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The map label for this gene is gmk [H]

Identifier: 153933883

GI number: 153933883

Start: 2522511

End: 2523140

Strand: Reverse

Name: gmk [H]

Synonym: CLB_2387

Alternate gene names: 153933883

Gene position: 2523140-2522511 (Counterclockwise)

Preceding gene: 153933909

Following gene: 153933120

Centisome position: 65.31

GC content: 28.73

Gene sequence:

>630_bases
ATGGCTAAAAAAGGACTTCTTATAGTTATTTCTGGACCATCTGGTGCAGGAAAAGGAACTATATGCAAAGAACTTTTAAA
AAAGGAAGACCTATGGGTATCAGTTTCTGCCACCACTAGATCTCCAAGAAAGGGAGAGGAAAATGGAGTACATTATTTTT
TCTTAAATAAAGATGAATTTAATGAAAGAATAGAGAAAGATGATTTTTTAGAATATGCTAAAGTTCATCAAAATTTATAT
GGAACTCCTAAATCTAGTGTTTTAGAAAAGATTAATAATGGTAATAATGTAATATTAGAGATAGATATTCAAGGAGCTTT
AAAAGTAAAAGAAACTTATCCAGAAGGAATATTTATATTTATATTGCCTCCTTCTATGGAAGAATTAAAAAATAGAATAA
TAAATAGAGGCAGTGAAACAGCAGAAACTTTAATGATAAGATTTAAAGCTGCTTACAAAGAAATAAATTATGTATCAAAA
TATAATTATGCAGTAGTAAATGATACAGTGGAGGACGCAGTTAATAAGGTAAGAAGTATTATATTAGCGGAAAGCTGTAG
AGTTGATAGAATGAAGGATACAATATTAGCATCAAAGGAGGAATTTATTCATGAGCAATTCTATGATTAA

Upstream 100 bases:

>100_bases
ATAGTGATCATGTTATTTTATCAGCAGTTCAGCCAGAAACAGTAGCTCATAGATTAGCTTCTAAAGCAGAAGAGGAAGAT
ATAAATGAGGGAGAAGAGTA

Downstream 100 bases:

>100_bases
TCCATCAATAGTAAATTTATTAGAAAAGGTTGATGACAGATACTCATTAGTAACTATAACATCTAAAAGATCAAGGCAAT
TAATAGATGGAGCAAAACCA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MAKKGLLIVISGPSGAGKGTICKELLKKEDLWVSVSATTRSPRKGEENGVHYFFLNKDEFNERIEKDDFLEYAKVHQNLY
GTPKSSVLEKINNGNNVILEIDIQGALKVKETYPEGIFIFILPPSMEELKNRIINRGSETAETLMIRFKAAYKEINYVSK
YNYAVVNDTVEDAVNKVRSIILAESCRVDRMKDTILASKEEFIHEQFYD

Sequences:

>Translated_209_residues
MAKKGLLIVISGPSGAGKGTICKELLKKEDLWVSVSATTRSPRKGEENGVHYFFLNKDEFNERIEKDDFLEYAKVHQNLY
GTPKSSVLEKINNGNNVILEIDIQGALKVKETYPEGIFIFILPPSMEELKNRIINRGSETAETLMIRFKAAYKEINYVSK
YNYAVVNDTVEDAVNKVRSIILAESCRVDRMKDTILASKEEFIHEQFYD
>Mature_208_residues
AKKGLLIVISGPSGAGKGTICKELLKKEDLWVSVSATTRSPRKGEENGVHYFFLNKDEFNERIEKDDFLEYAKVHQNLYG
TPKSSVLEKINNGNNVILEIDIQGALKVKETYPEGIFIFILPPSMEELKNRIINRGSETAETLMIRFKAAYKEINYVSKY
NYAVVNDTVEDAVNKVRSIILAESCRVDRMKDTILASKEEFIHEQFYD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=35.4497354497354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=35.4497354497354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=35.4497354497354, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=29.8913043478261, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=28.1609195402299, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI14780902, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI21361598, Length=186, Percent_Identity=26.3440860215054, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=43.2291666666667, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=39.5348837209302, Blast_Score=126, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=39.5348837209302, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=27.4725274725275, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71984092, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.0765027322404, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=39.010989010989, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45551002, Length=135, Percent_Identity=34.0740740740741, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23821; Mature: 23689

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKGLLIVISGPSGAGKGTICKELLKKEDLWVSVSATTRSPRKGEENGVHYFFLNKDEF
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEECHHHH
NERIEKDDFLEYAKVHQNLYGTPKSSVLEKINNGNNVILEIDIQGALKVKETYPEGIFIF
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCEEEE
ILPPSMEELKNRIINRGSETAETLMIRFKAAYKEINYVSKYNYAVVNDTVEDAVNKVRSI
EECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHH
ILAESCRVDRMKDTILASKEEFIHEQFYD
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKKGLLIVISGPSGAGKGTICKELLKKEDLWVSVSATTRSPRKGEENGVHYFFLNKDEF
CCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEECHHHH
NERIEKDDFLEYAKVHQNLYGTPKSSVLEKINNGNNVILEIDIQGALKVKETYPEGIFIF
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCEEEE
ILPPSMEELKNRIINRGSETAETLMIRFKAAYKEINYVSKYNYAVVNDTVEDAVNKVRSI
EECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHH
ILAESCRVDRMKDTILASKEEFIHEQFYD
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]