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The map label for this gene is paaX [H]

Identifier: 154244845

GI number: 154244845

Start: 998122

End: 999039

Strand: Direct

Name: paaX [H]

Synonym: Xaut_0895

Alternate gene names: 154244845

Gene position: 998122-999039 (Clockwise)

Preceding gene: 154244844

Following gene: 154244846

Centisome position: 18.8

GC content: 70.37

Gene sequence:

>918_bases
ATGGTCTCGGCCGGGGTTTCCGCTTCCGCTTATCTCGCGCTATGGAACGCCATGTCGCGCCGCGCCCTCGATCTCATCCT
CGACCATGTCCGCGCCGAGCCCTCGCGCACCTGGTCCATCATCGTCACCATCTATGGCGATGCCATCGTGCCGCGCGGCG
GCTCGGTGTGGCTCGGCACCCTGCTTGCCTTCTTCAAGGGGCTGGATATCGCCGACGGGGTGGTGCGCACCGCCATGTCG
CGCCTCGCCGCCGACGGCTGGCTGACGCGCACCCGCATCGGCCGCAACAGCTTCTATGGTCTCGCCGACAAGGGTCGCGA
GACCTTCGCCCGCGCCACCGAGCACATCTACAGCCACCGCCCGCCGGAATGGCGCGGCCACTTCCAGATGCTGCTCATCG
AGCCCGCCGCGCGGGAAGGCGCGCGCGCCGCGCTGGATGCGGCCGGCTATGGGGTTCCCCTGCCGGGCGTCTTCATCGCG
CCGGCAGGCGCCGAGGTGCCGGAGGAGGCGCTGGCCGCCCTGCGGCTTGAGGTTTCGGGCACGCCGGAGGCCCAGCAGGA
ACTGGCGGGCCGCGCCTGGCGGCTGGAGGAGACGGCGCAGGCGTATGTGAGCTTCATGGAGGTGTTCGCGCCCCTGCGCG
CGGCGCTGGCGGCGGGGGAAACCCTCACCGACCTTGAGGCCATGGTGGCACGGGTGCTGCTCATCCATGAATATCGCCGC
ATCGTGCTGCGCGATCCCATCCTGCCGGCCGCTATCCTGCCCGCCGACTGGCCCGGCCCGGCGGCCCGTGCCCTGTGCGC
CGACATCTATGCCCATGTGATCGCCGCGTCCGAGCGCTGGCTCGATGACAACGCCGTGGGCGAGGACGGCGATCCGCTGC
CGGCCAGCGCTAAAATCGGGCGTCGTTTCAAGGACTAA

Upstream 100 bases:

>100_bases
CGCCGGGCTCCGCCGTCCACCGCCAAGGCCGGACGGCGCAAGGCGGATTAGACCGCGAGCCGGGCAAATGGCTTCAATTT
GCTCGGTGAATCGCCTTCCT

Downstream 100 bases:

>100_bases
GCGCCCTTCTCGCTCCACCTGGGTCACCCGGAGCGGATATGATGCGCCGCAATATGTTACGAAAATAGATTGCTATAGAA
TTTTTCGTAATATATAAAAC

Product: PaaX family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MVSAGVSASAYLALWNAMSRRALDLILDHVRAEPSRTWSIIVTIYGDAIVPRGGSVWLGTLLAFFKGLDIADGVVRTAMS
RLAADGWLTRTRIGRNSFYGLADKGRETFARATEHIYSHRPPEWRGHFQMLLIEPAAREGARAALDAAGYGVPLPGVFIA
PAGAEVPEEALAALRLEVSGTPEAQQELAGRAWRLEETAQAYVSFMEVFAPLRAALAAGETLTDLEAMVARVLLIHEYRR
IVLRDPILPAAILPADWPGPAARALCADIYAHVIAASERWLDDNAVGEDGDPLPASAKIGRRFKD

Sequences:

>Translated_305_residues
MVSAGVSASAYLALWNAMSRRALDLILDHVRAEPSRTWSIIVTIYGDAIVPRGGSVWLGTLLAFFKGLDIADGVVRTAMS
RLAADGWLTRTRIGRNSFYGLADKGRETFARATEHIYSHRPPEWRGHFQMLLIEPAAREGARAALDAAGYGVPLPGVFIA
PAGAEVPEEALAALRLEVSGTPEAQQELAGRAWRLEETAQAYVSFMEVFAPLRAALAAGETLTDLEAMVARVLLIHEYRR
IVLRDPILPAAILPADWPGPAARALCADIYAHVIAASERWLDDNAVGEDGDPLPASAKIGRRFKD
>Mature_305_residues
MVSAGVSASAYLALWNAMSRRALDLILDHVRAEPSRTWSIIVTIYGDAIVPRGGSVWLGTLLAFFKGLDIADGVVRTAMS
RLAADGWLTRTRIGRNSFYGLADKGRETFARATEHIYSHRPPEWRGHFQMLLIEPAAREGARAALDAAGYGVPLPGVFIA
PAGAEVPEEALAALRLEVSGTPEAQQELAGRAWRLEETAQAYVSFMEVFAPLRAALAAGETLTDLEAMVARVLLIHEYRR
IVLRDPILPAAILPADWPGPAARALCADIYAHVIAASERWLDDNAVGEDGDPLPASAKIGRRFKD

Specific function: Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of paaX is specifically inhibited by phenylacetyl-coenzyme A [H]

COG id: COG3327

COG function: function code K; Phenylacetic acid-responsive transcriptional repressor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787666, Length=301, Percent_Identity=35.5481727574751, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012906
- InterPro:   IPR013225
- InterPro:   IPR011965 [H]

Pfam domain/function: PF07848 PaaX; PF08223 PaaX_C [H]

EC number: NA

Molecular weight: Translated: 33060; Mature: 33060

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSAGVSASAYLALWNAMSRRALDLILDHVRAEPSRTWSIIVTIYGDAIVPRGGSVWLGT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEECCCCCCHHHHH
LLAFFKGLDIADGVVRTAMSRLAADGWLTRTRIGRNSFYGLADKGRETFARATEHIYSHR
HHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PPEWRGHFQMLLIEPAAREGARAALDAAGYGVPLPGVFIAPAGAEVPEEALAALRLEVSG
CCCCCCCEEEEEECCCHHCCHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHEECCC
TPEAQQELAGRAWRLEETAQAYVSFMEVFAPLRAALAAGETLTDLEAMVARVLLIHEYRR
CCHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IVLRDPILPAAILPADWPGPAARALCADIYAHVIAASERWLDDNAVGEDGDPLPASAKIG
HHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RRFKD
HCCCC
>Mature Secondary Structure
MVSAGVSASAYLALWNAMSRRALDLILDHVRAEPSRTWSIIVTIYGDAIVPRGGSVWLGT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEECCCCCCHHHHH
LLAFFKGLDIADGVVRTAMSRLAADGWLTRTRIGRNSFYGLADKGRETFARATEHIYSHR
HHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PPEWRGHFQMLLIEPAAREGARAALDAAGYGVPLPGVFIAPAGAEVPEEALAALRLEVSG
CCCCCCCEEEEEECCCHHCCHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHEECCC
TPEAQQELAGRAWRLEETAQAYVSFMEVFAPLRAALAAGETLTDLEAMVARVLLIHEYRR
CCHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IVLRDPILPAAILPADWPGPAARALCADIYAHVIAASERWLDDNAVGEDGDPLPASAKIG
HHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
RRFKD
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]