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The map label for this gene is adk [H]

Identifier: 152973977

GI number: 152973977

Start: 137806

End: 138456

Strand: Direct

Name: adk [H]

Synonym: Bcer98_0125

Alternate gene names: 152973977

Gene position: 137806-138456 (Clockwise)

Preceding gene: 152973976

Following gene: 152973978

Centisome position: 3.37

GC content: 40.4

Gene sequence:

>651_bases
ATGAACTTAATTCTAATGGGGCTTCCTGGTGCTGGTAAAGGTACACAAGCCGAACAGATTGTTGCCAAGTATAACATCCC
TCACATTTCAACAGGTGATATGTTCCGTGCAGCTATGAAGGCTGAAACTGAACTTGGTTTGCAAGCTAAATCTTTTATTG
ATAAAGGAGCGCTTGTTCCAGATGAGGTTACAATCGGAATCGTTCGTGAACGTTTGAGTCAAGAAGACTGCAAGAAAGGT
TTCTTGCTAGATGGGTTCCCACGAACAGTTGCACAAGCATCTGCGCTTGAAGAAATTATGAAAGATCTTGGCAAAAAAAT
CGACTATGTTTTAAACATTAATGTGGATTCAGGATTGCTGTTAAAACGTCTTACAGGCCGTCGCATTTGTAAAGAGTGCG
GTGCGACTTACCACTTAGAATTCAATCCGCCAGCAAAAGCTGACGTATGTGATAAATGTGGTGGCGAATTATATCAACGC
TCTGATGACAATGAAGAGACTGTAGCAAATCGTTTAGAAGTAAACATTAAGCAAACAAAACCATTGCTTGATTTCTACGA
GGAGCTGGGTTACTTACAAAGCATTAATGGTGAGCAAGATATCAATAAAGTATTTGCTGATATCGATGTTCTCATCGGAG
GCTTAGCGTAA

Upstream 100 bases:

>100_bases
GCCAACTGGTAAAACGCCATTACAAAGGGTTTATCAAACAGTGAGTAAGTGATGGGAAGAGAATGTCTTCCCTACATGCT
CATTATGAGGGGGAACAAAG

Downstream 100 bases:

>100_bases
TGATCATTTGCAAAACTCCTCGCGAGATAGAAATCATGCGAGAGGCTGGCAAGGTCGTTGCTTTAACTCATCAAGAGTTG
AAAAAGCATATTGCTCCAGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETELGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCKKG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLEVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Sequences:

>Translated_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETELGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCKKG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLEVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
>Mature_216_residues
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETELGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCKKG
FLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQR
SDDNEETVANRLEVNIKQTKPLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=42.4390243902439, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=42.4390243902439, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI19923437, Length=205, Percent_Identity=40.4878048780488, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=36.2790697674419, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=36.2790697674419, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=36.2790697674419, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=36.2790697674419, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=33.4928229665072, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=28.436018957346, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=29.5238095238095, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=29.5238095238095, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=48.1651376146789, Blast_Score=201, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=40.6698564593301, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=33.9805825242718, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17537943, Length=201, Percent_Identity=29.8507462686567, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=27.8846153846154, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=41.4285714285714, Blast_Score=181, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=36.734693877551, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=27.7511961722488, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=41.9811320754717, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=35.7142857142857, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=35.7142857142857, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=27.2300469483568, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=27.2300469483568, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=25.6038647342995, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=25.6038647342995, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23767; Mature: 23767

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETELGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCKKGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLEVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHHCCHHHHC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETELGLQAKSFIDKGALVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCC
DEVTIGIVRERLSQEDCKKGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLL
CHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHH
LKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLEVNIKQTK
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHCCCCCHHHHHHHHHCCHHHHC
PLLDFYEELGYLQSINGEQDINKVFADIDVLIGGLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA