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The map label for this gene is hisC

Identifier: 153936729

GI number: 153936729

Start: 1673079

End: 1674143

Strand: Direct

Name: hisC

Synonym: CLC_1602

Alternate gene names: 153936729

Gene position: 1673079-1674143 (Clockwise)

Preceding gene: 153936234

Following gene: 153936004

Centisome position: 44.49

GC content: 27.04

Gene sequence:

>1065_bases
ATGAGTAAATATTGGAGCAATATAACTAAAGATATAGAACCTTATGTATGTGGAGAGCAACCTAAGAATAAAAAAATTAT
AAAGTTAAATACTAATGAAAATCCATATCCTCCGTCACCCAAGGTATTGCAAGCTATAGAAAATGCTGCCAAGGATGATT
TAAGATTATATCCAGATCCAAATTGCGATACCTTAAGAAAAACTATAGCTAATTACTACAATTTAAGTAAGGAAGAAGTT
TTTATAGGAAATGGCTCTGATGAGGTTTTATCCCTTTCTTTTTTAACTTTTTTTAATCCAGAAGAGACTGTAGTTTTTTC
AGATATTAGTTATAGTTTTTATCCTGTTTATGCAAATTTATATAAATTAGATTATGAATTAGCAAAACTTAGAGAAGATT
TTTCTATAGATATTGAAGATTTTAAAAATACAAAAGGAGGAGCCATTATAACAAATCCTAATGCACCAACAGGATTGTAT
CTTTCCTTAGATTCAATAAAACAAATTTTAGAGGATAATATAAATAAGGTGGTTATGGTTGATGAAGCTTATATTGATTT
TGGAGGAGAATCTTCAGTAAGTCTTATAAAGGATTATCCTAATCTTTTAGTAATACAAACCTTATCTAAATCTCGATCTT
TAGCTGGAATGAGAATAGGATTTGCTTTAGGAAAAAAGGAGCTTATAGAGGGGTTAAATAGGATAAAAAATTCTTTTAAT
TCCTATACAATAGATAGAATTTCATCTTTAGCAGCTATAGAAGCCATAAAGGATGAAGAATATTTTAAGGAATGTACACT
AAAAGTAATAAAAACACGAAATTGGACTATAAATGAACTAGGGAAAATAGGATTTAAAATCATACCATCTAAAGCTAATT
TTATATTTATTACTCATGATACATATCAAGCTGAAGATATTTTGATAAAGCTAAGGGATGAAAATGTACTTGTTAGATAC
TTTAATAAAGATAGAATAAGTAATTATTTAAGGGTTAGTATAGGTTCTAAAGAAGAAATGGAGATTTTTATGGATAAAAT
AAAGAAGATTATAAATAAATTATAG

Upstream 100 bases:

>100_bases
AAGAAATGGATGTTTATGGAGCTATTGTAGGTAAAGCTATATATTCAGGGAATATTAATTTGAATGAAGCTATTAAAATT
ATAAACAAGGGGAGTTCTAA

Downstream 100 bases:

>100_bases
TTACTATATAAATAAAAATATATAGAAAGTATATATTAGAACATTATATATTTGGAAGATATAGATACAAAGAATAGGTT
TAAAAATATAGTAAGTAAAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDTLRKTIANYYNLSKEEV
FIGNGSDEVLSLSFLTFFNPEETVVFSDISYSFYPVYANLYKLDYELAKLREDFSIDIEDFKNTKGGAIITNPNAPTGLY
LSLDSIKQILEDNINKVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGKKELIEGLNRIKNSFN
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDILIKLRDENVLVRY
FNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL

Sequences:

>Translated_354_residues
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDTLRKTIANYYNLSKEEV
FIGNGSDEVLSLSFLTFFNPEETVVFSDISYSFYPVYANLYKLDYELAKLREDFSIDIEDFKNTKGGAIITNPNAPTGLY
LSLDSIKQILEDNINKVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGKKELIEGLNRIKNSFN
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDILIKLRDENVLVRY
FNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
>Mature_353_residues
SKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDPNCDTLRKTIANYYNLSKEEVF
IGNGSDEVLSLSFLTFFNPEETVVFSDISYSFYPVYANLYKLDYELAKLREDFSIDIEDFKNTKGGAIITNPNAPTGLYL
SLDSIKQILEDNINKVVMVDEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGKKELIEGLNRIKNSFNS
YTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHDTYQAEDILIKLRDENVLVRYF
NKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=24.5014245014245, Blast_Score=116, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=29.1005291005291, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CLOB1 (A7FU81)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383914.1
- ProteinModelPortal:   A7FU81
- SMR:   A7FU81
- STRING:   A7FU81
- GeneID:   5395320
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1591
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MRGELND
- ProtClustDB:   PRK05387
- BioCyc:   CBOT441770:CLB_1591-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40593; Mature: 40462

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDP
CCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCC
NCDTLRKTIANYYNLSKEEVFIGNGSDEVLSLSFLTFFNPEETVVFSDISYSFYPVYANL
CHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCEEEHHHHHH
YKLDYELAKLREDFSIDIEDFKNTKGGAIITNPNAPTGLYLSLDSIKQILEDNINKVVMV
HHHHHHHHHHHCCCCEEHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEE
DEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGKKELIEGLNRIKNSFN
EEEEEECCCCCCHHHHHCCCCEEEEEEHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHC
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHD
CEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCEEEEECC
TYQAEDILIKLRDENVLVRYFNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
CCCCCEEEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKYWSNITKDIEPYVCGEQPKNKKIIKLNTNENPYPPSPKVLQAIENAAKDDLRLYPDP
CCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECCCC
NCDTLRKTIANYYNLSKEEVFIGNGSDEVLSLSFLTFFNPEETVVFSDISYSFYPVYANL
CHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEECCCCEEEHHHHHH
YKLDYELAKLREDFSIDIEDFKNTKGGAIITNPNAPTGLYLSLDSIKQILEDNINKVVMV
HHHHHHHHHHHCCCCEEHHHHCCCCCCEEEECCCCCCEEEEEHHHHHHHHHCCCCEEEEE
DEAYIDFGGESSVSLIKDYPNLLVIQTLSKSRSLAGMRIGFALGKKELIEGLNRIKNSFN
EEEEEECCCCCCHHHHHCCCCEEEEEEHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHC
SYTIDRISSLAAIEAIKDEEYFKECTLKVIKTRNWTINELGKIGFKIIPSKANFIFITHD
CEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCCEEEEECC
TYQAEDILIKLRDENVLVRYFNKDRISNYLRVSIGSKEEMEIFMDKIKKIINKL
CCCCCEEEEEEECCCEEEEEECHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA