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The map label for this gene is intA [H]

Identifier: 154245019

GI number: 154245019

Start: 1227005

End: 1228102

Strand: Reverse

Name: intA [H]

Synonym: Xaut_1070

Alternate gene names: 154245019

Gene position: 1228102-1227005 (Counterclockwise)

Preceding gene: 154245021

Following gene: 154245015

Centisome position: 23.13

GC content: 67.03

Gene sequence:

>1098_bases
ATGTTCCGCCGCGATGGGAAGCGCCGGGAGATGGGGCTGGGCTCGGCAAGGGACGTGGGGCTCGCTGAGGCCCGCCAGAA
GGCCGAGGACGCCCGTCGCCTCACGGCAGAGCGGCAGGACCCGCTCGAAAGCCGGAAAGCCTCCATGACGCGCCAGAAGG
AGGCTGAGGAGGTTCCCTCCTTTGGCGCGTTCGCGGATGCCCTCGTCGAAAACATCGAAGGTGGGTTCCGGAACGACAAG
CACGTCTATCAGTGGAAACAGACCCTCGGGCCGGCCTACTGCGCGAAGATCCGTGACAAGAAGCTGGGCGAGATCACGAC
TGATGACGTGCTCGCCGTGCTTCAGCCCATCTGGCAGGAGAAGAACGAGACGGCCTCACGGCTCCGAGGTCGCATCGAAA
GGGTGCTGGATGCCGCCAAGGCCAAGGGGCTGCGCACGGGAGAGAACCCCGCCCGCTGGCGCGGCCACCTCGACACCCTC
CTGCCGAAGCGCCAGAAGCTCCAGCGCGGCCATCACCCTGCGATGCCCTACACCGAGGTGCCAGCCTTCCTCACCGAACT
GCGGACGCGGGAGGCCATGGCTGCGCGAGCGCTGGAGTTCGCCATCCTGACGGCCGCCCGGTCGGGTGAGGTACTGGGGG
CGATGTGGGGCGAGGTCGATCTCAAAGCCGAGGTGTGGACGGTGCCGGCCAATCGCATGAAGGCCGGGCGAGAACATCGT
GTGCCCCTCGCACCGCCCGCCATTGCGATCCTGAGGGCGCTGGCGGCCCTGCGCCCAGAGGATGACGACAAGGGTGCGTA
CATCTTCCCTGGGCAGCGGAAGGGCCGCCCCTTGAGCGGGATGGCCATGGAGATGCTGCTCCACCGCCAGAAGCTGGAGA
TCACCGTCCACGGCTTCCGCTCGTCTTTCCGGGACTGGGCAGCCGAGGAGACGGGCTTCCCACGGGAGATCGCCGAAGCC
GCCCTTGCCCATGTCGTGGGGGATGCCACCGAGCGGGCCTATCGCCGGGGTGATGCCTTGGAGAAGCGCCGCGAGCTGAT
GACGGCATGGGCGGCCCATTGCCAGCCAAAGACTGTGGAACGATGGATGGAGACATAA

Upstream 100 bases:

>100_bases
ACCGCACGGACCGTGGCAAACTTGAAGGAGCTGGGCCGCTGCGGACGGTGGTGGGCTCTACCTCCAAGTCGGCCCCACGG
GCACTAAGGCATGGCTCTTC

Downstream 100 bases:

>100_bases
AAGTATTATAATACTACTGTTTATAGAAAAGGGTGTCTTATGTGCCAAAATGCCGAAATCGCCGAAATTGAAATATAACG
TGTTTCCAATGACTTGAGGG

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MFRRDGKRREMGLGSARDVGLAEARQKAEDARRLTAERQDPLESRKASMTRQKEAEEVPSFGAFADALVENIEGGFRNDK
HVYQWKQTLGPAYCAKIRDKKLGEITTDDVLAVLQPIWQEKNETASRLRGRIERVLDAAKAKGLRTGENPARWRGHLDTL
LPKRQKLQRGHHPAMPYTEVPAFLTELRTREAMAARALEFAILTAARSGEVLGAMWGEVDLKAEVWTVPANRMKAGREHR
VPLAPPAIAILRALAALRPEDDDKGAYIFPGQRKGRPLSGMAMEMLLHRQKLEITVHGFRSSFRDWAAEETGFPREIAEA
ALAHVVGDATERAYRRGDALEKRRELMTAWAAHCQPKTVERWMET

Sequences:

>Translated_365_residues
MFRRDGKRREMGLGSARDVGLAEARQKAEDARRLTAERQDPLESRKASMTRQKEAEEVPSFGAFADALVENIEGGFRNDK
HVYQWKQTLGPAYCAKIRDKKLGEITTDDVLAVLQPIWQEKNETASRLRGRIERVLDAAKAKGLRTGENPARWRGHLDTL
LPKRQKLQRGHHPAMPYTEVPAFLTELRTREAMAARALEFAILTAARSGEVLGAMWGEVDLKAEVWTVPANRMKAGREHR
VPLAPPAIAILRALAALRPEDDDKGAYIFPGQRKGRPLSGMAMEMLLHRQKLEITVHGFRSSFRDWAAEETGFPREIAEA
ALAHVVGDATERAYRRGDALEKRRELMTAWAAHCQPKTVERWMET
>Mature_365_residues
MFRRDGKRREMGLGSARDVGLAEARQKAEDARRLTAERQDPLESRKASMTRQKEAEEVPSFGAFADALVENIEGGFRNDK
HVYQWKQTLGPAYCAKIRDKKLGEITTDDVLAVLQPIWQEKNETASRLRGRIERVLDAAKAKGLRTGENPARWRGHLDTL
LPKRQKLQRGHHPAMPYTEVPAFLTELRTREAMAARALEFAILTAARSGEVLGAMWGEVDLKAEVWTVPANRMKAGREHR
VPLAPPAIAILRALAALRPEDDDKGAYIFPGQRKGRPLSGMAMEMLLHRQKLEITVHGFRSSFRDWAAEETGFPREIAEA
ALAHVVGDATERAYRRGDALEKRRELMTAWAAHCQPKTVERWMET

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=352, Percent_Identity=30.6818181818182, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI145693166, Length=358, Percent_Identity=29.3296089385475, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788690, Length=374, Percent_Identity=24.8663101604278, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 41214; Mature: 41214

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRDGKRREMGLGSARDVGLAEARQKAEDARRLTAERQDPLESRKASMTRQKEAEEVPS
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
FGAFADALVENIEGGFRNDKHVYQWKQTLGPAYCAKIRDKKLGEITTDDVLAVLQPIWQE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
KNETASRLRGRIERVLDAAKAKGLRTGENPARWRGHLDTLLPKRQKLQRGHHPAMPYTEV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHH
PAFLTELRTREAMAARALEFAILTAARSGEVLGAMWGEVDLKAEVWTVPANRMKAGREHR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEECCEEEEECCHHHHHCCCCCC
VPLAPPAIAILRALAALRPEDDDKGAYIFPGQRKGRPLSGMAMEMLLHRQKLEITVHGFR
CCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEHHHH
SSFRDWAAEETGFPREIAEAALAHVVGDATERAYRRGDALEKRRELMTAWAAHCQPKTVE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RWMET
HHHCC
>Mature Secondary Structure
MFRRDGKRREMGLGSARDVGLAEARQKAEDARRLTAERQDPLESRKASMTRQKEAEEVPS
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
FGAFADALVENIEGGFRNDKHVYQWKQTLGPAYCAKIRDKKLGEITTDDVLAVLQPIWQE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
KNETASRLRGRIERVLDAAKAKGLRTGENPARWRGHLDTLLPKRQKLQRGHHPAMPYTEV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCCCHHHH
PAFLTELRTREAMAARALEFAILTAARSGEVLGAMWGEVDLKAEVWTVPANRMKAGREHR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEECCEEEEECCHHHHHCCCCCC
VPLAPPAIAILRALAALRPEDDDKGAYIFPGQRKGRPLSGMAMEMLLHRQKLEITVHGFR
CCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEHHHH
SSFRDWAAEETGFPREIAEAALAHVVGDATERAYRRGDALEKRRELMTAWAAHCQPKTVE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RWMET
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]