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The map label for this gene is cueR [H]

Identifier: 153948285

GI number: 153948285

Start: 3405161

End: 3405580

Strand: Reverse

Name: cueR [H]

Synonym: YpsIP31758_3026

Alternate gene names: 153948285

Gene position: 3405580-3405161 (Counterclockwise)

Preceding gene: 153949856

Following gene: 153949055

Centisome position: 72.1

GC content: 45.95

Gene sequence:

>420_bases
ATGAATATTAGCGATGTCGCGAAAAAAACCGGTTTAACCAGCAAAGCCATTCGTTTTTATGAAGAAAAAAAACTGGTGAC
GCCACCTGTCCGCATGGATAACGGCTATCGCAGCTACACGGCCAAACATATTGAAGAGCTAACGTTGCTGCGCCAGGCGC
GGCAAGTGGGTTTTACATTGGATGAGTGTCGTGAATTACTGGCATTATTTCATAACCCAGCACGGCACAGCGCGGATGTG
AAAGCAGCAACATTGCAAAAAGTAGCGGAAATTGAGCAACATATTAATGATTTGAATCAGATGCGTATGCGCTTGTTAGC
GTTGGCAGAAGAGTGTCCGGGGGATGAGGGCGCAGATTGCCCAATTATTAATAGCCTGGCGGGATGTTGCCATTCAAGCA
GTACGCTACCATTAAAATAA

Upstream 100 bases:

>100_bases
TCATAATATCGGGGGGCTTTTATTCCGCTTGACTGGTATGGCTATTTTCACTAAACATAGAGGTTAAACCTTCCCGCAAG
GGGAAGGTCAAGGGGGAATA

Downstream 100 bases:

>100_bases
TACGTTGCCATTAAAGTCATCGCTCGCCATCTGAGCAATAAGCACTATCTTTGACCTTGATGCCGCATCAGTGAATCACC
CGAATCACCTACCAAAGTAA

Product: Cu(I)-responsive transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRMDNGYRSYTAKHIEELTLLRQARQVGFTLDECRELLALFHNPARHSADV
KAATLQKVAEIEQHINDLNQMRMRLLALAEECPGDEGADCPIINSLAGCCHSSSTLPLK

Sequences:

>Translated_139_residues
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRMDNGYRSYTAKHIEELTLLRQARQVGFTLDECRELLALFHNPARHSADV
KAATLQKVAEIEQHINDLNQMRMRLLALAEECPGDEGADCPIINSLAGCCHSSSTLPLK
>Mature_139_residues
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRMDNGYRSYTAKHIEELTLLRQARQVGFTLDECRELLALFHNPARHSADV
KAATLQKVAEIEQHINDLNQMRMRLLALAEECPGDEGADCPIINSLAGCCHSSSTLPLK

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=72.5190839694656, Blast_Score=201, Evalue=1e-53,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=32.03125, Blast_Score=78, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15522; Mature: 15522

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRMDNGYRSYTAKHIEELTLLRQARQVGFTL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
DECRELLALFHNPARHSADVKAATLQKVAEIEQHINDLNQMRMRLLALAEECPGDEGADC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINSLAGCCHSSSTLPLK
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKKLVTPPVRMDNGYRSYTAKHIEELTLLRQARQVGFTL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCH
DECRELLALFHNPARHSADVKAATLQKVAEIEQHINDLNQMRMRLLALAEECPGDEGADC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINSLAGCCHSSSTLPLK
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]