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The map label for this gene is hbdA [H]

Identifier: 154246100

GI number: 154246100

Start: 2418648

End: 2419529

Strand: Reverse

Name: hbdA [H]

Synonym: Xaut_2157

Alternate gene names: 154246100

Gene position: 2419529-2418648 (Counterclockwise)

Preceding gene: 154246101

Following gene: 154246097

Centisome position: 45.57

GC content: 64.97

Gene sequence:

>882_bases
ATGCCGCTCGAGATCAAGAAGGTCGGGGTCATCGGCGCAGGCCAGATGGGCAACGGCATCGCGCACGTCTGCGCCCTCGC
CGGCTATGACGTATTCATCCATGACGCGGACCCCGACCGCATTCGCTCCGGCCTTGCCACCATCAACGGCAACATGGCCA
AGCAGGTCTCCAAAGGCACCGTGACCGAGGAAGCCCGGCAGGTGGCCCTCGCCCGCATCGGCATGGCCGAGCGCACCGAG
GACTTGGCCGACTGCGACCTCGTCATCGAATCGGCCACCGAGAAGGAAGAGGTGAAGCGCAAGATCTTCACCGGCCTCTG
CCAGGTGCTGCGGCCCGACGCGCTGCTCGCCTCCAACACCTCGTCCATCTCCATCACGCGCCTCGCCGCCGCCACCGACC
GCCCCGAGCGCTTCATCGGCATTCACTTCATGAATCCGGTGCCGCTGATGGAGCTGGTGGAGCTGGTGCGCGGCATCGCC
ACCGACGACGACACCTTCGAAAGCTCGAAGCAGTTCGTCACCCGGCTTCACAAGACCTATGCGGTGGCCGAGGACTTCCC
GGCTTTCATCGTCAACCGCATCCTTTTGCCCATGATCAACGAGGCCATCTACACCCTCTACGAGGGCGTCGGCAGCGTGG
ATTCCATCGACCGGGCCATGAAGCTCGGCGCGAACCATCCCATGGGACCGCTGCAGCTGGCCGACTTCATCGGCCTCGAC
ACCTGCCTGGCGGTCATGCAGGTGCTGCACGAGGGCCTGGCGGACTCCAAGTACCGCCCCTGTCCGCTGCTGGTGAAATA
TGTCGAAGCCGGATGGCTCGGCCGCAAGACCCAGCGCGGCTTCTACGATTATCGCGGCGAGAAGCCGGTCCCGACCCGCT
GA

Upstream 100 bases:

>100_bases
GCGCGAAAATGATCTAGAAACGAGCGGCCGGGCACGCCCCGGCCGCTGCCATCAGGGGCGCCGGCTCCTCCCCCCGGCTT
CAAGGTGAAACGAGAGAATC

Downstream 100 bases:

>100_bases
GCCGCCGCAGGGCGGCCTCAAGGCCGCCCGCTTGCCGGTGCGTCATGCGCGTCGGCGCCCTCCCCGCGCCCTCACCCCTC
CACGGCGACCCCCGGCAGTT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MPLEIKKVGVIGAGQMGNGIAHVCALAGYDVFIHDADPDRIRSGLATINGNMAKQVSKGTVTEEARQVALARIGMAERTE
DLADCDLVIESATEKEEVKRKIFTGLCQVLRPDALLASNTSSISITRLAAATDRPERFIGIHFMNPVPLMELVELVRGIA
TDDDTFESSKQFVTRLHKTYAVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDSIDRAMKLGANHPMGPLQLADFIGLD
TCLAVMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGEKPVPTR

Sequences:

>Translated_293_residues
MPLEIKKVGVIGAGQMGNGIAHVCALAGYDVFIHDADPDRIRSGLATINGNMAKQVSKGTVTEEARQVALARIGMAERTE
DLADCDLVIESATEKEEVKRKIFTGLCQVLRPDALLASNTSSISITRLAAATDRPERFIGIHFMNPVPLMELVELVRGIA
TDDDTFESSKQFVTRLHKTYAVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDSIDRAMKLGANHPMGPLQLADFIGLD
TCLAVMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGEKPVPTR
>Mature_292_residues
PLEIKKVGVIGAGQMGNGIAHVCALAGYDVFIHDADPDRIRSGLATINGNMAKQVSKGTVTEEARQVALARIGMAERTED
LADCDLVIESATEKEEVKRKIFTGLCQVLRPDALLASNTSSISITRLAAATDRPERFIGIHFMNPVPLMELVELVRGIAT
DDDTFESSKQFVTRLHKTYAVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDSIDRAMKLGANHPMGPLQLADFIGLDT
CLAVMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGEKPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.7543252595156, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.4592833876222, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI20127408, Length=285, Percent_Identity=30.1754385964912, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI68989263, Length=298, Percent_Identity=28.1879194630872, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI261878539, Length=298, Percent_Identity=28.1879194630872, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI115430219, Length=233, Percent_Identity=27.4678111587983, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=38.4083044982699, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=35.1851851851852, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790281, Length=283, Percent_Identity=32.5088339222615, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=40.1384083044983, Blast_Score=202, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=38.0622837370242, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=34.4947735191638, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=293, Percent_Identity=32.0819112627986, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508951, Length=293, Percent_Identity=32.0819112627986, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=293, Percent_Identity=32.0819112627986, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17558304, Length=293, Percent_Identity=30.3754266211604, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=26.4084507042254, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=281, Percent_Identity=25.6227758007117, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=32.1678321678322, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=32.1678321678322, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=32.1678321678322, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=25.1046025104602, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=23.7668161434978, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32181; Mature: 32049

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLEIKKVGVIGAGQMGNGIAHVCALAGYDVFIHDADPDRIRSGLATINGNMAKQVSKGT
CCCCEEEECEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCHHHHHHHCCC
VTEEARQVALARIGMAERTEDLADCDLVIESATEKEEVKRKIFTGLCQVLRPDALLASNT
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITRLAAATDRPERFIGIHFMNPVPLMELVELVRGIATDDDTFESSKQFVTRLHKTY
CCEEEEHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDSIDRAMKLGANHPMGPLQLADFIGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLAVMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGEKPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCC
>Mature Secondary Structure 
PLEIKKVGVIGAGQMGNGIAHVCALAGYDVFIHDADPDRIRSGLATINGNMAKQVSKGT
CCCEEEECEEECCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCHHHHHHHCCC
VTEEARQVALARIGMAERTEDLADCDLVIESATEKEEVKRKIFTGLCQVLRPDALLASNT
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHEECCC
SSISITRLAAATDRPERFIGIHFMNPVPLMELVELVRGIATDDDTFESSKQFVTRLHKTY
CCEEEEHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVDSIDRAMKLGANHPMGPLQLADFIGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLAVMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKTQRGFYDYRGEKPVPTR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]