Click here to switch to the map view.

The map label for this gene is cobT [H]

Identifier: 154245822

GI number: 154245822

Start: 2115702

End: 2117615

Strand: Direct

Name: cobT [H]

Synonym: Xaut_1878

Alternate gene names: 154245822

Gene position: 2115702-2117615 (Clockwise)

Preceding gene: 154245821

Following gene: 154245823

Centisome position: 39.85

GC content: 70.9

Gene sequence:

>1914_bases
TTGCGAGACGCCGCCATGGCCCCGACCAACCGCACTCCCGGAAAGGCGCCGAAGGAAGCCCCCGCCGAGCCCTTCAAGCG
GGCGGTGGCGGGCTGCTTCAAGGCCATCGCCGGCGTCTCCGAGTTCGAGGTGACCTTCGCCTCGGAGCGGCCGGCGCTGG
CGCCTGACCGGGTCCGCCTGCCCGAGCCGCCCCGCCGCTTCACCCTGCAGGATGCGGCCATCGTGCGCGGCCATGCGGAC
AGCCTCGCCCTGCGCCGGGCGTGCCACGACCCCAAGGTCCATCGCAAGATGCTGCCCCAGGGCGAGGTCGCACGCGCCGT
GTTCGAGGCGGTGGAGCAGGCCCGGGTGGAGGCCATCGGCGGCATCCGCATGCCGGGGGTGAAGCGCAACCTCGCGGCCA
TGCTGCAGGACCGCTACCACCGCGGCAGCTTCGCCGACATCACCGAGCGCTCGGAAGCGCCCATCGAGGACGCCATCGCC
CTCCTGGTGCGCGAGCGCCTCACCGGCGAGCCGCCGCCGCCGGACGCGCGCAAGATCGTGGAGCTGTGGCGCTCCTATAT
CGAGGACCGCGGCTCCGCCGACCTCGCCCGCCTGTCCGACAGCATCGAGAACCAGAAGCGCTTCGGCGAGATCGCCCGCG
ACCTGCTCGCCTCCCTGGACATGGGCGAGGAGAGCGGCCTCGACACCGAGCAGGAGCCCGACGATTCCGACGCCGAGGGC
GGCTCGCAGGAGGAGGGTGGCGAGAGCGGCGACGCCAAGGAGGACGAGAGCCAGCAGGGCGCTACCGAAGTCGAGGCCGA
ACTGTCCGAGGAGGACATGCCCGACAGCGCCGCCGAAAGCGATGCCGCCCCGCCCGCCGAGGCGCCGGACGGCACCGAAT
TGGGCGACAGCGAGGAGCCGGCCGAGCCCTGGCAGCCGCGCCCGCCCGTCACCCACGACAATCGCGGGCCGGAATACCAC
GCCTTCACCACCAAGTTCGATGAGGAGACCACGGCGGAGGACCTGTGCGACCCCGAGGAGCTGACGCGGCTGCGGTCCTA
TCTGGACAAGCAGCTCGCCCATCTCCAGGGCGTGGTGGCGCGCCTCGCCAACCGCTTGCAGCGGCGCCTGATGGCCCAGC
AGAACCGGGCCTGGGAGTTCGACCTGGAAGAGGGCGTGCTCGATCCGGCGCGGCTTGCCCGCGTCATCATGGATCCCACC
GCCGCCCTGTCCTTCAAGCGCGAGCGCGACACCGACTTCCGCGACACGGTGGTGACGCTGCTCATCGACAATTCCGGCTC
CATGCGCGGCCGGCCCATCACGGTGGCCGCCACCTGCGCCGACATCCTCGCCCGCACGCTGGAGCGCTGTGGGGTGAAGG
TGGAGGTGCTGGGCTTCACCACCAAGGCGTGGAAGGGCGGCCAATCCCGCGAGGGGTGGCTTGCCGCCGGCAAGCCGGTG
GGTCCCGGCCGGCTGAACGACCTGCGCCATATCATCTACAAGGCGGCCGACGCCCCATGGCGGCGGGCCCGGCGCAACCT
CGGCCTGATGATGCGCGAGGGCCTGCTGAAGGAGAATATCGACGGCGAGGCGCTGGACTGGGCGCACAAGCGCCTGCTGG
CCCGCACCGAATCCCGCCGCATCCTGATGATGATCTCCGACGGCGCGCCGGTGGACGACAGCACCCTCTCCGTGAATGCC
GGCAACTATCTGGAGCGCCACCTGCGGCACATCATCTCCGAGATCGAGACCCGCTCGCCGGTGGAGCTGATCGCCATCGG
CATCGGCCATGACGTGACGCGCTATTATCGCCGCGCCGTCACCATCGTGGATGCCGAGGAACTGGGCGGGGTGATGACCG
AGAAGCTGGCCGAGCTGTTCGAGGACGAACCGAGGGCCGCCCCCAAGGCCGCGGCGCGCGGTCGGCTTCATTGA

Upstream 100 bases:

>100_bases
GGCCGAGTTCTTCCAGCGCTGCTTCGGCCAGGAGCTGACCGAGAGCACCGTGAACGTCGCCTTGTCCTGAGCCGGGATCT
CCCGGCTCCCTTCTCCTGAC

Downstream 100 bases:

>100_bases
GGCGGCGCACCCGCTTCGCTTTCGGTTTCGCGGCGGCGGGGCTGGGCCTCGCCGCCGTGATCGCGGTGGCTACGTCCGCG
CTCCTGGCCAAGCCGCTGGC

Product: cobalt chelatase, pCobT subunit

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MRDAAMAPTNRTPGKAPKEAPAEPFKRAVAGCFKAIAGVSEFEVTFASERPALAPDRVRLPEPPRRFTLQDAAIVRGHAD
SLALRRACHDPKVHRKMLPQGEVARAVFEAVEQARVEAIGGIRMPGVKRNLAAMLQDRYHRGSFADITERSEAPIEDAIA
LLVRERLTGEPPPPDARKIVELWRSYIEDRGSADLARLSDSIENQKRFGEIARDLLASLDMGEESGLDTEQEPDDSDAEG
GSQEEGGESGDAKEDESQQGATEVEAELSEEDMPDSAAESDAAPPAEAPDGTELGDSEEPAEPWQPRPPVTHDNRGPEYH
AFTTKFDEETTAEDLCDPEELTRLRSYLDKQLAHLQGVVARLANRLQRRLMAQQNRAWEFDLEEGVLDPARLARVIMDPT
AALSFKRERDTDFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCGVKVEVLGFTTKAWKGGQSREGWLAAGKPV
GPGRLNDLRHIIYKAADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLARTESRRILMMISDGAPVDDSTLSVNA
GNYLERHLRHIISEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGVMTEKLAELFEDEPRAAPKAAARGRLH

Sequences:

>Translated_637_residues
MRDAAMAPTNRTPGKAPKEAPAEPFKRAVAGCFKAIAGVSEFEVTFASERPALAPDRVRLPEPPRRFTLQDAAIVRGHAD
SLALRRACHDPKVHRKMLPQGEVARAVFEAVEQARVEAIGGIRMPGVKRNLAAMLQDRYHRGSFADITERSEAPIEDAIA
LLVRERLTGEPPPPDARKIVELWRSYIEDRGSADLARLSDSIENQKRFGEIARDLLASLDMGEESGLDTEQEPDDSDAEG
GSQEEGGESGDAKEDESQQGATEVEAELSEEDMPDSAAESDAAPPAEAPDGTELGDSEEPAEPWQPRPPVTHDNRGPEYH
AFTTKFDEETTAEDLCDPEELTRLRSYLDKQLAHLQGVVARLANRLQRRLMAQQNRAWEFDLEEGVLDPARLARVIMDPT
AALSFKRERDTDFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCGVKVEVLGFTTKAWKGGQSREGWLAAGKPV
GPGRLNDLRHIIYKAADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLARTESRRILMMISDGAPVDDSTLSVNA
GNYLERHLRHIISEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGVMTEKLAELFEDEPRAAPKAAARGRLH
>Mature_637_residues
MRDAAMAPTNRTPGKAPKEAPAEPFKRAVAGCFKAIAGVSEFEVTFASERPALAPDRVRLPEPPRRFTLQDAAIVRGHAD
SLALRRACHDPKVHRKMLPQGEVARAVFEAVEQARVEAIGGIRMPGVKRNLAAMLQDRYHRGSFADITERSEAPIEDAIA
LLVRERLTGEPPPPDARKIVELWRSYIEDRGSADLARLSDSIENQKRFGEIARDLLASLDMGEESGLDTEQEPDDSDAEG
GSQEEGGESGDAKEDESQQGATEVEAELSEEDMPDSAAESDAAPPAEAPDGTELGDSEEPAEPWQPRPPVTHDNRGPEYH
AFTTKFDEETTAEDLCDPEELTRLRSYLDKQLAHLQGVVARLANRLQRRLMAQQNRAWEFDLEEGVLDPARLARVIMDPT
AALSFKRERDTDFRDTVVTLLIDNSGSMRGRPITVAATCADILARTLERCGVKVEVLGFTTKAWKGGQSREGWLAAGKPV
GPGRLNDLRHIIYKAADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLARTESRRILMMISDGAPVDDSTLSVNA
GNYLERHLRHIISEIETRSPVELIAIGIGHDVTRYYRRAVTIVDAEELGGVMTEKLAELFEDEPRAAPKAAARGRLH

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 70456; Mature: 70456

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAAMAPTNRTPGKAPKEAPAEPFKRAVAGCFKAIAGVSEFEVTFASERPALAPDRVRL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCCC
PEPPRRFTLQDAAIVRGHADSLALRRACHDPKVHRKMLPQGEVARAVFEAVEQARVEAIG
CCCCCCEEECHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
GIRMPGVKRNLAAMLQDRYHRGSFADITERSEAPIEDAIALLVRERLTGEPPPPDARKIV
CCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ELWRSYIEDRGSADLARLSDSIENQKRFGEIARDLLASLDMGEESGLDTEQEPDDSDAEG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GSQEEGGESGDAKEDESQQGATEVEAELSEEDMPDSAAESDAAPPAEAPDGTELGDSEEP
CCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AEPWQPRPPVTHDNRGPEYHAFTTKFDEETTAEDLCDPEELTRLRSYLDKQLAHLQGVVA
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RLANRLQRRLMAQQNRAWEFDLEEGVLDPARLARVIMDPTAALSFKRERDTDFRDTVVTL
HHHHHHHHHHHHHHCCCEECCHHHCCCCHHHHHHHHHCCHHHHHCCHHCCCCHHHEEEEE
LIDNSGSMRGRPITVAATCADILARTLERCGVKVEVLGFTTKAWKGGQSREGWLAAGKPV
EECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCEECCCCC
GPGRLNDLRHIIYKAADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLARTESRR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
ILMMISDGAPVDDSTLSVNAGNYLERHLRHIISEIETRSPVELIAIGIGHDVTRYYRRAV
EEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
TIVDAEELGGVMTEKLAELFEDEPRAAPKAAARGRLH
HEECHHHHCHHHHHHHHHHHCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MRDAAMAPTNRTPGKAPKEAPAEPFKRAVAGCFKAIAGVSEFEVTFASERPALAPDRVRL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCCCC
PEPPRRFTLQDAAIVRGHADSLALRRACHDPKVHRKMLPQGEVARAVFEAVEQARVEAIG
CCCCCCEEECHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
GIRMPGVKRNLAAMLQDRYHRGSFADITERSEAPIEDAIALLVRERLTGEPPPPDARKIV
CCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ELWRSYIEDRGSADLARLSDSIENQKRFGEIARDLLASLDMGEESGLDTEQEPDDSDAEG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GSQEEGGESGDAKEDESQQGATEVEAELSEEDMPDSAAESDAAPPAEAPDGTELGDSEEP
CCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AEPWQPRPPVTHDNRGPEYHAFTTKFDEETTAEDLCDPEELTRLRSYLDKQLAHLQGVVA
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RLANRLQRRLMAQQNRAWEFDLEEGVLDPARLARVIMDPTAALSFKRERDTDFRDTVVTL
HHHHHHHHHHHHHHCCCEECCHHHCCCCHHHHHHHHHCCHHHHHCCHHCCCCHHHEEEEE
LIDNSGSMRGRPITVAATCADILARTLERCGVKVEVLGFTTKAWKGGQSREGWLAAGKPV
EECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCEECCCCC
GPGRLNDLRHIIYKAADAPWRRARRNLGLMMREGLLKENIDGEALDWAHKRLLARTESRR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCE
ILMMISDGAPVDDSTLSVNAGNYLERHLRHIISEIETRSPVELIAIGIGHDVTRYYRRAV
EEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHH
TIVDAEELGGVMTEKLAELFEDEPRAAPKAAARGRLH
HEECHHHHCHHHHHHHHHHHCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]