| Definition | Sinorhizobium medicae WSM419 chromosome, complete genome. |
|---|---|
| Accession | NC_009636 |
| Length | 3,781,904 |
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The map label for this gene is mrcA [H]
Identifier: 150396181
GI number: 150396181
Start: 1036481
End: 1038934
Strand: Direct
Name: mrcA [H]
Synonym: Smed_0960
Alternate gene names: 150396181
Gene position: 1036481-1038934 (Clockwise)
Preceding gene: 150396180
Following gene: 150396182
Centisome position: 27.41
GC content: 61.41
Gene sequence:
>2454_bases ATGATCAGACTGATTGGATATTTTTTCGGCATTGGTGCGTTTCTGCTGCTTGGCGCTGCCGCGGCCGTCGCCGTTTATCT CGGCGCCGTAACGAAGGACCTGCCGGATTACGAGGTGCTGGCCAATTATTCGCCTCCGGTGACGACGCGCTTTCATGCCG GCAACGGTGCATTGATGGCCGAATATGCACGTGAGCGCCGCTTGTATCTGCCGATCCAGGCGATACCCGATCGCGTCAAG GCTGCATTCATCTCGGCGGAGGACAAGAATTTCTACCGGCATCCCGGCATCGACGTGACCGGTCTGGCGCGCGCCATTGC CGTCAATCTGCAGAATCTCGGCTCCGGCCGGCGCCCGGTCGGTGCATCGACGATTACCCAGCAGGTCGCCAAGAACTTCC TTCTGAGTTCCGACCAGACATATGAGCGCAAGATCAAGGAAGCGATCCTCTCCTTCCGCATCGAACAGGCCTACAGCAAG GACCGGATTCTCGAACTTTATCTCAACGAGATTTTCTTCGGCCTCAATTCCTACGGCATAGCAGGGGCGGCGCTGACCTA TTTCGACAAGTCCGTAACCGAACTGACGATAGCCGAGACCGCCTATCTGGCGGCCCTGCCCAAGGGACCGGCCAATTATC ACCCGTACCGTAACGTCGAGGCTGCGATCGAGCGTCGCAACTGGGTCATAGATCGCATGGTCGAAAACGGCTATGTCACC AAGGCCGACGGCGAAGAGGCAAAACAGCAGCCGCTCGGCGTCTCGCCCCGCCGCGGCGGTGCACACCTTTTTGCTTCCGA CTTCTTTGCCGAGGAGGTGCGTCGGCAGATCATTCAGAAATACGGTGACAAGGCGCTTTACGAGGGCGGGCTTTCCGTGC GCACGTCTTTGGATCCACGGCTGCAGATCTCGGCACGCAAGGCGTTGCAGGCCGGGCTTTTGAGCTATGACGAGCGGCGT GGCTTTCACGGTCCTGTAAAAACGATCGAGATCGGCGGCGACTGGGGAGAGCCGCTGAGCAAGATTCCGAGGCTCAGCGA CGTGCCGGAATGGAAACTGGCGGTTGTCCTTTCGGTGGATAGCGAAGGCGCCGAAATCGGTATCCAGCCGGACAAGGAGG CCTCGGGCAAGATCGTGGCGGAACGGGTGACCGGGCGTATCGCGGCGAAGAACATGCAGTGGGCCTATCGCTCCGCAGGC GGAAAGCGCAAGACCGCAAAATCGCCGGAAGGGGTCGTCGGACCGGGCGACGTTATCTATGTCGAGCCGTTGGAAGAGGC GAGCGAGTATCGGCTGCGCCAGCCGCCGAAAGTGCAGGGTGGGCTGGTCGCAATGGATCCGCATACCGGCCGCGTGCTGG CTATGGTCGGCGGGTTCTCCTATGGGCAATCCGAATTCAACCGTGCAACCCAGGCAATGCGCCAGCCCGGCTCCGCTTTC AAGCCCTTCGTCTACGCTGCGGCCCTCGACAACGGCTATACGCCGGCATCGGTCATTCTGGATGCGCCGATCGAGATCGT TGCCGGCGGCCAGGTCTGGCGGCCCGAGAACTATGGCGGCGGTTCTGCCGGACCTTCGACGTTGCGTCTCGGCATCGAGA AATCGCGTAACCTGATGACGGTACGGCTCGCCAACGACCTGGGGATGAACATCGTCGCCGAATATGCCGAACGTTTCGGG ATCTACGACAAGATGGCGCCGCTTCTTGCAATGTCGCTCGGCTCCGGCGAAACGACCGTTCTGCGTCTCGTCTCCGCCTA TGCCGTCATCGCCAATGGCGGCAAGCAGATCAAGCCGTCGCTGATCGACCGCATCCAGGATCGCTACGGCAAAACCATTT TCCGCCACGAGGATCGCGCTTGCGAAAACTGCAATGCCGGCGACTGGGCGGAGCAGGAAGAGCCGGAGCTGATCGACAAG CGCGAACAGGTCCTCGATCCGATGACCTCCTATCAGATCACCTCCATGATGGAAGGCGTGGTCGCACGCGGGACGGCAGC GGGCAAGATCAAGCTGGACCGTCCCGTCGCGGGCAAGACCGGCACCACCAATGACGAGAAGGACGCCTGGTTCGTGGGCT ATACGCCGGATCTCGTTGCGGGGCTCTATCTCGGATTCGACGAACCGGCTCCGCTCGGTCGCGGAGCGACGGGCGGGGGC CTGGCAGCGCCGATCTTCAACACCTTCATGCAGAACGCCGTGGAGGGGACGCGTCCCGGCAAATTCGTGGTTCCCGAAGG CATGAGCCTCATTCCCGTCAACCGTAAGACCGGCATGGCGGCCGTCGAGGGCGAGCCGGATACGATTATCGAAGCCTTCA AGCCGGGCACCGGCCCTGCGGACACCTTCTCCGTCATTGGCGACCTGGACGAGTATGCACCGCCGGAAGAGATATTGAGG AGCTCTCCGCAGGCCAACCAGGCCGTAACCTCCGGCTCCAACGGCCTGTTCTGA
Upstream 100 bases:
>100_bases TCTTTTGAAAGAGTTTGGCGGGGTCGACTTCGTTCGCGGACCATGAGCTTACGGACACGATCCTGCAAAGGGACGATAAT AAGATACCGGTACCTGACTG
Downstream 100 bases:
>100_bases TTCCCTCCTTCCAGATGCATGTCGCCCGAAAGTGGATACCGGCTTCGGGAGCAAGATCTGCACGAACCAACATGATGCCC GTCGCCTTTACATCGGCGGC
Product: 1A family penicillin-binding protein
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 817; Mature: 817
Protein sequence:
>817_residues MIRLIGYFFGIGAFLLLGAAAAVAVYLGAVTKDLPDYEVLANYSPPVTTRFHAGNGALMAEYARERRLYLPIQAIPDRVK AAFISAEDKNFYRHPGIDVTGLARAIAVNLQNLGSGRRPVGASTITQQVAKNFLLSSDQTYERKIKEAILSFRIEQAYSK DRILELYLNEIFFGLNSYGIAGAALTYFDKSVTELTIAETAYLAALPKGPANYHPYRNVEAAIERRNWVIDRMVENGYVT KADGEEAKQQPLGVSPRRGGAHLFASDFFAEEVRRQIIQKYGDKALYEGGLSVRTSLDPRLQISARKALQAGLLSYDERR GFHGPVKTIEIGGDWGEPLSKIPRLSDVPEWKLAVVLSVDSEGAEIGIQPDKEASGKIVAERVTGRIAAKNMQWAYRSAG GKRKTAKSPEGVVGPGDVIYVEPLEEASEYRLRQPPKVQGGLVAMDPHTGRVLAMVGGFSYGQSEFNRATQAMRQPGSAF KPFVYAAALDNGYTPASVILDAPIEIVAGGQVWRPENYGGGSAGPSTLRLGIEKSRNLMTVRLANDLGMNIVAEYAERFG IYDKMAPLLAMSLGSGETTVLRLVSAYAVIANGGKQIKPSLIDRIQDRYGKTIFRHEDRACENCNAGDWAEQEEPELIDK REQVLDPMTSYQITSMMEGVVARGTAAGKIKLDRPVAGKTGTTNDEKDAWFVGYTPDLVAGLYLGFDEPAPLGRGATGGG LAAPIFNTFMQNAVEGTRPGKFVVPEGMSLIPVNRKTGMAAVEGEPDTIIEAFKPGTGPADTFSVIGDLDEYAPPEEILR SSPQANQAVTSGSNGLF
Sequences:
>Translated_817_residues MIRLIGYFFGIGAFLLLGAAAAVAVYLGAVTKDLPDYEVLANYSPPVTTRFHAGNGALMAEYARERRLYLPIQAIPDRVK AAFISAEDKNFYRHPGIDVTGLARAIAVNLQNLGSGRRPVGASTITQQVAKNFLLSSDQTYERKIKEAILSFRIEQAYSK DRILELYLNEIFFGLNSYGIAGAALTYFDKSVTELTIAETAYLAALPKGPANYHPYRNVEAAIERRNWVIDRMVENGYVT KADGEEAKQQPLGVSPRRGGAHLFASDFFAEEVRRQIIQKYGDKALYEGGLSVRTSLDPRLQISARKALQAGLLSYDERR GFHGPVKTIEIGGDWGEPLSKIPRLSDVPEWKLAVVLSVDSEGAEIGIQPDKEASGKIVAERVTGRIAAKNMQWAYRSAG GKRKTAKSPEGVVGPGDVIYVEPLEEASEYRLRQPPKVQGGLVAMDPHTGRVLAMVGGFSYGQSEFNRATQAMRQPGSAF KPFVYAAALDNGYTPASVILDAPIEIVAGGQVWRPENYGGGSAGPSTLRLGIEKSRNLMTVRLANDLGMNIVAEYAERFG IYDKMAPLLAMSLGSGETTVLRLVSAYAVIANGGKQIKPSLIDRIQDRYGKTIFRHEDRACENCNAGDWAEQEEPELIDK REQVLDPMTSYQITSMMEGVVARGTAAGKIKLDRPVAGKTGTTNDEKDAWFVGYTPDLVAGLYLGFDEPAPLGRGATGGG