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The map label for this gene is tibA [H]

Identifier: 153947750

GI number: 153947750

Start: 1507072

End: 1509351

Strand: Reverse

Name: tibA [H]

Synonym: YpsIP31758_1288

Alternate gene names: 153947750

Gene position: 1509351-1507072 (Counterclockwise)

Preceding gene: 153948155

Following gene: 153949579

Centisome position: 31.96

GC content: 44.39

Gene sequence:

>2280_bases
TTGAACACCAATAGTAAAAAAACCTACCTTAGCATTGCTATTTCATCCATTCTTTACGCCTCAACAGCAATGAACGCAAA
CGCCGATTCATGTACTGATTATACTGTCACTGATATTTGTGAGCAGAGTAAATATGGTGCGGGTGAATTTCATAATATTA
AGCTGGGTGATGGTGTCACTGCTGGTAGCGAAGATCACCATTTTGTCTTTAATGGTGAAGGATATGAATTATACAATTCT
AACGCGAATTTCTCTGCTCAAATTGCCTCAGGTACCATTCGCTATACCGAAGTGAACAACAGTCACTTTACTGTAAACGC
TCACCATTTTCCGGATGATACCATCTATGCCGGCCGTGCAGAAAATACCACATTGAATGATAGCCTGATGTGGGTGGCAA
CATCGGCTGATCAGACACTGGCTAAAGGTAATTCAATGGTCGTTGTTTCCACCCAAATGGCCATGGTTGATCAAATTTTT
GTTACGACGTTGAATGATGGTAGCCTTCCATTTGATCCCGTCACTACCAATAGCCGCTATGAAGATACGTCATATGAAAT
GTTATGGGGTATGAAAAACGAGGCAAAAGGGTGGGATACCAAAGCCACATCGCATGACTCCGTATTTGTTGATGCCAGCA
AGCAGTCTATCGAAGCCAATGGTCACAGCATTGGTGCCACATTTTATGGTAGGGCCACTCAGGTGGTCAAAGCTGGCGGT
GAGTCACAGGATACCCACTTATTTGATCACAGTTATTCCTGGGTATATGCCGAGGCTAAATTAACCGGTCTGACGGAGGT
TAATGACGCTGCCACTGTCTATCTGAATGCCGCAGCAACTCAAGGTGCTTACGCTGAGAATGTCGTTCTCAACGGCGAAG
ATACAACATTGATGGTGCGCGCGAGTCTGGATAACAATGCCTATGCCACGGTGGATAACCTAATATTGAATGGCGGTGAA
GTGGTTTTCCAGCAGAGCTCTGGCGACCAATATGCTTCATTAAACATCGGCACACTTTCCGGCTCGGGCTCCTTCCTATT
CAATACCTCTATTGCTGAGGGGAAAGGAAACTTCGTGACTATCGCCAATGCCAGTGGGGAACATAAGGTGATAGTTAACG
ACTCTGGCCATGAGATCACCTCACCTGATATGACCACATTGGACTTGATTCACGATCTCAGTGGTGATGCAACATTCACA
CTGGCCTCTATTTCTGGAGCTAACATCATTGAAGTCGATGGCGGCACTTACGTATATAGCTTGAATACCTGGGATAATTC
CGCACGAGCTGGCGGAAATCTGTGGTATTTAGGCTCAGGTTTGAATACAGGCACTGAGCTTGAACCCGAACCTGAAGAGA
AAACAACCCCGTCAACGGATGCAGTGTTGAGTATGGCCTCATCCAACCAGTTTATTTTCGATGGTGAAATGCAAAATCTG
CGTTTTCGTAAAGGGGATTTAAATAATAATAAAGGTGATGGCGCCAGTGTTTGGGGGCGTTATTTAACCAACAATACTCG
GGTCAATGCTGCTCATGATGCCGCTTACCGTTTGCAACAAGATGGCTTTGAAATTGGTGCTGATAAAGTGCTGGAAATGT
CTTCAGGCCAATTAGTCTTGGGCGGTTTTACCTCTTATAGCAATAACCGAGTGAAACATGCTCGTAGTGGGAACAGTACG
GTTGATAGTTATAGCTTGGGTGCCTACGGCACTTATTTCGATAACAGTGGTTATTATGTCGATACCGTCGTTAAAGCCAA
CCGTTTTAAAAACTCACTGAATGCCCATATGACCAACGGCGGTTCGGTACAAAGTGATTATAACCAGAATGCAATCGGTG
GCTCACTGGAAGCCGGTTATCACTACAGCCTGTCGAATAATTGGTTCGTAGAGCCTTATGTTCGTACCAGCTATTACACG
GCACAGGATAAAGATATTGTGCTGAATAATGGCATGACAGCGAATATTGATAATAACCGCTCAGCTAAAGGTGAAATAGG
TACACATCTGGGAACGAAGATTGACCTGAATAATGGGGCTATCATCCGCCCTTATGCCAAAGTCGCTATTGAACGAGAGT
TCATCAAATCAAATACCGTGACGATCAATCAGGTTAACGACTTTAATAATGATTTATCAGGACATACCGCGAAGTATGGT
TTAGGCATGGATATCAACCTGATGAAACAGACTTCCGTTTATGCCGAAGCCAATTACCGCAACGGGACTCATGTGGAGTC
ACCTATCATGGCTAATATCGGTTTCCGGATTAATTTCTAA

Upstream 100 bases:

>100_bases
ATTAATTAATCATCATTAATGAGCAATGTAAAATCACAGCGTATCAATGTGGAATACGTAAATTTAATGAAATTAAAAAA
TAAATTGGAGTATTGTTACA

Downstream 100 bases:

>100_bases
AGAACATACCAGATGAGTGGTTTCCCGCGATAATGCGGGAAACCATTTTTTTGCTCAATAGATTAAACATGTCTACCCAC
GTTACTTCGAGCTACATCTT

Product: autotransporter protein

Products: NA

Alternate protein names: Glycoprotein TibA [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MNTNSKKTYLSIAISSILYASTAMNANADSCTDYTVTDICEQSKYGAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSHFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVTTNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARSGNST
VDSYSLGAYGTYFDNSGYYVDTVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIVLNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF

Sequences:

>Translated_759_residues
MNTNSKKTYLSIAISSILYASTAMNANADSCTDYTVTDICEQSKYGAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSHFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVTTNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARSGNST
VDSYSLGAYGTYFDNSGYYVDTVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIVLNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
>Mature_759_residues
MNTNSKKTYLSIAISSILYASTAMNANADSCTDYTVTDICEQSKYGAGEFHNIKLGDGVTAGSEDHHFVFNGEGYELYNS
NANFSAQIASGTIRYTEVNNSHFTVNAHHFPDDTIYAGRAENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIF
VTTLNDGSLPFDPVTTNSRYEDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVRASLDNNAYATVDNLILNGGE
VVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVTIANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFT
LASISGANIIEVDGGTYVYSLNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVLGGFTSYSNNRVKHARSGNST
VDSYSLGAYGTYFDNSGYYVDTVVKANRFKNSLNAHMTNGGSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYT
AQDKDIVLNNGMTANIDNNRSAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF

Specific function: Mediates both adhesion to and invasion of human intestine epithelial cells. Also mediates bacterial cell aggregation via intercellular TibA-TibA interaction. Enhances biofilm formation [H]

COG id: COG3468

COG function: function code MU; Type V secretory pathway, adhesin AidA

Gene ontology:

Cell location: Adhesin/invasin TibA translocator:Cell outer membrane; Multi-pass membrane protein (Potential). Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

Organism=Escherichia coli, GI87082145, Length=556, Percent_Identity=31.6546762589928, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787452, Length=483, Percent_Identity=25.2587991718427, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR012332
- InterPro:   IPR011050
- InterPro:   IPR004899
- InterPro:   IPR003991 [H]

Pfam domain/function: PF03797 Autotransporter; PF03212 Pertactin [H]

EC number: NA

Molecular weight: Translated: 82229; Mature: 82229

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNSKKTYLSIAISSILYASTAMNANADSCTDYTVTDICEQSKYGAGEFHNIKLGDGVT
CCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCC
AGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSHFTVNAHHFPDDTIYAGRA
CCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEEEEECCCEEEEEEEECCCCCEEECCC
ENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVTTNSRY
CCCEECCCEEEEEECCCHHHHCCCCEEEEEEHHHHEEEEEEEEECCCCCCCCCCCCCCCC
EDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCC
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVR
CCCCCEEEECCCEEEEEEEEEECCEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEE
ASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVT
EECCCCCEEEEEHEEECCCEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEE
IANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYS
EECCCCCEEEEECCCCCEECCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEE
LNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCC
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVL
EEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
GGFTSYSNNRVKHARSGNSTVDSYSLGAYGTYFDNSGYYVDTVVKANRFKNSLNAHMTNG
EEEECCCCCCEEEECCCCCCCCEEECCCEEEEECCCCEEEEEEEEHHHHHCCCCEEECCC
GSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIVLNNGMTANIDNNR
CCCCCCCCCCCCCCCCCCCEEEECCCCEEECCEEEEEEEECCCCEEEEECCEEEECCCCC
SAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
CCCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
CCCEEEEEEECEEEEEECCCCCCCCCCCEEEECCEEEEC
>Mature Secondary Structure
MNTNSKKTYLSIAISSILYASTAMNANADSCTDYTVTDICEQSKYGAGEFHNIKLGDGVT
CCCCCCEEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCC
AGSEDHHFVFNGEGYELYNSNANFSAQIASGTIRYTEVNNSHFTVNAHHFPDDTIYAGRA
CCCCCCEEEECCCCEEEECCCCCEEEEEECCEEEEEEECCCEEEEEEEECCCCCEEECCC
ENTTLNDSLMWVATSADQTLAKGNSMVVVSTQMAMVDQIFVTTLNDGSLPFDPVTTNSRY
CCCEECCCEEEEEECCCHHHHCCCCEEEEEEHHHHEEEEEEEEECCCCCCCCCCCCCCCC
EDTSYEMLWGMKNEAKGWDTKATSHDSVFVDASKQSIEANGHSIGATFYGRATQVVKAGG
CCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCEEEEEEECCEEEEEECCC
ESQDTHLFDHSYSWVYAEAKLTGLTEVNDAATVYLNAAATQGAYAENVVLNGEDTTLMVR
CCCCCEEEECCCEEEEEEEEEECCEECCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEE
ASLDNNAYATVDNLILNGGEVVFQQSSGDQYASLNIGTLSGSGSFLFNTSIAEGKGNFVT
EECCCCCEEEEEHEEECCCEEEEEECCCCCEEEEEEEEECCCCCEEEEEEEECCCCCEEE
IANASGEHKVIVNDSGHEITSPDMTTLDLIHDLSGDATFTLASISGANIIEVDGGTYVYS
EECCCCCEEEEECCCCCEECCCCCCHHHHHHHCCCCCEEEEEEECCCCEEEECCCEEEEE
LNTWDNSARAGGNLWYLGSGLNTGTELEPEPEEKTTPSTDAVLSMASSNQFIFDGEMQNL
EECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHEEEECCCCCEEEECCCCCC
RFRKGDLNNNKGDGASVWGRYLTNNTRVNAAHDAAYRLQQDGFEIGADKVLEMSSGQLVL
EEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
GGFTSYSNNRVKHARSGNSTVDSYSLGAYGTYFDNSGYYVDTVVKANRFKNSLNAHMTNG
EEEECCCCCCEEEECCCCCCCCEEECCCEEEEECCCCEEEEEEEEHHHHHCCCCEEECCC
GSVQSDYNQNAIGGSLEAGYHYSLSNNWFVEPYVRTSYYTAQDKDIVLNNGMTANIDNNR
CCCCCCCCCCCCCCCCCCCEEEECCCCEEECCEEEEEEEECCCCEEEEECCEEEECCCCC
SAKGEIGTHLGTKIDLNNGAIIRPYAKVAIEREFIKSNTVTINQVNDFNNDLSGHTAKYG
CCCCCCCCCCCCEEECCCCCEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEE
LGMDINLMKQTSVYAEANYRNGTHVESPIMANIGFRINF
CCCEEEEEEECEEEEEECCCCCCCCCCCEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10417177 [H]