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The map label for this gene is gcvPB [H]

Identifier: 154246140

GI number: 154246140

Start: 2456099

End: 2457670

Strand: Reverse

Name: gcvPB [H]

Synonym: Xaut_2197

Alternate gene names: 154246140

Gene position: 2457670-2456099 (Counterclockwise)

Preceding gene: 154246141

Following gene: 154246136

Centisome position: 46.29

GC content: 70.42

Gene sequence:

>1572_bases
ATGAACCGCGAAGGCCGCGGCGCCACCACGCCGCATTCCATTGCCCTCACCGGCCCGCAGACCTTCACCGGCAACCGCGC
GCTCGACCTGGAGGAAGGGCTGATCTTCGAGATCGGCCGCACCGAGGTGACAGGCGTCGACATTCCCGAGCCCGCGCCGT
TCCGCGAGCGCCTCGGCACACAGGCGCGTACCGCGCCGCTGGACCTGCCCGGCCTCAGCGAGCCGGAGGCTATGCGCCAT
TACGTGCGCCTGTCGCGCATGAACTACGGCATCGACAGCGGCCTGTTCCCGCTCGGCTCGTGCACCATGAAGCACAATCC
GCGCCTCAACGAGAAGATGGCGCGGCTGCCGGGCTTTGCCGACATCCATCCGCTGCAGCCGCAATCCACGGTGAAGGGCG
CGCTGGGCCTGATGGCGGAGCTGTCGCGCTATCTGCTGGAATTGACCGGCATGCAGGCGGTGGCGCTCACTCCCAAGGCC
GGCGCCCACGGCGAACTGTGCGGCATGATGGCCATCAAGGCCGCCCATGCCGCCCGCGGCGATGGCGCCACCCGTCACGT
GGTGCTGGTGCCGGAGAGCGCCCACGGTACCAATCCCGCCACCGCCGCCCTCATCGGCTATCAGGTGCGCTCCATCCCCG
CCCGCGCCGACGGCACGGTGGATCCGGAGGCGGTGAAATCCGCGCTCGGCCCGGAGGTGGCGGCGCTGATGCTGACCAAT
CCCAACACCTGCGGGCTGTTCGAGCGCGACGTGGTGGCCATCGCCGAGGCGGTGCACGGCGCCGGCGCCTATTTCTATTC
GGACGGCGCCAATTTCAACGCCATCCTCGGCAAGGTGCGCATCGCCGACCTCGGGGTCGATGCCATGCACATCAACCTGC
ACAAGACCTTCTCCACGCCCCACGGCGGCGGCGGGCCGGGCGCGGGGCCGGTGGTGCTCTCCGACGCGCTCGCCCCCTTT
GCCCCTGTACCGGCACTGGTGGCCACCGCCGACGGGCTGGCGTTGGTGGAAGACGAGGGCGCGGAGGGCGCCCAGCAGGC
GCTAGGCCGCATGAGCGCCTTCCACGGCCAGATGGGCATGTTCGTGCGCGCCCTGGCGTGGATGCTTTCTCACGGCGCGG
ACGGTATGCGGCAGGCCTCGGAAGACGCGGTGCTGTCGGCCAATTACATCCGCGCCAGCCTCATGGACCTCATGAGCGCG
CCCTTCGCCGAGCGGCCGGCCATGCACGAGGCGCTGTTCGACGACGCCTGGCTGGCCGGCACCGGCCTCACCACCCTGGA
CGTGGCCAAGGCCCTGATCGATGAGGGCTACCACCCCATGACGGTGTATTTCCCGCTGGTGGTGCACGGCGCCATGCTCA
TCGAGCCCACGGAGAGCGAATCCAAGGCCTCGCTGGACCTGTTCATCGCCGCGCTGCGGGACCTCGCCATGGCCGCCAAG
GCCGGGGACAAGGAGCGCTTCCTCGGCGCTCCCTATTACGCCCCGCGCCGCCGCCTGGACGAAACCCGCGCCGCCCGCGC
CCCGGTGCTGCGCTGGGTGAAGCCGGCGCCCGTGGCCGACGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
CGAAATCGGGCCTCGACGACCTCATCCTCGTCGCCGCCACCGAGACGACCACCGAGGACGACCGCGCCGCCTATGCCGCC
GCCCTGAAGGAGGTGCTGTG

Downstream 100 bases:

>100_bases
CCTCAGCGCCTCCCGCCTGCTCGCGACCACGCAGGGAGCCGGCGGGAGGCGTCTTCGAGCACGGCTCTCAGCCCCGAAAC
GACGAAAACCCGCGGGGGCA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNREGRGATTPHSIALTGPQTFTGNRALDLEEGLIFEIGRTEVTGVDIPEPAPFRERLGTQARTAPLDLPGLSEPEAMRH
YVRLSRMNYGIDSGLFPLGSCTMKHNPRLNEKMARLPGFADIHPLQPQSTVKGALGLMAELSRYLLELTGMQAVALTPKA
GAHGELCGMMAIKAAHAARGDGATRHVVLVPESAHGTNPATAALIGYQVRSIPARADGTVDPEAVKSALGPEVAALMLTN
PNTCGLFERDVVAIAEAVHGAGAYFYSDGANFNAILGKVRIADLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSDALAPF
APVPALVATADGLALVEDEGAEGAQQALGRMSAFHGQMGMFVRALAWMLSHGADGMRQASEDAVLSANYIRASLMDLMSA
PFAERPAMHEALFDDAWLAGTGLTTLDVAKALIDEGYHPMTVYFPLVVHGAMLIEPTESESKASLDLFIAALRDLAMAAK
AGDKERFLGAPYYAPRRRLDETRAARAPVLRWVKPAPVADAAE

Sequences:

>Translated_523_residues
MNREGRGATTPHSIALTGPQTFTGNRALDLEEGLIFEIGRTEVTGVDIPEPAPFRERLGTQARTAPLDLPGLSEPEAMRH
YVRLSRMNYGIDSGLFPLGSCTMKHNPRLNEKMARLPGFADIHPLQPQSTVKGALGLMAELSRYLLELTGMQAVALTPKA
GAHGELCGMMAIKAAHAARGDGATRHVVLVPESAHGTNPATAALIGYQVRSIPARADGTVDPEAVKSALGPEVAALMLTN
PNTCGLFERDVVAIAEAVHGAGAYFYSDGANFNAILGKVRIADLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSDALAPF
APVPALVATADGLALVEDEGAEGAQQALGRMSAFHGQMGMFVRALAWMLSHGADGMRQASEDAVLSANYIRASLMDLMSA
PFAERPAMHEALFDDAWLAGTGLTTLDVAKALIDEGYHPMTVYFPLVVHGAMLIEPTESESKASLDLFIAALRDLAMAAK
AGDKERFLGAPYYAPRRRLDETRAARAPVLRWVKPAPVADAAE
>Mature_523_residues
MNREGRGATTPHSIALTGPQTFTGNRALDLEEGLIFEIGRTEVTGVDIPEPAPFRERLGTQARTAPLDLPGLSEPEAMRH
YVRLSRMNYGIDSGLFPLGSCTMKHNPRLNEKMARLPGFADIHPLQPQSTVKGALGLMAELSRYLLELTGMQAVALTPKA
GAHGELCGMMAIKAAHAARGDGATRHVVLVPESAHGTNPATAALIGYQVRSIPARADGTVDPEAVKSALGPEVAALMLTN
PNTCGLFERDVVAIAEAVHGAGAYFYSDGANFNAILGKVRIADLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSDALAPF
APVPALVATADGLALVEDEGAEGAQQALGRMSAFHGQMGMFVRALAWMLSHGADGMRQASEDAVLSANYIRASLMDLMSA
PFAERPAMHEALFDDAWLAGTGLTTLDVAKALIDEGYHPMTVYFPLVVHGAMLIEPTESESKASLDLFIAALRDLAMAAK
AGDKERFLGAPYYAPRRRLDETRAARAPVLRWVKPAPVADAAE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=406, Percent_Identity=36.6995073891626, Blast_Score=214, Evalue=2e-55,
Organism=Escherichia coli, GI1789269, Length=406, Percent_Identity=38.6699507389163, Blast_Score=242, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17535605, Length=405, Percent_Identity=35.5555555555556, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32564013, Length=361, Percent_Identity=36.01108033241, Blast_Score=194, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6323843, Length=408, Percent_Identity=36.0294117647059, Blast_Score=226, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24645648, Length=408, Percent_Identity=36.2745098039216, Blast_Score=212, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 55283; Mature: 55283

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREGRGATTPHSIALTGPQTFTGNRALDLEEGLIFEIGRTEVTGVDIPEPAPFRERLGT
CCCCCCCCCCCCEEEEECCCEECCCEEEECCCCCEEEECCCEECCCCCCCCCCHHHHCCC
QARTAPLDLPGLSEPEAMRHYVRLSRMNYGIDSGLFPLGSCTMKHNPRLNEKMARLPGFA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
DIHPLQPQSTVKGALGLMAELSRYLLELTGMQAVALTPKAGAHGELCGMMAIKAAHAARG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC
DGATRHVVLVPESAHGTNPATAALIGYQVRSIPARADGTVDPEAVKSALGPEVAALMLTN
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEEEC
PNTCGLFERDVVAIAEAVHGAGAYFYSDGANFNAILGKVRIADLGVDAMHINLHKTFSTP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHEEEEEEECCCEEEEEEEEEEECCC
HGGGGPGAGPVVLSDALAPFAPVPALVATADGLALVEDEGAEGAQQALGRMSAFHGQMGM
CCCCCCCCCCHHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
FVRALAWMLSHGADGMRQASEDAVLSANYIRASLMDLMSAPFAERPAMHEALFDDAWLAG
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
TGLTTLDVAKALIDEGYHPMTVYFPLVVHGAMLIEPTESESKASLDLFIAALRDLAMAAK
CCCHHHHHHHHHHHCCCCCEEEEEHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AGDKERFLGAPYYAPRRRLDETRAARAPVLRWVKPAPVADAAE
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNREGRGATTPHSIALTGPQTFTGNRALDLEEGLIFEIGRTEVTGVDIPEPAPFRERLGT
CCCCCCCCCCCCEEEEECCCEECCCEEEECCCCCEEEECCCEECCCCCCCCCCHHHHCCC
QARTAPLDLPGLSEPEAMRHYVRLSRMNYGIDSGLFPLGSCTMKHNPRLNEKMARLPGFA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
DIHPLQPQSTVKGALGLMAELSRYLLELTGMQAVALTPKAGAHGELCGMMAIKAAHAARG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCC
DGATRHVVLVPESAHGTNPATAALIGYQVRSIPARADGTVDPEAVKSALGPEVAALMLTN
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEEEC
PNTCGLFERDVVAIAEAVHGAGAYFYSDGANFNAILGKVRIADLGVDAMHINLHKTFSTP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHEEEEEEECCCEEEEEEEEEEECCC
HGGGGPGAGPVVLSDALAPFAPVPALVATADGLALVEDEGAEGAQQALGRMSAFHGQMGM
CCCCCCCCCCHHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
FVRALAWMLSHGADGMRQASEDAVLSANYIRASLMDLMSAPFAERPAMHEALFDDAWLAG
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
TGLTTLDVAKALIDEGYHPMTVYFPLVVHGAMLIEPTESESKASLDLFIAALRDLAMAAK
CCCHHHHHHHHHHHCCCCCEEEEEHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AGDKERFLGAPYYAPRRRLDETRAARAPVLRWVKPAPVADAAE
CCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]