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The map label for this gene is hom-1 [H]

Identifier: 153936966

GI number: 153936966

Start: 1753949

End: 1755226

Strand: Direct

Name: hom-1 [H]

Synonym: CLC_1667

Alternate gene names: 153936966

Gene position: 1753949-1755226 (Clockwise)

Preceding gene: 153936863

Following gene: 153937722

Centisome position: 46.64

GC content: 29.73

Gene sequence:

>1278_bases
GTGGAAAAAGTTAAAATTGCGTTATTAGGATTAGGAAATGTAGGTAAAGGTGTTTGGAATATATTAAAGACAAATAAAGA
AGCCATAATTAAAAGGGCCGGTTATGATATAGAAATATCAAAAATATTGGTAAAGGATATAAATAAACAAAGAGGAATAG
AGGTTCCTAAAGAATTATTAACTACAAATGTAGAAGAAATATTTAATGATGATAGTATAAAAATTGTAGTAGAGGTTATA
GGTGGGCTGCAGCCTGCTAAAGAATATATACTAAGATCTATAAAAAATAAAAAACATGTTATAACTGCTAACAAAATGCT
TATTGCAACTAATGGTAAAGAAATTTTTGAAGAAGCTAAAAAACAAGGGGTAATTGTAAATTTGGAGGCTAGTGTGGCTG
GAGGAATCCCTGTAATAAATAGCATAAATGAAAGTTTAACTGCTAATAAAATAGAGGAAATTGTGGGTATAATTAATGGA
ACTACAAATTATATATTAACTAAAATGACTTTAGAAGGTATGAGCTTTGAAGAAGCACTTAAAGAAGCACAAGAAAAGGG
CTATGCAGAGGCAGACCCAACTTCTGATGTGGAAGGTTATGATGCAGTTTATAAATTAGCTATATTAACTACTTTAGCTT
TTGAAACAAATGTAAATGTAAATGATATATATGTAGAGGGAATAACTAAGATAAAAGCAAAAGATATAGAATATTCAAAG
GAGTTAGGATATGTTATAAAACTTTTAGCCATAGTTAAAGAGGTTAATGAAAAGCTTGAACTTAGGGTTCATCCGACAAT
GATTCCATCAATTCATCCTTTAGCTAATGTTAATGATTCCTTTAATTCAATTTTTATTAAAGGTAATGCGGTAGGAGATT
TGATGCTTTATGGAAGAGGAGCAGGAGAACTTCCTACAGGAAGTGCAGTAGTTGGAGATATAATATCTGTTCTAAGAAAT
GAAGGTGTTCCTCCTATGGATAAAAGCTATATTGATAGGGAAATAGCACCTGTAGATAATTTTAAATCTCAATATTATTT
AAGAATTTCTGTAAAAGAGGAGGCAGGGGTTTTGGCAAAAATCACTGCTATATTAGGGGAAAATAATGTAAGTATTTTAT
CCTTTATACAGAAACCTAAAAAAGAAGATTTTGTATCCATAGTGCTGGTAACTCATGATACTTTTGAGGGAAATATAAAT
AAATCCATAGAAAAAATAAAGAATTTAGATGTAGTAGACAAAATAAAGAGTGTCATAAGGATTGAAAATTTAAGCTAA

Upstream 100 bases:

>100_bases
TAAGAAAGACTATATTCTTTGAAAAGAATTTTTAAGTTCAAAGTAGATTAAAAAAATTTTAAAACTAGTAATCTGTTTAC
AAAAAAAGGGGGCAAAAATT

Downstream 100 bases:

>100_bases
TTAAAACAAGGTGTTTCACCATAAAAAGATTTAAATTTAACACAGAAAATATAAAAAATACACGTGTTAGATCATATAAA
TAAACTTTAGTAGTTCTTAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MEKVKIALLGLGNVGKGVWNILKTNKEAIIKRAGYDIEISKILVKDINKQRGIEVPKELLTTNVEEIFNDDSIKIVVEVI
GGLQPAKEYILRSIKNKKHVITANKMLIATNGKEIFEEAKKQGVIVNLEASVAGGIPVINSINESLTANKIEEIVGIING
TTNYILTKMTLEGMSFEEALKEAQEKGYAEADPTSDVEGYDAVYKLAILTTLAFETNVNVNDIYVEGITKIKAKDIEYSK
ELGYVIKLLAIVKEVNEKLELRVHPTMIPSIHPLANVNDSFNSIFIKGNAVGDLMLYGRGAGELPTGSAVVGDIISVLRN
EGVPPMDKSYIDREIAPVDNFKSQYYLRISVKEEAGVLAKITAILGENNVSILSFIQKPKKEDFVSIVLVTHDTFEGNIN
KSIEKIKNLDVVDKIKSVIRIENLS

