| Definition | Xanthobacter autotrophicus Py2 chromosome, complete genome. |
|---|---|
| Accession | NC_009720 |
| Length | 5,308,934 |
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The map label for this gene is gno [H]
Identifier: 154244425
GI number: 154244425
Start: 511976
End: 512731
Strand: Direct
Name: gno [H]
Synonym: Xaut_0468
Alternate gene names: 154244425
Gene position: 511976-512731 (Clockwise)
Preceding gene: 154244424
Following gene: 154244429
Centisome position: 9.64
GC content: 72.35
Gene sequence:
>756_bases TTGACCCATCCCTTCTCGCTGGACGGCCAGACCGCCCTCGTCACCGGCTCGGTGGCCGGCCTCGGCTATGAGATCGCGAC CGCCCTCGCGCTGGCGGGGGCCCATGTGCTGGTGAACGGCCGCGACGCCGCCCGCCTCGGCCCGGCGGTGACCGCCATCA TCCGCAAGGGCGGCAAGGCCGAGCCGTTCGTGCTCGACGTGTGCGATGCCGAGGCGGTCACCAAGGCCATCGCGGCGGCG CCGCCCATCCATATCCTCGTCAACAACGCCGGCGCCCGCGACCGGCGCGGCTTCCTCGACATGGAGGACGCCGCGTTCCG CCGACTCGTGGAGCTGGACCTGTTCGCCCCCGCCCATCTCACGCGGGAGGTGGCCAAAGCCATGGTGGCGCGCGGCAAGG GCGGGCGTATCATCAACATCACCTCCATCGCCGGGCCGCTGTCGCGGGCGGGGGATGCCGCCTACACCACCGCGAAGGGC GGGTTGGAGGCGCTGACACGGGCGCTCGCCGCCGATCTCGGGCCGCACGCCATCACGGTGAACGCCATCGCGCCAGGCTA TTTCCTCACCGAGCCCAATGCCGAGCTGGCCCGCGACCAGGCGGTGGGGGAATGGCTGTCGCGCCGCACCTCGCTTGCCC GCTGGGGGCGGCCGGACGAGGTGGCGGGGGCGGCGGTGTTCCTCGCCTCGCCCGCCGCTTCCTATGTCACCGGTCATGTG CTGGCGGTGGACGGCGGCTACATGGCGCACTTCTGA
Upstream 100 bases:
>100_bases TCTGCGGCGCGCTGCTGGGCTATGTTCTGGCCTGACGGCTTGGCCGGAGTGTGCGCCAGACGGTAGGAAGGCGGGATCGC CCAATGGCCGGGAGCCCGCC
Downstream 100 bases:
>100_bases GCGGCTTCGCTCTTTCCGCGTTCTTTCGCTCAAGCGCCGCGCGGGGCTTCCAGGCGCCTTCGCTCAATCGCCGCGCGGGC TTGAGCGCGCGGCTGCAGTG
Product: gluconate 5-dehydrogenase
Products: NA
Alternate protein names: 5-keto-D-gluconate 5-reductase [H]
Number of amino acids: Translated: 251; Mature: 250
Protein sequence:
>251_residues MTHPFSLDGQTALVTGSVAGLGYEIATALALAGAHVLVNGRDAARLGPAVTAIIRKGGKAEPFVLDVCDAEAVTKAIAAA PPIHILVNNAGARDRRGFLDMEDAAFRRLVELDLFAPAHLTREVAKAMVARGKGGRIINITSIAGPLSRAGDAAYTTAKG GLEALTRALAADLGPHAITVNAIAPGYFLTEPNAELARDQAVGEWLSRRTSLARWGRPDEVAGAAVFLASPAASYVTGHV LAVDGGYMAHF
Sequences:
>Translated_251_residues MTHPFSLDGQTALVTGSVAGLGYEIATALALAGAHVLVNGRDAARLGPAVTAIIRKGGKAEPFVLDVCDAEAVTKAIAAA PPIHILVNNAGARDRRGFLDMEDAAFRRLVELDLFAPAHLTREVAKAMVARGKGGRIINITSIAGPLSRAGDAAYTTAKG GLEALTRALAADLGPHAITVNAIAPGYFLTEPNAELARDQAVGEWLSRRTSLARWGRPDEVAGAAVFLASPAASYVTGHV LAVDGGYMAHF >Mature_250_residues THPFSLDGQTALVTGSVAGLGYEIATALALAGAHVLVNGRDAARLGPAVTAIIRKGGKAEPFVLDVCDAEAVTKAIAAAP PIHILVNNAGARDRRGFLDMEDAAFRRLVELDLFAPAHLTREVAKAMVARGKGGRIINITSIAGPLSRAGDAAYTTAKGG LEALTRALAADLGPHAITVNAIAPGYFLTEPNAELARDQAVGEWLSRRTSLARWGRPDEVAGAAVFLASPAASYVTGHVL AVDGGYMAHF
Specific function: Involved in the non-phosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate. Dependent on NADP, almost inactive with NAD [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=32.5102880658436, Blast_Score=127, Evalue=8e-30, Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=34.2629482071713, Blast_Score=123, Evalue=2e-28, Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=30.4, Blast_Score=98, Evalue=7e-21, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=30.327868852459, Blast_Score=96, Evalue=2e-20, Organism=Homo sapiens, GI10190704, Length=258, Percent_Identity=32.5581395348837, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=32.7800829875519, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI126723750, Length=254, Percent_Identity=29.5275590551181, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.0155642023346, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=30.6532663316583, Blast_Score=81, Evalue=9e-16, Organism=Homo sapiens, GI59889578, Length=169, Percent_Identity=37.2781065088757, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI126723191, Length=188, Percent_Identity=32.4468085106383, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI4504505, Length=195, Percent_Identity=35.3846153846154, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI66933014, Length=247, Percent_Identity=26.7206477732794, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=29.8429319371728, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI33667109, Length=210, Percent_Identity=30.4761904761905, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI4503817, Length=234, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI31542939, Length=215, Percent_Identity=27.906976744186, Blast_Score=70, Evalue=2e-12, Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=38.0952380952381, Blast_Score=171, Evalue=3e-44, Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=37.3493975903614, Blast_Score=142, Evalue=2e-35, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=34.6456692913386, Blast_Score=135, Evalue=3e-33, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=38.5245901639344, Blast_Score=133, Evalue=1e-32, Organism=Escherichia coli, GI1788459, Length=250, Percent_Identity=36.4, Blast_Score=122, Evalue=2e-29, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=35.6, Blast_Score=121, Evalue=5e-29, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=32.8125, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=32.1138211382114, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=31.9672131147541, Blast_Score=91, Evalue=8e-20, Organism=Escherichia coli, GI1789057, Length=175, Percent_Identity=30.2857142857143, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=28.515625, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=30.2788844621514, Blast_Score=62, Evalue=4e-11, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=32.258064516129, Blast_Score=114, Evalue=7e-26, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=33.0677290836653, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=31.9230769230769, Blast_Score=110, Evalue=5e-25, Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=31.3953488372093, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=30.7392996108949, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=30.6513409961686, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=31.3008130081301, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=32.2834645669291, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=30.3846153846154, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.5193798449612, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562908, Length=267, Percent_Identity=31.4606741573034, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=28.4552845528455, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.1787072243346, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=27.9352226720648, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=29.6153846153846, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=27.1317829457364, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=32.046332046332, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17536025, Length=263, Percent_Identity=28.1368821292776, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17561272, Length=255, Percent_Identity=30.5882352941176, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=27.906976744186, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17559104, Length=258, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=28.5171102661597, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI71982365, Length=222, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=28.0155642023346, Blast_Score=81, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6322861, Length=196, Percent_Identity=31.6326530612245, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6322067, Length=194, Percent_Identity=27.319587628866, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=33.0578512396694, Blast_Score=109, Evalue=1e-24, Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=32.6612903225806, Blast_Score=109, Evalue=1e-24, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.9838056680162, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=31.8548387096774, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=28.4, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=30.2788844621514, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24644337, Length=168, Percent_Identity=36.3095238095238, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=26.6009852216749, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.69 [H]
Molecular weight: Translated: 25967; Mature: 25836
Theoretical pI: Translated: 7.80; Mature: 7.80
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTHPFSLDGQTALVTGSVAGLGYEIATALALAGAHVLVNGRDAARLGPAVTAIIRKGGKA CCCCCCCCCCEEEEECCHHHCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCC EPFVLDVCDAEAVTKAIAAAPPIHILVNNAGARDRRGFLDMEDAAFRRLVELDLFAPAHL CCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH TREVAKAMVARGKGGRIINITSIAGPLSRAGDAAYTTAKGGLEALTRALAADLGPHAITV HHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCCEEECCCCHHHHHHHHHHCCCCCEEEE NAIAPGYFLTEPNAELARDQAVGEWLSRRTSLARWGRPDEVAGAAVFLASPAASYVTGHV EEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEECCCHHHHCCEE LAVDGGYMAHF EEECCCEECCC >Mature Secondary Structure THPFSLDGQTALVTGSVAGLGYEIATALALAGAHVLVNGRDAARLGPAVTAIIRKGGKA CCCCCCCCCEEEEECCHHHCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCC EPFVLDVCDAEAVTKAIAAAPPIHILVNNAGARDRRGFLDMEDAAFRRLVELDLFAPAHL CCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH TREVAKAMVARGKGGRIINITSIAGPLSRAGDAAYTTAKGGLEALTRALAADLGPHAITV HHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCCEEECCCCHHHHHHHHHHCCCCCEEEE NAIAPGYFLTEPNAELARDQAVGEWLSRRTSLARWGRPDEVAGAAVFLASPAASYVTGHV EEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEEEECCCHHHHCCEE LAVDGGYMAHF EEECCCEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7751271 [H]