LAAPIFNTFMQNAVEGTRPGKFVVPEGMSLIPVNRKTGMAAVEGEPDTIIEAFKPGTGPADTFSVIGDLDEYAPPEEILR SSPQANQAVTSGSNGLF >Mature_817_residues MIRLIGYFFGIGAFLLLGAAAAVAVYLGAVTKDLPDYEVLANYSPPVTTRFHAGNGALMAEYARERRLYLPIQAIPDRVK AAFISAEDKNFYRHPGIDVTGLARAIAVNLQNLGSGRRPVGASTITQQVAKNFLLSSDQTYERKIKEAILSFRIEQAYSK DRILELYLNEIFFGLNSYGIAGAALTYFDKSVTELTIAETAYLAALPKGPANYHPYRNVEAAIERRNWVIDRMVENGYVT KADGEEAKQQPLGVSPRRGGAHLFASDFFAEEVRRQIIQKYGDKALYEGGLSVRTSLDPRLQISARKALQAGLLSYDERR GFHGPVKTIEIGGDWGEPLSKIPRLSDVPEWKLAVVLSVDSEGAEIGIQPDKEASGKIVAERVTGRIAAKNMQWAYRSAG GKRKTAKSPEGVVGPGDVIYVEPLEEASEYRLRQPPKVQGGLVAMDPHTGRVLAMVGGFSYGQSEFNRATQAMRQPGSAF KPFVYAAALDNGYTPASVILDAPIEIVAGGQVWRPENYGGGSAGPSTLRLGIEKSRNLMTVRLANDLGMNIVAEYAERFG IYDKMAPLLAMSLGSGETTVLRLVSAYAVIANGGKQIKPSLIDRIQDRYGKTIFRHEDRACENCNAGDWAEQEEPELIDK REQVLDPMTSYQITSMMEGVVARGTAAGKIKLDRPVAGKTGTTNDEKDAWFVGYTPDLVAGLYLGFDEPAPLGRGATGGG LAAPIFNTFMQNAVEGTRPGKFVVPEGMSLIPVNRKTGMAAVEGEPDTIIEAFKPGTGPADTFSVIGDLDEYAPPEEILR SSPQANQAVTSGSNGLF
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=846, Percent_Identity=32.6241134751773, Blast_Score=420, Evalue=1e-118, Organism=Escherichia coli, GI1786343, Length=260, Percent_Identity=36.5384615384615, Blast_Score=159, Evalue=5e-40, Organism=Escherichia coli, GI1788867, Length=187, Percent_Identity=36.3636363636364, Blast_Score=115, Evalue=2e-26, Organism=Escherichia coli, GI1789601, Length=169, Percent_Identity=36.6863905325444, Blast_Score=99, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 88589; Mature: 88589
Theoretical pI: Translated: 6.26; Mature: 6.26
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIRLIGYFFGIGAFLLLGAAAAVAVYLGAVTKDLPDYEVLANYSPPVTTRFHAGNGALMA CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCEEEEECCCCCHHH EYARERRLYLPIQAIPDRVKAAFISAEDKNFYRHPGIDVTGLARAIAVNLQNLGSGRRPV HHHHCCEEEEEHHHCCHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC GASTITQQVAKNFLLSSDQTYERKIKEAILSFRIEQAYSKDRILELYLNEIFFGLNSYGI CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCC AGAALTYFDKSVTELTIAETAYLAALPKGPANYHPYRNVEAAIERRNWVIDRMVENGYVT HHHHHHHHHCHHHHEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE KADGEEAKQQPLGVSPRRGGAHLFASDFFAEEVRRQIIQKYGDKALYEGGLSVRTSLDPR CCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCC LQISARKALQAGLLSYDERRGFHGPVKTIEIGGDWGEPLSKIPRLSDVPEWKLAVVLSVD EEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCEEEEEEEEEC SEGAEIGIQPDKEASGKIVAERVTGRIAAKNMQWAYRSAGGKRKTAKSPEGVVGPGDVIY CCCCEECCCCCCCCCCCEEHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEE VEPLEEASEYRLRQPPKVQGGLVAMDPHTGRVLAMVGGFSYGQSEFNRATQAMRQPGSAF ECCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC KPFVYAAALDNGYTPASVILDAPIEIVAGGQVWRPENYGGGSAGPSTLRLGIEKSRNLMT CCEEEEEECCCCCCCHHEEEECCEEEEECCEEECCCCCCCCCCCCHHEEEEECCCCCEEE VRLANDLGMNIVAEYAERFGIYDKMAPLLAMSLGSGETTVLRLVSAYAVIANGGKQIKPS EEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH LIDRIQDRYGKTIFRHEDRACENCNAGDWAEQEEPELIDKREQVLDPMTSYQITSMMEGV HHHHHHHHHCCHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH VARGTAAGKIKLDRPVAGKTGTTNDEKDAWFVGYTPDLVAGLYLGFDEPAPLGRGATGGG HHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCC LAAPIFNTFMQNAVEGTRPGKFVVPEGMSLIPVNRKTGMAAVEGEPDTIIEAFKPGTGPA HHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCCEEECCCCHHHHHHCCCCCCCH DTFSVIGDLDEYAPPEEILRSSPQANQAVTSGSNGLF HHHHHHHCHHHCCCHHHHHHCCCCCHHHHCCCCCCCC >Mature Secondary Structure MIRLIGYFFGIGAFLLLGAAAAVAVYLGAVTKDLPDYEVLANYSPPVTTRFHAGNGALMA CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCCEEEEECCCCCHHH EYARERRLYLPIQAIPDRVKAAFISAEDKNFYRHPGIDVTGLARAIAVNLQNLGSGRRPV HHHHCCEEEEEHHHCCHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC GASTITQQVAKNFLLSSDQTYERKIKEAILSFRIEQAYSKDRILELYLNEIFFGLNSYGI CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCC AGAALTYFDKSVTELTIAETAYLAALPKGPANYHPYRNVEAAIERRNWVIDRMVENGYVT HHHHHHHHHCHHHHEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEE KADGEEAKQQPLGVSPRRGGAHLFASDFFAEEVRRQIIQKYGDKALYEGGLSVRTSLDPR CCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCC LQISARKALQAGLLSYDERRGFHGPVKTIEIGGDWGEPLSKIPRLSDVPEWKLAVVLSVD EEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCCCCCCEEEEEEEEEC SEGAEIGIQPDKEASGKIVAERVTGRIAAKNMQWAYRSAGGKRKTAKSPEGVVGPGDVIY CCCCEECCCCCCCCCCCEEHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEE VEPLEEASEYRLRQPPKVQGGLVAMDPHTGRVLAMVGGFSYGQSEFNRATQAMRQPGSAF ECCHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC KPFVYAAALDNGYTPASVILDAPIEIVAGGQVWRPENYGGGSAGPSTLRLGIEKSRNLMT CCEEEEEECCCCCCCHHEEEECCEEEEECCEEECCCCCCCCCCCCHHEEEEECCCCCEEE VRLANDLGMNIVAEYAERFGIYDKMAPLLAMSLGSGETTVLRLVSAYAVIANGGKQIKPS EEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHH LIDRIQDRYGKTIFRHEDRACENCNAGDWAEQEEPELIDKREQVLDPMTSYQITSMMEGV HHHHHHHHHCCHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH VARGTAAGKIKLDRPVAGKTGTTNDEKDAWFVGYTPDLVAGLYLGFDEPAPLGRGATGGG HHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCC LAAPIFNTFMQNAVEGTRPGKFVVPEGMSLIPVNRKTGMAAVEGEPDTIIEAFKPGTGPA HHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCCEEECCCCHHHHHHCCCCCCCH DTFSVIGDLDEYAPPEEILRSSPQANQAVTSGSNGLF HHHHHHHCHHHCCCHHHHHHCCCCCHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA