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The map label for this gene is yleA [C]

Identifier: 150398286

GI number: 150398286

Start: 3238468

End: 3239742

Strand: Reverse

Name: yleA [C]

Synonym: Smed_3092

Alternate gene names: 150398286

Gene position: 3239742-3238468 (Counterclockwise)

Preceding gene: 150398287

Following gene: 150398285

Centisome position: 85.66

GC content: 64.08

Gene sequence:

>1275_bases
TTGAGCGGCGTCGAGGTCATAACCTTCGGCTGCCGTCTGAACACCTACGAATCGGAAGTGATGCGGGCAGAGGCCGAAAA
GGCGGGGCTGAACAATGCCGTGCTCGTCAACACCTGCGCCGTGACCGCCGAGGCGGTGCGCCAGGCGCGCCAGGCCATCC
GCCGCGCGCGGCGCGAGAACCCGCACGCCCGTATCATCGTCACCGGCTGCGCCGCGCAGACCGAGAAGGAAACTTTCGCG
GAGATGGCGGAGGTGGACGCGGTTCTCGGCAATGAGGAGAAGCTCACGAGCGCTTCCTATCGCTCGCTGCCCGATTTCGG
CGTCTCGGCCGAGGAGAAACTCCGGGTGAACGATATCATGAGCGTGCGCGCCACCGCGCCGCAAATGGTGAAGCATATCG
ACGGGCACGTGCGTGCCTTCATCCAGGTGCAGAATGGCTGTGATCATCGCTGCACCTTCTGCATCATCCCTTATGGACGC
GGCAATTCCCGCTCGGTGCCGATGGGCGCCGTCGTCGACCAGGCGAGACGCCTTGTCGAGGGCGGCTATCGCGAGATCGT
GCTGACCGGCGTCGATGCCACCAGCTACGGCGCCGACCTGCCCGGAACGCCAACCCTCGGACTTCTCGCCAAGACCTTGC
TGAAGCAGGTCCCGGAGATCCTTCGTCTACGGCTTTCCTCCATCGACAGCATCGAGGCGGACGTCCATCTTCTCGATCTC
ATTGCCGAAGAGCCGCGTTTCATGCCGCATCTGCATCTCTCGCTGCAGCATGGCGACGACCTGATGCTGAAGCGGATGAA
GCGGCGGCATTCAAGTGCCGACGCGCGCGCCTTCTGCGCGGAGGTCCTTCGGCTCCGACCCGAAATCAGTTTCAGCGCCG
ACATGATCGCCGGCTTTCCGACCGAGACCGAGGCGATGTTCCAGAATGCCGTCAGGCTTGCTGAGGATTGCGGCCTTGCG
CATCTGCACGTCTTCCCCTACAGCCCACGCCCCGGCACGCCGGCGGCCCGCATGCCGCAGCTCGACCGCGTGCTCGTCAA
AGAGCGTGCCGCACGCCTGCGTGCAAAGGGCGCCGAGCTCCATACGGTCCATCTCGAACGCATGGTCGGCAGCAGGCAAA
TGGTGCTGGTGGAGATGAACGGTCTGGCACATACCGAAAACTTCACGCTCGTCGATGCGGCCGGCCTCGAGCCGCGATCG
CTCGTTGCGGCCGAAATCACCGGCCATAACGGCAAGCATCTGACGATCAAGCGCAAACAGATGGCTGCGGCCTGA

Upstream 100 bases:

>100_bases
CCGGCCCGGCCGAATGGGAATGGTCCGGCACGCTCGACCCTGTCACCGGCATTTTCGAGCGGAACGAGCCGGAGAGCGGC
GACATCGGAGCCCGAGCGCC

Downstream 100 bases:

>100_bases
TAGCGGACATTCATTCCCATGGCGATTGGTTTCATCAAGAAGATCTTCTCCTTCGGCAAGGACGCCGTCGACGAGAAACC
CGCGCCGCCGCAGGAGGTTT

Product: MiaB-like tRNA modifying enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSGVEVITFGCRLNTYESEVMRAEAEKAGLNNAVLVNTCAVTAEAVRQARQAIRRARRENPHARIIVTGCAAQTEKETFA
EMAEVDAVLGNEEKLTSASYRSLPDFGVSAEEKLRVNDIMSVRATAPQMVKHIDGHVRAFIQVQNGCDHRCTFCIIPYGR
GNSRSVPMGAVVDQARRLVEGGYREIVLTGVDATSYGADLPGTPTLGLLAKTLLKQVPEILRLRLSSIDSIEADVHLLDL
IAEEPRFMPHLHLSLQHGDDLMLKRMKRRHSSADARAFCAEVLRLRPEISFSADMIAGFPTETEAMFQNAVRLAEDCGLA
HLHVFPYSPRPGTPAARMPQLDRVLVKERAARLRAKGAELHTVHLERMVGSRQMVLVEMNGLAHTENFTLVDAAGLEPRS
LVAAEITGHNGKHLTIKRKQMAAA

Sequences:

>Translated_424_residues
MSGVEVITFGCRLNTYESEVMRAEAEKAGLNNAVLVNTCAVTAEAVRQARQAIRRARRENPHARIIVTGCAAQTEKETFA
EMAEVDAVLGNEEKLTSASYRSLPDFGVSAEEKLRVNDIMSVRATAPQMVKHIDGHVRAFIQVQNGCDHRCTFCIIPYGR
GNSRSVPMGAVVDQARRLVEGGYREIVLTGVDATSYGADLPGTPTLGLLAKTLLKQVPEILRLRLSSIDSIEADVHLLDL
IAEEPRFMPHLHLSLQHGDDLMLKRMKRRHSSADARAFCAEVLRLRPEISFSADMIAGFPTETEAMFQNAVRLAEDCGLA
HLHVFPYSPRPGTPAARMPQLDRVLVKERAARLRAKGAELHTVHLERMVGSRQMVLVEMNGLAHTENFTLVDAAGLEPRS
LVAAEITGHNGKHLTIKRKQMAAA
>Mature_423_residues
SGVEVITFGCRLNTYESEVMRAEAEKAGLNNAVLVNTCAVTAEAVRQARQAIRRARRENPHARIIVTGCAAQTEKETFAE
MAEVDAVLGNEEKLTSASYRSLPDFGVSAEEKLRVNDIMSVRATAPQMVKHIDGHVRAFIQVQNGCDHRCTFCIIPYGRG
NSRSVPMGAVVDQARRLVEGGYREIVLTGVDATSYGADLPGTPTLGLLAKTLLKQVPEILRLRLSSIDSIEADVHLLDLI
AEEPRFMPHLHLSLQHGDDLMLKRMKRRHSSADARAFCAEVLRLRPEISFSADMIAGFPTETEAMFQNAVRLAEDCGLAH
LHVFPYSPRPGTPAARMPQLDRVLVKERAARLRAKGAELHTVHLERMVGSRQMVLVEMNGLAHTENFTLVDAAGLEPRSL
VAAEITGHNGKHLTIKRKQMAAA

Specific function: Unknown

COG id: COG0621

COG function: function code J; 2-methylthioadenine synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MTTase N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI93277076, Length=393, Percent_Identity=29.5165394402036, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI28872784, Length=457, Percent_Identity=26.0393873085339, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI28872782, Length=457, Percent_Identity=26.0393873085339, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1786882, Length=423, Percent_Identity=28.1323877068558, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787057, Length=391, Percent_Identity=28.9002557544757, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17553146, Length=418, Percent_Identity=28.7081339712919, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71996771, Length=308, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21356207, Length=425, Percent_Identity=27.5294117647059, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI19922432, Length=368, Percent_Identity=29.0760869565217, Blast_Score=131, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR005839
- InterPro:   IPR020612
- InterPro:   IPR013848
- InterPro:   IPR006467
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM; PF00919 UPF0004 [H]

EC number: NA

Molecular weight: Translated: 46647; Mature: 46516

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS01278 UPF0004

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVEVITFGCRLNTYESEVMRAEAEKAGLNNAVLVNTCAVTAEAVRQARQAIRRARREN
CCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
PHARIIVTGCAAQTEKETFAEMAEVDAVLGNEEKLTSASYRSLPDFGVSAEEKLRVNDIM
CCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHEHHHHHH
SVRATAPQMVKHIDGHVRAFIQVQNGCDHRCTFCIIPYGRGNSRSVPMGAVVDQARRLVE
HHHHHHHHHHHHHCCHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
GGYREIVLTGVDATSYGADLPGTPTLGLLAKTLLKQVPEILRLRLSSIDSIEADVHLLDL
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAEEPRFMPHLHLSLQHGDDLMLKRMKRRHSSADARAFCAEVLRLRPEISFSADMIAGFP
HHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC
TETEAMFQNAVRLAEDCGLAHLHVFPYSPRPGTPAARMPQLDRVLVKERAARLRAKGAEL
CHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
HTVHLERMVGSRQMVLVEMNGLAHTENFTLVDAAGLEPRSLVAAEITGHNGKHLTIKRKQ
EEEHHHHHHCCCEEEEEEECCCEECCCEEEEECCCCCCHHEEEEEEECCCCCEEEEEHHH
MAAA
HCCC
>Mature Secondary Structure 
SGVEVITFGCRLNTYESEVMRAEAEKAGLNNAVLVNTCAVTAEAVRQARQAIRRARREN
CCCEEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCC
PHARIIVTGCAAQTEKETFAEMAEVDAVLGNEEKLTSASYRSLPDFGVSAEEKLRVNDIM
CCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHEHHHHHH
SVRATAPQMVKHIDGHVRAFIQVQNGCDHRCTFCIIPYGRGNSRSVPMGAVVDQARRLVE
HHHHHHHHHHHHHCCHHEEEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
GGYREIVLTGVDATSYGADLPGTPTLGLLAKTLLKQVPEILRLRLSSIDSIEADVHLLDL
CCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IAEEPRFMPHLHLSLQHGDDLMLKRMKRRHSSADARAFCAEVLRLRPEISFSADMIAGFP
HHCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC
TETEAMFQNAVRLAEDCGLAHLHVFPYSPRPGTPAARMPQLDRVLVKERAARLRAKGAEL
CHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
HTVHLERMVGSRQMVLVEMNGLAHTENFTLVDAAGLEPRSLVAAEITGHNGKHLTIKRKQ
EEEHHHHHHCCCEEEEEEECCCEECCCEEEEECCCCCCHHEEEEEEECCCCCEEEEEHHH
MAAA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]