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The map label for this gene is trxA [H]

Identifier: 152976919

GI number: 152976919

Start: 3288231

End: 3288545

Strand: Reverse

Name: trxA [H]

Synonym: Bcer98_3221

Alternate gene names: 152976919

Gene position: 3288545-3288231 (Counterclockwise)

Preceding gene: 152976920

Following gene: 152976918

Centisome position: 80.46

GC content: 37.14

Gene sequence:

>315_bases
ATGGCAATTGTAAACGCAACTGACCAAAGCTTCGCAGCCGAAATAAGCGAAGGTGTTGTATTATTAGATTTTTGGGCACC
ATGGTGTGGACCTTGTAAAATGATCGCTCCTGTATTAGAAGAAATTGATGCAGAATTAGGCGATAAAGTAAAAGTAGTAA
AAGTGGATGTTGATGAAAACCAAGAAACTGCTCGTCAATTCGAAGTAATGAGCATTCCAGCTCTTTTCGTCTTAAAAGAT
GGTAAAGTGGTTGATCAAGCATTAGGTTACAAACCAAAAGAAGCGTTAGTAGAATTAGTTTCTAAACACTTCTAA

Upstream 100 bases:

>100_bases
GCACATTTTTTTGTTACAATACATAACGATACATAATATTCGCCACGTATATAAGATAATGATATACTCTTGGTAGAATA
CACTTGAAGGAGGAAATGAA

Downstream 100 bases:

>100_bases
AAAGAAAAGCGTTGCCCTGTTGGCAGCGTTTTTTTCTTTTCATTAAAACTATTTTCCATTCATTTGTTTTAAAAAGTTCG
GTCATTTGAAAACCAAACCC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIVNATDQSFAAEISEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGDKVKVVKVDVDENQETARQFEVMSIPALFVLKD
GKVVDQALGYKPKEALVELVSKHF

Sequences:

>Translated_104_residues
MAIVNATDQSFAAEISEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGDKVKVVKVDVDENQETARQFEVMSIPALFVLKD
GKVVDQALGYKPKEALVELVSKHF
>Mature_103_residues
AIVNATDQSFAAEISEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGDKVKVVKVDVDENQETARQFEVMSIPALFVLKDG
KVVDQALGYKPKEALVELVSKHF

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=87, Percent_Identity=40.2298850574713, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI42794771, Length=97, Percent_Identity=35.0515463917526, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI224493972, Length=97, Percent_Identity=35.0515463917526, Blast_Score=63, Evalue=4e-11,
Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=31.4285714285714, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=40.3846153846154, Blast_Score=91, Evalue=1e-20,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=39.1304347826087, Blast_Score=84, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509965, Length=92, Percent_Identity=39.1304347826087, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=86, Percent_Identity=31.3953488372093, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=39.7727272727273, Blast_Score=70, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=74, Percent_Identity=43.2432432432432, Blast_Score=68, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=39.7260273972603, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=41.1764705882353, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=44.3037974683544, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=44.3037974683544, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573567, Length=87, Percent_Identity=40.2298850574713, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=70, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18859803, Length=102, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11463; Mature: 11332

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVNATDQSFAAEISEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGDKVKVVKVDVDEN
CEEECCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETARQFEVMSIPALFVLKDGKVVDQALGYKPKEALVELVSKHF
HHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AIVNATDQSFAAEISEGVVLLDFWAPWCGPCKMIAPVLEEIDAELGDKVKVVKVDVDEN
EEECCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETARQFEVMSIPALFVLKDGKVVDQALGYKPKEALVELVSKHF
HHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]