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The map label for this gene is dnaX [H]

Identifier: 150398618

GI number: 150398618

Start: 3636635

End: 3638512

Strand: Direct

Name: dnaX [H]

Synonym: Smed_3432

Alternate gene names: 150398618

Gene position: 3636635-3638512 (Clockwise)

Preceding gene: 150398615

Following gene: 150398619

Centisome position: 96.16

GC content: 64.91

Gene sequence:

>1878_bases
ATGAGCGACGAAGCGCCCACTTCAATCCCGATTTCATCCGTCGAGAAGCCCGCCGCCTACCGTGTTCTGGCGCGCAAATA
CCGCCCCAAGGACTTCTCCGATCTGATGGTCGGACAGGAGCCTATGGTGCGTACGCTCACCAACGCCTTCGAGACCGGCC
GCATCGCTCAGGCCTATATGCTGACCGGCGTGCGCGGAGTCGGCAAGACGACGACGGCGCGCATCCTGGCGCGGGCGCTG
AATTACAAGACCACCGGGATCGACAAGCCCACCATCGACCTGAGGCTCCCCGGCGAGCACTGCCAGGCGATCATGGACGG
CCGCCATGTCGACGTGATCGAGATGGACGCCGCCTCGCATACCGGCATCGACGATATCCGCGAGATCATCGAGCAGGTGC
GCTACCGGCCGGTATCGGCGCGCTACAAGGTGTATATCATCGATGAAGTGCACATGCTCTCGACGCAGGCCTTCAATGGG
CTGCTGAAGACGCTCGAGGAGCCGCCGGAGCATGTGAAGTTCATTTTCGCGACGACGGAGATCCGTAAGGTTCCGATTAC
CGTTCTGTCGCGCTGCCAGCGCTTCGATCTGCGGCGGATCAGCGCTTCCGATCTGGTCGGTCTCTTTTCCACCATTCTCG
GCAAGGAGGGTGTTCCCTTCGATCCGGAGGCATTGGCAATGGTCGCCCGCGCGGCGGAAGGCTCGGCGCGTGACGGCCTG
TCGCTGCTCGACCAGGCGATCGCCCATGGTGGCGGCTCGGTCGAGGTTGAAACCGTGCGCTCGATGCTCGGACTTGCCGA
CAGGGCGCGGATCGTCGATCTTTTCGAGCACATCATAAAGGGCGATGTCGCCGCCGCGCTGCACGAATTCGCCGCGCAAT
ATGAAGCAGGCGCCAATCCGACGGTAGTCCTGACAGACCTTGCCGACTTCACCCATCTGGTGACACGGCTGAAATATGTG
CCTGATGCGATCAACGACCAATCCCTGAGCGAGATCGAGCGTCGGCACGGGGCGGAATTCGCCGGCAGCGTTGCCGTGAC
GACGCTGTCGCGCATCTGGCAGATGCTGCTCAAGGGCATACCCGAGGCGGAGAGTTCGGCGCGCCCCGCGGGTGCTGCCG
AGATGGTGCTGATCAGGCTTGCCCATGCGGCCCATCTGCCTTCGCCCGAAGAGGCGGCCCGGCGGCTCCTCGATCTTTCG
GGCAGCGAAGGAGCCGGGCGCCCGTCGCCGAATGGCGGTGGCGGTGGCGGTGGTGCGCAGGCGTTTGCCGCCGCGTCGGT
CGAGGCTCGCGCCGTAGCGACGGGTGCGTCGCGCGCCAGCGGCAACGGCGCGACCATGCTGCGCGCGGTGCCGAACTCGG
CGGCGCAACCGGTCGAGGTTGGCCGCATCGAAGAGCGTCCGATTGCAAGCCCGGCTGCGAAGCCCGAACCGAAGGTGCCG
GTCAACTCGGTCGGCGACATCGCCGATCTCTGCGCGAAGAACCGGGATATAAAGCTGAAGACGCTGGTGCGTGGTTTCCT
GAGGCTCGTGCATATCGAGCCCGGCCGGCTCGACGTCAACCTGCCCGACGATGCGCCGAAGACGCTCTTGAACGAACTCG
CCGTCAAGCTCAAGGAGTGGACCGGGATCCATTGGGTCGTGAGCTACAGCCGCGAACAGGGCGAGCCGACCCTGGCCGAG
GCCGAGCAGCGCGCCCAGGAACAGCGCGTCAACGATGCGCGCGAAGATCCTGTCGTCGCTGCCATTCTTGCGCGCTTTCC
CGGCGCGAGGATCACAGATGTTCGCATCCGCGCGGCGGAAGAGGAGATCGAGAACCTCGCACCGGCCGCGGCCGAATCCG
AGGACGGCGATATCGTCCCGGGGGACGATATCGAATAG

Upstream 100 bases:

>100_bases
CCTCCCACCTTCTCCGTCCTGTCGGGACACCACCTTCTTCGTCCCAGTCGGGGCCTTCTTCGTCCCAGTCGGGGCAAGAG
TTCGAACAGCGGCAGGGTCG

Downstream 100 bases:

>100_bases
GCGCATCGCAGCGATGCGGCACTTTGGAGCACTTCCAGGAAGACTGTGTAAAGGTTTTCCGCCCGGACGTGCGTAGCGAT
AAAACACTTGGAAATACCAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MSDEAPTSIPISSVEKPAAYRVLARKYRPKDFSDLMVGQEPMVRTLTNAFETGRIAQAYMLTGVRGVGKTTTARILARAL
NYKTTGIDKPTIDLRLPGEHCQAIMDGRHVDVIEMDAASHTGIDDIREIIEQVRYRPVSARYKVYIIDEVHMLSTQAFNG
LLKTLEEPPEHVKFIFATTEIRKVPITVLSRCQRFDLRRISASDLVGLFSTILGKEGVPFDPEALAMVARAAEGSARDGL
SLLDQAIAHGGGSVEVETVRSMLGLADRARIVDLFEHIIKGDVAAALHEFAAQYEAGANPTVVLTDLADFTHLVTRLKYV
PDAINDQSLSEIERRHGAEFAGSVAVTTLSRIWQMLLKGIPEAESSARPAGAAEMVLIRLAHAAHLPSPEEAARRLLDLS
GSEGAGRPSPNGGGGGGGAQAFAAASVEARAVATGASRASGNGATMLRAVPNSAAQPVEVGRIEERPIASPAAKPEPKVP
VNSVGDIADLCAKNRDIKLKTLVRGFLRLVHIEPGRLDVNLPDDAPKTLLNELAVKLKEWTGIHWVVSYSREQGEPTLAE
AEQRAQEQRVNDAREDPVVAAILARFPGARITDVRIRAAEEEIENLAPAAAESEDGDIVPGDDIE

Sequences:

>Translated_625_residues
MSDEAPTSIPISSVEKPAAYRVLARKYRPKDFSDLMVGQEPMVRTLTNAFETGRIAQAYMLTGVRGVGKTTTARILARAL
NYKTTGIDKPTIDLRLPGEHCQAIMDGRHVDVIEMDAASHTGIDDIREIIEQVRYRPVSARYKVYIIDEVHMLSTQAFNG
LLKTLEEPPEHVKFIFATTEIRKVPITVLSRCQRFDLRRISASDLVGLFSTILGKEGVPFDPEALAMVARAAEGSARDGL
SLLDQAIAHGGGSVEVETVRSMLGLADRARIVDLFEHIIKGDVAAALHEFAAQYEAGANPTVVLTDLADFTHLVTRLKYV
PDAINDQSLSEIERRHGAEFAGSVAVTTLSRIWQMLLKGIPEAESSARPAGAAEMVLIRLAHAAHLPSPEEAARRLLDLS
GSEGAGRPSPNGGGGGGGAQAFAAASVEARAVATGASRASGNGATMLRAVPNSAAQPVEVGRIEERPIASPAAKPEPKVP
VNSVGDIADLCAKNRDIKLKTLVRGFLRLVHIEPGRLDVNLPDDAPKTLLNELAVKLKEWTGIHWVVSYSREQGEPTLAE
AEQRAQEQRVNDAREDPVVAAILARFPGARITDVRIRAAEEEIENLAPAAAESEDGDIVPGDDIE
>Mature_624_residues
SDEAPTSIPISSVEKPAAYRVLARKYRPKDFSDLMVGQEPMVRTLTNAFETGRIAQAYMLTGVRGVGKTTTARILARALN
YKTTGIDKPTIDLRLPGEHCQAIMDGRHVDVIEMDAASHTGIDDIREIIEQVRYRPVSARYKVYIIDEVHMLSTQAFNGL
LKTLEEPPEHVKFIFATTEIRKVPITVLSRCQRFDLRRISASDLVGLFSTILGKEGVPFDPEALAMVARAAEGSARDGLS
LLDQAIAHGGGSVEVETVRSMLGLADRARIVDLFEHIIKGDVAAALHEFAAQYEAGANPTVVLTDLADFTHLVTRLKYVP
DAINDQSLSEIERRHGAEFAGSVAVTTLSRIWQMLLKGIPEAESSARPAGAAEMVLIRLAHAAHLPSPEEAARRLLDLSG
SEGAGRPSPNGGGGGGGAQAFAAASVEARAVATGASRASGNGATMLRAVPNSAAQPVEVGRIEERPIASPAAKPEPKVPV
NSVGDIADLCAKNRDIKLKTLVRGFLRLVHIEPGRLDVNLPDDAPKTLLNELAVKLKEWTGIHWVVSYSREQGEPTLAEA
EQRAQEQRVNDAREDPVVAAILARFPGARITDVRIRAAEEEIENLAPAAAESEDGDIVPGDDIE

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI31563534, Length=285, Percent_Identity=23.5087719298246, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1786676, Length=377, Percent_Identity=42.1750663129974, Blast_Score=279, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17554730, Length=230, Percent_Identity=25.2173913043478, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=314, Percent_Identity=21.656050955414, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17647857, Length=285, Percent_Identity=24.9122807017544, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 67337; Mature: 67206

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDEAPTSIPISSVEKPAAYRVLARKYRPKDFSDLMVGQEPMVRTLTNAFETGRIAQAYM
CCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LTGVRGVGKTTTARILARALNYKTTGIDKPTIDLRLPGEHCQAIMDGRHVDVIEMDAASH
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCC
TGIDDIREIIEQVRYRPVSARYKVYIIDEVHMLSTQAFNGLLKTLEEPPEHVKFIFATTE
CCHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECH
IRKVPITVLSRCQRFDLRRISASDLVGLFSTILGKEGVPFDPEALAMVARAAEGSARDGL
HHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCH
SLLDQAIAHGGGSVEVETVRSMLGLADRARIVDLFEHIIKGDVAAALHEFAAQYEAGANP
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TVVLTDLADFTHLVTRLKYVPDAINDQSLSEIERRHGAEFAGSVAVTTLSRIWQMLLKGI
EEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
PEAESSARPAGAAEMVLIRLAHAAHLPSPEEAARRLLDLSGSEGAGRPSPNGGGGGGGAQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
AFAAASVEARAVATGASRASGNGATMLRAVPNSAAQPVEVGRIEERPIASPAAKPEPKVP
HHHHHCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VNSVGDIADLCAKNRDIKLKTLVRGFLRLVHIEPGRLDVNLPDDAPKTLLNELAVKLKEW
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHHHHHHHHHHH
TGIHWVVSYSREQGEPTLAEAEQRAQEQRVNDAREDPVVAAILARFPGARITDVRIRAAE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEHHHH
EEIENLAPAAAESEDGDIVPGDDIE
HHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDEAPTSIPISSVEKPAAYRVLARKYRPKDFSDLMVGQEPMVRTLTNAFETGRIAQAYM
CCCCCCCCCHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
LTGVRGVGKTTTARILARALNYKTTGIDKPTIDLRLPGEHCQAIMDGRHVDVIEMDAASH
HHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCC
TGIDDIREIIEQVRYRPVSARYKVYIIDEVHMLSTQAFNGLLKTLEEPPEHVKFIFATTE
CCHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECH
IRKVPITVLSRCQRFDLRRISASDLVGLFSTILGKEGVPFDPEALAMVARAAEGSARDGL
HHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCH
SLLDQAIAHGGGSVEVETVRSMLGLADRARIVDLFEHIIKGDVAAALHEFAAQYEAGANP
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TVVLTDLADFTHLVTRLKYVPDAINDQSLSEIERRHGAEFAGSVAVTTLSRIWQMLLKGI
EEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
PEAESSARPAGAAEMVLIRLAHAAHLPSPEEAARRLLDLSGSEGAGRPSPNGGGGGGGAQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
AFAAASVEARAVATGASRASGNGATMLRAVPNSAAQPVEVGRIEERPIASPAAKPEPKVP
HHHHHCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VNSVGDIADLCAKNRDIKLKTLVRGFLRLVHIEPGRLDVNLPDDAPKTLLNELAVKLKEW
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCEEEECCCCCCHHHHHHHHHHHHHHH
TGIHWVVSYSREQGEPTLAEAEQRAQEQRVNDAREDPVVAAILARFPGARITDVRIRAAE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEHHHH
EEIENLAPAAAESEDGDIVPGDDIE
HHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]