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The map label for this gene is fadA [H]

Identifier: 152977274

GI number: 152977274

Start: 3653222

End: 3654394

Strand: Reverse

Name: fadA [H]

Synonym: Bcer98_3596

Alternate gene names: 152977274

Gene position: 3654394-3653222 (Counterclockwise)

Preceding gene: 152977275

Following gene: 152977273

Centisome position: 89.41

GC content: 43.48

Gene sequence:

>1173_bases
ATGAGAGAAGCTGTCATTGTTGCAGGAGCAAGAACTCCGGTTGGAAAAGCAAAAAAAGGTTCATTAAAAACAGTTCGTCC
AGATGATTTAGGAGCGTTAGTCGTAAAAGAAACGTTAAAACGTGCGAATTATGAAGGACCGATTGATGATTTAATTTTTG
GATGTGCGATGCCAGAAGCTGAACAAGGCTTAAATATGGCACGGAATATCGGTGGATTAGCAGGCCTTTCTTATGATGTT
CCAGCTATTACAATTAACCGCTACTGCTCTTCAGGCTTGCAAAGTATCGCTTACGGTGCAGAGCGCATTATGCTAGGACA
CTCTGAGGCGGTATTATCTGGCGGAGCTGAATCGATGAGTTTAGTTCCGATGATGGGGCATGTTGTTCGTCCTAATAGCC
GACTTGTTGAAGTAGCACCAGAATATTATATGGGAATGGGACATACAGCAGAGCAAGTTGCGATGAAATACGGAATTTCT
CGCGAGGAGCAAGATGCATTTGCAGTTAGAAGTCATCAACGTGCTGCAAAGGCATTAGCTGAAGGGAAATTTACGGATGA
AACAGTGCCTGTAGAAGTAACGTTGCGCATTGTTAACGAAAATAACAAATTGGAAGAAGAAACTATTACGTTTTCACAAG
ATGAAGGAGTAAGAGCAGATACAACGCTAGAGGTACTTGGGAAATTACGTCCGGCTTTCAACGTTCGTGGTTCCGTAACG
GCTGGTAATTCATCGCAAATGAGCGATGGTGCAGCATCTGTACTACTAATGGATCGTGAAAAAGCAGTGAGCGATGGCAT
GAAGCCAATGGCGAAATTCCGCTCTTTTGCAGTAGCCGGTGTGCCGCCAGAAGTAATGGGAATCGGTCCAATTGCGGCGA
TTCCAAAAGCTTTAAAATTAGCGGGATTAGAGCTATCTGATATTGGTTTATTTGAACTAAACGAAGCTTTTGCTTCTCAA
TCGATTCAAGTCATTCGTGAGCTTGGATTAGATGAGGAAAAAGTAAACGTAAATGGCGGTGCAATTGCACTTGGACATCC
ACTCGGTTGTACAGGAGCGAAATTAACATTATCTCTTATTCATGAGATGAAACGACGCAATGAGCAATTCGGTATCGTAA
CGATGTGCATCGGCGGGGGAATGGGAGCTGCGGGAGTGTTTGAACTTCTATAA

Upstream 100 bases:

>100_bases
TATGAGTTTAATAAGTGAGATGAAATCACAAGCAAGAATGCAGCACATGCTTGTAAAAGGAAAGCCATTACGTAACTAAT
AACGAGGGGAGATATCGTTC

Downstream 100 bases:

>100_bases
AATGTGGAAGCGATGTAACGGTTCGAAAAAATAAAGGAAGAGCTAGTATCTCTCGTTACATGAGAGATACAGCTTATGAA
AATATGAAGGAGGAATTTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MREAVIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEVAPEYYMGMGHTAEQVAMKYGIS
REEQDAFAVRSHQRAAKALAEGKFTDETVPVEVTLRIVNENNKLEEETITFSQDEGVRADTTLEVLGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMKPMAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL

Sequences:

>Translated_390_residues
MREAVIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEVAPEYYMGMGHTAEQVAMKYGIS
REEQDAFAVRSHQRAAKALAEGKFTDETVPVEVTLRIVNENNKLEEETITFSQDEGVRADTTLEVLGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMKPMAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL
>Mature_390_residues
MREAVIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEAEQGLNMARNIGGLAGLSYDV
PAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMSLVPMMGHVVRPNSRLVEVAPEYYMGMGHTAEQVAMKYGIS
REEQDAFAVRSHQRAAKALAEGKFTDETVPVEVTLRIVNENNKLEEETITFSQDEGVRADTTLEVLGKLRPAFNVRGSVT
AGNSSQMSDGAASVLLMDREKAVSDGMKPMAKFRSFAVAGVPPEVMGIGPIAAIPKALKLAGLELSDIGLFELNEAFASQ
SIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLIHEMKRRNEQFGIVTMCIGGGMGAAGVFELL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=390, Percent_Identity=47.1794871794872, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=40.547263681592, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=40.1015228426396, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=33.4862385321101, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=33.2480818414322, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=46.7005076142132, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=43.8423645320197, Blast_Score=307, Evalue=9e-85,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=43.2762836185819, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=40.3940886699507, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=36.5155131264916, Blast_Score=221, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI133906874, Length=399, Percent_Identity=39.8496240601504, Blast_Score=277, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17535921, Length=402, Percent_Identity=34.3283582089552, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=32.25, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=31.8181818181818, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=29.0076335877863, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=40.5541561712846, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=34.5, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=43.0693069306931, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI17648125, Length=397, Percent_Identity=38.5390428211587, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24640423, Length=400, Percent_Identity=35, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=32.183908045977, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41406; Mature: 41406

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
EQGLNMARNIGGLAGLSYDVPAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMS
HHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCHHHEEECCCHHHHCCCCCCEE
LVPMMGHVVRPNSRLVEVAPEYYMGMGHTAEQVAMKYGISREEQDAFAVRSHQRAAKALA
HHHHHHHEECCCCCEEEECHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EGKFTDETVPVEVTLRIVNENNKLEEETITFSQDEGVRADTTLEVLGKLRPAFNVRGSVT
CCCCCCCCCCEEEEEEEECCCCCCCHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEE
AGNSSQMSDGAASVLLMDREKAVSDGMKPMAKFRSFAVAGVPPEVMGIGPIAAIPKALKL
CCCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLFELNEAFASQSIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HEMKRRNEQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC
>Mature Secondary Structure
MREAVIVAGARTPVGKAKKGSLKTVRPDDLGALVVKETLKRANYEGPIDDLIFGCAMPEA
CCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCH
EQGLNMARNIGGLAGLSYDVPAITINRYCSSGLQSIAYGAERIMLGHSEAVLSGGAESMS
HHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCHHHEEECCCHHHHCCCCCCEE
LVPMMGHVVRPNSRLVEVAPEYYMGMGHTAEQVAMKYGISREEQDAFAVRSHQRAAKALA
HHHHHHHEECCCCCEEEECHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
EGKFTDETVPVEVTLRIVNENNKLEEETITFSQDEGVRADTTLEVLGKLRPAFNVRGSVT
CCCCCCCCCCEEEEEEEECCCCCCCHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEE
AGNSSQMSDGAASVLLMDREKAVSDGMKPMAKFRSFAVAGVPPEVMGIGPIAAIPKALKL
CCCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHEEECCCCHHHHCCCCHHHHHHHHHH
AGLELSDIGLFELNEAFASQSIQVIRELGLDEEKVNVNGGAIALGHPLGCTGAKLTLSLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HEMKRRNEQFGIVTMCIGGGMGAAGVFELL
HHHHHCCCCCCEEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]