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The map label for this gene is frdD

Identifier: 153948817

GI number: 153948817

Start: 4138594

End: 4138950

Strand: Direct

Name: frdD

Synonym: YpsIP31758_3670

Alternate gene names: 153948817

Gene position: 4138594-4138950 (Clockwise)

Preceding gene: 153948369

Following gene: 153950672

Centisome position: 87.62

GC content: 49.86

Gene sequence:

>357_bases
ATGAATCAAGTCCCTAAACGCTCCGATGAACCGATCTTCTGGGGTCTGTTTGGTGCGGGTGGCATGTGGGGTGCAATTAT
TGCCCCTGTGATTATTCTGCTGGTCGCGATTTTGTTGCCATTGGGTGCATTCCCAGGCGACGCGCTGAGCTACGAACGCA
TTCTGGCATTTTGTCAGAGCTTTATTGGCCGGGTATTCCTGCTGCTGATGATCATTTTGCCTTTGTGGTGCGGTTTACAC
CGTATTCATCATGCAATGCATGATTTGAAAATCCACGTCCCGGCAGGGAAATGGGTATTCTATGGCCTTGCGGCAATCTT
GAGTGTGGTCACTTTTATCGGTGTACTGACGCTGTAG

Upstream 100 bases:

>100_bases
ATGGGTCCAGAGCCAATGATTAAGGCGCTATGGGTTGTGACTGTCGTGGCTAGCGCGATTATCCTGGCTGTCGCCTTACT
CTAACCCGGAGGAGAAAAAG

Downstream 100 bases:

>100_bases
CCGTAGTCACCACATGCCATATTCGCGGCCTGCTGTTCTGGCAGGCCGTTCTTTGGTTAAAGCGCTCAGTTCGGTTGCCA
AAATTTTACGACTCATTTGA

Product: fumarate reductase subunit D

Products: fumarate; reduced acceptor

Alternate protein names: Fumarate reductase 13 kDa hydrophobic protein

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MNQVPKRSDEPIFWGLFGAGGMWGAIIAPVIILLVAILLPLGAFPGDALSYERILAFCQSFIGRVFLLLMIILPLWCGLH
RIHHAMHDLKIHVPAGKWVFYGLAAILSVVTFIGVLTL

Sequences:

>Translated_118_residues
MNQVPKRSDEPIFWGLFGAGGMWGAIIAPVIILLVAILLPLGAFPGDALSYERILAFCQSFIGRVFLLLMIILPLWCGLH
RIHHAMHDLKIHVPAGKWVFYGLAAILSVVTFIGVLTL
>Mature_118_residues
MNQVPKRSDEPIFWGLFGAGGMWGAIIAPVIILLVAILLPLGAFPGDALSYERILAFCQSFIGRVFLLLMIILPLWCGLH
RIHHAMHDLKIHVPAGKWVFYGLAAILSVVTFIGVLTL

Specific function: Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane

COG id: COG3080

COG function: function code C; Fumarate reductase subunit D

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the frdD family

Homologues:

Organism=Escherichia coli, GI1790594, Length=118, Percent_Identity=85.5932203389831, Blast_Score=207, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FRDD_YERPE (Q8ZIX8)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AE0044
- RefSeq:   NP_667951.1
- RefSeq:   NP_991905.1
- RefSeq:   YP_002345435.1
- ProteinModelPortal:   Q8ZIX8
- SMR:   Q8ZIX8
- GeneID:   1145561
- GeneID:   1173202
- GeneID:   2765953
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0357
- KEGG:   ypk:y0614
- KEGG:   ypm:YP_0512
- HOGENOM:   HBG297136
- OMA:   HRIHHGM
- ProtClustDB:   PRK05470
- BioCyc:   YPES187410:Y0614-MONOMER
- BioCyc:   YPES214092:YPO0357-MONOMER
- HAMAP:   MF_00709
- InterPro:   IPR003418
- ProDom:   PD015693

Pfam domain/function: PF02313 Fumarate_red_D

EC number: 1.3.99.1

Molecular weight: Translated: 12990; Mature: 12990

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ef44764)-; HASH(0x23706fbc)-; HASH(0x2378da0c)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVPKRSDEPIFWGLFGAGGMWGAIIAPVIILLVAILLPLGAFPGDALSYERILAFCQS
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FIGRVFLLLMIILPLWCGLHRIHHAMHDLKIHVPAGKWVFYGLAAILSVVTFIGVLTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MNQVPKRSDEPIFWGLFGAGGMWGAIIAPVIILLVAILLPLGAFPGDALSYERILAFCQS
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FIGRVFLLLMIILPLWCGLHRIHHAMHDLKIHVPAGKWVFYGLAAILSVVTFIGVLTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: succinate; acceptor

Specific reaction: succinate + acceptor = fumarate + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430