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The map label for this gene is deoA

Identifier: 150398531

GI number: 150398531

Start: 3542078

End: 3543394

Strand: Direct

Name: deoA

Synonym: Smed_3342

Alternate gene names: 150398531

Gene position: 3542078-3543394 (Clockwise)

Preceding gene: 150398530

Following gene: 150398538

Centisome position: 93.66

GC content: 66.89

Gene sequence:

>1317_bases
ATGGCGATGCTCCCGCAGGAAGTCATACGTAAGAAAAGGGATGGCGGCAGGCTCGTTCCGGCGGAGATCGCCGGTTTCAT
CGAGGGTCTGGCCGATGGCTCGATCTCGGAAGGTCAGGCCGCCGCTTTCGCCATGGCGGTCTGGTTCTCCGGCATGAGCC
GGGACGAATGTGTGGCGCTGACGCTGGCGATGCGCGATTCCGGGGAGACGCTCGACTGGGGCGAGTTCGGGCGCCCGGTT
GTCGACAAGCACTCGACCGGCGGCGTCGGCGATAATGTCTCTCTGATGCTGGCGCCGATTGTCGCCGCCTGCGGACCTGT
GGTCCCGATGATCTCAGGTCGTGGGCTCGGCCATACCGGCGGCACGCTCGACAAGCTCGAGTCTATCCCGGGCTACAATA
TCCAGCCCTCGCCAGAGCTGTTTCGCCGCGTGGTCGACGAGGTCGGCTGCGCCATCATCGGCCAGACGGCCAATCTCGCC
CCCGCCGACAAGCGCCTCTATGCAATCCGCGACGTGACGGCGACGGTCGACTCCGTGCCACTGATCACCGCATCGATCCT
GTCGAAAAAGCTCGCCGCGGGGCTTCAGTCACTGGTACTCGACGTCAAGCTCGGCAATGGCTCCTTCATGACGGATCCAG
CCGAGACCGAAATTCTGGCCCGTTCGCTTGTCGAGGTCGCCAATGGCGCGGGCGTGCGCACCTCGGCGCTGATCACCGAC
ATGAACGAGCCATTGGCGGACGCGGCCGGCAACGCGCTCGAAGTCGAGAACTGCCTTGCTTATCTCAGCGGCAAGAAGGC
GGGAACCCGCCTCGATCGGGTGGTCATGGCCTTTGCGGCGGAAATGCTCGCCGCAGCGGGCGTGTCGGCGCACAAGGCTG
AAGGCGAGGCCATGGCCCGCCGTGCCCTGGAGAGCGGCGAGGCTTTGGAACGCTTCGGCCTCATGGTGCATCGGCTCGGC
GGCCCCGCCGATTTCGTGGAACGGCCCGAGGCCTATCTCGAACGGGCGCCGGCGATCGTGCCGGTCGCGGCGGCCCGCGA
CGGCTATCTGGCCGCCTGCGAGACGCGCGAACTCGGAATGGCGGTCATCGCGCTCGGCGGCGGGCGCCGGCGGCCGGACG
ACCGAATCGATCATCGCGTCGGCCTTGCCGGATTGAGACCGCTCCGGACGAAGGTGGAAAAGGGTGAGCCGATCGCTTTT
GTCCATGGCGCCGACCGCGACCAGGCCGAGGCGGTCGCAAAGCGGGTGGCAACGCTCTACGCGATCGCGGAGGAGGCGCC
CGCGCAACGCCCGGTGATCGCGTCAAGGCTCGTTTGA

Upstream 100 bases:

>100_bases
CGGGGCCGAGCTCAGCCATGAAGAAACCAAGGAAATGGCGCCGCTTGGCGGCACGCGCCTGGCGGCCATCCTGAAGGAAA
TGGTCGCGAGCGAAGGCTGA

Downstream 100 bases:

>100_bases
CCGGATGAAGCGCGCCGTTATCCGGCAGCGCTACTTCGTTCCGTACATGCGGTCGCCGGCATCCCCAAGACCTGGAACGA
TATAGCCCAACTCGTTGAGG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MAMLPQEVIRKKRDGGRLVPAEIAGFIEGLADGSISEGQAAAFAMAVWFSGMSRDECVALTLAMRDSGETLDWGEFGRPV
VDKHSTGGVGDNVSLMLAPIVAACGPVVPMISGRGLGHTGGTLDKLESIPGYNIQPSPELFRRVVDEVGCAIIGQTANLA
PADKRLYAIRDVTATVDSVPLITASILSKKLAAGLQSLVLDVKLGNGSFMTDPAETEILARSLVEVANGAGVRTSALITD
MNEPLADAAGNALEVENCLAYLSGKKAGTRLDRVVMAFAAEMLAAAGVSAHKAEGEAMARRALESGEALERFGLMVHRLG
GPADFVERPEAYLERAPAIVPVAAARDGYLAACETRELGMAVIALGGGRRRPDDRIDHRVGLAGLRPLRTKVEKGEPIAF
VHGADRDQAEAVAKRVATLYAIAEEAPAQRPVIASRLV

Sequences:

>Translated_438_residues
MAMLPQEVIRKKRDGGRLVPAEIAGFIEGLADGSISEGQAAAFAMAVWFSGMSRDECVALTLAMRDSGETLDWGEFGRPV
VDKHSTGGVGDNVSLMLAPIVAACGPVVPMISGRGLGHTGGTLDKLESIPGYNIQPSPELFRRVVDEVGCAIIGQTANLA
PADKRLYAIRDVTATVDSVPLITASILSKKLAAGLQSLVLDVKLGNGSFMTDPAETEILARSLVEVANGAGVRTSALITD
MNEPLADAAGNALEVENCLAYLSGKKAGTRLDRVVMAFAAEMLAAAGVSAHKAEGEAMARRALESGEALERFGLMVHRLG
GPADFVERPEAYLERAPAIVPVAAARDGYLAACETRELGMAVIALGGGRRRPDDRIDHRVGLAGLRPLRTKVEKGEPIAF
VHGADRDQAEAVAKRVATLYAIAEEAPAQRPVIASRLV
>Mature_437_residues
AMLPQEVIRKKRDGGRLVPAEIAGFIEGLADGSISEGQAAAFAMAVWFSGMSRDECVALTLAMRDSGETLDWGEFGRPVV
DKHSTGGVGDNVSLMLAPIVAACGPVVPMISGRGLGHTGGTLDKLESIPGYNIQPSPELFRRVVDEVGCAIIGQTANLAP
ADKRLYAIRDVTATVDSVPLITASILSKKLAAGLQSLVLDVKLGNGSFMTDPAETEILARSLVEVANGAGVRTSALITDM
NEPLADAAGNALEVENCLAYLSGKKAGTRLDRVVMAFAAEMLAAAGVSAHKAEGEAMARRALESGEALERFGLMVHRLGG
PADFVERPEAYLERAPAIVPVAAARDGYLAACETRELGMAVIALGGGRRRPDDRIDHRVGLAGLRPLRTKVEKGEPIAFV
HGADRDQAEAVAKRVATLYAIAEEAPAQRPVIASRLV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=44.0097799511002, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=44.0097799511002, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=44.0097799511002, Blast_Score=279, Evalue=3e-75,
Organism=Escherichia coli, GI1790842, Length=437, Percent_Identity=52.6315789473684, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_SINMW (A6UET3)

Other databases:

- EMBL:   CP000738
- RefSeq:   YP_001328998.1
- ProteinModelPortal:   A6UET3
- SMR:   A6UET3
- STRING:   A6UET3
- GeneID:   5324226
- GenomeReviews:   CP000738_GR
- KEGG:   smd:Smed_3342
- eggNOG:   COG0213
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- BioCyc:   SMED366394:SMED_3342-MONOMER
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 45990; Mature: 45859

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMLPQEVIRKKRDGGRLVPAEIAGFIEGLADGSISEGQAAAFAMAVWFSGMSRDECVAL
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
TLAMRDSGETLDWGEFGRPVVDKHSTGGVGDNVSLMLAPIVAACGPVVPMISGRGLGHTG
EEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCC
GTLDKLESIPGYNIQPSPELFRRVVDEVGCAIIGQTANLAPADKRLYAIRDVTATVDSVP
CCHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCHHHEEEHHHHHHHHHCCH
LITASILSKKLAAGLQSLVLDVKLGNGSFMTDPAETEILARSLVEVANGAGVRTSALITD
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
MNEPLADAAGNALEVENCLAYLSGKKAGTRLDRVVMAFAAEMLAAAGVSAHKAEGEAMAR
CCCHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RALESGEALERFGLMVHRLGGPADFVERPEAYLERAPAIVPVAAARDGYLAACETRELGM
HHHHCCHHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCEEEEECCCCCCEEEECCCCCCE
AVIALGGGRRRPDDRIDHRVGLAGLRPLRTKVEKGEPIAFVHGADRDQAEAVAKRVATLY
EEEEECCCCCCCHHHHHHHHCHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
AIAEEAPAQRPVIASRLV
HHHHHCCCCCCCHHHHCC
>Mature Secondary Structure 
AMLPQEVIRKKRDGGRLVPAEIAGFIEGLADGSISEGQAAAFAMAVWFSGMSRDECVAL
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
TLAMRDSGETLDWGEFGRPVVDKHSTGGVGDNVSLMLAPIVAACGPVVPMISGRGLGHTG
EEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCC
GTLDKLESIPGYNIQPSPELFRRVVDEVGCAIIGQTANLAPADKRLYAIRDVTATVDSVP
CCHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCHHHEEEHHHHHHHHHCCH
LITASILSKKLAAGLQSLVLDVKLGNGSFMTDPAETEILARSLVEVANGAGVRTSALITD
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHC
MNEPLADAAGNALEVENCLAYLSGKKAGTRLDRVVMAFAAEMLAAAGVSAHKAEGEAMAR
CCCHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RALESGEALERFGLMVHRLGGPADFVERPEAYLERAPAIVPVAAARDGYLAACETRELGM
HHHHCCHHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCEEEEECCCCCCEEEECCCCCCE
AVIALGGGRRRPDDRIDHRVGLAGLRPLRTKVEKGEPIAFVHGADRDQAEAVAKRVATLY
EEEEECCCCCCCHHHHHHHHCHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHH
AIAEEAPAQRPVIASRLV
HHHHHCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA