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The map label for this gene is ndh [H]

Identifier: 152969660

GI number: 152969660

Start: 1254541

End: 1255845

Strand: Direct

Name: ndh [H]

Synonym: KPN_01106

Alternate gene names: 152969660

Gene position: 1254541-1255845 (Clockwise)

Preceding gene: 152969659

Following gene: 152969661

Centisome position: 23.6

GC content: 58.31

Gene sequence:

>1305_bases
ATGACTACGCCATTGAAAAAAATCGTAATTGTGGGTGGCGGCGCTGGCGGACTGGAACTGGCAACTCAGCTGGGGAGAAA
GTTAGGGCGCCATAAGAAAGCGAAAATCACCCTGGTGGACCGTAACCACAGCCATCTGTGGAAGCCGCTGCTGCACGAAG
TGGCCACCGGTTCTCTGGATGAAGGCGTTGATGCGCTGAGCTATCTGGCCCATGCCCGCAACCACGGTTTCCAGTTCCAG
CTGGGCTCGGTGGTTGATATCAACCGCGAAGGGAAAACCATCACCCTCGGCGAGCTGCGCAATGAAAAAGGCGAGCTGCT
GGTGGCTGAGCGTAAACTGCCGTACGACACGCTGGTCATGGCGTTGGGCAGTACCTCGAATGACTTTAATACCCCTGGCG
TAAAAGAGAACTGCATTTTCCTCGACAACCCGCACCAGGCGCGTCGCTTCCATCAGGAAATGCTCAACCTGTTCCTTAAA
TACTCTGCTAACCTCGGCGCTAACGGTAAAGTAAATATCGCCATCGTCGGCGGCGGCGCCACCGGCGTGGAGCTCTCCGC
TGAGTTGCACAATGCGGTGAAACAGCTGCACAGCTACGGCTACAAAGGGCTGACCAACGAAGCGCTGAACGTCACGCTGG
TCGAGGCGGGCGAGCGCATTCTGCCTGCGCTGCCGCCGCGCATTTCCGGGGCAGCGCATAATGAGCTGACTAAGCTGGGC
GTACGGGTTCTGACGCAGACCATGGTCACCAGCGCGGATGCGGGCGGCCTGCACACTAAAGATGGCGAATATATTGAGGC
GGATCTAATGGTCTGGGCGGCGGGGATCAAAGCGCCAGATTTCATGAAAGAGATCGGCGGCCTCGAAACCAACCGTATCA
ATCAGCTGGTGGTCGAGCCGACGCTGCAGACTACCCGCGATGCGGATATTTTCGCCATCGGCGACTGCGCCTCCTGCGCC
CGTCCGGAAGGCGGCTTTGTGCCTCCGCGGGCCCAGGCGGCGCACCAGATGGCTACCTGCGCGCTGAACAACATCCTGGC
GCAGATGAAAGGCAAACCGCTGAAGGCATACACCTATAAAGACCATGGCTCGCTGGTGTCGCTGTCAAATTACTCCACCG
TCGGCAGCCTGATGGGTAACCTGATGCGCGGTTCGATGATGGTGGAAGGGCGCATTGCGCGCTTCGTGTATATCTCCCTG
TACCGTATGCACCAGATTGCTCTGCATGGTTACTTCAAGACCGGCCTGATGATGCTGGTCGGGCGCATCAACCGCATCAT
TCGCCCGCGCCTGAAGCTGCACTAA

Upstream 100 bases:

>100_bases
TCGACAGTGCTGAATGGTTTCATTAACGTAACTTGTTGTTAAATAAAGGCTATTTCAATAACTTTTATTTAACAATTGGT
TAATAATTTTAGGGGTACAC

Downstream 100 bases:

>100_bases
TCGCTGTCGCGACCCGGAGGCGCGCTCTGAGGGCGCCTCCGGGCTCTTCTGCTGGAACCGCAGAGATCCCGCTCGGAATC
CTCTGAATCCCTTTGATTTG

Product: respiratory NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTPLKKIVIVGGGAGGLELATQLGRKLGRHKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQ
LGSVVDINREGKTITLGELRNEKGELLVAERKLPYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISGAAHNELTKLG
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFMKEIGGLETNRINQLVVEPTLQTTRDADIFAIGDCASCA
RPEGGFVPPRAQAAHQMATCALNNILAQMKGKPLKAYTYKDHGSLVSLSNYSTVGSLMGNLMRGSMMVEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGRINRIIRPRLKLH

Sequences:

>Translated_434_residues
MTTPLKKIVIVGGGAGGLELATQLGRKLGRHKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQ
LGSVVDINREGKTITLGELRNEKGELLVAERKLPYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISGAAHNELTKLG
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFMKEIGGLETNRINQLVVEPTLQTTRDADIFAIGDCASCA
RPEGGFVPPRAQAAHQMATCALNNILAQMKGKPLKAYTYKDHGSLVSLSNYSTVGSLMGNLMRGSMMVEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGRINRIIRPRLKLH
>Mature_433_residues
TTPLKKIVIVGGGAGGLELATQLGRKLGRHKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQL
GSVVDINREGKTITLGELRNEKGELLVAERKLPYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKY
SANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISGAAHNELTKLGV
RVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFMKEIGGLETNRINQLVVEPTLQTTRDADIFAIGDCASCAR
PEGGFVPPRAQAAHQMATCALNNILAQMKGKPLKAYTYKDHGSLVSLSNYSTVGSLMGNLMRGSMMVEGRIARFVYISLY
RMHQIALHGYFKTGLMMLVGRINRIIRPRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=434, Percent_Identity=93.5483870967742, Blast_Score=831, Evalue=0.0,
Organism=Escherichia coli, GI1789065, Length=358, Percent_Identity=25.1396648044693, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323794, Length=355, Percent_Identity=29.2957746478873, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323515, Length=460, Percent_Identity=25, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320118, Length=349, Percent_Identity=26.0744985673352, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47259; Mature: 47127

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLKKIVIVGGGAGGLELATQLGRKLGRHKKAKITLVDRNHSHLWKPLLHEVATGSLD
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFQFQLGSVVDINREGKTITLGELRNEKGELLVAERKLPYDTLVM
HHHHHHHHHHHHHCCCCEEEECCEEEECCCCCEEEHHHHCCCCCCEEEEECCCCHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGANGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISGAAHNELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHH
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFMKEIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDADIFAIGDCASCARPEGGFVPPRAQAAHQMATCALNNILAQMKGKPLKAYTYK
CCCCCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DHGSLVSLSNYSTVGSLMGNLMRGSMMVEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRINRIIRPRLKLH
HHHHHHHCCHHCCC
>Mature Secondary Structure 
TTPLKKIVIVGGGAGGLELATQLGRKLGRHKKAKITLVDRNHSHLWKPLLHEVATGSLD
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFQFQLGSVVDINREGKTITLGELRNEKGELLVAERKLPYDTLVM
HHHHHHHHHHHHHCCCCEEEECCEEEECCCCCEEEHHHHCCCCCCEEEEECCCCHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGANGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISGAAHNELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHH
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFMKEIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDADIFAIGDCASCARPEGGFVPPRAQAAHQMATCALNNILAQMKGKPLKAYTYK
CCCCCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
DHGSLVSLSNYSTVGSLMGNLMRGSMMVEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRINRIIRPRLKLH
HHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]