Sequences:

>Translated_425_residues
MEKVKIALLGLGNVGKGVWNILKTNKEAIIKRAGYDIEISKILVKDINKQRGIEVPKELLTTNVEEIFNDDSIKIVVEVI
GGLQPAKEYILRSIKNKKHVITANKMLIATNGKEIFEEAKKQGVIVNLEASVAGGIPVINSINESLTANKIEEIVGIING
TTNYILTKMTLEGMSFEEALKEAQEKGYAEADPTSDVEGYDAVYKLAILTTLAFETNVNVNDIYVEGITKIKAKDIEYSK
ELGYVIKLLAIVKEVNEKLELRVHPTMIPSIHPLANVNDSFNSIFIKGNAVGDLMLYGRGAGELPTGSAVVGDIISVLRN
EGVPPMDKSYIDREIAPVDNFKSQYYLRISVKEEAGVLAKITAILGENNVSILSFIQKPKKEDFVSIVLVTHDTFEGNIN
KSIEKIKNLDVVDKIKSVIRIENLS
>Mature_425_residues
MEKVKIALLGLGNVGKGVWNILKTNKEAIIKRAGYDIEISKILVKDINKQRGIEVPKELLTTNVEEIFNDDSIKIVVEVI
GGLQPAKEYILRSIKNKKHVITANKMLIATNGKEIFEEAKKQGVIVNLEASVAGGIPVINSINESLTANKIEEIVGIING
TTNYILTKMTLEGMSFEEALKEAQEKGYAEADPTSDVEGYDAVYKLAILTTLAFETNVNVNDIYVEGITKIKAKDIEYSK
ELGYVIKLLAIVKEVNEKLELRVHPTMIPSIHPLANVNDSFNSIFIKGNAVGDLMLYGRGAGELPTGSAVVGDIISVLRN
EGVPPMDKSYIDREIAPVDNFKSQYYLRISVKEEAGVLAKITAILGENNVSILSFIQKPKKEDFVSIVLVTHDTFEGNIN
KSIEKIKNLDVVDKIKSVIRIENLS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=23.1843575418994, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786183, Length=255, Percent_Identity=26.2745098039216, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46825; Mature: 46825

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKIALLGLGNVGKGVWNILKTNKEAIIKRAGYDIEISKILVKDINKQRGIEVPKELL
CCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHCCHHCCCCCCHHHH
TTNVEEIFNDDSIKIVVEVIGGLQPAKEYILRSIKNKKHVITANKMLIATNGKEIFEEAK
HCCHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHH
KQGVIVNLEASVAGGIPVINSINESLTANKIEEIVGIINGTTNYILTKMTLEGMSFEEAL
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHH
KEAQEKGYAEADPTSDVEGYDAVYKLAILTTLAFETNVNVNDIYVEGITKIKAKDIEYSK
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHEEECCCCCHHH
ELGYVIKLLAIVKEVNEKLELRVHPTMIPSIHPLANVNDSFNSIFIKGNAVGDLMLYGRG
HHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECC
AGELPTGSAVVGDIISVLRNEGVPPMDKSYIDREIAPVDNFKSQYYLRISVKEEAGVLAK
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHH
ITAILGENNVSILSFIQKPKKEDFVSIVLVTHDTFEGNINKSIEKIKNLDVVDKIKSVIR
HHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
IENLS
HCCCC
>Mature Secondary Structure
MEKVKIALLGLGNVGKGVWNILKTNKEAIIKRAGYDIEISKILVKDINKQRGIEVPKELL
CCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHCCHHCCCCCCHHHH
TTNVEEIFNDDSIKIVVEVIGGLQPAKEYILRSIKNKKHVITANKMLIATNGKEIFEEAK
HCCHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHCCCCEEEEECEEEEEECCHHHHHHHH
KQGVIVNLEASVAGGIPVINSINESLTANKIEEIVGIINGTTNYILTKMTLEGMSFEEAL
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHH
KEAQEKGYAEADPTSDVEGYDAVYKLAILTTLAFETNVNVNDIYVEGITKIKAKDIEYSK
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHEEECCCCCHHH
ELGYVIKLLAIVKEVNEKLELRVHPTMIPSIHPLANVNDSFNSIFIKGNAVGDLMLYGRG
HHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEEECC
AGELPTGSAVVGDIISVLRNEGVPPMDKSYIDREIAPVDNFKSQYYLRISVKEEAGVLAK
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHH
ITAILGENNVSILSFIQKPKKEDFVSIVLVTHDTFEGNINKSIEKIKNLDVVDKIKSVIR
HHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
IENLS
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]