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The map label for this gene is paaJ [H]

Identifier: 154244855

GI number: 154244855

Start: 1007886

End: 1009094

Strand: Direct

Name: paaJ [H]

Synonym: Xaut_0905

Alternate gene names: 154244855

Gene position: 1007886-1009094 (Clockwise)

Preceding gene: 154244854

Following gene: 154244856

Centisome position: 18.98

GC content: 71.05

Gene sequence:

>1209_bases
ATGGCGCACGCCTTTATCTGCGATTTCGCGCGCACCCCCATCGGCCGCTATGCCGGCGCCCTGAAGGATGTGCGCGCCGA
CGACCTCGCCGCCCATCCCATCCGCGTGCTGAAGGAGCGCAACCCAGGCGTCGACTGGGAGGCGGTGGACGATGTCATCC
TCGGCTGCGCCAACCAGGCGGGGGAGGACAACCGCGACGTGGCCCGCATGGCGGCTCTACTTGCCGGCCTGCCGGTGAGC
GCCCCGGGCACCACCGTGAACCGCCTGTGCGGCTCCGGCCTCGACGCGGTGGGCATCGGCGCCCGCGCCATCATGACCGG
CGACGCCGACCTCATCGTCGCCGGCGGGGTGGAGAGCATGACCCGCGCGCCCTTCGTCCAGGGCAAGGCGCAGGAGGCGT
TTTCCCGGCAGGCGGAGATCTATGACACCACCATCGGCTGGCGCTTCGTGAACCCGCTGATGAAGGCGCAGTATGGCGTG
GATTCCATGCCGGAGACCGGCGAGAACGTGGCCGAGGACTTCCAGGTTTCCCGCGCCGACCAGGACCTGTTCGCGTATCG
CTCCCAGCAGCGGGTGAAGGCGGCCCAGGATGCCGGCTTCTTCGCCCGCGAGATCGCGCCCATCGAGGTGAAGGGTAAGA
AGGGCGCTGTGATCCGCGTGGAGGCGGACGAGCATCCGCGCGCCGAGACCACGCTGGAGCAGCTCGCCGGCCTGAAGGCC
CCGTTCCGCAAGGCCGGTGGCACGGTGACGGCGGGCAATGCCTCGGGTGTCAACGACGGGGCCGGGGCGCTCATCCTCGC
TTCCGAGGCGGCGGCGAAGAAGTATGGCCTCACCCCCCGCGCCCGTGTGGTGTCGGTGGTGCAGGCGGGGGTGCCGCCGC
GCATCATGGGCATTGGCCCGGCGCCGGCGACGCGCAAACTTCTGGAGAAGAACGGCCTCGCGCTGGCGGACATCGACCTC
ATTGAGCTGAACGAGGCCTTCGCCGCCCAGGCCCTCGCCGTGCTGCGCCAGCTGGGCCTTCCCGACGACGCGGAGCATGT
GAACCCGAACGGCGGGGCCATCGCGCTCGGCCATCCGCTGGGCATGTCCGGCGCGCGGCTCGCCATGACGGCGGTGAGCG
CGCTGGAGGTGCGCGGCGGCACCCGGGCGGTGGCCACCATGTGCATCGGCGTCGGCCAGGGCATCGCCGCCCTCATCGAG
AGGGTCTGA

Upstream 100 bases:

>100_bases
ACGCCTGCATGACGGATTCAGCCTTCGTGGCGAGCCGCTTCCGCGTGGTGTGCGTGCGCCGCCCGGCCGCCGCCTGAAAC
CTGACATCAGGAGAAGAACA

Downstream 100 bases:

>100_bases
GCCGTGGATGCCGTGACACCTCCGGTCACCGTCACGCGCCATGGCGGCGGGCAAGGCAAGGTCGGCGTGATCGCCATTGA
TTTTGCGCCGGTGAATGCCC

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MAHAFICDFARTPIGRYAGALKDVRADDLAAHPIRVLKERNPGVDWEAVDDVILGCANQAGEDNRDVARMAALLAGLPVS
APGTTVNRLCGSGLDAVGIGARAIMTGDADLIVAGGVESMTRAPFVQGKAQEAFSRQAEIYDTTIGWRFVNPLMKAQYGV
DSMPETGENVAEDFQVSRADQDLFAYRSQQRVKAAQDAGFFAREIAPIEVKGKKGAVIRVEADEHPRAETTLEQLAGLKA
PFRKAGGTVTAGNASGVNDGAGALILASEAAAKKYGLTPRARVVSVVQAGVPPRIMGIGPAPATRKLLEKNGLALADIDL
IELNEAFAAQALAVLRQLGLPDDAEHVNPNGGAIALGHPLGMSGARLAMTAVSALEVRGGTRAVATMCIGVGQGIAALIE
RV

Sequences:

>Translated_402_residues
MAHAFICDFARTPIGRYAGALKDVRADDLAAHPIRVLKERNPGVDWEAVDDVILGCANQAGEDNRDVARMAALLAGLPVS
APGTTVNRLCGSGLDAVGIGARAIMTGDADLIVAGGVESMTRAPFVQGKAQEAFSRQAEIYDTTIGWRFVNPLMKAQYGV
DSMPETGENVAEDFQVSRADQDLFAYRSQQRVKAAQDAGFFAREIAPIEVKGKKGAVIRVEADEHPRAETTLEQLAGLKA
PFRKAGGTVTAGNASGVNDGAGALILASEAAAKKYGLTPRARVVSVVQAGVPPRIMGIGPAPATRKLLEKNGLALADIDL
IELNEAFAAQALAVLRQLGLPDDAEHVNPNGGAIALGHPLGMSGARLAMTAVSALEVRGGTRAVATMCIGVGQGIAALIE
RV
>Mature_401_residues
AHAFICDFARTPIGRYAGALKDVRADDLAAHPIRVLKERNPGVDWEAVDDVILGCANQAGEDNRDVARMAALLAGLPVSA
PGTTVNRLCGSGLDAVGIGARAIMTGDADLIVAGGVESMTRAPFVQGKAQEAFSRQAEIYDTTIGWRFVNPLMKAQYGVD
SMPETGENVAEDFQVSRADQDLFAYRSQQRVKAAQDAGFFAREIAPIEVKGKKGAVIRVEADEHPRAETTLEQLAGLKAP
FRKAGGTVTAGNASGVNDGAGALILASEAAAKKYGLTPRARVVSVVQAGVPPRIMGIGPAPATRKLLEKNGLALADIDLI
ELNEAFAAQALAVLRQLGLPDDAEHVNPNGGAIALGHPLGMSGARLAMTAVSALEVRGGTRAVATMCIGVGQGIAALIER
V

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=46.4646464646465, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=43.3249370277078, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=42.964824120603, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4557237, Length=404, Percent_Identity=36.3861386138614, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=34.2723004694836, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=31.2977099236641, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=70.6467661691542, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=47.2772277227723, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=43.9506172839506, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI87082165, Length=402, Percent_Identity=42.7860696517413, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788683, Length=400, Percent_Identity=29.75, Blast_Score=141, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=45.0248756218905, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI25147385, Length=407, Percent_Identity=36.6093366093366, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=34.320987654321, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=33.2558139534884, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=31.6953316953317, Blast_Score=158, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=38.6138613861386, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=36.2282878411911, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=44.9131513647643, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=40.5940594059406, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=35.7142857142857, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=33.8028169014084, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24585051, Length=333, Percent_Identity=27.9279279279279, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921506, Length=333, Percent_Identity=26.1261261261261, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41873; Mature: 41742

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAFICDFARTPIGRYAGALKDVRADDLAAHPIRVLKERNPGVDWEAVDDVILGCANQA
CCCEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
GEDNRDVARMAALLAGLPVSAPGTTVNRLCGSGLDAVGIGARAIMTGDADLIVAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCHHHH
TRAPFVQGKAQEAFSRQAEIYDTTIGWRFVNPLMKAQYGVDSMPETGENVAEDFQVSRAD
HHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCH
QDLFAYRSQQRVKAAQDAGFFAREIAPIEVKGKKGAVIRVEADEHPRAETTLEQLAGLKA
HHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCC
PFRKAGGTVTAGNASGVNDGAGALILASEAAAKKYGLTPRARVVSVVQAGVPPRIMGIGP
CHHHCCCEEEECCCCCCCCCCCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCC
APATRKLLEKNGLALADIDLIELNEAFAAQALAVLRQLGLPDDAEHVNPNGGAIALGHPL
CHHHHHHHHHCCCEEEEEEHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
GMSGARLAMTAVSALEVRGGTRAVATMCIGVGQGIAALIERV
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
AHAFICDFARTPIGRYAGALKDVRADDLAAHPIRVLKERNPGVDWEAVDDVILGCANQA
CCEEEHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
GEDNRDVARMAALLAGLPVSAPGTTVNRLCGSGLDAVGIGARAIMTGDADLIVAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCHHHH
TRAPFVQGKAQEAFSRQAEIYDTTIGWRFVNPLMKAQYGVDSMPETGENVAEDFQVSRAD
HHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCH
QDLFAYRSQQRVKAAQDAGFFAREIAPIEVKGKKGAVIRVEADEHPRAETTLEQLAGLKA
HHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCC
PFRKAGGTVTAGNASGVNDGAGALILASEAAAKKYGLTPRARVVSVVQAGVPPRIMGIGP
CHHHCCCEEEECCCCCCCCCCCEEEEECHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCC
APATRKLLEKNGLALADIDLIELNEAFAAQALAVLRQLGLPDDAEHVNPNGGAIALGHPL
CHHHHHHHHHCCCEEEEEEHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCC
GMSGARLAMTAVSALEVRGGTRAVATMCIGVGQGIAALIERV
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10766858 [H]