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The map label for this gene is ywlC [H]

Identifier: 151222232

GI number: 151222232

Start: 2236285

End: 2237331

Strand: Reverse

Name: ywlC [H]

Synonym: NWMN_2020

Alternate gene names: 151222232

Gene position: 2237331-2236285 (Counterclockwise)

Preceding gene: 151222233

Following gene: 151222231

Centisome position: 77.71

GC content: 35.24

Gene sequence:

>1047_bases
TTGGATACTAAAATTTGGGATGTTAGAGAATATAATGAAGATTTACAGCAATATCCTAAAATTAATGAAATAAAAGACAT
TGTTTTAAACGGTGGTTTAATAGGTTTACCAACTGAAACAGTTTATGGACTTGCAGCAAATGCGACAGATGAAGAAGCTG
TAGCTAAAATATATGAAGCTAAAGGCCGTCCATCTGACAATCCGCTTATTGTTCATATACACAGTAAAGGTCAATTAAAA
GATTTTACATATACTTTGGATCCACGCGTAGAAAAGTTAATGCAGGCATTCTGGCCGGGCCCTATTTCGTTTATATTGCC
GTTAAAGCTAGGCTATCTATGTCGAAAAGTTTCTGGAGGTTTATCATCAGTTGCTGTTAGAATGCCAAGCCATTCTGTAG
GTAGACAATTATTACAAATCATAAATGAACCTCTAGCTGCTCCAAGTGCTAATTTAAGTGGTAGACCTTCACCAACAACT
TTCAATCATGTATATCAAGATTTGAATGGCCGTATCGATGGTATTGTTCAAGCTGAACAAAGTGAAGAAGGATTAGAAAG
TACGGTTTTAGATTGCACATCTTTTCCTTATAAAATTGCAAGACCTGGTTCTATAACAGCAGCAATGATTACAGAAATAC
TTCCGAATAGTATCGCCCATGCTGATTATAATGATACTGAACAGCCAATTGCACCAGGTATGAAGTATAAGCATTACTCA
CCCAATACACCACTTACAATTATTACAGATATTGAGAGCAAAATTGGAAATGACGGTAAAGATTGGTCTTCTATAGCTTT
TATTGTGCCGAGTAATAAGGTGGCGTTTATACCAAGTGAAGCGCAATTCATTCAATTATGTCAGGATGACAATGATGTTA
AACAAGCAAGTCATAATCTTTATGATGTGTTACATTCACTTGATGAAAATGAAAATATTTCAGCGGCGTATATATACGGC
TTTGAGCTGAATGATAATACAGAAGCAATTATGAATCGCATGTTAAAAGCTGCAGGTAATCACATTATTAAAGGATGTGA
ACTATGA

Upstream 100 bases:

>100_bases
TCTCATTTAAATGGTAATTAGAAGTTATGCCTTTGCTATGATTAGTTAAGTGCATAGCTTTTTGCTTTATATTATGATAA
ATAAGAAAGGCGTGATTAAG

Downstream 100 bases:

>100_bases
AGATTTTATTCGTTTGTACAGGTAACACATGTCGTAGCCCATTAGCGGAAAGTATTGCAAAAGAGGTTATGCCAAATCAT
CAATTTGAATCAAGAGGTAT

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYGLAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLK
DFTYTLDPRVEKLMQAFWPGPISFILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTT
FNHVYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADYNDTEQPIAPGMKYKHYS
PNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQFIQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYG
FELNDNTEAIMNRMLKAAGNHIIKGCEL

Sequences:

>Translated_348_residues
MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYGLAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLK
DFTYTLDPRVEKLMQAFWPGPISFILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTT
FNHVYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADYNDTEQPIAPGMKYKHYS
PNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQFIQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYG
FELNDNTEAIMNRMLKAAGNHIIKGCEL
>Mature_348_residues
MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYGLAANATDEEAVAKIYEAKGRPSDNPLIVHIHSKGQLK
DFTYTLDPRVEKLMQAFWPGPISFILPLKLGYLCRKVSGGLSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTT
FNHVYQDLNGRIDGIVQAEQSEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADYNDTEQPIAPGMKYKHYS
PNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQFIQLCQDDNDVKQASHNLYDVLHSLDENENISAAYIYG
FELNDNTEAIMNRMLKAAGNHIIKGCEL

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=207, Percent_Identity=32.3671497584541, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI2367210, Length=156, Percent_Identity=34.6153846153846, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537239, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=378, Percent_Identity=31.2169312169312, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI78707274, Length=184, Percent_Identity=31.5217391304348, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 38446; Mature: 38446

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYGLAANATDEEAVAKIYEA
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHEEECCCCCHHHHHHHHHH
KGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPISFILPLKLGYLCRKVSGG
CCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
LSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNHVYQDLNGRIDGIVQAEQ
HHHEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCH
SEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADYNDTEQPIAPGMKYKHYS
HHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQFIQLCQDDNDVKQASHNL
CCCCEEEEEECHHHCCCCCCCCCEEEEEEECCEEEEECCHHHHHHHHCCCCHHHHHHHHH
YDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHIIKGCEL
HHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MDTKIWDVREYNEDLQQYPKINEIKDIVLNGGLIGLPTETVYGLAANATDEEAVAKIYEA
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHEEECCCCCHHHHHHHHHH
KGRPSDNPLIVHIHSKGQLKDFTYTLDPRVEKLMQAFWPGPISFILPLKLGYLCRKVSGG
CCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
LSSVAVRMPSHSVGRQLLQIINEPLAAPSANLSGRPSPTTFNHVYQDLNGRIDGIVQAEQ
HHHEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCH
SEEGLESTVLDCTSFPYKIARPGSITAAMITEILPNSIAHADYNDTEQPIAPGMKYKHYS
HHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
PNTPLTIITDIESKIGNDGKDWSSIAFIVPSNKVAFIPSEAQFIQLCQDDNDVKQASHNL
CCCCEEEEEECHHHCCCCCCCCCEEEEEEECCEEEEECCHHHHHHHHCCCCHHHHHHHHH
YDVLHSLDENENISAAYIYGFELNDNTEAIMNRMLKAAGNHIIKGCEL
HHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]