Click here to switch to the map view.

The map label for this gene is tesB [H]

Identifier: 154246153

GI number: 154246153

Start: 2472441

End: 2473385

Strand: Reverse

Name: tesB [H]

Synonym: Xaut_2210

Alternate gene names: 154246153

Gene position: 2473385-2472441 (Counterclockwise)

Preceding gene: 154246155

Following gene: 154246152

Centisome position: 46.59

GC content: 69.52

Gene sequence:

>945_bases
ATGGCGTGTTCGGACCCCATCCCTTCCCTCCGGAGCGCACTGCGCGCCGGCGTTTTCAGCGAGCCAAGCCCTATGACCGG
ATCACCGTCCGACGTGGATACGCTTTTGGGCATCCTCGACCTCGAACCCCTTGAAATCAACCTGTTCCGCGGTCGCACCG
TCACCCCGGACGGGGGCCGGGTGTTCGGCGGGCAGGTGGTAGCGCAGGCGCTGGTGGCGGCGCGGCGCACGGTGGAGGCC
GAGCGCGTCACCCATTCGCTGCACGGCTATTTCCTGCTGGGCGGTGATCCCCGCGTGCCCATCATCTACGATGTGGACCG
CATCCGCGATGGGCGCTCCTTCACCACCCGCCGCGTGGTGGCGATCCAGCACGGCCAGGCCATCTTCAGCATGGCGGTGT
CGTTCCAGGTGGTGGAAGAAGGGCTGCACCACCAGGGCGCCATGCCGGACGTGCCGGCGCCGGAGGACCTGCCCTCCGAC
GATGCCTGGCGCGACAAGCTGATGGCGCGTTTTCCCGCCGCCGCCAAGCGAGACTGGATGGCGCTGCGGCCGTTGGAGGT
GAAGCCCACCAGCCTCGACCCCGCCTATCTCGGCGCGCCCGGCGCCCGGCCCAGCATGTGGCTGCGCACCCGCGGCCCGC
TGCCGGACGATCTGCCCACACATCAGGCGGTGCTTGCCTACGCTTCGGACCTCGCGCTGCTCCAGGCGGCCCTTTTGCCG
CACGGCAAGTCGGTCTTCGACCGCGACATGCAGGTGGCGAGCCTCGACCATGCCCTGTGGTTCCACCGCCCGTTCCGGGC
CGACGACTGGCTGCTCTACACCCAGGAGAGCCCCACGGCCGCCGGTGCACGCGGTTTTTGCCGCGGTGAAATCTTCACCC
GGGACGGCACGCTGGTGGCTTCAGCGGCACAAGAGGGCCTGATGCGGCCCGTCAGCCCCCGCTGA

Upstream 100 bases:

>100_bases
CCGCCGGCCGGCGCCGATCCTCTATCCGTTCCGCCGCGCTTCGTCCCACCCTAAAGGGAAGGCGGCTGACGCAAAGGGAC
TTGACGCAATCCGCGCGAGC

Downstream 100 bases:

>100_bases
AGAGCCCGAAACGGTATTGAAACACTCTATCTCGCGGCTGCGAAGACGGCGTGCCAATCCCTTGTGCGTTAAGATCAATA
ATTAGGCAAAAAAAGCGGCA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MACSDPIPSLRSALRAGVFSEPSPMTGSPSDVDTLLGILDLEPLEINLFRGRTVTPDGGRVFGGQVVAQALVAARRTVEA
ERVTHSLHGYFLLGGDPRVPIIYDVDRIRDGRSFTTRRVVAIQHGQAIFSMAVSFQVVEEGLHHQGAMPDVPAPEDLPSD
DAWRDKLMARFPAAAKRDWMALRPLEVKPTSLDPAYLGAPGARPSMWLRTRGPLPDDLPTHQAVLAYASDLALLQAALLP
HGKSVFDRDMQVASLDHALWFHRPFRADDWLLYTQESPTAAGARGFCRGEIFTRDGTLVASAAQEGLMRPVSPR

Sequences:

>Translated_314_residues
MACSDPIPSLRSALRAGVFSEPSPMTGSPSDVDTLLGILDLEPLEINLFRGRTVTPDGGRVFGGQVVAQALVAARRTVEA
ERVTHSLHGYFLLGGDPRVPIIYDVDRIRDGRSFTTRRVVAIQHGQAIFSMAVSFQVVEEGLHHQGAMPDVPAPEDLPSD
DAWRDKLMARFPAAAKRDWMALRPLEVKPTSLDPAYLGAPGARPSMWLRTRGPLPDDLPTHQAVLAYASDLALLQAALLP
HGKSVFDRDMQVASLDHALWFHRPFRADDWLLYTQESPTAAGARGFCRGEIFTRDGTLVASAAQEGLMRPVSPR
>Mature_313_residues
ACSDPIPSLRSALRAGVFSEPSPMTGSPSDVDTLLGILDLEPLEINLFRGRTVTPDGGRVFGGQVVAQALVAARRTVEAE
RVTHSLHGYFLLGGDPRVPIIYDVDRIRDGRSFTTRRVVAIQHGQAIFSMAVSFQVVEEGLHHQGAMPDVPAPEDLPSDD
AWRDKLMARFPAAAKRDWMALRPLEVKPTSLDPAYLGAPGARPSMWLRTRGPLPDDLPTHQAVLAYASDLALLQAALLPH
GKSVFDRDMQVASLDHALWFHRPFRADDWLLYTQESPTAAGARGFCRGEIFTRDGTLVASAAQEGLMRPVSPR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=292, Percent_Identity=43.1506849315069, Blast_Score=223, Evalue=1e-58,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=49.4423791821561, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71988741, Length=299, Percent_Identity=40.8026755852843, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17558508, Length=315, Percent_Identity=39.6825396825397, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI115532456, Length=277, Percent_Identity=38.6281588447653, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531889, Length=277, Percent_Identity=38.6281588447653, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17531885, Length=277, Percent_Identity=38.6281588447653, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71982224, Length=296, Percent_Identity=35.472972972973, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI212645202, Length=268, Percent_Identity=33.5820895522388, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322480, Length=343, Percent_Identity=26.530612244898, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 34318; Mature: 34186

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACSDPIPSLRSALRAGVFSEPSPMTGSPSDVDTLLGILDLEPLEINLFRGRTVTPDGGR
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEECCCCCE
VFGGQVVAQALVAARRTVEAERVTHSLHGYFLLGGDPRVPIIYDVDRIRDGRSFTTRRVV
EEHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEEHHHCCCCCCCCCEEEE
AIQHGQAIFSMAVSFQVVEEGLHHQGAMPDVPAPEDLPSDDAWRDKLMARFPAAAKRDWM
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCE
ALRPLEVKPTSLDPAYLGAPGARPSMWLRTRGPLPDDLPTHQAVLAYASDLALLQAALLP
EECCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
HGKSVFDRDMQVASLDHALWFHRPFRADDWLLYTQESPTAAGARGFCRGEIFTRDGTLVA
CCCHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEECCEEEECCCCEEE
SAAQEGLMRPVSPR
HHHHHCCCCCCCCC
>Mature Secondary Structure 
ACSDPIPSLRSALRAGVFSEPSPMTGSPSDVDTLLGILDLEPLEINLFRGRTVTPDGGR
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEECCCCCE
VFGGQVVAQALVAARRTVEAERVTHSLHGYFLLGGDPRVPIIYDVDRIRDGRSFTTRRVV
EEHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEEHHHCCCCCCCCCEEEE
AIQHGQAIFSMAVSFQVVEEGLHHQGAMPDVPAPEDLPSDDAWRDKLMARFPAAAKRDWM
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCE
ALRPLEVKPTSLDPAYLGAPGARPSMWLRTRGPLPDDLPTHQAVLAYASDLALLQAALLP
EECCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
HGKSVFDRDMQVASLDHALWFHRPFRADDWLLYTQESPTAAGARGFCRGEIFTRDGTLVA
CCCHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEECCEEEECCCCEEE
SAAQEGLMRPVSPR
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]