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The map label for this gene is thrS [H]

Identifier: 152976959

GI number: 152976959

Start: 3327254

End: 3329185

Strand: Reverse

Name: thrS [H]

Synonym: Bcer98_3262

Alternate gene names: 152976959

Gene position: 3329185-3327254 (Counterclockwise)

Preceding gene: 152976960

Following gene: 152976958

Centisome position: 81.46

GC content: 37.22

Gene sequence:

>1932_bases
ATGGCAGATGTAGTTAAAATTACTTTCCCTGATGGAGCTGTTAAGGAGTTTCCTAAAGGAATAACAACTGAAGAAATCGC
AGCTTCTATTAGCCCAGGCTTAAAGAAAAAAGCTGTGGCTGGAAAATTGAATGATGAGATGCTTGATCTTCGTACACCAA
TTGAAAAAGACGGTGCAATTTCAATTGTTACATTAGATTCTGAGGATGGTTTATATATTTTACGCCATTCAACAGCTCAT
CTATTAGCTCAAGCGTTAAAACGTTTATATAAAGATGTGAAGCTTGGTATTGGACCAGTAATCGAAAACGGCTTCTATTA
TGATATTGATATGGAAGAAGCAATTACCGTTGAAGATTTCCCAAAAATTGAAAAAGAAATGCAAAAGATTGTAAATGAAA
ACTTAGAAATTGTTCGTCATGAAGTGCCTCGCGCCGAAGCTCTTCGTCGTTATGAGGAAATTAATGATGAACTAAAATTA
GAATTGATTAACGACCTTCCAGAAGATGCTGTTATTTCAATTTATGAACAAGGCGAATTCTTCGATCTTTGCCGCGGTGT
GCATCTTCCATCTACAGGGAAGATTAAAGTGTTTAAATTGTTAAGCGTTGCAGGTGCTTACTGGCGCGGTGATAGCAACA
ATAAAATGCTACAACGTATTTACGGTACTGCATTCGTGAAGAAAGCAGAATTAGATGAACATATGCGTATGCTTGAAGAA
GCAAAAGAACGTGATCATCGTAAATTAGGTAAAGAGTTGAAATTATTTACAAATAATCAAAAAGTGGGACAAGGTTTACC
TCTTTGGTTACCAAAAGGTGCAACAATTCGCCGTATTATTGAGCGCTACATTGTTGATAAAGAGGTAAGCTTAGGTTATA
ACCACGTATATACTCCAGTATTAGGAAGCAGAGAACTTTACGAAACTTCTGGTCACTGGAATCACTATCGTGATGGCATG
TTCCCATCTATGCAGATGGATAATGAAGAATTAGTTCTTCGTCCAATGAACTGTCCTCATCATATGATGGTTTATAAAAA
CGACATTCACAGTTATCGTGAATTACCAATCCGCATTGCAGAACTTGGAACAATGCATCGTTATGAAATGTCTGGTGCGT
TATCTGGACTACAACGTGTACGTGGAATGACTTTAAATGATGCACATATCTTCGTCCGTCCAGATCAAATTAAAGAAGAG
TTAAAACGTGTTGTGAACTTAACTTTAGAAGTATACAAAGACTTTGGTTTAGAAAATTATTCATTCCGTCTATCTTACCG
CGATCCAGAAGATACTAAAAAGTACTATGCGGATGATGAAATGTGGGAAAAAGCACAAGGAATGTTAAAAGAAGCAATGG
ACGAAATGGGACTTGAATACTATGAAGCTGAAGGTGAAGCGGCATTCTATGGTCCAAAACTTGATGTTCAAGTTCGTACT
GCACTTGGAAAAGACGAGACACTGTCAACAGTTCAATTAGACTTCTTACTTCCAGAGCGTTTTGAATTAACTTACGTTGG
TGAAGACGGAAAACAACATCGTCCAGTAGTTATTCACCGAGGTGTCGTATCTACTATGGAACGATTCGTTGCTTTCTTAA
TTGAAGAGTATAAAGGTGCATTCCCAACTTGGTTAGCACCAGTTCAAGTACAAGTTATTCCAGTTTCTCCGCAAGTGCAC
TTAGACTATGCGAAGAAAGTGCAAGAAGAATTGCAACGTGCTGGTATTCGTGTTGAAGTAGATACACGTGAAGAAAAAAT
TGGTTACAAAATCCGTGAAGCACAAATGCAAAAAATTCCATACATGCTTGTAGTAGGTGATAATGAAGTTGCTGAAAATG
GCGTGAATGTACGTAAATATGGTGAACAAAAATCAGAAACAATTGCATTAGATGCCTTTGTTGATATGATTAAAGTTGAA
GGGAAACGATAA

Upstream 100 bases:

>100_bases
GTTTAGTTAATTGGAACAAGGGTGGAACCACGAATTCAACACTCGTCCCTTTTATGGGGATGAGTGTTTTTTATTTTGAG
AAGAAGAGGAGTGACCAGTG

Downstream 100 bases:

>100_bases
GAAAGTCGCGGCATGCCGCGACTTTCTTGCTGAATACATATAGTAATGAAATGATACTAATCATAAAAAAGTATTGCATG
TATTCGTGTTGTTTGTTACA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 643; Mature: 642

Protein sequence:

>643_residues
MADVVKITFPDGAVKEFPKGITTEEIAASISPGLKKKAVAGKLNDEMLDLRTPIEKDGAISIVTLDSEDGLYILRHSTAH
LLAQALKRLYKDVKLGIGPVIENGFYYDIDMEEAITVEDFPKIEKEMQKIVNENLEIVRHEVPRAEALRRYEEINDELKL
ELINDLPEDAVISIYEQGEFFDLCRGVHLPSTGKIKVFKLLSVAGAYWRGDSNNKMLQRIYGTAFVKKAELDEHMRMLEE
AKERDHRKLGKELKLFTNNQKVGQGLPLWLPKGATIRRIIERYIVDKEVSLGYNHVYTPVLGSRELYETSGHWNHYRDGM
FPSMQMDNEELVLRPMNCPHHMMVYKNDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKEE
LKRVVNLTLEVYKDFGLENYSFRLSYRDPEDTKKYYADDEMWEKAQGMLKEAMDEMGLEYYEAEGEAAFYGPKLDVQVRT
ALGKDETLSTVQLDFLLPERFELTYVGEDGKQHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVQVIPVSPQVH
LDYAKKVQEELQRAGIRVEVDTREEKIGYKIREAQMQKIPYMLVVGDNEVAENGVNVRKYGEQKSETIALDAFVDMIKVE
GKR

Sequences:

>Translated_643_residues
MADVVKITFPDGAVKEFPKGITTEEIAASISPGLKKKAVAGKLNDEMLDLRTPIEKDGAISIVTLDSEDGLYILRHSTAH
LLAQALKRLYKDVKLGIGPVIENGFYYDIDMEEAITVEDFPKIEKEMQKIVNENLEIVRHEVPRAEALRRYEEINDELKL
ELINDLPEDAVISIYEQGEFFDLCRGVHLPSTGKIKVFKLLSVAGAYWRGDSNNKMLQRIYGTAFVKKAELDEHMRMLEE
AKERDHRKLGKELKLFTNNQKVGQGLPLWLPKGATIRRIIERYIVDKEVSLGYNHVYTPVLGSRELYETSGHWNHYRDGM
FPSMQMDNEELVLRPMNCPHHMMVYKNDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKEE
LKRVVNLTLEVYKDFGLENYSFRLSYRDPEDTKKYYADDEMWEKAQGMLKEAMDEMGLEYYEAEGEAAFYGPKLDVQVRT
ALGKDETLSTVQLDFLLPERFELTYVGEDGKQHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVQVIPVSPQVH
LDYAKKVQEELQRAGIRVEVDTREEKIGYKIREAQMQKIPYMLVVGDNEVAENGVNVRKYGEQKSETIALDAFVDMIKVE
GKR
>Mature_642_residues
ADVVKITFPDGAVKEFPKGITTEEIAASISPGLKKKAVAGKLNDEMLDLRTPIEKDGAISIVTLDSEDGLYILRHSTAHL
LAQALKRLYKDVKLGIGPVIENGFYYDIDMEEAITVEDFPKIEKEMQKIVNENLEIVRHEVPRAEALRRYEEINDELKLE
LINDLPEDAVISIYEQGEFFDLCRGVHLPSTGKIKVFKLLSVAGAYWRGDSNNKMLQRIYGTAFVKKAELDEHMRMLEEA
KERDHRKLGKELKLFTNNQKVGQGLPLWLPKGATIRRIIERYIVDKEVSLGYNHVYTPVLGSRELYETSGHWNHYRDGMF
PSMQMDNEELVLRPMNCPHHMMVYKNDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKEEL
KRVVNLTLEVYKDFGLENYSFRLSYRDPEDTKKYYADDEMWEKAQGMLKEAMDEMGLEYYEAEGEAAFYGPKLDVQVRTA
LGKDETLSTVQLDFLLPERFELTYVGEDGKQHRPVVIHRGVVSTMERFVAFLIEEYKGAFPTWLAPVQVQVIPVSPQVHL
DYAKKVQEELQRAGIRVEVDTREEKIGYKIREAQMQKIPYMLVVGDNEVAENGVNVRKYGEQKSETIALDAFVDMIKVEG
KR

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=634, Percent_Identity=38.01261829653, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI38570111, Length=641, Percent_Identity=36.5054602184087, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI20070344, Length=635, Percent_Identity=35.2755905511811, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1788013, Length=613, Percent_Identity=42.7406199021207, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71984184, Length=644, Percent_Identity=37.5776397515528, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71984192, Length=644, Percent_Identity=37.5776397515528, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322112, Length=634, Percent_Identity=35.9621451104101, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322654, Length=392, Percent_Identity=36.4795918367347, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24583842, Length=617, Percent_Identity=38.0875202593193, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI28574141, Length=617, Percent_Identity=38.0875202593193, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583839, Length=617, Percent_Identity=38.0875202593193, Blast_Score=454, Evalue=1e-127,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73996; Mature: 73865

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVVKITFPDGAVKEFPKGITTEEIAASISPGLKKKAVAGKLNDEMLDLRTPIEKDGAI
CCCEEEEECCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHHCCCCCCCCCE
SIVTLDSEDGLYILRHSTAHLLAQALKRLYKDVKLGIGPVIENGFYYDIDMEEAITVEDF
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCCCCCCHHHH
PKIEKEMQKIVNENLEIVRHEVPRAEALRRYEEINDELKLELINDLPEDAVISIYEQGEF
HHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCH
FDLCRGVHLPSTGKIKVFKLLSVAGAYWRGDSNNKMLQRIYGTAFVKKAELDEHMRMLEE
HHHHCCCCCCCCCCEEHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKERDHRKLGKELKLFTNNQKVGQGLPLWLPKGATIRRIIERYIVDKEVSLGYNHVYTPV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHCCCHHCCCCCEEECCC
LGSRELYETSGHWNHYRDGMFPSMQMDNEELVLRPMNCPHHMMVYKNDIHSYRELPIRIA
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHHHHCCEEEE
ELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKEELKRVVNLTLEVYKDFGLENY
HHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
SFRLSYRDPEDTKKYYADDEMWEKAQGMLKEAMDEMGLEYYEAEGEAAFYGPKLDVQVRT
EEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCEEEEE
ALGKDETLSTVQLDFLLPERFELTYVGEDGKQHRPVVIHRGVVSTMERFVAFLIEEYKGA
CCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
FPTWLAPVQVQVIPVSPQVHLDYAKKVQEELQRAGIRVEVDTREEKIGYKIREAQMQKIP
CCCEECCEEEEEEECCCCEEHHHHHHHHHHHHHCCCEEEECCCHHHHCCHHHHHHHHHCC
YMLVVGDNEVAENGVNVRKYGEQKSETIALDAFVDMIKVEGKR
EEEEECCCHHHHCCCCHHHCCCCCCCEEEHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADVVKITFPDGAVKEFPKGITTEEIAASISPGLKKKAVAGKLNDEMLDLRTPIEKDGAI
CCEEEEECCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHCCCCCHHHHHCCCCCCCCCE
SIVTLDSEDGLYILRHSTAHLLAQALKRLYKDVKLGIGPVIENGFYYDIDMEEAITVEDF
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEECCCEEEEECCCCCCCHHHH
PKIEKEMQKIVNENLEIVRHEVPRAEALRRYEEINDELKLELINDLPEDAVISIYEQGEF
HHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCH
FDLCRGVHLPSTGKIKVFKLLSVAGAYWRGDSNNKMLQRIYGTAFVKKAELDEHMRMLEE
HHHHCCCCCCCCCCEEHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKERDHRKLGKELKLFTNNQKVGQGLPLWLPKGATIRRIIERYIVDKEVSLGYNHVYTPV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHCCCHHCCCCCEEECCC
LGSRELYETSGHWNHYRDGMFPSMQMDNEELVLRPMNCPHHMMVYKNDIHSYRELPIRIA
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECHHHHHHHCCEEEE
ELGTMHRYEMSGALSGLQRVRGMTLNDAHIFVRPDQIKEELKRVVNLTLEVYKDFGLENY
HHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCE
SFRLSYRDPEDTKKYYADDEMWEKAQGMLKEAMDEMGLEYYEAEGEAAFYGPKLDVQVRT
EEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCEEEEE
ALGKDETLSTVQLDFLLPERFELTYVGEDGKQHRPVVIHRGVVSTMERFVAFLIEEYKGA
CCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCC
FPTWLAPVQVQVIPVSPQVHLDYAKKVQEELQRAGIRVEVDTREEKIGYKIREAQMQKIP
CCCEECCEEEEEEECCCCEEHHHHHHHHHHHHHCCCEEEECCCHHHHCCHHHHHHHHHCC
YMLVVGDNEVAENGVNVRKYGEQKSETIALDAFVDMIKVEGKR
EEEEECCCHHHHCCCCHHHCCCCCCCEEEHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA