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The map label for this gene is fadE [H]

Identifier: 152977273

GI number: 152977273

Start: 3651336

End: 3653120

Strand: Reverse

Name: fadE [H]

Synonym: Bcer98_3595

Alternate gene names: 152977273

Gene position: 3653120-3651336 (Counterclockwise)

Preceding gene: 152977274

Following gene: 152977272

Centisome position: 89.38

GC content: 38.21

Gene sequence:

>1785_bases
ATGGAAAAAACAGTGGGGAATGCAGTAAAGGGCGGTAGCTTTTTAATTGATGAGATTACAATTGATCAAGTATTTACACC
AGAAGATTATACAGATGAGCATAAAATGATAGCAAAAACAACAGAAGACTTTATCGTAAATGAGGTTTTGCCAGAGCTTG
AATATTTAGAGCAACATGAGTTTGATCGTTCTGTTCGTCTATTGAAAGAAGCTGGTGAACTAGGATTATTAGGGGCTGAT
GTACCAGAAGAGTACGGCGGAATTGGTCTTGATAAAGTGAGTTCGGCTTTAATTGCTGAGAAATTTGCGCGCGCTGGTGG
GTTTGCTATTACACATGGTGCTCACGTCGGTATCGGATCATTACCAATCGTATTATTTGGTAACGAAGATCAGAAGAAAA
AATATTTACCACTACTTGCAACTGGTGAAAAGTTAGCTGCATATGCATTAACTGAGCCAGGATCTGGGTCTGATGCATTA
GGTGCAAAAACCACTGCACGTTTAAATGCAGAAGGTACGCACTATGTGTTAAACGGAGAAAAACAATGGATTACAAACTC
AGCCTTTGCGGATGTGTTTATCGTATATGCAAAAGTTGATGGCGAGCACTTTTCTGCATTTATCGTAGAAAAAGAATATC
CAGGTGTATCGACAAGCCCTGAAGAAAAGAAAATGGGTATTAAATGTTCATCAACTCGTACATTAATTTTAGAAGATGCA
TTAGTACCAAAAGAAAATGTTCTTGGCGAAATTGGTAAAGGGCATGTGATTGCATTTAATATTTTAAATATCGGCCGTTA
TAAACTAGGTGTTGGTACAGTTGGATCGGCAAAACGCGCAATAGAAATTTCAGCAGAATATGCGAACCAGCGTCAACAAT
TTAAGCAACCAATCGCTCGTTTCCCATTAATTCAAGAAAAGCTTGCGAATATGGCAGCGAAAACATATGCAGCGGAAAGT
TCTGTTTATCGTACAGTGGGCTTATTTGAAAGTCGTATGAGCACATTAACTGAGAAAGAAGTAAAAGATGGGAAAGCAGT
AGCAGCTTCAATTGCAGAATATGCAATTGAGTGTTCATTAAATAAAGTATTTGGTTCTGAAGTATTAGATTATGTAGTAG
ATGAAGGAGTACAAATTCACGGTGGTTATGGATTCATGGCAGAGTATGAGATTGAAAGAATGTATCGTGATTCTCGTATT
AACCGTATTTTCGAAGGAACGAACGAAATTAACCGTTTAATCGTACCGGGTACGTTCTTACGTAAAGCAATGAAAGGGGA
ACTACCATTACTGCAAAAAGCACAAAAACTACAAGAAGAATTAATGATGATGATGCCAGAAGAAGTAGGCGATGAGCCAT
TAGCACTTCAAAAACATTTAGTCAAGAATGCGAAGAAAATCGGCTTAATGGTAGCTGGATTAGCAGCTCAAAAATACGGT
AAAGCGCTTGAGAAAGAACAGGAAATTCTTGTGAATATTGCTGATATTGTAAGTAATTTATACGCAATGGAATCAGCCTT
GCTCCGTACGGAAAAAGCAATCAAAGCAACGGGTCTTGAAAAGAATAAACAAAAAGTATTATACACGGAAGTATTCTGTC
AAGAAGCGTTCAACCAAATTGAAGCAGATGCAAAAGAAACAATTATCGCAGTGGAAAACGGTGATATGTTGCGCATGATG
CTATCAGCGCTTCGCAAACTAACTCGCCACACGCCAATGAATGTTATTCCGAAGAAGCGTGAAATTGCAGCGAAGATTTT
AGAGGAGGAGCGTTATATAGTTTAA

Upstream 100 bases:

>100_bases
ATGTGGAAGCGATGTAACGGTTCGAAAAAATAAAGGAAGAGCTAGTATCTCTCGTTACATGAGAGATACAGCTTATGAAA
ATATGAAGGAGGAATTTTTC

Downstream 100 bases:

>100_bases
TACGTAACAAAAAAACAGTCACTTAGGTGGCTGTTTTTTGTATTAGTCAGAAAATTTTAGATACAAGAAACGATGCACTG
ATCGTTGGTGATGCTTTCCA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MEKTVGNAVKGGSFLIDEITIDQVFTPEDYTDEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFARAGGFAITHGAHVGIGSLPIVLFGNEDQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKVDGEHFSAFIVEKEYPGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENVLGEIGKGHVIAFNILNIGRYKLGVGTVGSAKRAIEISAEYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLTEKEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYVVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKHLVKNAKKIGLMVAGLAAQKYG
KALEKEQEILVNIADIVSNLYAMESALLRTEKAIKATGLEKNKQKVLYTEVFCQEAFNQIEADAKETIIAVENGDMLRMM
LSALRKLTRHTPMNVIPKKREIAAKILEEERYIV

Sequences:

>Translated_594_residues
MEKTVGNAVKGGSFLIDEITIDQVFTPEDYTDEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFARAGGFAITHGAHVGIGSLPIVLFGNEDQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKVDGEHFSAFIVEKEYPGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENVLGEIGKGHVIAFNILNIGRYKLGVGTVGSAKRAIEISAEYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLTEKEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYVVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKHLVKNAKKIGLMVAGLAAQKYG
KALEKEQEILVNIADIVSNLYAMESALLRTEKAIKATGLEKNKQKVLYTEVFCQEAFNQIEADAKETIIAVENGDMLRMM
LSALRKLTRHTPMNVIPKKREIAAKILEEERYIV
>Mature_594_residues
MEKTVGNAVKGGSFLIDEITIDQVFTPEDYTDEHKMIAKTTEDFIVNEVLPELEYLEQHEFDRSVRLLKEAGELGLLGAD
VPEEYGGIGLDKVSSALIAEKFARAGGFAITHGAHVGIGSLPIVLFGNEDQKKKYLPLLATGEKLAAYALTEPGSGSDAL
GAKTTARLNAEGTHYVLNGEKQWITNSAFADVFIVYAKVDGEHFSAFIVEKEYPGVSTSPEEKKMGIKCSSTRTLILEDA
LVPKENVLGEIGKGHVIAFNILNIGRYKLGVGTVGSAKRAIEISAEYANQRQQFKQPIARFPLIQEKLANMAAKTYAAES
SVYRTVGLFESRMSTLTEKEVKDGKAVAASIAEYAIECSLNKVFGSEVLDYVVDEGVQIHGGYGFMAEYEIERMYRDSRI
NRIFEGTNEINRLIVPGTFLRKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKHLVKNAKKIGLMVAGLAAQKYG
KALEKEQEILVNIADIVSNLYAMESALLRTEKAIKATGLEKNKQKVLYTEVFCQEAFNQIEADAKETIIAVENGDMLRMM
LSALRKLTRHTPMNVIPKKREIAAKILEEERYIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=555, Percent_Identity=35.6756756756757, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI4557235, Length=567, Percent_Identity=34.5679012345679, Blast_Score=269, Evalue=5e-72,
Organism=Homo sapiens, GI76496475, Length=567, Percent_Identity=34.5679012345679, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI4557233, Length=410, Percent_Identity=34.8780487804878, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI7656849, Length=398, Percent_Identity=32.4120603015075, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI187960098, Length=395, Percent_Identity=35.1898734177215, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI4557231, Length=396, Percent_Identity=35.1010101010101, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI226958412, Length=397, Percent_Identity=33.5012594458438, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI226958414, Length=360, Percent_Identity=35.2777777777778, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI4501859, Length=393, Percent_Identity=31.0432569974555, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4501857, Length=412, Percent_Identity=31.7961165048544, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=31.4861460957179, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI7669494, Length=293, Percent_Identity=35.1535836177474, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI38505218, Length=339, Percent_Identity=26.8436578171091, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI48976061, Length=423, Percent_Identity=23.8770685579196, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI211971008, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081958, Length=394, Percent_Identity=30.4568527918782, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI87082384, Length=286, Percent_Identity=25.5244755244755, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081702, Length=406, Percent_Identity=25.3694581280788, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=520, Percent_Identity=38.2692307692308, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=41.0112359550562, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=34.8167539267016, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=33.5, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=33.5917312661499, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=391, Percent_Identity=34.0153452685422, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=392, Percent_Identity=33.4183673469388, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17508101, Length=390, Percent_Identity=31.2820512820513, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=395, Percent_Identity=29.873417721519, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17534353, Length=392, Percent_Identity=29.8469387755102, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=37.4517374517375, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=38.2352941176471, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=289, Percent_Identity=31.1418685121107, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17505929, Length=404, Percent_Identity=26.4851485148515, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17551932, Length=404, Percent_Identity=26.4851485148515, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=26.2295081967213, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=379, Percent_Identity=25.8575197889182, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563383, Length=378, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540912, Length=281, Percent_Identity=24.5551601423488, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=345, Percent_Identity=24.3478260869565, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363737, Length=473, Percent_Identity=38.0549682875264, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21356377, Length=413, Percent_Identity=36.0774818401937, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24646207, Length=401, Percent_Identity=34.6633416458853, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=34.5177664974619, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24666513, Length=389, Percent_Identity=33.1619537275064, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI19920834, Length=286, Percent_Identity=32.8671328671329, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45550141, Length=337, Percent_Identity=24.0356083086053, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221473076, Length=337, Percent_Identity=24.0356083086053, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 65694; Mature: 65694

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTVGNAVKGGSFLIDEITIDQVFTPEDYTDEHKMIAKTTEDFIVNEVLPELEYLEQHE
CCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFARAGGFAITHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEECCCC
LPIVLFGNEDQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGE
CCEEEECCCCCCCCCCCEEECCCHHEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKVDGEHFSAFIVEKEYPGVSTSPEEKKMGIKCSSTRTLILEDA
HHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCEEECCCCEEEEECC
LVPKENVLGEIGKGHVIAFNILNIGRYKLGVGTVGSAKRAIEISAEYANQRQQFKQPIAR
CCCCHHHHHCCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
FPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLTEKEVKDGKAVAASIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NKVFGSEVLDYVVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFL
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
RKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKHLVKNAKKIGLMVAGLAAQKYG
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALEKEQEILVNIADIVSNLYAMESALLRTEKAIKATGLEKNKQKVLYTEVFCQEAFNQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EADAKETIIAVENGDMLRMMLSALRKLTRHTPMNVIPKKREIAAKILEEERYIV
CCCCHHEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKTVGNAVKGGSFLIDEITIDQVFTPEDYTDEHKMIAKTTEDFIVNEVLPELEYLEQHE
CCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRSVRLLKEAGELGLLGADVPEEYGGIGLDKVSSALIAEKFARAGGFAITHGAHVGIGS
HHHHHHHHHHCCCCCEECCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCEEECCCEECCCC
LPIVLFGNEDQKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGE
CCEEEECCCCCCCCCCCEEECCCHHEEEEECCCCCCCCCCCCCCEEEECCCCCEEEECCC
KQWITNSAFADVFIVYAKVDGEHFSAFIVEKEYPGVSTSPEEKKMGIKCSSTRTLILEDA
HHHHCCCHHEEEEEEEEEECCCCEEEEEEEECCCCCCCCCHHHHCCEEECCCCEEEEECC
LVPKENVLGEIGKGHVIAFNILNIGRYKLGVGTVGSAKRAIEISAEYANQRQQFKQPIAR
CCCCHHHHHCCCCCCEEEEEEEECCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
FPLIQEKLANMAAKTYAAESSVYRTVGLFESRMSTLTEKEVKDGKAVAASIAEYAIECSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NKVFGSEVLDYVVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFL
HHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCEEECCHHHH
RKAMKGELPLLQKAQKLQEELMMMMPEEVGDEPLALQKHLVKNAKKIGLMVAGLAAQKYG
HHHHCCCCHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALEKEQEILVNIADIVSNLYAMESALLRTEKAIKATGLEKNKQKVLYTEVFCQEAFNQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EADAKETIIAVENGDMLRMMLSALRKLTRHTPMNVIPKKREIAAKILEEERYIV
CCCCHHEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]