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The map label for this gene is ltrA [H]

Identifier: 152976870

GI number: 152976870

Start: 3216642

End: 3218273

Strand: Reverse

Name: ltrA [H]

Synonym: Bcer98_3169

Alternate gene names: 152976870

Gene position: 3218273-3216642 (Counterclockwise)

Preceding gene: 152976871

Following gene: 152976869

Centisome position: 78.74

GC content: 34.74

Gene sequence:

>1632_bases
ATGGCAACAAATCCATTTCATCAGTTGGACGTTATAAGGAAAGCTTCTCAAAATGGTAAAATAATAACAGATTGTTACCG
TCTGATGTATAAAAGAGAACTATGGATTAAAGCATACGTAAAGCTATATCCGAATGCAGGGAATCTAACAAAAGGAACGT
CTGAAGAAACAATCGATGGTTTTTACTTACAAAAGATTGATGAAATCATTGACCAACTCAAGAAGGGGATGTTTCGTTTT
GCACCTGTAAGAAGAGCTTATATTTCAAAAGCAAACGGTAAAAAGAGACCTCTAGGAGTTCCGAACTTTAAAGATAAGTT
GGTACAAGAAGTAATGAGAATGATTTTGGAAAATGTTTATGAACCAACATTCTCAGATAACTCTCATGGATTTAGAGAAG
GGAGAAGCTGTCACACAGCATTATCCCAAATCAAGAACACATGGAAGGGATTAACATGGTGTATAGAAGGAGCCATAAAA
GGCTTCTTTGATCATATTGACCATTCTGTACTCATAAATCTTATTTCAAAAAGAATGAATGACCATCGTTTTCTTCTACT
TATCCACAATGCACTTGCAAGTGGTGTGATGGAAAACTGGACTTATCAAAAAACATACAGCGGTACACCACAGGGCGGTA
TTCTCTCCCCCTTATTAGCTAATATCTATCTTCATGAGTTTGACATATTTTTGGAAAAGCAAATAGAGAAGTTTGATAAA
GAGAAATTAAGGGCGAGAAATAAAGAATATACTAAAATACACTCGGAAATCCGTTCGCTTTCTCGAAAAGTCAAAAGCTT
AGATGACAGAACAGGGCATCGATTATGGAAAGGCAGAGAGAAAGTGATAGAAACTATCGCAGAGTTAAAGCGCAAACAGA
TTGGTATTTCCTCTGTCAATCCTATGGATAATGACTATCAAAAAATGAAGTATGTTCGTTATGCTGATGATTTTGTAATA
GGGATAGCTGGTTCCAAAGATTGTGCAGTGAATATAAAAGAAACGATAAAGAATTTTCTAAAACAAGAACTGCATCTTGA
ATTAAGTGAAGAAAAAACACTTATCAACCACTTGGAGAATCCAATTTCCTTTCTTGGATATGAATTTCGTAAGTGGAATG
AAATAAAAAGGACTAGGGTCTTGTATAAAAACCATAAACAGAGGGCTCTCTCAAGAGCAATTAAGTTGGAAATTCCCAAA
AAGAAAATGAAAGAATTTGCTATAAAAAACGGATATGGTAATCTTGATAATTTCAAAAGTATACATCGAGCAAAGCTGCT
TAATAATTCAGAGTTGGAGATTCTGTGTACCTATAACGCTGAACTGCGAGGAATTGCAAACTACTACAAGCTAGCGAATA
ATTACCATCATTTAGATAAGTTGTTTTATTTAGCGGAGAGTAGTTTCATCAAAACCATAGCTAATAAACGTAGAAGCACC
TCAATGAAAGTGGCTACAAGCATGAGAACCCACAAACAAGGAGTACTTTGTCTAGTAAGAAAAGATCAACATAACAATGA
AAAACTTTATCAGTTTGTGAAATTAAAAGACCTGCCTAAACATAAGGGTGCGATTAAAGTTGATACACCAGAAATAGACT
CATACGTGAATACAATGAAATATTTTGGGTGA

Upstream 100 bases:

>100_bases
TAACGGAGTCTCCATAGTACTCAACGTTTGCTTGTAATGAGTTTAGCAAGGGGAAGGGAGACAGGTTGATGTTAACGTCA
ATGAGAAAGGAGTCATGAAT

Downstream 100 bases:

>100_bases
ACGGATTTTGAAAAGCGTTTGTTGGCAAATAGATGTGAAGCGTGCGGTACAACAAAAGGTCAGATGGAAGTTCACTACAT
TAGAAAGCTAAAGAACTGGA

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MATNPFHQLDVIRKASQNGKIITDCYRLMYKRELWIKAYVKLYPNAGNLTKGTSEETIDGFYLQKIDEIIDQLKKGMFRF
APVRRAYISKANGKKRPLGVPNFKDKLVQEVMRMILENVYEPTFSDNSHGFREGRSCHTALSQIKNTWKGLTWCIEGAIK
GFFDHIDHSVLINLISKRMNDHRFLLLIHNALASGVMENWTYQKTYSGTPQGGILSPLLANIYLHEFDIFLEKQIEKFDK
EKLRARNKEYTKIHSEIRSLSRKVKSLDDRTGHRLWKGREKVIETIAELKRKQIGISSVNPMDNDYQKMKYVRYADDFVI
GIAGSKDCAVNIKETIKNFLKQELHLELSEEKTLINHLENPISFLGYEFRKWNEIKRTRVLYKNHKQRALSRAIKLEIPK
KKMKEFAIKNGYGNLDNFKSIHRAKLLNNSELEILCTYNAELRGIANYYKLANNYHHLDKLFYLAESSFIKTIANKRRST
SMKVATSMRTHKQGVLCLVRKDQHNNEKLYQFVKLKDLPKHKGAIKVDTPEIDSYVNTMKYFG

Sequences:

>Translated_543_residues
MATNPFHQLDVIRKASQNGKIITDCYRLMYKRELWIKAYVKLYPNAGNLTKGTSEETIDGFYLQKIDEIIDQLKKGMFRF
APVRRAYISKANGKKRPLGVPNFKDKLVQEVMRMILENVYEPTFSDNSHGFREGRSCHTALSQIKNTWKGLTWCIEGAIK
GFFDHIDHSVLINLISKRMNDHRFLLLIHNALASGVMENWTYQKTYSGTPQGGILSPLLANIYLHEFDIFLEKQIEKFDK
EKLRARNKEYTKIHSEIRSLSRKVKSLDDRTGHRLWKGREKVIETIAELKRKQIGISSVNPMDNDYQKMKYVRYADDFVI
GIAGSKDCAVNIKETIKNFLKQELHLELSEEKTLINHLENPISFLGYEFRKWNEIKRTRVLYKNHKQRALSRAIKLEIPK
KKMKEFAIKNGYGNLDNFKSIHRAKLLNNSELEILCTYNAELRGIANYYKLANNYHHLDKLFYLAESSFIKTIANKRRST
SMKVATSMRTHKQGVLCLVRKDQHNNEKLYQFVKLKDLPKHKGAIKVDTPEIDSYVNTMKYFG
>Mature_542_residues
ATNPFHQLDVIRKASQNGKIITDCYRLMYKRELWIKAYVKLYPNAGNLTKGTSEETIDGFYLQKIDEIIDQLKKGMFRFA
PVRRAYISKANGKKRPLGVPNFKDKLVQEVMRMILENVYEPTFSDNSHGFREGRSCHTALSQIKNTWKGLTWCIEGAIKG
FFDHIDHSVLINLISKRMNDHRFLLLIHNALASGVMENWTYQKTYSGTPQGGILSPLLANIYLHEFDIFLEKQIEKFDKE
KLRARNKEYTKIHSEIRSLSRKVKSLDDRTGHRLWKGREKVIETIAELKRKQIGISSVNPMDNDYQKMKYVRYADDFVIG
IAGSKDCAVNIKETIKNFLKQELHLELSEEKTLINHLENPISFLGYEFRKWNEIKRTRVLYKNHKQRALSRAIKLEIPKK
KMKEFAIKNGYGNLDNFKSIHRAKLLNNSELEILCTYNAELRGIANYYKLANNYHHLDKLFYLAESSFIKTIANKRRSTS
MKVATSMRTHKQGVLCLVRKDQHNNEKLYQFVKLKDLPKHKGAIKVDTPEIDSYVNTMKYFG

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=467, Percent_Identity=33.4047109207709, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6226521, Length=497, Percent_Identity=32.3943661971831, Blast_Score=226, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 63433; Mature: 63302

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCC
>Mature Secondary Structure 
ATNPFHQLDVIRKASQNGKIITDCYRLMYKRELWIKAYVKLYPNAGNLTKGTSEETIDG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH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HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]