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The map label for this gene is yciK [H]

Identifier: 154246340

GI number: 154246340

Start: 2676980

End: 2677726

Strand: Reverse

Name: yciK [H]

Synonym: Xaut_2399

Alternate gene names: 154246340

Gene position: 2677726-2676980 (Counterclockwise)

Preceding gene: 154246341

Following gene: 154246331

Centisome position: 50.44

GC content: 69.75

Gene sequence:

>747_bases
ATGACCGCCGACCGGCCCCTCGCCGACAAGATCGCCCTCGTCACCGGCGCCACCCGCGGCATTGGCGCGGCCACCGCCAT
CGCACTGGCCCGGGCCGGCGCCCATGTGGTCTGCGTCGGCCGTTCCGATGGCGGGCTCCAGGACATCGACGACAACATCC
GTGCCGTGGGCGGCACCGCCACCCTGGTGCCGCTCGACCTCAAGGATTCCGAGGCCATCGACCGGCTCGGTGGCGTGCTG
TTCGAGCGCTACAGGCGGCTCGACGTGTTCGTGGCCAATGCTGGCGTGCTCGGCCCGCTGTCGCCGCTGGGCCATGTCTA
TCCCAAGGACTGGGACGACATCGTCGCGGTGAACCTCACCGCCAACTGGCGCTGCGTGCGCTCGTTCGATCCGCTCCTGA
AGCTGTCGCCGGCCGGGCGGGTGGTGATGATCTCCTCCGGCGCCGCCCACAAGGCGCGGGCTTATTGGGGCCCCTACGCC
CTCACCAAGGCGGGGCTGGAAGTGATGGCCCGCACCTGGGCGGCGGAGAGCGTCTCCGGCAATCTCAAGGTGAACCTGTT
CAACCCCGGACCCATCCGCACCCTGATGCGGGCCAAGGCGTTTCCGGGCGAGGACCCCATGACCCTCCCCGCCCCCGAGG
AGGCGGCCGCCGCCATCCTGCCCCTGTGCCTCCCCACCTTCATGGAAACCGGCAAGCTCTACGACTTCCCCCAGGGCAAG
CTGCTGAGCTTCCAGATGCCGGTGTGA

Upstream 100 bases:

>100_bases
TTTCGCTCCTGGCCGAGGCGAGCTGAGACGCGCCTCTTGAAAAGCCCTCCCCCCAACCTGCGGGGGAGGGTGTTTTTTCC
CTTCAGTCCACGGAAGCCGC

Downstream 100 bases:

>100_bases
GGGGTCTGAGCGGGCGCCAAGCTGGACGGCATAGCGCACGCGTGTCTCGCAGATCTCCTTGATCCGCTGGTTCAGCTCGG
CCTGCGTGCCTCGCTTCGAC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTADRPLADKIALVTGATRGIGAATAIALARAGAHVVCVGRSDGGLQDIDDNIRAVGGTATLVPLDLKDSEAIDRLGGVL
FERYRRLDVFVANAGVLGPLSPLGHVYPKDWDDIVAVNLTANWRCVRSFDPLLKLSPAGRVVMISSGAAHKARAYWGPYA
LTKAGLEVMARTWAAESVSGNLKVNLFNPGPIRTLMRAKAFPGEDPMTLPAPEEAAAAILPLCLPTFMETGKLYDFPQGK
LLSFQMPV

Sequences:

>Translated_248_residues
MTADRPLADKIALVTGATRGIGAATAIALARAGAHVVCVGRSDGGLQDIDDNIRAVGGTATLVPLDLKDSEAIDRLGGVL
FERYRRLDVFVANAGVLGPLSPLGHVYPKDWDDIVAVNLTANWRCVRSFDPLLKLSPAGRVVMISSGAAHKARAYWGPYA
LTKAGLEVMARTWAAESVSGNLKVNLFNPGPIRTLMRAKAFPGEDPMTLPAPEEAAAAILPLCLPTFMETGKLYDFPQGK
LLSFQMPV
>Mature_247_residues
TADRPLADKIALVTGATRGIGAATAIALARAGAHVVCVGRSDGGLQDIDDNIRAVGGTATLVPLDLKDSEAIDRLGGVLF
ERYRRLDVFVANAGVLGPLSPLGHVYPKDWDDIVAVNLTANWRCVRSFDPLLKLSPAGRVVMISSGAAHKARAYWGPYAL
TKAGLEVMARTWAAESVSGNLKVNLFNPGPIRTLMRAKAFPGEDPMTLPAPEEAAAAILPLCLPTFMETGKLYDFPQGKL
LSFQMPV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=194, Percent_Identity=31.4432989690722, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4504505, Length=239, Percent_Identity=28.8702928870293, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI5031737, Length=232, Percent_Identity=29.7413793103448, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=32.1052631578947, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI126723191, Length=188, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=25.6, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1787526, Length=242, Percent_Identity=38.0165289256198, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=32.0855614973262, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87082100, Length=234, Percent_Identity=30.3418803418803, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=26.7206477732794, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=206, Percent_Identity=30.0970873786408, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=27.7551020408163, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87082160, Length=191, Percent_Identity=27.2251308900524, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786812, Length=192, Percent_Identity=26.0416666666667, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786701, Length=186, Percent_Identity=27.9569892473118, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=207, Percent_Identity=31.8840579710145, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=210, Percent_Identity=30, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=203, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=195, Percent_Identity=29.7435897435897, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=193, Percent_Identity=31.0880829015544, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17555612, Length=231, Percent_Identity=29.8701298701299, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=194, Percent_Identity=31.4432989690722, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=193, Percent_Identity=25.3886010362694, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=199, Percent_Identity=28.1407035175879, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=29.4416243654822, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=235, Percent_Identity=24.2553191489362, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=30.6122448979592, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=248, Percent_Identity=27.0161290322581, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322226, Length=206, Percent_Identity=27.6699029126214, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28571526, Length=219, Percent_Identity=29.6803652968037, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=29.3814432989691, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI23397609, Length=190, Percent_Identity=33.6842105263158, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=218, Percent_Identity=26.1467889908257, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24644339, Length=196, Percent_Identity=29.5918367346939, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648944, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=189, Percent_Identity=29.1005291005291, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639444, Length=221, Percent_Identity=26.2443438914027, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=24.7524752475248, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26363; Mature: 26232

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADRPLADKIALVTGATRGIGAATAIALARAGAHVVCVGRSDGGLQDIDDNIRAVGGTA
CCCCCCCHHHEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCEE
TLVPLDLKDSEAIDRLGGVLFERYRRLDVFVANAGVLGPLSPLGHVYPKDWDDIVAVNLT
EEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEE
ANWRCVRSFDPLLKLSPAGRVVMISSGAAHKARAYWGPYALTKAGLEVMARTWAAESVSG
CCEEEECCCCCCEEECCCCCEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCC
NLKVNLFNPGPIRTLMRAKAFPGEDPMTLPAPEEAAAAILPLCLPTFMETGKLYDFPQGK
CEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCC
LLSFQMPV
EEEEECCC
>Mature Secondary Structure 
TADRPLADKIALVTGATRGIGAATAIALARAGAHVVCVGRSDGGLQDIDDNIRAVGGTA
CCCCCCHHHEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEECCEE
TLVPLDLKDSEAIDRLGGVLFERYRRLDVFVANAGVLGPLSPLGHVYPKDWDDIVAVNLT
EEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEE
ANWRCVRSFDPLLKLSPAGRVVMISSGAAHKARAYWGPYALTKAGLEVMARTWAAESVSG
CCEEEECCCCCCEEECCCCCEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCC
NLKVNLFNPGPIRTLMRAKAFPGEDPMTLPAPEEAAAAILPLCLPTFMETGKLYDFPQGK
CEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCC
LLSFQMPV
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]