36.0294117647059, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI45551003, Length=272, Percent_Identity=36.0294117647059, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=36.1867704280156, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28571528, Length=260, Percent_Identity=35.7692307692308, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=34.8178137651822, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI62472511, Length=236, Percent_Identity=33.0508474576271, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646446, Length=236, Percent_Identity=33.0508474576271, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646448, Length=236, Percent_Identity=33.0508474576271, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646452, Length=236, Percent_Identity=33.0508474576271, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646450, Length=236, Percent_Identity=33.0508474576271, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI19921140, Length=251, Percent_Identity=28.6852589641434, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32996; Mature: 32996

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPEIIQYCPLMPGLEAALAERFTVHRFFEDKDPEGFLAHHAGTIRGFVTGGHLGLPPDL
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCEEEEEECCCCCCCCCC
GAKLPALEIVAINGVGFDKVDLNEAKRRGVRVANTPDVLTEDVADLAIGLSIALLRQIVK
CCCCCEEEEEEECCCCCCCCCHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDAYVRAGQWLGGDLALGAKVSRRRFGIFGLGRIGRAIARRLEGFDAQIAYSDRVNLDVP
CCCEEEECCCCCCCEEECCHHHHHHCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
YDFEDTPQALAARSDVFVVAAAASAETRNVIDRSVIDAIGPKGIIVNVARGSLVDEPALL
CCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
AALKEGRIGGAALDVFADEPRVPDGFFGLPNVVLTPHMASATGETRQAMADLVLANLVAH
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHH
FAGEPLPTALV
HCCCCCCCCCC
>Mature Secondary Structure
MKPEIIQYCPLMPGLEAALAERFTVHRFFEDKDPEGFLAHHAGTIRGFVTGGHLGLPPDL
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCEEEEEECCCCCCCCCC
GAKLPALEIVAINGVGFDKVDLNEAKRRGVRVANTPDVLTEDVADLAIGLSIALLRQIVK
CCCCCEEEEEEECCCCCCCCCHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
GDAYVRAGQWLGGDLALGAKVSRRRFGIFGLGRIGRAIARRLEGFDAQIAYSDRVNLDVP
CCCEEEECCCCCCCEEECCHHHHHHCCEEEHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
YDFEDTPQALAARSDVFVVAAAASAETRNVIDRSVIDAIGPKGIIVNVARGSLVDEPALL
CCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHH
AALKEGRIGGAALDVFADEPRVPDGFFGLPNVVLTPHMASATGETRQAMADLVLANLVAH
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCHHCCCCHHHHHHHHHHHHHHHHH
FAGEPLPTALV
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA