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The map label for this gene is hemF

Identifier: 153949579

GI number: 153949579

Start: 1501057

End: 1501986

Strand: Reverse

Name: hemF

Synonym: YpsIP31758_1280

Alternate gene names: 153949579

Gene position: 1501986-1501057 (Counterclockwise)

Preceding gene: 153947750

Following gene: 153950500

Centisome position: 31.8

GC content: 53.23

Gene sequence:

>930_bases
ATGAACTCACCCGATATAGCCCTAATCAAAACCTACCTGCTCACTTTGCAGGATAACATCTGTGGGGCCTTGGCTCAGGC
CGATGGTCACGCCGAATTCACGGAAGAGTGCTGGGTCCGCGAAGAAGGTGGCGGTGGCCGCAGCCGGGTCTTGGTTAATG
GCGCTGTATTCGAACAAGCTGGGGTTAACTTCTCCCATGTGTCCGGGGCGATGTTACCCGCCTCTGCCACTGCTCACCGG
CCAGAGTTGGCGGGCCGCAGTTTTCAGGCGCTGGGCGTGTCGCTGGTTATTCATCCGCTAAATCCTTATCTGCCTACCAG
CCACGCCAATGTGCGGTTCTTTATTGCTGAGAAACCCGGTGAAGACGCCGTGTGGTGGTTTGGCGGTGGTTTTGATTTAA
CCCCGTACTACGGCTTTGAAGAAGATGCCATTCATTGGCATCAGGTAGCGCATAGCCTTTGCCAGCCATTCGGCGAGCAA
ATCTATCCGCGCTATAAAAAATGGTGTGATGACTATTTTTATATTAAACATCGCCAGGAAGCCCGTGGTATTGGCGGCCT
GTTTTTTGACGATCTGAATAGTCCTGATTTTATGACCTGCTTTAATTTCACCCAAGCCGTTGGCGATGGCTTCCTGGCGG
CTTATATGCCAATCGTCGCGCGGCGTAAAGCCCTGGGCTGGGGTGATCGAGAGCGTCAATTCCAGCTTTATCGCCGGGGC
CGCTATGTCGAGTTCAATCTAGTCTGGGATCGCGGTACGTTGTTCGGCCTGCAAACGGGTGGGCGCACTGAATCTATTTT
GATGTCCCTGCCGCCGTTGGTGCGCTGGGAATATAACTATCAGCCAGAGGCAGATAGTGCAGAAGCCGCGTTGTACCGCG
ATTTTCTGCCGGTAAAAGACTGGTTAGCGATTAAAGGAGAAACACACTAA

Upstream 100 bases:

>100_bases
TAAAAGTAAGCGGCCGCGCGGATCCATACTGGCAGTACAAAAATAGAGGGAAATTGGGGTATACTTAGCGCCTGAAAATT
GCCACCAGTGAACCCCTCTG

Downstream 100 bases:

>100_bases
TGCAGATTTGGGTCGATGCGGACGCCTGTCCCAATGTGATTAAAGAGGTCTTATTTCGCGCCGCTGATCGTACCGGCATG
ATGGTGACATTGGTCGCTAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNSPDIALIKTYLLTLQDNICGALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH

Sequences:

>Translated_309_residues
MNSPDIALIKTYLLTLQDNICGALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH
>Mature_309_residues
MNSPDIALIKTYLLTLQDNICGALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHR
PELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQ
IYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=46.6887417218543, Blast_Score=274, Evalue=1e-73,
Organism=Escherichia coli, GI1788777, Length=300, Percent_Identity=75.3333333333333, Blast_Score=479, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=42.5, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=49.0066225165563, Blast_Score=290, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_YERP3 (A7FG82)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400260.1
- ProteinModelPortal:   A7FG82
- SMR:   A7FG82
- STRING:   A7FG82
- GeneID:   5385440
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1280
- NMPDR:   fig|349747.3.peg.1263
- eggNOG:   COG0408
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- ProtClustDB:   PRK05330
- BioCyc:   YPSE349747:YPSIP31758_1280-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 34991; Mature: 34991

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 108-108 BINDING 94-94

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPDIALIKTYLLTLQDNICGALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCEEEEEECEEHHHC
GVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPG
CCCHHHCCCCCCCCCCCCCCCHHCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEECCC
EDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQE
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
ARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKD
CEEEEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCH
WLAIKGETH
HEEECCCCC
>Mature Secondary Structure
MNSPDIALIKTYLLTLQDNICGALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCEEEEEECEEHHHC
GVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPG
CCCHHHCCCCCCCCCCCCCCCHHCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEECCC
EDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQE
CCEEEEEECCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHH
ARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRG
CCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
RYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKD
CEEEEEEEECCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCH
WLAIKGETH
HEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA