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The map label for this gene is hpd [H]

Identifier: 152974072

GI number: 152974072

Start: 238095

End: 239213

Strand: Direct

Name: hpd [H]

Synonym: Bcer98_0228

Alternate gene names: 152974072

Gene position: 238095-239213 (Clockwise)

Preceding gene: 152974071

Following gene: 152974073

Centisome position: 5.83

GC content: 37.62

Gene sequence:

>1119_bases
ATGAAACAACAATCTATGGATGCGTTGACTGCACAAATGGAGGATTTTTTCCCAGTACGTGATGTAGACCATGTAGAATT
TTATGTAGGAAATGCAAAGCAGGCAAGTTATTATCTTGCAAGAGCATTTGGCTTCAAAATCGTAGCTTATTCTGGATTAG
AGACAGGAAACCGCGAAAAGGTATCTTATGTTCTTGTACAAAAAAATATGCGCTTTGTTGTGTCTGGAGCATTAAATAGT
GATAATCGTATCGCAGAATTTGTAAAACTTCATGGAGATGGGGTAAAAGACGTTGCGCTACTTGTTGACGATGTCGAGAA
AGCATACTCAGAAGCTGTGAAACGAGGTGCTGTTGCAATTTCCCCTCCGGAAGAGTTAACAGATGAGAATGGAGCAATAA
AAAAAGCAGTAATTGGTACGTATGGGGATACAATTCATACGCTTGTAGAGCGTAAAAACTATAAAGGAACATTTATGCCT
GGCTATGAAAAAGCTGAGTTCGAAGTCCCATCAGAAGAAGCAGGTTTAATTGCTGTAGACCATGTTGTCGGTAACGTTGA
GAAAATGGAAGAATGGGTTAGCTATTACGAAAATGTTATGGGCTTTAAACAAATGATTCATTTTGATGATGAAGATATTA
GTACGGAATATTCTGCGTTGATGTCAAAAGTTATGACAAATGGAAGTCGTATTAAATTCCCGATTAATGAGCCTGCAGAA
GGGAAACGAAAGTCGCAAATACAAGAATACTTAGAGTTTTACAATGGTGAGGGTGTACAACACCTTGCATTGTTAACAAA
TGATATTGTCAAAACAGTTGAAGCGCTTCGTGCCAATGGAGTTGAATTTTTAGACACACCAGATACGTATTATGAAGAAT
TAACGGCACGTGTCGGAGAAATCGATGAGGAAGTTGAAAAATTAAAAGAGCTTAAGATTTTAGTAGACCGTGATGATGAA
GGATACTTACTACAAATTTTTACAAAACCGATTGTAGATCGTCCAACCTTATTTATTGAAATTATTCAGCGTAAAGGATC
TCGTGGATTCGGAGAAGGGAACTTTAAGGCGTTATTTGAATCAATTGAAAGAGAGCAAGAACGTCGCGGAAACCTATAA

Upstream 100 bases:

>100_bases
TTGTTAGCTTGCTAACTAATTTGCTATTAGTATCTGAAAGAGTTTTCGAATGGTTGTAAGTATGTAATATTCAATTCATT
TACAGGGGGATGAGAAAGTT

Downstream 100 bases:

>100_bases
AATGTATATCCACCAGTAAGAAATCGGACTGCTGGTGGATACGTTATTTGATGATAAGCAGGGAGGAGTATTGATGAAAT
TTGTTACGTTTCGTCTTCCT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKQQSMDALTAQMEDFFPVRDVDHVEFYVGNAKQASYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALNS
DNRIAEFVKLHGDGVKDVALLVDDVEKAYSEAVKRGAVAISPPEELTDENGAIKKAVIGTYGDTIHTLVERKNYKGTFMP
GYEKAEFEVPSEEAGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDEDISTEYSALMSKVMTNGSRIKFPINEPAE
GKRKSQIQEYLEFYNGEGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYEELTARVGEIDEEVEKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Sequences:

>Translated_372_residues
MKQQSMDALTAQMEDFFPVRDVDHVEFYVGNAKQASYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALNS
DNRIAEFVKLHGDGVKDVALLVDDVEKAYSEAVKRGAVAISPPEELTDENGAIKKAVIGTYGDTIHTLVERKNYKGTFMP
GYEKAEFEVPSEEAGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDEDISTEYSALMSKVMTNGSRIKFPINEPAE
GKRKSQIQEYLEFYNGEGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYEELTARVGEIDEEVEKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL
>Mature_372_residues
MKQQSMDALTAQMEDFFPVRDVDHVEFYVGNAKQASYYLARAFGFKIVAYSGLETGNREKVSYVLVQKNMRFVVSGALNS
DNRIAEFVKLHGDGVKDVALLVDDVEKAYSEAVKRGAVAISPPEELTDENGAIKKAVIGTYGDTIHTLVERKNYKGTFMP
GYEKAEFEVPSEEAGLIAVDHVVGNVEKMEEWVSYYENVMGFKQMIHFDDEDISTEYSALMSKVMTNGSRIKFPINEPAE
GKRKSQIQEYLEFYNGEGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYEELTARVGEIDEEVEKLKELKILVDRDDE
GYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFESIEREQERRGNL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=362, Percent_Identity=48.8950276243094, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI285002264, Length=344, Percent_Identity=48.8372093023256, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI14249394, Length=374, Percent_Identity=26.7379679144385, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555220, Length=364, Percent_Identity=49.1758241758242, Blast_Score=336, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17550752, Length=366, Percent_Identity=36.8852459016393, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24667510, Length=363, Percent_Identity=49.0358126721763, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI21356105, Length=294, Percent_Identity=51.3605442176871, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 42160; Mature: 42160

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQSMDALTAQMEDFFPVRDVDHVEFYVGNAKQASYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALNSDNRIAEFVKLHGDGVKDVALLVDDVEKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
SPPEELTDENGAIKKAVIGTYGDTIHTLVERKNYKGTFMPGYEKAEFEVPSEEAGLIAVD
CCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDEDISTEYSALMSKVMTNGSRIKFPINEPAE
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGEGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYEELTARVGE
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHH
IDEEVEKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC
>Mature Secondary Structure
MKQQSMDALTAQMEDFFPVRDVDHVEFYVGNAKQASYYLARAFGFKIVAYSGLETGNREK
CCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCEEEEEECCCCCCCCCC
VSYVLVQKNMRFVVSGALNSDNRIAEFVKLHGDGVKDVALLVDDVEKAYSEAVKRGAVAI
EEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEE
SPPEELTDENGAIKKAVIGTYGDTIHTLVERKNYKGTFMPGYEKAEFEVPSEEAGLIAVD
CCHHHHCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEH
HVVGNVEKMEEWVSYYENVMGFKQMIHFDDEDISTEYSALMSKVMTNGSRIKFPINEPAE
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCC
GKRKSQIQEYLEFYNGEGVQHLALLTNDIVKTVEALRANGVEFLDTPDTYYEELTARVGE
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHH
IDEEVEKLKELKILVDRDDEGYLLQIFTKPIVDRPTLFIEIIQRKGSRGFGEGNFKALFE
HHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
SIEREQERRGNL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8071207; 11572948; 12692562 [H]