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The map label for this gene is cbh [H]

Identifier: 154246306

GI number: 154246306

Start: 2638832

End: 2639938

Strand: Direct

Name: cbh [H]

Synonym: Xaut_2364

Alternate gene names: 154246306

Gene position: 2638832-2639938 (Clockwise)

Preceding gene: 154246304

Following gene: 154246309

Centisome position: 49.71

GC content: 67.21

Gene sequence:

>1107_bases
TTGAAACGCATCCTGGCAGCTGCGCTTGCAGCATTCCTTCCCATCCAGAACGCCGGGCTGGCCGTGGCCTGCACGGCGGT
GAACGTGGTCGCGGCCGACAAGACCGTGATCGCCGGCCGCACCATGGAATGGGCATTCGACATGAAATGGACGCTCAAGA
GCATCCCCAAGGGCACGTCGCTGACGCTGACCGCCCCGACCGACCTCGGCCTGCCTGAGAAGACGGTGGCGACCCTCTAT
TCCGTCGTGGGCATCAGTGCCGAGGTCATTCCCGGCGGCGCCATCGTCGAGGGGCAGAACGCGGCCGGCCTCGGCATGAG
CGGCAATTTCCTGCCCGGATTCACCACCTACCAGACGGTCACCAAGGCGGACACGTCCTACGTCTCCATCCTCGGCTTCG
GCGCCTGGGCGCTCGGGATGAACGGCTCGGTGGCCGAGGTGCGCGCCGCTTTGGCGAAGATCAAGGTCTGGGCCGATGCC
TCGCTGCCGAGCGGGCCGACGCCGCCCACCCTCCACATGGTCTTCACTGACCGCTCGGGCGCCAGCATTGTCGTGGAATA
TGTCGGCGGAGAACTGCAGATCCACGACAATGTGGCGAGCGTCCTCACCAACTCGCCGCCCTACGACTGGCACCTCCTGA
ACCTGCGCAACTATCTCAACCTCTCCACCATGGGCGTCGGCGACCGCCGGTTCGGGACGGCCAACGTCACCGCCATCGGC
CAGGGCGGCGGCGCCACCGGGCTGCCGGGCGACTTCACCCCGCCCTCGCGCTTCGTGCGGGCGGCCTTCATGCGCCATTC
CATGGCCCAGCCGAAGGACGCCGCCACCGCCACCGCCGCCATCGGCCACGTCCTGAACACCGTGGATATTCCGCTGGGCG
TCGCCCAGAGCAAGGACGGCGACACGGTCGTCTCGGACTACACCCAGTGGGTGGCCATCAAGGATCTCACCCACAACCGG
ATGATGATCTCGGACTATGCCCACCGGGCGACCTTCCTGACCCTCGATCTCGATGCGATCTTCGCCCAGGACAAGCCGAG
TGCGCGGCTGGTCACGGACCTGCCGTTTCCGGCCGCGGTGGACGGGACGGCCGCGCTCCGGAACTGA

Upstream 100 bases:

>100_bases
CGCTCAATGCGGGTTCATCGGAAATCAGGCATTCCAGCGTCACGTTCAGGCGCAGGCGGCGAGACTAAAACAATCAGAAC
ACAAGATGGAGGACGCTTCC

Downstream 100 bases:

>100_bases
ACCGGCGGGCCGGCGCGCAGCCCCTCAGGCCGCCGGCCCCTCGGCCTCTCAGACCAGGGCGTGGCGCGCCACCTGCTCGC
CCACCTCGAACACCCGCTTG

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKRILAAALAAFLPIQNAGLAVACTAVNVVAADKTVIAGRTMEWAFDMKWTLKSIPKGTSLTLTAPTDLGLPEKTVATLY
SVVGISAEVIPGGAIVEGQNAAGLGMSGNFLPGFTTYQTVTKADTSYVSILGFGAWALGMNGSVAEVRAALAKIKVWADA
SLPSGPTPPTLHMVFTDRSGASIVVEYVGGELQIHDNVASVLTNSPPYDWHLLNLRNYLNLSTMGVGDRRFGTANVTAIG
QGGGATGLPGDFTPPSRFVRAAFMRHSMAQPKDAATATAAIGHVLNTVDIPLGVAQSKDGDTVVSDYTQWVAIKDLTHNR
MMISDYAHRATFLTLDLDAIFAQDKPSARLVTDLPFPAAVDGTAALRN

Sequences:

>Translated_368_residues
MKRILAAALAAFLPIQNAGLAVACTAVNVVAADKTVIAGRTMEWAFDMKWTLKSIPKGTSLTLTAPTDLGLPEKTVATLY
SVVGISAEVIPGGAIVEGQNAAGLGMSGNFLPGFTTYQTVTKADTSYVSILGFGAWALGMNGSVAEVRAALAKIKVWADA
SLPSGPTPPTLHMVFTDRSGASIVVEYVGGELQIHDNVASVLTNSPPYDWHLLNLRNYLNLSTMGVGDRRFGTANVTAIG
QGGGATGLPGDFTPPSRFVRAAFMRHSMAQPKDAATATAAIGHVLNTVDIPLGVAQSKDGDTVVSDYTQWVAIKDLTHNR
MMISDYAHRATFLTLDLDAIFAQDKPSARLVTDLPFPAAVDGTAALRN
>Mature_368_residues
MKRILAAALAAFLPIQNAGLAVACTAVNVVAADKTVIAGRTMEWAFDMKWTLKSIPKGTSLTLTAPTDLGLPEKTVATLY
SVVGISAEVIPGGAIVEGQNAAGLGMSGNFLPGFTTYQTVTKADTSYVSILGFGAWALGMNGSVAEVRAALAKIKVWADA
SLPSGPTPPTLHMVFTDRSGASIVVEYVGGELQIHDNVASVLTNSPPYDWHLLNLRNYLNLSTMGVGDRRFGTANVTAIG
QGGGATGLPGDFTPPSRFVRAAFMRHSMAQPKDAATATAAIGHVLNTVDIPLGVAQSKDGDTVVSDYTQWVAIKDLTHNR
MMISDYAHRATFLTLDLDAIFAQDKPSARLVTDLPFPAAVDGTAALRN

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 38631; Mature: 38631

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILAAALAAFLPIQNAGLAVACTAVNVVAADKTVIAGRTMEWAFDMKWTLKSIPKGTS
CHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCEEEECCEEEEEEECEEHHHHCCCCCE
LTLTAPTDLGLPEKTVATLYSVVGISAEVIPGGAIVEGQNAAGLGMSGNFLPGFTTYQTV
EEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHH
TKADTSYVSILGFGAWALGMNGSVAEVRAALAKIKVWADASLPSGPTPPTLHMVFTDRSG
HHCCCCEEEEEECCEEEECCCCCHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEEECCCC
ASIVVEYVGGELQIHDNVASVLTNSPPYDWHLLNLRNYLNLSTMGVGDRRFGTANVTAIG
CEEEEEECCCEEEECCCHHHHHCCCCCCCEEEEEHHHHCCEEEECCCCCCCCCCEEEEEE
QGGGATGLPGDFTPPSRFVRAAFMRHSMAQPKDAATATAAIGHVLNTVDIPLGVAQSKDG
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DTVVSDYTQWVAIKDLTHNRMMISDYAHRATFLTLDLDAIFAQDKPSARLVTDLPFPAAV
CEEHHHHHHEEEEEECCCCEEEEECCCCCEEEEEEEHHHEECCCCCCCEEEEECCCCCCC
DGTAALRN
CCHHHCCC
>Mature Secondary Structure
MKRILAAALAAFLPIQNAGLAVACTAVNVVAADKTVIAGRTMEWAFDMKWTLKSIPKGTS
CHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCEEEECCEEEEEEECEEHHHHCCCCCE
LTLTAPTDLGLPEKTVATLYSVVGISAEVIPGGAIVEGQNAAGLGMSGNFLPGFTTYQTV
EEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHH
TKADTSYVSILGFGAWALGMNGSVAEVRAALAKIKVWADASLPSGPTPPTLHMVFTDRSG
HHCCCCEEEEEECCEEEECCCCCHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEEECCCC
ASIVVEYVGGELQIHDNVASVLTNSPPYDWHLLNLRNYLNLSTMGVGDRRFGTANVTAIG
CEEEEEECCCEEEECCCHHHHHCCCCCCCEEEEEHHHHCCEEEECCCCCCCCCCEEEEEE
QGGGATGLPGDFTPPSRFVRAAFMRHSMAQPKDAATATAAIGHVLNTVDIPLGVAQSKDG
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DTVVSDYTQWVAIKDLTHNRMMISDYAHRATFLTLDLDAIFAQDKPSARLVTDLPFPAAV
CEEHHHHHHEEEEEECCCCEEEEECCCCCEEEEEEEHHHEECCCCCCCEEEEECCCCCCC
DGTAALRN
CCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]