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The map label for this gene is etfA [H]

Identifier: 154246101

GI number: 154246101

Start: 2419671

End: 2420615

Strand: Reverse

Name: etfA [H]

Synonym: Xaut_2158

Alternate gene names: 154246101

Gene position: 2420615-2419671 (Counterclockwise)

Preceding gene: 154246102

Following gene: 154246100

Centisome position: 45.6

GC content: 69.52

Gene sequence:

>945_bases
ATGGCAACTTTGCTGCTCGCCGAACACGACAATTCGGCTCTCAACGGCGTCACCGCCAAGGCACTCAGCGCCGCCGCCGC
CCTCGGTGGCCCGGTGCACATCCTGGTGGCCGGCCAGAACGCCAAGGGCGTCGCCGATGCCGCGGCCAAGCTTTCCGGCG
TGGAAAAGGTGCTGCTGGCGGACGACGCGCTCTATGCCCACCGCCTCGCCGAGCCGCTCGCCGCGCTCATCGTGGCGCTG
GCCCCTGGCTATGACGCCATCGTCGGCCCCTCCACGGCGGTGGCCAAGAACGTGCTGCCGCGCGTGGCCGCCCTGCTGGA
CGTGATGCAGGTGTCGGACATCACCAAGGTGGTGGCCCCCGACACCTTCGAGCGGCCCATCTATGCGGGCAACGCCATTC
AGACCGTGAAGTCCTCGGACGCCAAGAAGGTGATCACGGTGCGCACCGCCTCCTTTGGCGCCACCAGCGAGGGTGGCACC
GCCGCGGTCGAGGCCATCGCGGCGGTGGCCGATCCCGGCGTCTCCACCTTCGTGGAGGAGACCATCGCGGCCTCCGACCG
TCCGGAGCTGACGGCGGCGAAGATCATCGTCTCCGGCGGCCGCGCCCTGGGCTCGCGGGAGAAGTTCGCCGAGCTGATCG
AGCCGCTGGCCGACGTGCTGGGCGCGGCGGTGGGCGCCTCGCGCGCCGCGGTGGACGCGGGCTATGCCCCCAACGACTGG
CAGGTGGGCCAGACCGGCAAGGTGGTGGCCCCGGAGCTGTACATCGCGCTGGGCATTTCCGGCGCCATCCAGCATCTGGC
CGGCATGAAGGACAGCAAGGTCATCGTCGCCGTCAACAAGGACGAGGAGGCCCCCATCTTCCAGGTGGCCGACTACGGCC
TCGTCGGCGACATCAACACCGTCATCCCCGAGCTCAAGGCGGAACTCGCCAAGGCGAAGGGATAA

Upstream 100 bases:

>100_bases
TGCTTTCCACCGCGGAACCCGCGGGCCGCAAGGCGGGCGTGAAGGTGGGCTCGGTGGCCGAGCTGGTGGCGAAGCTCAAG
GATGAGGCGGGGGTGATCTG

Downstream 100 bases:

>100_bases
GGCCAAAGCGTTTTCGCGCGCGGTGCCCCCCATTCAACGCGGCGCGAAAATGATCTAGAAACGAGCGGCCGGGCACGCCC
CGGCCGCTGCCATCAGGGGC

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MATLLLAEHDNSALNGVTAKALSAAAALGGPVHILVAGQNAKGVADAAAKLSGVEKVLLADDALYAHRLAEPLAALIVAL
APGYDAIVGPSTAVAKNVLPRVAALLDVMQVSDITKVVAPDTFERPIYAGNAIQTVKSSDAKKVITVRTASFGATSEGGT
AAVEAIAAVADPGVSTFVEETIAASDRPELTAAKIIVSGGRALGSREKFAELIEPLADVLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPELYIALGISGAIQHLAGMKDSKVIVAVNKDEEAPIFQVADYGLVGDINTVIPELKAELAKAKG

Sequences:

>Translated_314_residues
MATLLLAEHDNSALNGVTAKALSAAAALGGPVHILVAGQNAKGVADAAAKLSGVEKVLLADDALYAHRLAEPLAALIVAL
APGYDAIVGPSTAVAKNVLPRVAALLDVMQVSDITKVVAPDTFERPIYAGNAIQTVKSSDAKKVITVRTASFGATSEGGT
AAVEAIAAVADPGVSTFVEETIAASDRPELTAAKIIVSGGRALGSREKFAELIEPLADVLGAAVGASRAAVDAGYAPNDW
QVGQTGKVVAPELYIALGISGAIQHLAGMKDSKVIVAVNKDEEAPIFQVADYGLVGDINTVIPELKAELAKAKG
>Mature_313_residues
ATLLLAEHDNSALNGVTAKALSAAAALGGPVHILVAGQNAKGVADAAAKLSGVEKVLLADDALYAHRLAEPLAALIVALA
PGYDAIVGPSTAVAKNVLPRVAALLDVMQVSDITKVVAPDTFERPIYAGNAIQTVKSSDAKKVITVRTASFGATSEGGTA
AVEAIAAVADPGVSTFVEETIAASDRPELTAAKIIVSGGRALGSREKFAELIEPLADVLGAAVGASRAAVDAGYAPNDWQ
VGQTGKVVAPELYIALGISGAIQHLAGMKDSKVIVAVNKDEEAPIFQVADYGLVGDINTVIPELKAELAKAKG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=313, Percent_Identity=53.9936102236422, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI189181759, Length=277, Percent_Identity=55.2346570397112, Blast_Score=280, Evalue=9e-76,
Organism=Escherichia coli, GI1786226, Length=232, Percent_Identity=35.3448275862069, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787990, Length=264, Percent_Identity=33.7121212121212, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082157, Length=226, Percent_Identity=30.0884955752212, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=311, Percent_Identity=54.0192926045016, Blast_Score=304, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6325261, Length=294, Percent_Identity=47.2789115646259, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=55.7692307692308, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=55.7692307692308, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31755; Mature: 31623

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLLLAEHDNSALNGVTAKALSAAAALGGPVHILVAGQNAKGVADAAAKLSGVEKVLLA
CCEEEEEECCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
DDALYAHRLAEPLAALIVALAPGYDAIVGPSTAVAKNVLPRVAALLDVMQVSDITKVVAP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFERPIYAGNAIQTVKSSDAKKVITVRTASFGATSEGGTAAVEAIAAVADPGVSTFVEE
CCCCCCEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
TIAASDRPELTAAKIIVSGGRALGSREKFAELIEPLADVLGAAVGASRAAVDAGYAPNDW
HHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPELYIALGISGAIQHLAGMKDSKVIVAVNKDEEAPIFQVADYGLVGDINT
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHH
VIPELKAELAKAKG
HHHHHHHHHHHCCC
>Mature Secondary Structure 
ATLLLAEHDNSALNGVTAKALSAAAALGGPVHILVAGQNAKGVADAAAKLSGVEKVLLA
CEEEEEECCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
DDALYAHRLAEPLAALIVALAPGYDAIVGPSTAVAKNVLPRVAALLDVMQVSDITKVVAP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DTFERPIYAGNAIQTVKSSDAKKVITVRTASFGATSEGGTAAVEAIAAVADPGVSTFVEE
CCCCCCEECCCHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
TIAASDRPELTAAKIIVSGGRALGSREKFAELIEPLADVLGAAVGASRAAVDAGYAPNDW
HHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
QVGQTGKVVAPELYIALGISGAIQHLAGMKDSKVIVAVNKDEEAPIFQVADYGLVGDINT
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCHHH
VIPELKAELAKAKG
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]