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The map label for this gene is gcvPA

Identifier: 154246141

GI number: 154246141

Start: 2457670

End: 2459010

Strand: Reverse

Name: gcvPA

Synonym: Xaut_2198

Alternate gene names: 154246141

Gene position: 2459010-2457670 (Counterclockwise)

Preceding gene: 154246142

Following gene: 154246140

Centisome position: 46.32

GC content: 69.5

Gene sequence:

>1341_bases
ATGCGCTATCTCCCCCTCACCCCCGAGGACCGCGCCGAGATGCTGGCGCGGATCGGCGTAGCCAGCGTGGATGAGCTGTT
CGTCGACATCCCCGCCGACAAGCGCGAGACCGCGCTGCCGCGCCTCGCCCTCCACAAGAGCGAGCTGGAGGTGGAGCGCA
CGCTTGCCCGCCTCGCCGGGCAGAACGTGCCGGCGGGCTCGGTGCCCTTCTTCGTGGGCGCCGGGGCCTATCGCCACCAT
GTGCCGGCCACCGTCGACCATCTGATCCAGCGCTCGGAATTCCTCACCTCCTACACGCCGTACCAGCCCGAGATCGCCCA
GGGCACGCTGCAATATCTGTTCGAGTTCCAGACCCAGGTGGCCGAGCTCACCGCCATGGAGGTGGCCAACGCCTCCATGT
ATGACGGCTCCACCGCCGCCGCCGAGGCGGTGCTGATGGCCCATCGCGTCACCAGGCGCCGCAAGGCGGTGCTGGCGGGC
AACCTGCATCCGCACTATCGCTCGACCATCGAGACCGTCTCGCGCTATGCCGCCGACGAGGTAGTGGCGCTGCCTCCCGC
CCCGTTCGGCGAGGAAGACCTCATCACCCCCATCGACGACACGGTGTCCTGCGTGGTGGTGCAGTCGCCGGACGTGTTCG
GCAATCTCGTCGACCTGAAGCCCATCGCCGAGGCCGCCCACAAGGCCGGCGCGCTGCTGGTGGCGGTGTTCACGGAAGCG
GTGGCGCTGGGCCTCATCGAGCCGCCGGGGGCGCAGGGCGCCGACATCGTGGTGGGCGAGGGCCAGTCCATCGGCAATGC
GCTGAATTTCGGCGGGCCTTATGTGGGCCTGTTCGCCACGCGGCAGAAATTCGTGCGCCAGATGCCGGGGCGCCTTGCCG
GCGAGACGGTGGACGCGGAAGGCCGGCGCGGCTTCGTGCTGACCCTCTCCACCCGCGAGCAGCACATCCGCCGCGAGAAG
GCCACCTCCAACATCTGCACCAATTCTGGCCTCTGCGCGCTGGCCTTCACCATCCACATGAGCCTGCTGGGCAAGACCGG
TCTCACCCGCCTCGCCCGCGCCAACCATGCGGCCGCCTGTGACCTCGCGGACCGGCTGGCGGCGGTGAAGGGGGCGAGCG
TCGTCAACGACACCTTCTTCAACGAATTCACCCTGCGCGTGCCCGGCCCGGCGGCGGACGTGGTGGAGAAGCTGGCGGCG
AAAGGCATCCTCGCCGGCGTGCCCTATTCCCGCCTCGCGCCGAAATCGGGCCTCGACGACCTCATCCTCGTCGCCGCCAC
CGAGACGACCACCGAGGACGACCGCGCCGCCTATGCCGCCGCCCTGAAGGAGGTGCTGTGA

Upstream 100 bases:

>100_bases
CATCCACCACCGGGCGCACGAGGAGTGCTTCATCGCCCATTCCGTGCGCGCGGAGATCGTCATCACGCCGCGCTTCACCA
CCGCCTGACCCGGGATTCCC

Downstream 100 bases:

>100_bases
TGAACCGCGAAGGCCGCGGCGCCACCACGCCGCATTCCATTGCCCTCACCGGCCCGCAGACCTTCACCGGCAACCGCGCG
CTCGACCTGGAGGAAGGGCT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRYLPLTPEDRAEMLARIGVASVDELFVDIPADKRETALPRLALHKSELEVERTLARLAGQNVPAGSVPFFVGAGAYRHH
VPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQVAELTAMEVANASMYDGSTAAAEAVLMAHRVTRRRKAVLAG
NLHPHYRSTIETVSRYAADEVVALPPAPFGEEDLITPIDDTVSCVVVQSPDVFGNLVDLKPIAEAAHKAGALLVAVFTEA
VALGLIEPPGAQGADIVVGEGQSIGNALNFGGPYVGLFATRQKFVRQMPGRLAGETVDAEGRRGFVLTLSTREQHIRREK
ATSNICTNSGLCALAFTIHMSLLGKTGLTRLARANHAAACDLADRLAAVKGASVVNDTFFNEFTLRVPGPAADVVEKLAA
KGILAGVPYSRLAPKSGLDDLILVAATETTTEDDRAAYAAALKEVL

Sequences:

>Translated_446_residues
MRYLPLTPEDRAEMLARIGVASVDELFVDIPADKRETALPRLALHKSELEVERTLARLAGQNVPAGSVPFFVGAGAYRHH
VPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQVAELTAMEVANASMYDGSTAAAEAVLMAHRVTRRRKAVLAG
NLHPHYRSTIETVSRYAADEVVALPPAPFGEEDLITPIDDTVSCVVVQSPDVFGNLVDLKPIAEAAHKAGALLVAVFTEA
VALGLIEPPGAQGADIVVGEGQSIGNALNFGGPYVGLFATRQKFVRQMPGRLAGETVDAEGRRGFVLTLSTREQHIRREK
ATSNICTNSGLCALAFTIHMSLLGKTGLTRLARANHAAACDLADRLAAVKGASVVNDTFFNEFTLRVPGPAADVVEKLAA
KGILAGVPYSRLAPKSGLDDLILVAATETTTEDDRAAYAAALKEVL
>Mature_446_residues
MRYLPLTPEDRAEMLARIGVASVDELFVDIPADKRETALPRLALHKSELEVERTLARLAGQNVPAGSVPFFVGAGAYRHH
VPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQVAELTAMEVANASMYDGSTAAAEAVLMAHRVTRRRKAVLAG
NLHPHYRSTIETVSRYAADEVVALPPAPFGEEDLITPIDDTVSCVVVQSPDVFGNLVDLKPIAEAAHKAGALLVAVFTEA
VALGLIEPPGAQGADIVVGEGQSIGNALNFGGPYVGLFATRQKFVRQMPGRLAGETVDAEGRRGFVLTLSTREQHIRREK
ATSNICTNSGLCALAFTIHMSLLGKTGLTRLARANHAAACDLADRLAAVKGASVVNDTFFNEFTLRVPGPAADVVEKLAA
KGILAGVPYSRLAPKSGLDDLILVAATETTTEDDRAAYAAALKEVL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=443, Percent_Identity=34.3115124153499, Blast_Score=244, Evalue=2e-64,
Organism=Escherichia coli, GI1789269, Length=441, Percent_Identity=30.8390022675737, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=397, Percent_Identity=35.7682619647355, Blast_Score=198, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=411, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24645648, Length=430, Percent_Identity=35.5813953488372, Blast_Score=234, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_XANP2 (A7IHE9)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417099.1
- ProteinModelPortal:   A7IHE9
- SMR:   A7IHE9
- STRING:   A7IHE9
- GeneID:   5424377
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2198
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   XAUT78245:XAUT_2198-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47691; Mature: 47691

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLPLTPEDRAEMLARIGVASVDELFVDIPADKRETALPRLALHKSELEVERTLARLAG
CCCCCCCCHHHHHHHHHHCHHHHHHHEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHC
QNVPAGSVPFFVGAGAYRHHVPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQV
CCCCCCCCCEEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AELTAMEVANASMYDGSTAAAEAVLMAHRVTRRRKAVLAGNLHPHYRSTIETVSRYAADE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VVALPPAPFGEEDLITPIDDTVSCVVVQSPDVFGNLVDLKPIAEAAHKAGALLVAVFTEA
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCHHHHHHHHHHHCHHHHHHHHHH
VALGLIEPPGAQGADIVVGEGQSIGNALNFGGPYVGLFATRQKFVRQMPGRLAGETVDAE
HHHCCCCCCCCCCCEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCC
GRRGFVLTLSTREQHIRREKATSNICTNSGLCALAFTIHMSLLGKTGLTRLARANHAAAC
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLADRLAAVKGASVVNDTFFNEFTLRVPGPAADVVEKLAAKGILAGVPYSRLAPKSGLDD
HHHHHHHHHCCCHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
LILVAATETTTEDDRAAYAAALKEVL
EEEEEEECCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MRYLPLTPEDRAEMLARIGVASVDELFVDIPADKRETALPRLALHKSELEVERTLARLAG
CCCCCCCCHHHHHHHHHHCHHHHHHHEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHC
QNVPAGSVPFFVGAGAYRHHVPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQV
CCCCCCCCCEEECCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AELTAMEVANASMYDGSTAAAEAVLMAHRVTRRRKAVLAGNLHPHYRSTIETVSRYAADE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
VVALPPAPFGEEDLITPIDDTVSCVVVQSPDVFGNLVDLKPIAEAAHKAGALLVAVFTEA
EEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCHHHHHHHHHHHCHHHHHHHHHH
VALGLIEPPGAQGADIVVGEGQSIGNALNFGGPYVGLFATRQKFVRQMPGRLAGETVDAE
HHHCCCCCCCCCCCEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCC
GRRGFVLTLSTREQHIRREKATSNICTNSGLCALAFTIHMSLLGKTGLTRLARANHAAAC
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLADRLAAVKGASVVNDTFFNEFTLRVPGPAADVVEKLAAKGILAGVPYSRLAPKSGLDD
HHHHHHHHHCCCHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCCCC
LILVAATETTTEDDRAAYAAALKEVL
EEEEEEECCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA