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The map label for this gene is ycgM [C]

Identifier: 152974073

GI number: 152974073

Start: 239287

End: 240243

Strand: Direct

Name: ycgM [C]

Synonym: Bcer98_0229

Alternate gene names: 152974073

Gene position: 239287-240243 (Clockwise)

Preceding gene: 152974072

Following gene: 152974074

Centisome position: 5.85

GC content: 40.02

Gene sequence:

>957_bases
ATGAAATTTGTTACGTTTCGTCTTCCTTCACAAGAGATGCGAGCAGGGTGGCTAGAAGGCGATCAAGTGATTGATATGAA
TATAGCAAGTGGTGGCGTACTTCCTTCTACAATGCTGGCTTTTTTAGAGAAAGCGAATGAGCACTTAGAGATTGCACGTC
GTATTCAAAAGCCGACAAGTGGTATATACCCTTTAGAACATGTGGAACTTTGTGCTGCACTTCCAAATCCGAGCAGTATA
CGCGATTTCTATGCTTTTGAACAACATGTCAAAACAGCCCGTGGGCGTCGTGGTTTAGATGTCGTTCCTGAATGGTATGA
TATTGCGGTTTTTTATTTTACGAATCACCGTGCTGTAATCGGTCCAGATCATGTTGTCATTGGACCAAAGAATACCGAAA
AGCTTGATTATGAATTAGAAATTGCTTGTGTTATAGGGAAAGAAGGTAGAGATATTCCGCGTGAACAAGCGGAAGAATAT
ATTTTTGGTTATTGTATTATGAATGATTGGAGTGCAAGGGATTTACAGGCAAAAGAGATGAAAGTAGGGCTTGGGCCAGC
AAAAGGAAAAGATTTTGCCACTTCATTAGGTGCTTATCTTGTTACAAAAGATGAGCTGGACATATATCGATTACAGGATC
GTTATAACTTGGAAATGACCGCCCGTGTAAATGGAAATCTCTTATCCAAAGGGAATTTTCAAGATATTTATTATACGTTT
GCAGAAATGATTGAGCGTGCCTCTGAAAATGTTACGTTATACCCTGGAGATGTAATAGGTTCTGGAACAGTAGGGACTGG
ATGCATTTTAGAATTAGGGACGGAGCAGTGGCTACAAGATGGCGATGTAGTAGAACTTGAAATTACAGGATTAGGTACAC
TGCGTAATACAATTAAAAAAGAGATGAAAGCAGGTGATGACCATGTATTATCGTCACATGGGAGAACTTCCCCATAA

Upstream 100 bases:

>100_bases
GAGCAAGAACGTCGCGGAAACCTATAAAATGTATATCCACCAGTAAGAAATCGGACTGCTGGTGGATACGTTATTTGATG
ATAAGCAGGGAGGAGTATTG

Downstream 100 bases:

>100_bases
AAGACATGTACAATTTCGTAAAAAAGATGGATCACTTTACCGTGAACAAGTAATGGGAACAAAAGGTTTTTCGGGTACAC
AATCCATTTTATATCATCAC

Product: fumarylacetoacetate (FAA) hydrolase

Products: acetoacetate; fumarate

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKFVTFRLPSQEMRAGWLEGDQVIDMNIASGGVLPSTMLAFLEKANEHLEIARRIQKPTSGIYPLEHVELCAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIAVFYFTNHRAVIGPDHVVIGPKNTEKLDYELEIACVIGKEGRDIPREQAEEY
IFGYCIMNDWSARDLQAKEMKVGLGPAKGKDFATSLGAYLVTKDELDIYRLQDRYNLEMTARVNGNLLSKGNFQDIYYTF
AEMIERASENVTLYPGDVIGSGTVGTGCILELGTEQWLQDGDVVELEITGLGTLRNTIKKEMKAGDDHVLSSHGRTSP

Sequences:

>Translated_318_residues
MKFVTFRLPSQEMRAGWLEGDQVIDMNIASGGVLPSTMLAFLEKANEHLEIARRIQKPTSGIYPLEHVELCAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIAVFYFTNHRAVIGPDHVVIGPKNTEKLDYELEIACVIGKEGRDIPREQAEEY
IFGYCIMNDWSARDLQAKEMKVGLGPAKGKDFATSLGAYLVTKDELDIYRLQDRYNLEMTARVNGNLLSKGNFQDIYYTF
AEMIERASENVTLYPGDVIGSGTVGTGCILELGTEQWLQDGDVVELEITGLGTLRNTIKKEMKAGDDHVLSSHGRTSP
>Mature_318_residues
MKFVTFRLPSQEMRAGWLEGDQVIDMNIASGGVLPSTMLAFLEKANEHLEIARRIQKPTSGIYPLEHVELCAALPNPSSI
RDFYAFEQHVKTARGRRGLDVVPEWYDIAVFYFTNHRAVIGPDHVVIGPKNTEKLDYELEIACVIGKEGRDIPREQAEEY
IFGYCIMNDWSARDLQAKEMKVGLGPAKGKDFATSLGAYLVTKDELDIYRLQDRYNLEMTARVNGNLLSKGNFQDIYYTF
AEMIERASENVTLYPGDVIGSGTVGTGCILELGTEQWLQDGDVVELEITGLGTLRNTIKKEMKAGDDHVLSSHGRTSP

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=305, Percent_Identity=31.8032786885246, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI40786394, Length=305, Percent_Identity=31.1475409836066, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557587, Length=273, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI13654274, Length=176, Percent_Identity=28.9772727272727, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI66348062, Length=138, Percent_Identity=31.1594202898551, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI215422413, Length=138, Percent_Identity=31.1594202898551, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17568863, Length=269, Percent_Identity=29.368029739777, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28572127, Length=189, Percent_Identity=37.037037037037, Blast_Score=121, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24657182, Length=274, Percent_Identity=29.1970802919708, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663695, Length=169, Percent_Identity=29.585798816568, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28571789, Length=180, Percent_Identity=27.2222222222222, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: 3.7.1.2

Molecular weight: Translated: 35617; Mature: 35617

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVTFRLPSQEMRAGWLEGDQVIDMNIASGGVLPSTMLAFLEKANEHLEIARRIQKPTS
CCEEEEECCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GIYPLEHVELCAALPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIAVFYFTNHRAVI
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCEEEE
GPDHVVIGPKNTEKLDYELEIACVIGKEGRDIPREQAEEYIFGYCIMNDWSARDLQAKEM
CCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCCHHHE
KVGLGPAKGKDFATSLGAYLVTKDELDIYRLQDRYNLEMTARVNGNLLSKGNFQDIYYTF
EECCCCCCCCHHHHHHCEEEEEECCCEEEEECCCCCEEEEEEECCCEECCCCCHHHHHHH
AEMIERASENVTLYPGDVIGSGTVGTGCILELGTEQWLQDGDVVELEITGLGTLRNTIKK
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHCCCCCEEEEEEECCHHHHHHHHH
EMKAGDDHVLSSHGRTSP
HHHCCCCCEECCCCCCCC
>Mature Secondary Structure
MKFVTFRLPSQEMRAGWLEGDQVIDMNIASGGVLPSTMLAFLEKANEHLEIARRIQKPTS
CCEEEEECCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GIYPLEHVELCAALPNPSSIRDFYAFEQHVKTARGRRGLDVVPEWYDIAVFYFTNHRAVI
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCEEEE
GPDHVVIGPKNTEKLDYELEIACVIGKEGRDIPREQAEEYIFGYCIMNDWSARDLQAKEM
CCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCCHHHE
KVGLGPAKGKDFATSLGAYLVTKDELDIYRLQDRYNLEMTARVNGNLLSKGNFQDIYYTF
EECCCCCCCCHHHHHHCEEEEEECCCEEEEECCCCCEEEEEEECCCEECCCCCHHHHHHH
AEMIERASENVTLYPGDVIGSGTVGTGCILELGTEQWLQDGDVVELEITGLGTLRNTIKK
HHHHHHCCCCEEEECCCCCCCCCCCCCEEEEECCHHHCCCCCEEEEEEECCHHHHHHHHH
EMKAGDDHVLSSHGRTSP
HHHCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]