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The map label for this gene is gcvT [H]

Identifier: 150398501

GI number: 150398501

Start: 3504719

End: 3505852

Strand: Direct

Name: gcvT [H]

Synonym: Smed_3311

Alternate gene names: 150398501

Gene position: 3504719-3505852 (Clockwise)

Preceding gene: 150398500

Following gene: 150398502

Centisome position: 92.67

GC content: 59.79

Gene sequence:

>1134_bases
ATGGCTTTATCCTGGCGTTTCTCCGCCTTGGCGGATCGACATCGCGCTCTCGGATCGAAACTGGAGGACTGGAGCGGCAT
GGGGACCGCCTGGACCTATGAAAAGGACATGTCCGAAGAGCATGTCGCGATCCGTACGAAAGCCGGGATCATGGATGTTT
CCGGCCTGAAGAAAGTGCATCTGGTCGGTCCGCATGCCATTGCCGTGCTCGATTACATCACCACCCGCGACATGACGAAA
ATTTATCCCGGCCGCTCCGTCTATGCCTGCATGCTGAACGACCGTGGGCATTTCACCGACGACTGCATCGTCTACCGCAC
CGGCCCCAATTCCTGGATGCTGGTCCACGGCTCCGGTTCCGGCTACGAGGAGATCGTGAAGCAGGCTGCGGGCCGTAACT
GCGCAGTGCTGTTCGACGACGATCTGCATGATCTGTCGCTGCAGGGGCCGCTTGCGGTCGACTATCTCGACAAACACGTA
CCGGGCATCCGCGACCTCAAATATTTCCATCACATGCAGACGACGCTCTTTGGCGCTCCGGTCATGATTTCGCGCACCGG
CTATACCGGAGAGCGCGGTTATGAAATCTTCGTGCGCGGCCAGGATGCGGTCATGGTCTGGGACCGTATCCTCTCGGAAG
GCAAGGAGATGGGCATCATCCCCTGCTGTTTCAGCGTGCTCGACATGCTGCGGGTGGAAAGCTACCTGCTCTTTTATCCC
TACGACAATTCGCAGATGTACCCCTTCGCCGACCAGCCGCCGGGCGACAGCCTATGGGAACTCGGCCTCGATTTCACCGT
CAGTCCCGGCAAGGCGGGCTTCCGTGGCGCCGAGGAACATGCGCGGCTGAAAGGCAAGGAGCGCTTCAAGATTTTCGGCA
TGCTGATCGACGCCGATGGCCCGGCCGATCTCGGGGACGAGGTCTATGCCGAAGACAGGAAGGTCGGCGTAATCACCTGT
CCGAGCTATTCGACACTGACGAAGAAGTCCATGGCGATCGCCCGTTTGGACGTCGACAAGGCCGTCCAGGGCGCGAAGCT
GGAGGTGCGCGGCAAGAACCTCGACGCTAGAGCGATCGCCCACACGCTGACATTCGACGATCCGGAGAAGAAGAAGAGAA
CGGCCGTCGGTTAG

Upstream 100 bases:

>100_bases
CGCCGGGCCGGGAAAAATAATCGGGCTGGCTTGCCTCCACGTGGAATTCTGAATATATTCAGGAAATAAATATTCCGTAT
GGGAAAAAAGAGGGAACGAA

Downstream 100 bases:

>100_bases
GAGAGGCGGCCATGCTTGTCGAAGGCATTAAGAGCCGTCCGGTCTATATGGGACTTTCCATCCAGCCGCGCGCCCGGCGG
CACATCTTCGCACTGGAAGG

Product: glycine cleavage T protein (aminomethyl transferase)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MALSWRFSALADRHRALGSKLEDWSGMGTAWTYEKDMSEEHVAIRTKAGIMDVSGLKKVHLVGPHAIAVLDYITTRDMTK
IYPGRSVYACMLNDRGHFTDDCIVYRTGPNSWMLVHGSGSGYEEIVKQAAGRNCAVLFDDDLHDLSLQGPLAVDYLDKHV
PGIRDLKYFHHMQTTLFGAPVMISRTGYTGERGYEIFVRGQDAVMVWDRILSEGKEMGIIPCCFSVLDMLRVESYLLFYP
YDNSQMYPFADQPPGDSLWELGLDFTVSPGKAGFRGAEEHARLKGKERFKIFGMLIDADGPADLGDEVYAEDRKVGVITC
PSYSTLTKKSMAIARLDVDKAVQGAKLEVRGKNLDARAIAHTLTFDDPEKKKRTAVG

Sequences:

>Translated_377_residues
MALSWRFSALADRHRALGSKLEDWSGMGTAWTYEKDMSEEHVAIRTKAGIMDVSGLKKVHLVGPHAIAVLDYITTRDMTK
IYPGRSVYACMLNDRGHFTDDCIVYRTGPNSWMLVHGSGSGYEEIVKQAAGRNCAVLFDDDLHDLSLQGPLAVDYLDKHV
PGIRDLKYFHHMQTTLFGAPVMISRTGYTGERGYEIFVRGQDAVMVWDRILSEGKEMGIIPCCFSVLDMLRVESYLLFYP
YDNSQMYPFADQPPGDSLWELGLDFTVSPGKAGFRGAEEHARLKGKERFKIFGMLIDADGPADLGDEVYAEDRKVGVITC
PSYSTLTKKSMAIARLDVDKAVQGAKLEVRGKNLDARAIAHTLTFDDPEKKKRTAVG
>Mature_376_residues
ALSWRFSALADRHRALGSKLEDWSGMGTAWTYEKDMSEEHVAIRTKAGIMDVSGLKKVHLVGPHAIAVLDYITTRDMTKI
YPGRSVYACMLNDRGHFTDDCIVYRTGPNSWMLVHGSGSGYEEIVKQAAGRNCAVLFDDDLHDLSLQGPLAVDYLDKHVP
GIRDLKYFHHMQTTLFGAPVMISRTGYTGERGYEIFVRGQDAVMVWDRILSEGKEMGIIPCCFSVLDMLRVESYLLFYPY
DNSQMYPFADQPPGDSLWELGLDFTVSPGKAGFRGAEEHARLKGKERFKIFGMLIDADGPADLGDEVYAEDRKVGVITCP
SYSTLTKKSMAIARLDVDKAVQGAKLEVRGKNLDARAIAHTLTFDDPEKKKRTAVG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=353, Percent_Identity=26.3456090651558, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI44662838, Length=377, Percent_Identity=25.1989389920424, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI257796258, Length=361, Percent_Identity=25.7617728531856, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1789272, Length=347, Percent_Identity=27.9538904899135, Blast_Score=104, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17560118, Length=253, Percent_Identity=24.1106719367589, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320222, Length=376, Percent_Identity=27.1276595744681, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129441, Length=368, Percent_Identity=26.6304347826087, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130091, Length=334, Percent_Identity=25.4491017964072, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42054; Mature: 41922

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSWRFSALADRHRALGSKLEDWSGMGTAWTYEKDMSEEHVAIRTKAGIMDVSGLKKVH
CCCEEHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCCEEEEEECCCEEECCCCCEEE
LVGPHAIAVLDYITTRDMTKIYPGRSVYACMLNDRGHFTDDCIVYRTGPNSWMLVHGSGS
EECCHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCC
GYEEIVKQAAGRNCAVLFDDDLHDLSLQGPLAVDYLDKHVPGIRDLKYFHHMQTTLFGAP
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
VMISRTGYTGERGYEIFVRGQDAVMVWDRILSEGKEMGIIPCCFSVLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEE
YDNSQMYPFADQPPGDSLWELGLDFTVSPGKAGFRGAEEHARLKGKERFKIFGMLIDADG
CCCCEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEEEEEECCC
PADLGDEVYAEDRKVGVITCPSYSTLTKKSMAIARLDVDKAVQGAKLEVRGKNLDARAIA
CCCCCCHHHHCCCEEEEEECCCCHHHHHHHHEEEEECHHHHCCCCEEEEECCCCCHHHEE
HTLTFDDPEKKKRTAVG
EEECCCCHHHHHHCCCC
>Mature Secondary Structure 
ALSWRFSALADRHRALGSKLEDWSGMGTAWTYEKDMSEEHVAIRTKAGIMDVSGLKKVH
CCEEHHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCCCEEEEEECCCEEECCCCCEEE
LVGPHAIAVLDYITTRDMTKIYPGRSVYACMLNDRGHFTDDCIVYRTGPNSWMLVHGSGS
EECCHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCC
GYEEIVKQAAGRNCAVLFDDDLHDLSLQGPLAVDYLDKHVPGIRDLKYFHHMQTTLFGAP
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
VMISRTGYTGERGYEIFVRGQDAVMVWDRILSEGKEMGIIPCCFSVLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEE
YDNSQMYPFADQPPGDSLWELGLDFTVSPGKAGFRGAEEHARLKGKERFKIFGMLIDADG
CCCCEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEEEEEECCC
PADLGDEVYAEDRKVGVITCPSYSTLTKKSMAIARLDVDKAVQGAKLEVRGKNLDARAIA
CCCCCCHHHHCCCEEEEEECCCCHHHHHHHHEEEEECHHHHCCCCEEEEECCCCCHHHEE
HTLTFDDPEKKKRTAVG
EEECCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]