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The map label for this gene is coaBC [H]

Identifier: 153931189

GI number: 153931189

Start: 2521123

End: 2522310

Strand: Reverse

Name: coaBC [H]

Synonym: CLB_2385

Alternate gene names: 153931189

Gene position: 2522310-2521123 (Counterclockwise)

Preceding gene: 153933120

Following gene: 153933517

Centisome position: 65.29

GC content: 29.97

Gene sequence:

>1188_bases
ATGAATAAAAAATGTGTAGTATTAGGTGTAACAGGAGGAATAGCTAGCTATAAAGCTCTAGATATAGTGAGCAAACTAAA
AAAGCTTAATTATGATGTAAATGTAATAATGACAAAGTCTGCACTACAGTTTATACATCCACTACCTTTTCAAAGTTTAA
GTGGTAATATGGTTTCAAAGGATATGTTTGAAGAACCAAAAGCCTTTGAAATACAACATATATCCTTAGCTAAAAAGGCA
GATATGATATTGGTAGCTCCTGCTACAGCTAATATTATTGGAAAAGTAGCTAATGGTATAGCTGATGATATGTTATCTAC
TACTATAATGGCAGCTACTTGTCCTGTAGTATTTGTACCAGCTATGAATACAAACATGTATAAAAATCCTATAGTAAAAA
ATAATATAGAAAAACTAAAAGGCTTTGGTTATGAATTTATTAACCCTATATCTGGAAGACTAGCCTGTGGAGATGTAGGG
GAAGGTAAAATGGCTGATACTGAAGATATAGTAGAAATAGCAGATAGTATGCTTTATCCTATAAAAGACTTAATAGGGAA
AAATATACTAGTTACTGCAGGGCCTACCCTAGCACCTATAGATCCAGTAAGATACATAACAAATAAATCTTCTGGAAAAA
TGGGATATTCTATAGCAAAGGAAGCTAGAGATAGAGGTGCAAAGGTTACATTAGTATCTGGCCCTACAAACTTAAAAACA
CCTTTAGGCTTGGATATAATAAAAGTTAATACAAATGAAGAGATGCTTAAAGCTGTTAAAGATAATTTTGAAAGGCAGCA
TATAGTTATAAAATCTGCAGCTGTGGCAGATTACAAACCTAAAGAATATAAAGAGCATAAAATAAAAAAAACCGGTGATA
ATTTCAATTTAGAGCTAATAAAAGATAAAGATATTTTAAAAGAATTAGGACTAATAAAAAAGAATCAAATATTGGTAGGC
TTTGCAGCAGAAAGTAAAGATCTTTTAGATAATGCTAAATCTAAATTAGAGAAAAAAAACTTAGATTTTATAGTAGCAAA
TAATATCCTGTCAAAGGAAACAGGATTTGCATCAGAGGACAATTTGGTTACAATAGTATCTAAAGATGGATGTATTAAAA
ATTTAGAAAAGATGTCTAAAAGAGAAGTGGCTAAAGAGATATTTGATACTATATTAAATAAAAAATAA

Upstream 100 bases:

>100_bases
CTTGTAGATATAGATTCAACTAAACCTGTTACAGTAGCAATAAATGAAATACATGAAGGAAAAATAACCTATAAAACAGT
TAAAGAAGGAATAAAATAAA

Downstream 100 bases:

>100_bases
TATGAAAATAAAAGAGAGGCAATAACCTTATAAGTTAAGCCTCTTTTATTTAGCGGATAAACAGGTGCCTAGGCAATAAT
ATAGAGTTTTAGCTCTATGT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLAKKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDNFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIVSKDGCIKNLEKMSKREVAKEIFDTILNKK

Sequences:

>Translated_395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLAKKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDNFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIVSKDGCIKNLEKMSKREVAKEIFDTILNKK
>Mature_395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLAKKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDNFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIVSKDGCIKNLEKMSKREVAKEIFDTILNKK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=37.7777777777778, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI87082301, Length=371, Percent_Identity=43.1266846361186, Blast_Score=291, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=186, Percent_Identity=34.9462365591398, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322762, Length=199, Percent_Identity=32.1608040201005, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43369; Mature: 43369

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSK
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCH
DMFEEPKAFEIQHISLAKKADMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVP
HHHCCCCCEEEEEEHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVGEGKMADTEDIVEIADSMLYP
CCCCCCCCCCCHHCCHHHHHCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
IKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
HHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDNFNLELI
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHCCCCCCEEEEE
KDKDILKELGLIKKNQILVGFAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASED
CCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCC
NLVTIVSKDGCIKNLEKMSKREVAKEIFDTILNKK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSK
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCH
DMFEEPKAFEIQHISLAKKADMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVP
HHHCCCCCEEEEEEHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVGEGKMADTEDIVEIADSMLYP
CCCCCCCCCCCHHCCHHHHHCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
IKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
HHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDNFNLELI
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHCCCCCCEEEEE
KDKDILKELGLIKKNQILVGFAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASED
CCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCC
NLVTIVSKDGCIKNLEKMSKREVAKEIFDTILNKK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]