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The map label for this gene is envZ [H]

Identifier: 154246099

GI number: 154246099

Start: 2417155

End: 2418576

Strand: Direct

Name: envZ [H]

Synonym: Xaut_2156

Alternate gene names: 154246099

Gene position: 2417155-2418576 (Clockwise)

Preceding gene: 154246098

Following gene: 154246108

Centisome position: 45.53

GC content: 72.5

Gene sequence:

>1422_bases
GTGAGGACCCTGCGCGCGCAGGTAACCGCGCTTCTGGTGGTGGCCGTTCTGGTGGTGACGGCGCTGGCCAACGTCGCCTC
TTTCTTTCTGACCCATCCCGAATGGCCCCCCTTCGACGAAGGCGACAAGGCTCAGGACATCGCCCTCCTCGCTGATCTGG
CGGTGGCGGTGCCGGTCACGGGCGCACCTGTGACCGTGTTCGGCGGGGGGCGCGGGGTGATCCAGAAGGCGCCGCCCGAC
GGCGAGATCGACCAGGTGGCCACGCGCATGCTGGCCGACGGTCTCGCCCGCCTCGGCCGCAGGATGCCGGTGCGGGTGTT
GCGGCCGGGACCCGCAAGCCAGAAAGGTCCAGGCCAGGCCGGATTCGGCCCCCCGGGCCCAGGTCAAGCCGGGCCAGGTG
AGCCGGGACCGCCCAATGTGGACCCGGGGCGACCGGGCCCGGACCATTCTGGCCCTGATGAGGGTCCCGCGCTTACGGCG
CTCGGCCTTGCCGACGGGCGCTGGCTGGTGATCCAGCGGCGCTTCGGTCCCATGGGCCCGCCCTCCGGACCGCCGGGCGG
CACCTTCGGCTTTGCCACCTGGCTCGCCTTCATGGTGGCGGGGGTGACGCTGGTGGTGGTGTTTGCAGTGCGGAGGCTGA
CCAAGCCCCTGTCCCTCATCGAGGAGGCGGCCGGGCGCATTGGCCCTGACGGCGAACTGCCGGTGCTGCCAGAGGAGGGG
CCGACGGAGGTGCGCGCGGCGGCGGCCGCCATTAACCGCCTGTCGGCGCGCCTGAAGGTGGCCATGGACAGCCGGATGCG
CATCGTGGCGGGCGCCGCCCACGACCTGCGCACGCCGCTCACCCGCATGCGCCTGCGCGCCGAGTTCATCCCCGATGACG
AGGAGCGCGCCCAGTGGCTGTCCGACCTGGAGGAACTCGACCGCATCGCCGACAGCGCCATCCGGCTGGTGCGCGAGGAG
GTGGAAGGTGGACCGGAGGAGATCGTGCGTCTCGACGATCTGGTGGATGGTGTTGTCGCCGAAGTGGTCGAGGCGCGCCG
GCCCGTCCGCCTCGTGCGTGCATCACCGGCGGCGGTGCGCGGGCGGCCCTTGTCGCTGAAGCGGGCGGTGCGCAACCTGG
TGGTCAATGCCGCCACCCATGGCGGCGGCGCGCGGGTGTCTGTCAGCGCCGAGGCCGGCCGGGTGGTGCTGCTCATCGAG
GATGACGGCCCCGGCATTCCCGAGGCGCTGATGGGGCAGGTGTTCGAGCCGTTCTTCCGGGTGGATCCGGCGCGCCAGGT
CAAGATTCCCGGCGCGGGGCTCGGGCTTGCCATCGCCAACGAGATCGTCTCGCGCCACGGCGGCCGCCTCACCCTCGCCA
ACCGGCCCGGCGGCGGCCTGCTGCAGCGGGTGGAACTGCCGGGGGTCGCCGTGGAGGGGTGA

Upstream 100 bases:

>100_bases
TGCGGCGCAAGCTCGGCGACCAGGGCGCGTTCCAGATCCTGAAGACCCTGCGCAACGGCGGCTATCAGCTGGCGGTGCGG
GTGGACCGGGAGGACGCCTC

Downstream 100 bases:

>100_bases
GGGCGCGGGGAGGGCGCCGACGCGCATGACGCACCGGCAAGCGGGCGGCCTTGAGGCCGCCCTGCGGCGGCTCAGCGGGT
CGGGACCGGCTTCTCGCCGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRTLRAQVTALLVVAVLVVTALANVASFFLTHPEWPPFDEGDKAQDIALLADLAVAVPVTGAPVTVFGGGRGVIQKAPPD
GEIDQVATRMLADGLARLGRRMPVRVLRPGPASQKGPGQAGFGPPGPGQAGPGEPGPPNVDPGRPGPDHSGPDEGPALTA
LGLADGRWLVIQRRFGPMGPPSGPPGGTFGFATWLAFMVAGVTLVVVFAVRRLTKPLSLIEEAAGRIGPDGELPVLPEEG
PTEVRAAAAAINRLSARLKVAMDSRMRIVAGAAHDLRTPLTRMRLRAEFIPDDEERAQWLSDLEELDRIADSAIRLVREE
VEGGPEEIVRLDDLVDGVVAEVVEARRPVRLVRASPAAVRGRPLSLKRAVRNLVVNAATHGGGARVSVSAEAGRVVLLIE
DDGPGIPEALMGQVFEPFFRVDPARQVKIPGAGLGLAIANEIVSRHGGRLTLANRPGGGLLQRVELPGVAVEG

Sequences:

>Translated_473_residues
MRTLRAQVTALLVVAVLVVTALANVASFFLTHPEWPPFDEGDKAQDIALLADLAVAVPVTGAPVTVFGGGRGVIQKAPPD
GEIDQVATRMLADGLARLGRRMPVRVLRPGPASQKGPGQAGFGPPGPGQAGPGEPGPPNVDPGRPGPDHSGPDEGPALTA
LGLADGRWLVIQRRFGPMGPPSGPPGGTFGFATWLAFMVAGVTLVVVFAVRRLTKPLSLIEEAAGRIGPDGELPVLPEEG
PTEVRAAAAAINRLSARLKVAMDSRMRIVAGAAHDLRTPLTRMRLRAEFIPDDEERAQWLSDLEELDRIADSAIRLVREE
VEGGPEEIVRLDDLVDGVVAEVVEARRPVRLVRASPAAVRGRPLSLKRAVRNLVVNAATHGGGARVSVSAEAGRVVLLIE
DDGPGIPEALMGQVFEPFFRVDPARQVKIPGAGLGLAIANEIVSRHGGRLTLANRPGGGLLQRVELPGVAVEG
>Mature_473_residues
MRTLRAQVTALLVVAVLVVTALANVASFFLTHPEWPPFDEGDKAQDIALLADLAVAVPVTGAPVTVFGGGRGVIQKAPPD
GEIDQVATRMLADGLARLGRRMPVRVLRPGPASQKGPGQAGFGPPGPGQAGPGEPGPPNVDPGRPGPDHSGPDEGPALTA
LGLADGRWLVIQRRFGPMGPPSGPPGGTFGFATWLAFMVAGVTLVVVFAVRRLTKPLSLIEEAAGRIGPDGELPVLPEEG
PTEVRAAAAAINRLSARLKVAMDSRMRIVAGAAHDLRTPLTRMRLRAEFIPDDEERAQWLSDLEELDRIADSAIRLVREE
VEGGPEEIVRLDDLVDGVVAEVVEARRPVRLVRASPAAVRGRPLSLKRAVRNLVVNAATHGGGARVSVSAEAGRVVLLIE
DDGPGIPEALMGQVFEPFFRVDPARQVKIPGAGLGLAIANEIVSRHGGRLTLANRPGGGLLQRVELPGVAVEG

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=38.4341637010676, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790551, Length=273, Percent_Identity=27.8388278388278, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=28.9036544850498, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=28.1954887218045, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1787894, Length=280, Percent_Identity=28.9285714285714, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=30.9027777777778, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786783, Length=276, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=28.2157676348548, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=31.0810810810811, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=275, Percent_Identity=26.1818181818182, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=25.8771929824561, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=26.0416666666667, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788549, Length=210, Percent_Identity=27.6190476190476, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=26.0330578512397, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49561; Mature: 49561

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLRAQVTALLVVAVLVVTALANVASFFLTHPEWPPFDEGDKAQDIALLADLAVAVPVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
GAPVTVFGGGRGVIQKAPPDGEIDQVATRMLADGLARLGRRMPVRVLRPGPASQKGPGQA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCC
GFGPPGPGQAGPGEPGPPNVDPGRPGPDHSGPDEGPALTALGLADGRWLVIQRRFGPMGP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCC
PSGPPGGTFGFATWLAFMVAGVTLVVVFAVRRLTKPLSLIEEAAGRIGPDGELPVLPEEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PTEVRAAAAAINRLSARLKVAMDSRMRIVAGAAHDLRTPLTRMRLRAEFIPDDEERAQWL
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SDLEELDRIADSAIRLVREEVEGGPEEIVRLDDLVDGVVAEVVEARRPVRLVRASPAAVR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHC
GRPLSLKRAVRNLVVNAATHGGGARVSVSAEAGRVVLLIEDDGPGIPEALMGQVFEPFFR
CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
VDPARQVKIPGAGLGLAIANEIVSRHGGRLTLANRPGGGLLQRVELPGVAVEG
CCCCCEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCEECCC
>Mature Secondary Structure
MRTLRAQVTALLVVAVLVVTALANVASFFLTHPEWPPFDEGDKAQDIALLADLAVAVPVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
GAPVTVFGGGRGVIQKAPPDGEIDQVATRMLADGLARLGRRMPVRVLRPGPASQKGPGQA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCC
GFGPPGPGQAGPGEPGPPNVDPGRPGPDHSGPDEGPALTALGLADGRWLVIQRRFGPMGP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCC
PSGPPGGTFGFATWLAFMVAGVTLVVVFAVRRLTKPLSLIEEAAGRIGPDGELPVLPEEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
PTEVRAAAAAINRLSARLKVAMDSRMRIVAGAAHDLRTPLTRMRLRAEFIPDDEERAQWL
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SDLEELDRIADSAIRLVREEVEGGPEEIVRLDDLVDGVVAEVVEARRPVRLVRASPAAVR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHC
GRPLSLKRAVRNLVVNAATHGGGARVSVSAEAGRVVLLIEDDGPGIPEALMGQVFEPFFR
CCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
VDPARQVKIPGAGLGLAIANEIVSRHGGRLTLANRPGGGLLQRVELPGVAVEG
CCCCCEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]